MX393138B - Compuestos de microarn y metodos para modular la actividad de mir-21. - Google Patents
Compuestos de microarn y metodos para modular la actividad de mir-21.Info
- Publication number
- MX393138B MX393138B MX2019003090A MX2019003090A MX393138B MX 393138 B MX393138 B MX 393138B MX 2019003090 A MX2019003090 A MX 2019003090A MX 2019003090 A MX2019003090 A MX 2019003090A MX 393138 B MX393138 B MX 393138B
- Authority
- MX
- Mexico
- Prior art keywords
- activity
- mir
- methods
- compositions
- modulating mir
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/343—Spatial arrangement of the modifications having patterns, e.g. ==--==--==--
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161478767P | 2011-04-25 | 2011-04-25 | |
| US201161565779P | 2011-12-01 | 2011-12-01 | |
| PCT/US2012/034880 WO2012148952A1 (en) | 2011-04-25 | 2012-04-25 | Microrna compounds and methods for modulating mir-21 activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2019003090A MX2019003090A (es) | 2019-07-18 |
| MX393138B true MX393138B (es) | 2025-03-24 |
Family
ID=46025979
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019003090A MX393138B (es) | 2011-04-25 | 2012-04-25 | Compuestos de microarn y metodos para modular la actividad de mir-21. |
| MX2013012452A MX2013012452A (es) | 2011-04-25 | 2012-04-25 | Compuestos de microarn y metodos para modular la actividad de mir-21. |
| MX2019003089A MX2019003089A (es) | 2011-04-25 | 2013-10-23 | Compuestos de microarn y metodos para modular la actividad de mir-21. |
| MX2022000212A MX2022000212A (es) | 2011-04-25 | 2013-10-23 | Compuestos de microarn y metodos para modular la actividad de mir-21. |
| MX2022006595A MX2022006595A (es) | 2011-04-25 | 2013-10-23 | Compuestos de microarn y metodos para modular la actividad de mir-21. |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013012452A MX2013012452A (es) | 2011-04-25 | 2012-04-25 | Compuestos de microarn y metodos para modular la actividad de mir-21. |
| MX2019003089A MX2019003089A (es) | 2011-04-25 | 2013-10-23 | Compuestos de microarn y metodos para modular la actividad de mir-21. |
| MX2022000212A MX2022000212A (es) | 2011-04-25 | 2013-10-23 | Compuestos de microarn y metodos para modular la actividad de mir-21. |
| MX2022006595A MX2022006595A (es) | 2011-04-25 | 2013-10-23 | Compuestos de microarn y metodos para modular la actividad de mir-21. |
Country Status (30)
| Country | Link |
|---|---|
| US (7) | US9181547B2 (enExample) |
| EP (3) | EP3933040A1 (enExample) |
| JP (2) | JP6320292B2 (enExample) |
| KR (2) | KR20190063482A (enExample) |
| CN (3) | CN113151272A (enExample) |
| AU (4) | AU2012249851B2 (enExample) |
| BR (1) | BR112013027187A2 (enExample) |
| CA (2) | CA3165397A1 (enExample) |
| CL (1) | CL2013003105A1 (enExample) |
| CO (1) | CO6821889A2 (enExample) |
| CY (1) | CY1120304T1 (enExample) |
| DK (2) | DK3211082T3 (enExample) |
| EA (1) | EA025894B1 (enExample) |
| ES (2) | ES2868950T3 (enExample) |
| HR (2) | HRP20170557T2 (enExample) |
| HU (2) | HUE054129T2 (enExample) |
| IL (3) | IL229032B (enExample) |
| LT (2) | LT3211082T (enExample) |
| MX (5) | MX393138B (enExample) |
| MY (2) | MY187685A (enExample) |
| NZ (1) | NZ717921A (enExample) |
| PH (1) | PH12013502199A1 (enExample) |
| PL (2) | PL2702155T3 (enExample) |
| PT (2) | PT3211082T (enExample) |
| RS (1) | RS61775B1 (enExample) |
| SG (1) | SG194636A1 (enExample) |
| SI (2) | SI2702155T1 (enExample) |
| TW (2) | TWI607016B (enExample) |
| UA (1) | UA115652C2 (enExample) |
| WO (1) | WO2012148952A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2534300T3 (es) | 2004-11-12 | 2015-04-21 | Asuragen, Inc. | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
| MX393138B (es) | 2011-04-25 | 2025-03-24 | Sanofi Sa | Compuestos de microarn y metodos para modular la actividad de mir-21. |
| US9193971B2 (en) * | 2012-04-10 | 2015-11-24 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Methods for the treatment of nonalcoholic steatohepatitis |
| MY173600A (en) | 2012-04-25 | 2020-02-08 | Sanofi Sa | Microrna compounds and methods for modulating mir-21 activity |
| UA116639C2 (uk) | 2012-10-09 | 2018-04-25 | РДг'ĐźĐ»Đ”Ń ĐąĐ”ŃĐ°Đż'ĐźŃŃĐșŃ ĐĐœĐș. | ĐĄĐżĐŸŃĐŸĐ±Đž Đ»ŃĐșŃĐČĐ°ĐœĐœŃ ŃĐžĐœĐŽŃĐŸĐŒŃ Đ°Đ»ŃĐżĐŸŃŃĐ° |
| CA2889044A1 (en) | 2012-11-15 | 2014-05-22 | Roche Innovation Center Copenhagen A/S | Anti apob antisense conjugate compounds |
| JP2016518842A (ja) | 2013-05-01 | 2016-06-30 | ăŹă°ă«ăč ă»ă©ăă„ăŒăăŁăŻăč ă€ăłăłăŒăăŹă€ăăă | ăă€ăŻăïŒČïŒźïŒĄććç©ăăăłïœïœïŒČâïŒïŒïŒăăąăžă„ăŹăŒăăăæčæł |
| WO2015061536A1 (en) * | 2013-10-25 | 2015-04-30 | Regulus Therapeutics Inc. | Microrna compounds and methods for modulating mir-21 activity |
| KR101625755B1 (ko) | 2013-11-18 | 2016-05-30 | ìžì°ëíê” ì°ííë „ëš | ïœïœïŒČïŒźïŒĄ ì€í°ì§ ë° ìŽì ì©ë |
| US10358643B2 (en) * | 2014-01-30 | 2019-07-23 | Hoffmann-La Roche, Inc. | Poly oligomer compound with biocleavable conjugates |
| CN105734127A (zh) * | 2016-02-29 | 2016-07-06 | äžæ”·äžć»èŻć€§ćŠ | miR-21-3pćšć¶ć€çšäșæŁæ”æ©ææ„æ§èŸæ䌀çèŻćäžççšé |
| EP3449001B1 (en) * | 2016-04-29 | 2021-12-08 | Aptamir Therapeutics, Inc. | Inhibition of mir-22 mirna by apt-110 |
| US20180193270A1 (en) | 2016-11-29 | 2018-07-12 | PureTech Health LLC | Exosomes for delivery of therapeutic agents |
| DK3684949T3 (en) | 2017-09-22 | 2024-07-08 | Univ Washington | In situ combinatorial labeling of cellular molecules |
| CN108148911B (zh) * | 2018-03-02 | 2019-11-05 | ćčżć·ć»ç§ć€§ćŠéć±çŹŹäșć»éą | miR-582ćšć¶ć€ććè șçéȘšèœŹç§»çèŻæăéąćèŻćçćèŻç©äžçćșçš |
| TWI854980B (zh) | 2018-05-08 | 2024-09-11 | çŸćé·æ ŒćæŻæČ»çć Źćž | çšæŒèȘżçŻmir-122äčćŸźć°rnaććç©ćæčæł |
| CN110747266A (zh) * | 2018-07-23 | 2020-02-04 | æ·±ćłć èżææŻç ç©¶éą | miR-21ćmiR-21æźæććšæć¶éąéČ/æČ»ç1ćçłć°żç äžçćșçš |
| CN109880907A (zh) * | 2019-03-26 | 2019-06-14 | äžćœäșșæ°è§ŁæŸćçŹŹć «äžć»éą | äžç§èçç»è䟔èąèœŹç§»çććæșć¶ç 究æčæł |
| US11965162B2 (en) | 2020-04-16 | 2024-04-23 | The Johns Hopkins University | MicroRNA and inhibitors thereof and methods of treatment |
| WO2022165092A1 (en) * | 2021-01-29 | 2022-08-04 | Angion Biomedica Corp. | Methods for treatment of fibrotic diseases |
| CN122295113A (zh) * | 2023-11-22 | 2026-06-26 | ćœç«ć€§ćŠæłäșșäžæ”·ćœç«ć€§ćŠæșæ | ćæ§èŸç çéąéČć/ææČ»çć |
| CN120505413A (zh) * | 2025-07-15 | 2025-08-19 | æčćć·„çšćŠéą | äžç§ćșäșćŒç©äș€æąććșćG-ćéŸäœæŁæ”AKIçžć łmiRNAçæąéäœçł»ćæčæł |
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| ES2285841T3 (es) | 1998-05-22 | 2007-11-16 | Boys Town National Research Hospital | Uso de inhibidores del receptor de integrina alfa1beta1 e inhibidores de tgf-beta1 en el tratamiento de la enfermedad renal. |
| US20060008817A1 (en) * | 2000-12-08 | 2006-01-12 | Invitrogen Corporation | Methods and compositions for generating recombinant nucleic acid molecules |
| EP2428570B1 (en) | 2001-09-28 | 2018-05-23 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Microrna molecules |
| CA2504694C (en) | 2002-11-05 | 2013-10-01 | Isis Pharmaceuticals, Inc. | Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation |
| US20050124591A1 (en) | 2003-07-29 | 2005-06-09 | Jin Tian | Use of vitamin Ds to treat kidney disease |
| WO2005013901A2 (en) * | 2003-07-31 | 2005-02-17 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and compositions for use in modulation of small non-coding rnas |
| DK1661905T3 (da) | 2003-08-28 | 2012-07-23 | Takeshi Imanishi | Hidtil ukendte syntetiske nukleinsyrer af N-O-krydsbindingstype |
| EP2990410A1 (en) | 2004-08-10 | 2016-03-02 | Alnylam Pharmaceuticals Inc. | Chemically modified oligonucleotides |
| US20080187508A1 (en) | 2004-09-08 | 2008-08-07 | Boys Town National Research Hospital | Treatment of Golmerular Basement Membrane Disease Involving Matrix Metalloproteinase-12 |
| ES2534300T3 (es) | 2004-11-12 | 2015-04-21 | Asuragen, Inc. | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
| US20070099196A1 (en) | 2004-12-29 | 2007-05-03 | Sakari Kauppinen | Novel oligonucleotide compositions and probe sequences useful for detection and analysis of micrornas and their target mRNAs |
| US6995235B1 (en) | 2005-05-02 | 2006-02-07 | Univation Technologies, Llc | Methods of producing polyolefins and films therefrom |
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| DE602007009487D1 (de) | 2006-01-27 | 2010-11-11 | Isis Pharmaceutical Inc | 6-modifizierte bicyclische nukleinsÀureanaloga |
| EP2388328A1 (en) | 2006-01-27 | 2011-11-23 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and compositions for the use in modulation of micrornas |
| CA3042781C (en) | 2006-04-03 | 2021-10-19 | Roche Innovation Center Copenhagen A/S | Pharmaceutical composition comprising anti-mirna antisense oligonucleotides |
| EA201100811A1 (ru) * | 2006-04-03 | 2012-06-29 | ĐĄĐ°ĐœŃĐ°ŃĐžŃ Đ€Đ°ŃĐŒĐ° Đ/ĐĄ | ЀаŃĐŒĐ°ŃĐ”ĐČŃĐžŃĐ”ŃĐșĐ°Ń ĐșĐŸĐŒĐżĐŸĐ·ĐžŃĐžŃ |
| CA3144493A1 (en) | 2006-10-03 | 2008-04-10 | Arbutus Biopharma Corporation | Lipid containing formulations |
| JP2010505427A (ja) | 2006-10-09 | 2010-02-25 | ăžă„ăȘăąăčâăăă·ăăȘăąăłășâăŠăăă«ă·ăżăă ăŻăŒășăă«ă° | ćżçŸæŁăźèšșæćăłæČ»ççšăă€ăŻăïŒČïŒźïŒĄïŒïœïœïŒČïŒźïŒĄïŒ |
| EP2104735A2 (en) | 2006-12-08 | 2009-09-30 | Asuragen, INC. | Mir-21 regulated genes and pathways as targets for therapeutic intervention |
| WO2008086807A2 (en) | 2007-01-19 | 2008-07-24 | Exiqon A/S | Mediated cellular delivery of lna oligonucleotides |
| DK2170917T3 (da) | 2007-05-30 | 2012-10-08 | Isis Pharmaceuticals Inc | N-Substituerede bicycliske nukleinsyreanaloge med aminomethylenbro |
| WO2008154401A2 (en) | 2007-06-08 | 2008-12-18 | Isis Pharmaceuticals, Inc. | Carbocyclic bicyclic nucleic acid analogs |
| US20100261175A1 (en) | 2007-06-15 | 2010-10-14 | Exiqon A/S | Use of short oligonucleotides for reagent redundancy experiments in rna functional analysis |
| AU2008272918B2 (en) | 2007-07-05 | 2012-09-13 | Isis Pharmaceuticals, Inc. | 6-disubstituted bicyclic nucleic acid analogs |
| DK2205737T3 (da) * | 2007-10-04 | 2013-05-21 | Santaris Pharma As | Mikromirer |
| CN101980712B (zh) | 2007-10-29 | 2015-02-18 | é·ć€ææŻæČ»çć Źćž | çšäșèçæČ»ççé¶ććŸźć°rna |
| WO2009091972A2 (en) | 2008-01-18 | 2009-07-23 | Alnylam Pharmaceuticals, Inc. | Chemically modified oligonucleotides and small molecules for use in reducing micro rna activity levels and uses thereof |
| JP2011510678A (ja) | 2008-02-08 | 2011-04-07 | ăăă»ăłă” ăăŒă«ăăŁăłă° ăăŒă〠| ïœïœććŸ©äžćźćźæ§éąéŁéșäŒæ§éćźłăæČ»çăăăăăźæčæłćăłææź” |
| EP2096171A1 (en) * | 2008-02-27 | 2009-09-02 | Julius-Maximilians-UniversitĂ€t WĂŒrzburg | MicroRNA (miRNA) and down-stream targets for diagnostic and therapeutic purposes |
| EP2268811A1 (en) | 2008-03-07 | 2011-01-05 | Santaris Pharma A/S | Pharmaceutical compositions for treatment of microrna related diseases |
| JP2012518997A (ja) * | 2009-02-26 | 2012-08-23 | ăžă»ăȘăă€ăȘă»ăčăă€ăă»ăŠăăăŒă·ăăŁă»ăȘă”ăŒăă»ăăĄăŠăłăă€ă·ă§ăł | ć«ç æȘç”éšè ă«ăăăăă€ăŻăïœïœïœăăȘăăłă«éąéŁăăææăăăłæčæł |
| MA33488B1 (fr) * | 2009-06-08 | 2012-08-01 | Miragen Therapeutics | Motifs de modification chimique pour des inhibiteurs et mimétiques de miarn |
| WO2011126842A2 (en) | 2010-03-30 | 2011-10-13 | Regulus Therapeutics Inc. | Targeting micrornas for the treatment of cardiac disorders |
| MX393138B (es) | 2011-04-25 | 2025-03-24 | Sanofi Sa | Compuestos de microarn y metodos para modular la actividad de mir-21. |
| WO2013013165A2 (en) | 2011-07-21 | 2013-01-24 | The Trustees Of The University Of Pennsylvania | Use of lna compounds for therapeutic inhibition of mir-21 in systemic lupus erythematosus |
| MY173600A (en) | 2012-04-25 | 2020-02-08 | Sanofi Sa | Microrna compounds and methods for modulating mir-21 activity |
| EP2864482A4 (en) | 2012-06-21 | 2016-02-10 | Miragen Therapeutics Inc | OLIGONUCLEOTIDE INHIBITORS COMPRISING A BLOCKED NUCLEIC ACID PATTERN |
| CN104955950B (zh) | 2012-09-26 | 2019-04-26 | 米ć°ć æŻæČ»çćŠć Źćž | ć ·ææčćçè±é¶çčćŸè°±çćŻĄæ žè·é ž |
| UA116639C2 (uk) | 2012-10-09 | 2018-04-25 | РДг'ĐźĐ»Đ”Ń ĐąĐ”ŃĐ°Đż'ĐźŃŃĐșŃ ĐĐœĐș. | ĐĄĐżĐŸŃĐŸĐ±Đž Đ»ŃĐșŃĐČĐ°ĐœĐœŃ ŃĐžĐœĐŽŃĐŸĐŒŃ Đ°Đ»ŃĐżĐŸŃŃĐ° |
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