CA3165397A1 - Microrna compounds and methods for modulating mir-21 activity - Google Patents

Microrna compounds and methods for modulating mir-21 activity Download PDF

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Publication number
CA3165397A1
CA3165397A1 CA3165397A CA3165397A CA3165397A1 CA 3165397 A1 CA3165397 A1 CA 3165397A1 CA 3165397 A CA3165397 A CA 3165397A CA 3165397 A CA3165397 A CA 3165397A CA 3165397 A1 CA3165397 A1 CA 3165397A1
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nucleoside
certain embodiments
compound
mir
modified
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French (fr)
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Balkrishen Bhat
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Sanofi SA
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Sanofi SA
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/7088Compounds having three or more nucleosides or nucleotides
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    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
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    • A61P35/00Antineoplastic agents
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    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
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    • C12N2310/10Type of nucleic acid
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/32Chemical structure of the sugar
    • C12N2310/323Chemical structure of the sugar modified ring structure
    • C12N2310/3231Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/34Spatial arrangement of the modifications
    • C12N2310/343Spatial arrangement of the modifications having patterns, e.g. ==--==--==--
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/35Nature of the modification

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CA3165397A 2011-04-25 2012-04-25 Microrna compounds and methods for modulating mir-21 activity Pending CA3165397A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161478767P 2011-04-25 2011-04-25
US61/478,767 2011-04-25
US201161565779P 2011-12-01 2011-12-01
US61/565,779 2011-12-01
CA2833615A CA2833615C (en) 2011-04-25 2012-04-25 Microrna compounds and methods for modulating mir-21 activity

Related Parent Applications (1)

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CA2833615A Division CA2833615C (en) 2011-04-25 2012-04-25 Microrna compounds and methods for modulating mir-21 activity

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CA3165397A1 true CA3165397A1 (en) 2012-11-01

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CA2833615A Active CA2833615C (en) 2011-04-25 2012-04-25 Microrna compounds and methods for modulating mir-21 activity
CA3165397A Pending CA3165397A1 (en) 2011-04-25 2012-04-25 Microrna compounds and methods for modulating mir-21 activity

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US (7) US9181547B2 (enExample)
EP (3) EP2702155B9 (enExample)
JP (2) JP6320292B2 (enExample)
KR (2) KR20190063482A (enExample)
CN (3) CN113151272A (enExample)
AU (4) AU2012249851B2 (enExample)
BR (1) BR112013027187A2 (enExample)
CA (2) CA2833615C (enExample)
CL (1) CL2013003105A1 (enExample)
CO (1) CO6821889A2 (enExample)
CY (1) CY1120304T1 (enExample)
DK (2) DK2702155T3 (enExample)
EA (1) EA025894B1 (enExample)
ES (2) ES2868950T3 (enExample)
HR (2) HRP20170557T2 (enExample)
HU (2) HUE054129T2 (enExample)
IL (3) IL229032B (enExample)
LT (2) LT2702155T (enExample)
MX (5) MX393138B (enExample)
MY (2) MY187685A (enExample)
NZ (1) NZ717921A (enExample)
PH (1) PH12013502199A1 (enExample)
PL (2) PL3211082T3 (enExample)
PT (2) PT3211082T (enExample)
RS (1) RS61775B1 (enExample)
SG (1) SG194636A1 (enExample)
SI (2) SI3211082T1 (enExample)
TW (2) TWI698445B (enExample)
UA (1) UA115652C2 (enExample)
WO (1) WO2012148952A1 (enExample)

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WO2012148952A1 (en) 2012-11-01
AU2020201403A1 (en) 2020-03-12
DK3211082T3 (da) 2021-05-10
CN113249381A (zh) 2021-08-13
TWI607016B (zh) 2017-12-01
TW201300404A (zh) 2013-01-01
US20120270928A1 (en) 2012-10-25
IL273381A (en) 2020-05-31
AU2012249851A1 (en) 2013-10-31
AU2017219156A1 (en) 2017-09-21
UA115652C2 (uk) 2017-12-11
LT2702155T (lt) 2017-05-10
US20200291400A1 (en) 2020-09-17
PT3211082T (pt) 2021-04-28
EP2702155B9 (en) 2020-01-01
AU2012249851A8 (en) 2013-11-14
US12331294B2 (en) 2025-06-17
US8912161B2 (en) 2014-12-16
EP3933040A1 (en) 2022-01-05
CA2833615A1 (en) 2012-11-01
JP2014518619A (ja) 2014-08-07
ES2868950T3 (es) 2021-10-22
EA201391492A1 (ru) 2014-04-30
KR20140033062A (ko) 2014-03-17
DK2702155T3 (en) 2017-05-01
HRP20170557T2 (hr) 2020-02-21
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US20160138016A1 (en) 2016-05-19
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EA025894B1 (ru) 2017-02-28
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CA2833615C (en) 2022-08-30
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US20140107183A1 (en) 2014-04-17
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SI3211082T1 (sl) 2021-08-31
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