MX392340B - Anticuerpo anti cd73 humana. - Google Patents

Anticuerpo anti cd73 humana.

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Publication number
MX392340B
MX392340B MX2019006897A MX2019006897A MX392340B MX 392340 B MX392340 B MX 392340B MX 2019006897 A MX2019006897 A MX 2019006897A MX 2019006897 A MX2019006897 A MX 2019006897A MX 392340 B MX392340 B MX 392340B
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Mexico
Prior art keywords
amino acid
seq
acid sequence
sequence composed
acid residues
Prior art date
Application number
MX2019006897A
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English (en)
Other versions
MX2019006897A (es
Inventor
Fumio Osaki
Hanae Toyonaga
Masahito Sato
Tomohiro Eguchi
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Astellas Pharma Inc
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Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of MX2019006897A publication Critical patent/MX2019006897A/es
Publication of MX392340B publication Critical patent/MX392340B/es

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07—ORGANIC CHEMISTRY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2806—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD2
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    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/71—Decreased effector function due to an Fc-modification
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención se refiere a un anticuerpo anti CD73 humana mejorado en comparación con el anticuerpo de la técnica previa y que tiene la capacidad de recuperar las funciones de las células T suprimidas de manera dependiente de AMP. Medios de solución Se provee un anticuerpo anti CD73 humana que comprende una región variable de cadena pesada que comprende la CDR1 que consiste en la secuencia de aminoácidos de los números de aminoácidos 31 a 35 de la SEQ ID NO: 2, la CDR2 que consiste en la secuencia de aminoácidos de los número de aminoácidos 50 a 66 de la SEQ ID NO: 2, y la CDR3 que consiste en la secuencia de aminoácidos de los números de aminoácidos 99 a 112 de la SEQ ID NO: 2, y una región variable de cadena ligera que comprende la CDR1 que consiste en la secuencia de aminoácidos de los números de aminoácidos 24 a 34 de la SEQ ID NO: 4, la CDR2 que consiste en la secuencia de aminoácidos de los números de aminoácidos 50 a 56 de la SEQ ID NO: 4, y la CDR3 que consiste en la secuencia de aminoácidos de los números de aminoácidos 89 a 98 de la SEQ ID NO: 4.
MX2019006897A 2016-12-13 2017-12-12 Anticuerpo anti cd73 humana. MX392340B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2016241503 2016-12-13
PCT/JP2017/044578 WO2018110555A1 (ja) 2016-12-13 2017-12-12 抗ヒトｃｄ７３抗体

Publications (2)

Publication Number Publication Date
MX2019006897A MX2019006897A (es) 2019-08-22
MX392340B true MX392340B (es) 2025-03-21

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MX2019006897A MX392340B (es) 2016-12-13 2017-12-12 Anticuerpo anti cd73 humana.

Country Status (10)

Country Link
US (1) US11180554B2 (es)
EP (1) EP3556773A4 (es)
JP (1) JP6996516B2 (es)
KR (1) KR20190091281A (es)
CN (1) CN110072891A (es)
BR (1) BR112019011988A2 (es)
CA (1) CA3046432A1 (es)
MX (1) MX392340B (es)
RU (1) RU2754058C2 (es)
WO (1) WO2018110555A1 (es)

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