MX393997B - Factores de coagulacion de accion prolongada y metodos de produccion de los mismos. - Google Patents

Factores de coagulacion de accion prolongada y metodos de produccion de los mismos.

Info

Publication number
MX393997B
MX393997B MX2019000708A MX2019000708A MX393997B MX 393997 B MX393997 B MX 393997B MX 2019000708 A MX2019000708 A MX 2019000708A MX 2019000708 A MX2019000708 A MX 2019000708A MX 393997 B MX393997 B MX 393997B
Authority
MX
Mexico
Prior art keywords
methods
production
long
coagulation factors
acting coagulation
Prior art date
Application number
MX2019000708A
Other languages
English (en)
Other versions
MX2019000708A (es
Inventor
Gili Hart
Udi Eyal Fima
Original Assignee
Opko Biologics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48983616&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX393997(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US13/372,540 external-priority patent/US8759292B2/en
Application filed by Opko Biologics Ltd filed Critical Opko Biologics Ltd
Publication of MX2019000708A publication Critical patent/MX2019000708A/es
Publication of MX393997B publication Critical patent/MX393997B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Glass Compositions (AREA)

Abstract

Se describen polipéptidos que comprenden al menos un péptido de extremo carboxi (CTP) de gonadotropina coriónica unida al extremo carboxi pero no al extremo amino de un factor de coagulación y polinucleótidos que codifican los mismos. También se describen composiciones farmacéuticas que comprenden los polipéptidos y polinucleótidos de la invención y métodos de utilización y producción de los mismos.
MX2019000708A 2012-02-14 2013-02-05 Factores de coagulacion de accion prolongada y metodos de produccion de los mismos. MX393997B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13/372,540 US8759292B2 (en) 2006-02-03 2012-02-14 Long-acting coagulation factors and methods of producing same
PCT/IL2013/050107 WO2013121416A1 (en) 2012-02-14 2013-02-05 Long-acting coagulation factors and methods of producing same

Publications (2)

Publication Number Publication Date
MX2019000708A MX2019000708A (es) 2020-09-02
MX393997B true MX393997B (es) 2025-03-24

Family

ID=48983616

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2019000708A MX393997B (es) 2012-02-14 2013-02-05 Factores de coagulacion de accion prolongada y metodos de produccion de los mismos.
MX2014009910A MX362446B (es) 2012-02-14 2013-02-05 Factores de coagulacion de accion prolongada y metodos de produccion de los mismos.
MX2022008807A MX2022008807A (es) 2012-02-14 2014-08-14 Factores de coagulacion de accion prolongada y metodos de produccion de los mismos.

Family Applications After (2)

Application Number Title Priority Date Filing Date
MX2014009910A MX362446B (es) 2012-02-14 2013-02-05 Factores de coagulacion de accion prolongada y metodos de produccion de los mismos.
MX2022008807A MX2022008807A (es) 2012-02-14 2014-08-14 Factores de coagulacion de accion prolongada y metodos de produccion de los mismos.

Country Status (22)

Country Link
EP (4) EP4488289A3 (es)
JP (2) JP6242819B2 (es)
KR (3) KR102630953B1 (es)
CN (2) CN104427994A (es)
AU (3) AU2013219935B2 (es)
BR (1) BR122021004014B1 (es)
CA (1) CA2870621C (es)
CL (2) CL2014002183A1 (es)
CO (1) CO7131365A2 (es)
DK (2) DK2822576T3 (es)
EA (2) EA201790960A3 (es)
ES (3) ES2665319T3 (es)
HU (1) HUE053068T2 (es)
IL (2) IL264959B (es)
MX (3) MX393997B (es)
MY (1) MY172539A (es)
NO (1) NO2920022T3 (es)
PE (1) PE20142290A1 (es)
PL (2) PL3326642T3 (es)
PT (1) PT3791890T (es)
SG (1) SG11201404836QA (es)
WO (1) WO2013121416A1 (es)

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US9249407B2 (en) 2006-02-03 2016-02-02 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
WO2013121416A1 (en) * 2012-02-14 2013-08-22 Prolor Biotech Inc. Long-acting coagulation factors and methods of producing same
US12203113B2 (en) 2009-07-09 2025-01-21 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US9663778B2 (en) 2009-07-09 2017-05-30 OPKO Biologies Ltd. Long-acting coagulation factors and methods of producing same
US20150158926A1 (en) 2013-10-21 2015-06-11 Opko Biologics, Ltd. Long-acting polypeptides and methods of producing and administering same
WO2016092550A2 (en) * 2014-12-10 2016-06-16 Opko Biologics Ltd. Methods of producing long acting ctp-modified polypeptides
EP3988113A1 (en) * 2015-06-19 2022-04-27 OPKO Biologics Ltd. Long-acting coagulation factors and methods of producing same
AU2016301303B2 (en) 2015-08-03 2021-10-07 Bioverativ Therapeutics Inc. Factor IX fusion proteins and methods of making and using same
BR112019000610A2 (pt) * 2016-07-11 2019-07-02 Opko Biologics Ltd fator vii de coagulação de longa ação e métodos de produção do mesmo
CN107759694B (zh) 2016-08-19 2023-01-13 安源医药科技（上海）有限公司 双特异性抗体及其制备方法与用途
US11123438B2 (en) 2016-08-19 2021-09-21 Ampsource Biopharma Shanghai Inc. Linker peptide for constructing fusion protein
CN106279437B (zh) * 2016-08-19 2017-10-31 安源医药科技（上海）有限公司 高糖基化人凝血因子viii融合蛋白及其制备方法与用途
US11981718B2 (en) 2020-05-27 2024-05-14 Ampsource Biopharma Shanghai Inc. Dual-function protein for lipid and blood glucose regulation

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Also Published As

Publication number Publication date
HK1205460A1 (en) 2015-12-18
MX2022008807A (es) 2022-08-11
BR112014020198A2 (pt) 2018-05-15
EA201790960A3 (ru) 2018-01-31
ES2855133T3 (es) 2021-09-23
EP2822576B1 (en) 2018-01-10
DK3326642T3 (da) 2021-02-22
KR20200063274A (ko) 2020-06-04
MX2019000708A (es) 2020-09-02
EA201790960A2 (ru) 2017-09-29
MX2014009910A (es) 2015-09-28
AU2013219935A1 (en) 2014-09-25
EP2822576A1 (en) 2015-01-14
CL2017002233A1 (es) 2018-05-11
AU2013219935B2 (en) 2016-02-04
CA2870621C (en) 2022-08-09
AU2017219044A1 (en) 2017-09-14
CA2870621A1 (en) 2013-08-22
EP2822576A4 (en) 2015-11-25
MY172539A (en) 2019-11-30
KR102630953B1 (ko) 2024-01-29
PL3326642T3 (pl) 2021-06-14
AU2017219044B2 (en) 2019-05-30
CN109535245A (zh) 2019-03-29
KR102310704B1 (ko) 2021-10-08
MX362446B (es) 2019-01-18
JP2018065815A (ja) 2018-04-26
EA028578B1 (ru) 2017-12-29
EP4488289A3 (en) 2025-03-19
SG11201404836QA (en) 2014-12-30
CN104427994A (zh) 2015-03-18
BR122021004014B1 (pt) 2022-12-27
EP3326642A1 (en) 2018-05-30
NO2920022T3 (es) 2018-06-09
EP3791890A1 (en) 2021-03-17
HUE053068T2 (hu) 2021-06-28
EA201491519A1 (ru) 2014-12-30
AU2016202829B2 (en) 2017-05-25
AU2016202829A1 (en) 2016-05-19
PE20142290A1 (es) 2015-01-15
IL282121A (en) 2021-05-31
JP2015508771A (ja) 2015-03-23
CO7131365A2 (es) 2014-12-01
KR102118729B1 (ko) 2020-06-05
WO2013121416A1 (en) 2013-08-22
JP6510002B2 (ja) 2019-05-08
PL3791890T3 (pl) 2025-04-14
ES3010346T3 (en) 2025-04-02
ES2665319T3 (es) 2018-04-25
EP4488289A2 (en) 2025-01-08
KR20140134673A (ko) 2014-11-24
JP6242819B2 (ja) 2017-12-06
IL282121B (en) 2022-06-01
PT3791890T (pt) 2025-02-14
IL264959B (en) 2021-08-31
KR20210125595A (ko) 2021-10-18
EP3326642B1 (en) 2020-11-25
EP3791890B1 (en) 2024-11-13
DK2822576T3 (en) 2018-04-16
CL2014002183A1 (es) 2015-01-09

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