MX390589B - Analisis digital de analitos moleculares usando deteccion de molecula individual. - Google Patents

Analisis digital de analitos moleculares usando deteccion de molecula individual.

Info

Publication number
MX390589B
MX390589B MX2015006219A MX2015006219A MX390589B MX 390589 B MX390589 B MX 390589B MX 2015006219 A MX2015006219 A MX 2015006219A MX 2015006219 A MX2015006219 A MX 2015006219A MX 390589 B MX390589 B MX 390589B
Authority
MX
Mexico
Prior art keywords
single molecule
molecule detection
digital analysis
detection
molecular analytes
Prior art date
Application number
MX2015006219A
Other languages
English (en)
Other versions
MX2015006219A (es
Inventor
Bart Lee Staker
Bryan P Staker
Michael David Mclaughlin
Niandong Liu
Original Assignee
Pacific Biosciences California Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pacific Biosciences California Inc filed Critical Pacific Biosciences California Inc
Publication of MX2015006219A publication Critical patent/MX2015006219A/es
Publication of MX390589B publication Critical patent/MX390589B/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • H—ELECTRICITY
    • H03—ELECTRONIC CIRCUITRY
    • H03M—CODING; DECODING; CODE CONVERSION IN GENERAL
    • H03M13/00—Coding, decoding or code conversion, for error detection or error correction; Coding theory basic assumptions; Coding bounds; Error probability evaluation methods; Channel models; Simulation or testing of codes
    • H03M13/03—Error detection or forward error correction by redundancy in data representation, i.e. code words containing more digits than the source words
    • H03M13/05—Error detection or forward error correction by redundancy in data representation, i.e. code words containing more digits than the source words using block codes, i.e. a predetermined number of check bits joined to a predetermined number of information bits
    • H03M13/13—Linear codes
    • H03M13/15—Cyclic codes, i.e. cyclic shifts of codewords produce other codewords, e.g. codes defined by a generator polynomial, Bose-Chaudhuri-Hocquenghem [BCH] codes
    • H03M13/151—Cyclic codes, i.e. cyclic shifts of codewords produce other codewords, e.g. codes defined by a generator polynomial, Bose-Chaudhuri-Hocquenghem [BCH] codes using error location or error correction polynomials
    • H03M13/1515—Reed-Solomon codes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medical Informatics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Theoretical Computer Science (AREA)
  • Evolutionary Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
  • Evolutionary Computation (AREA)
  • Public Health (AREA)
  • Software Systems (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Bioethics (AREA)

Abstract

Se proporcionan métodos y sistemas para la detección de moléculas pequeñas de analitos usando señales digitales, cifrado de clave, y protocolos de comunicación. Los métodos proporcionan la detección de un gran número de proteínas, péptidos, moléculas de ARN, y moléculas de ADN en un único ensayo de detección óptica o eléctrica dentro de un gran rango dinámico.
MX2015006219A 2012-11-19 2013-11-19 Analisis digital de analitos moleculares usando deteccion de molecula individual. MX390589B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261728067P 2012-11-19 2012-11-19
US201361869020P 2013-08-22 2013-08-22
PCT/US2013/070797 WO2014078855A1 (en) 2012-11-19 2013-11-19 Digital analysis of molecular analytes using single molecule detection

Publications (2)

Publication Number Publication Date
MX2015006219A MX2015006219A (es) 2015-11-13
MX390589B true MX390589B (es) 2025-03-21

Family

ID=50731772

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015006219A MX390589B (es) 2012-11-19 2013-11-19 Analisis digital de analitos moleculares usando deteccion de molecula individual.
MX2022002931A MX2022002931A (es) 2012-11-19 2015-05-18 Analisis digital de analitos moleculares usando deteccion de molecula individual.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2022002931A MX2022002931A (es) 2012-11-19 2015-05-18 Analisis digital de analitos moleculares usando deteccion de molecula individual.

Country Status (13)

Country Link
US (4) US20150330974A1 (es)
EP (2) EP2920725B1 (es)
JP (1) JP6395718B2 (es)
KR (1) KR102061257B1 (es)
CN (1) CN105264532B (es)
AU (1) AU2013344340B2 (es)
CA (1) CA2891939C (es)
DK (1) DK2920725T3 (es)
ES (1) ES2905265T3 (es)
HU (1) HUE058723T2 (es)
MX (2) MX390589B (es)
RU (1) RU2670133C2 (es)
WO (1) WO2014078855A1 (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10829816B2 (en) 2012-11-19 2020-11-10 Apton Biosystems, Inc. Methods of analyte detection
CA2891939C (en) 2012-11-19 2020-10-27 Apton Biosystems, Inc. Digital analysis of molecular analytes using single molecule detection
AU2014308691A1 (en) 2013-08-22 2016-04-07 Apton Biosystems, Inc. Digital analysis of molecular analytes using electrical methods
WO2016011429A1 (en) 2014-07-17 2016-01-21 California Institute Of Technology Multiplex analysis of molecules in single cells by image correlation
US20170141793A1 (en) * 2015-11-13 2017-05-18 Microsoft Technology Licensing, Llc Error correction for nucleotide data stores
JP2020514746A (ja) 2016-12-01 2020-05-21 ノーティラス バイオテクノロジー インコーポレイテッド タンパク質をアッセイする方法
CN110582715B (zh) 2017-03-03 2022-04-29 雅普顿生物系统公司 具有加速跟踪的高速扫描系统
CN110730826A (zh) 2017-03-08 2020-01-24 密歇根大学董事会 分析物检测
WO2018170518A1 (en) 2017-03-17 2018-09-20 Apton Biosystems, Inc. Sequencing and high resolution imaging
US20200140933A1 (en) * 2017-03-23 2020-05-07 Apton Biosystems, Inc. Polymorphism detection with increased accuracy
JP7219718B2 (ja) 2017-03-31 2023-02-08 ユニバーシティ オブ ストラスクライド 赤外分光システム
CN111566261B (zh) 2017-08-18 2025-03-25 诺迪勒思附属公司 选择结合试剂的方法
EP4372383A3 (en) * 2017-10-23 2024-11-06 Nautilus Subsidiary, Inc. Methods and systems for protein identification
US11721412B2 (en) 2017-10-23 2023-08-08 Nautilus Subsidiary, Inc. Methods for identifying a protein in a sample of unknown proteins
KR102871187B1 (ko) * 2017-12-29 2025-10-14 노틸러스 서브시디어리, 인크. 단백질 식별을 위한 디코딩 접근법
WO2019148001A1 (en) * 2018-01-25 2019-08-01 Apton Biosystems, Inc. Methods and composition for high throughput single molecule protein detection systems
CN112236528A (zh) 2018-04-04 2021-01-15 诺迪勒思生物科技公司 产生纳米阵列和微阵列的方法
JP2022501026A (ja) * 2018-09-19 2022-01-06 アプトン バイオシステムズ インコーポレイテッド 高密度に詰め込まれた分析物の層および検出方法
US11993865B2 (en) 2018-11-20 2024-05-28 Nautilus Subsidiary, Inc. Selection of affinity reagents
WO2020223368A1 (en) 2019-04-29 2020-11-05 Nautilus Biotechnology, Inc. Methods and systems for integrated on-chip single-molecule detection
WO2021046378A1 (en) 2019-09-05 2021-03-11 Apton Biosystems, Inc. High speed scanning systems for super resolution imaging
WO2021087402A1 (en) 2019-10-30 2021-05-06 Nautilus Biotechnology, Inc. Flow cell systems and methods
EP4096694A4 (en) 2020-01-30 2024-01-24 Prognomiq Inc LUNG BIOMARKERS AND METHODS OF USE THEREOF
AU2021378290B2 (en) 2020-11-11 2025-10-30 Nautilus Subsidiary, Inc. Affinity reagents having enhanced binding and detection characteristics
US12334190B2 (en) 2021-03-31 2025-06-17 PrognomIQ, Inc. Multi-omic assessment using proteins and nucleic acids
US12387508B2 (en) 2021-09-10 2025-08-12 PrognomIQ, Inc. Direct classification of raw biomolecule measurement data
EP4402473A4 (en) 2021-09-13 2025-07-30 Prognomiq Inc ENHANCED DETECTION AND QUANTIFICATION OF BIOMOLECULES
KR20250022719A (ko) * 2022-06-15 2025-02-17 주식회사 씨젠 기술 문서를 생성하는 방법 및 장치

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5302509A (en) 1989-08-14 1994-04-12 Beckman Instruments, Inc. Method for sequencing polynucleotides
US5494810A (en) 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
WO1995011461A1 (en) 1993-10-20 1995-04-27 Cambridge Imaging Limited Improved imaging method and apparatus
US7569341B2 (en) 1994-01-31 2009-08-04 Trustees Of Boston University Nucleic acid directed immobilization arrays and methods of assembly
US6232465B1 (en) 1994-09-02 2001-05-15 Andrew C. Hiatt Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides
US6214987B1 (en) 1994-09-02 2001-04-10 Andrew C. Hiatt Compositions for enzyme catalyzed template-independent formation of phosphodiester bonds using protected nucleotides
US5763594A (en) 1994-09-02 1998-06-09 Andrew C. Hiatt 3' protected nucleotides for enzyme catalyzed template-independent creation of phosphodiester bonds
US6654505B2 (en) 1994-10-13 2003-11-25 Lynx Therapeutics, Inc. System and apparatus for sequential processing of analytes
US6852487B1 (en) 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US5853993A (en) * 1996-10-21 1998-12-29 Hewlett-Packard Company Signal enhancement method and kit
CA2335951C (en) * 1998-06-24 2013-07-30 Mark S. Chee Decoding of array sensors with microspheres
CA2342767C (en) * 1998-09-03 2009-11-03 Trellis Bioinformatics, Inc. Multihued labels
EP2177627B1 (en) 1999-02-23 2012-05-02 Caliper Life Sciences, Inc. Manipulation of microparticles in microfluidic systems
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US6376191B1 (en) 2000-03-22 2002-04-23 Mergen, Ltd. Microarray-based analysis of polynucleotide sequence variations
US20030207300A1 (en) 2000-04-28 2003-11-06 Matray Tracy J. Multiplex analytical platform using molecular tags
KR100917731B1 (ko) * 2001-05-11 2009-09-15 파나소닉 주식회사 생체분자 기판 및 그것을 이용한 검사 및 진단의 방법 및장치
US6636623B2 (en) * 2001-08-10 2003-10-21 Visiongate, Inc. Optical projection imaging system and method for automatically detecting cells with molecular marker compartmentalization associated with malignancy and disease
GB0129012D0 (en) 2001-12-04 2002-01-23 Solexa Ltd Labelled nucleotides
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
US7122319B2 (en) 2002-12-18 2006-10-17 Monogram Biosciences, Inc Multiplexed immunohistochemical assays using molecular tags
EP1615948B1 (en) 2003-04-18 2015-04-01 Becton Dickinson and Company Immuno-amplification
US20050250094A1 (en) 2003-05-30 2005-11-10 Nanosphere, Inc. Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes
CN1584592A (zh) * 2003-08-22 2005-02-23 中国科学院上海原子核研究所 免疫微阵列蛋白质芯片
US20050049796A1 (en) 2003-09-03 2005-03-03 Webb Peter G. Methods for encoding non-biological information on microarrays
US20050153320A1 (en) 2003-11-06 2005-07-14 Herron James N. Single base extension
WO2006014392A1 (en) 2004-07-02 2006-02-09 The General Hospital Corporation Endoscopic imaging probe comprising dual clad fibre
US7170050B2 (en) 2004-09-17 2007-01-30 Pacific Biosciences Of California, Inc. Apparatus and methods for optical analysis of molecules
CA2611671C (en) 2005-06-15 2013-10-08 Callida Genomics, Inc. Single molecule arrays for genetic and chemical analysis
US20090081688A1 (en) 2005-06-20 2009-03-26 Advanced Cell Diagnostics Methods of detecting nucleic acids in individual cells and of identifying rare cells from large heterogeneous cell populations
WO2007041382A1 (en) 2005-09-29 2007-04-12 General Hospital Corporation Arrangements and methods for providing multimodality microscopic imaging of one or more biological structures
US7960104B2 (en) 2005-10-07 2011-06-14 Callida Genomics, Inc. Self-assembled single molecule arrays and uses thereof
FI4282332T3 (fi) 2006-02-22 2024-07-08 Dexcom Inc Analyyttianturi
WO2008033167A2 (en) 2006-03-28 2008-03-20 Inanovate, Inc. Nano-particle biochip substrates
US20090317810A1 (en) 2006-04-17 2009-12-24 Epigenomics Ag Methods and nucleic acids for the detection of colorectal cell proliferative disorders
US7839507B2 (en) 2006-06-28 2010-11-23 Applied Biosystems, Llc Minimizing effects of dye crosstalk
US7838302B2 (en) 2006-08-07 2010-11-23 President And Fellows Of Harvard College Sub-diffraction limit image resolution and other imaging techniques
AU2007334393A1 (en) 2006-12-14 2008-06-26 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
EP2374902B1 (en) 2007-01-26 2017-11-01 Illumina, Inc. Nucleic acid sequencing system and method
EP2251435B1 (en) 2007-03-02 2013-10-16 DNA Electronics Ltd Sensing apparatus for monitoring nucleic acid amplification, using an ion-sensitive field effect transistor (ISFET) for pH sensing
US7769548B2 (en) 2007-05-10 2010-08-03 Illumina, Inc. Microarray analytical data stitching system and method
US9551026B2 (en) 2007-12-03 2017-01-24 Complete Genomincs, Inc. Method for nucleic acid detection using voltage enhancement
WO2009097626A2 (en) 2008-02-03 2009-08-06 Helicos Biosciences Corporation Paired-end reads in sequencing by synthesis
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US9524369B2 (en) 2009-06-15 2016-12-20 Complete Genomics, Inc. Processing and analysis of complex nucleic acid sequence data
US10072287B2 (en) 2009-09-10 2018-09-11 Centrillion Technology Holdings Corporation Methods of targeted sequencing
US8900850B2 (en) 2009-09-17 2014-12-02 Michael J. Lane Lateral flow based methods and assays for rapid and inexpensive diagnostic tests
CA2774576C (en) 2009-09-24 2017-12-12 Commonwealth Scientific And Industrial Research Organisation Method of contaminant prediction
EP3236264A3 (en) 2009-10-13 2017-11-08 Nanostring Technologies, Inc Protein detection via nanoreporters
US8965076B2 (en) 2010-01-13 2015-02-24 Illumina, Inc. Data processing system and methods
US8774494B2 (en) 2010-04-30 2014-07-08 Complete Genomics, Inc. Method and system for accurate alignment and registration of array for DNA sequencing
CN101865843B (zh) * 2010-05-04 2012-05-23 中国科学院深圳先进技术研究院 多组分生物标识物的检测方法
US8465922B2 (en) 2010-08-26 2013-06-18 Pacific Biosciences Of California, Inc. Methods and systems for monitoring reactions
US9671344B2 (en) 2010-08-31 2017-06-06 Complete Genomics, Inc. High-density biochemical array chips with asynchronous tracks for alignment correction by moiré averaging
US8175452B1 (en) 2010-10-26 2012-05-08 Complete Genomics, Inc. Method and system for imaging high density biochemical arrays with sub-pixel alignment
CN103843001B (zh) 2011-04-14 2017-06-09 考利达基因组股份有限公司 复杂核酸序列数据的处理和分析
GB201108678D0 (en) 2011-05-24 2011-07-06 Olink Ab Multiplexed proximity ligation assay
US9001231B2 (en) 2011-06-03 2015-04-07 Rambus Inc. Image acquisition using oversampled one-bit poisson statistics
WO2012175245A2 (en) 2011-06-21 2012-12-27 Illumina Cambridge Limited Methods and systems for data analysis
US20130265459A1 (en) 2011-06-28 2013-10-10 Pelican Imaging Corporation Optical arrangements for use with an array camera
US10704164B2 (en) 2011-08-31 2020-07-07 Life Technologies Corporation Methods, systems, computer readable media, and kits for sample identification
WO2014015269A1 (en) 2012-07-19 2014-01-23 Ariosa Diagnostics, Inc. Multiplexed sequential ligation-based detection of genetic variants
CA2891939C (en) 2012-11-19 2020-10-27 Apton Biosystems, Inc. Digital analysis of molecular analytes using single molecule detection
US10829816B2 (en) 2012-11-19 2020-11-10 Apton Biosystems, Inc. Methods of analyte detection
JP2014164004A (ja) 2013-02-22 2014-09-08 Hitachi High-Technologies Corp 蛍光顕微鏡
US9193998B2 (en) 2013-03-15 2015-11-24 Illumina, Inc. Super resolution imaging
CN105392897B (zh) 2013-03-19 2020-03-20 定向基因组学公司 靶序列的富集
CN110669826B (zh) 2013-04-30 2025-01-07 加州理工学院 通过顺序杂交编条形码的分子多重标记
US10510435B2 (en) 2013-04-30 2019-12-17 California Institute Of Technology Error correction of multiplex imaging analysis by sequential hybridization
AU2014308691A1 (en) 2013-08-22 2016-04-07 Apton Biosystems, Inc. Digital analysis of molecular analytes using electrical methods
ES2968004T3 (es) 2014-07-30 2024-05-06 Harvard College Construcción de bibliotecas de sondas
CN104372093B (zh) 2014-11-10 2016-09-21 博奥生物集团有限公司 一种基于高通量测序的snp检测方法
AU2016219943A1 (en) 2015-02-18 2017-10-12 Singular Bio, Inc. Assays for single molecule detection and use thereof
ES2984193T3 (es) 2015-03-31 2024-10-29 Illumina Cambridge Ltd Concatemerización de moldes en la superficie
SG11201803646YA (en) 2015-11-04 2018-05-30 Atreca Inc Combinatorial sets of nucleic acid barcodes for analysis of nucleic acids associated with single cells
JP2018535743A (ja) 2015-11-04 2018-12-06 ザ プロクター アンド ギャンブル カンパニー 薄型可撓性吸収性物品
US10612089B2 (en) 2016-01-12 2020-04-07 Bio-Rad Laboratories, Inc. Synthesizing barcoding sequences utilizing phase-shift blocks and uses thereof
WO2017161251A1 (en) 2016-03-17 2017-09-21 President And Fellows Of Harvard College Methods for detecting and identifying genomic nucleic acids
US11512344B2 (en) 2016-05-10 2022-11-29 Arizona Board Of Regents On Behalf Of Arizona State University Consecutive hybridization for multiplexed analysis of biological samples
WO2017205827A1 (en) 2016-05-26 2017-11-30 Singular Bio, Inc. Arrays for single molecule detection and uses thereof
CN109313328A (zh) 2016-06-21 2019-02-05 伊鲁米那股份有限公司 超分辨率显微术
GB201701296D0 (en) 2017-01-26 2017-03-15 Univ College Cork - Nat Univ Of Ireland Smart coded access optical sensor
CN110582715B (zh) 2017-03-03 2022-04-29 雅普顿生物系统公司 具有加速跟踪的高速扫描系统
WO2018170518A1 (en) 2017-03-17 2018-09-20 Apton Biosystems, Inc. Sequencing and high resolution imaging
US20200140933A1 (en) 2017-03-23 2020-05-07 Apton Biosystems, Inc. Polymorphism detection with increased accuracy
WO2019055852A1 (en) 2017-09-15 2019-03-21 Apton Biosystems, Inc. PROFILING OF HETEROGENEOUS UNICELLULAR ORGANISMS USING MOLECULAR BARCODE CODING
EP3762507A4 (en) 2018-03-09 2021-11-10 Illumina Cambridge Limited GENERALIZED STOCHASTIC SUPER-RESOLUTION SEQUENCING

Also Published As

Publication number Publication date
MX2015006219A (es) 2015-11-13
KR20150095691A (ko) 2015-08-21
US20150330974A1 (en) 2015-11-19
EP2920725B1 (en) 2021-11-10
EP4012716A1 (en) 2022-06-15
EP2920725A1 (en) 2015-09-23
KR102061257B1 (ko) 2019-12-31
HUE058723T2 (hu) 2022-09-28
EP2920725A4 (en) 2016-08-31
AU2013344340A1 (en) 2015-07-02
CN105264532A (zh) 2016-01-20
US20210072233A1 (en) 2021-03-11
CA2891939A1 (en) 2014-05-22
AU2013344340B2 (en) 2019-09-19
ES2905265T3 (es) 2022-04-07
DK2920725T3 (da) 2022-02-07
RU2015123570A (ru) 2017-01-10
WO2014078855A1 (en) 2014-05-22
JP2016502079A (ja) 2016-01-21
MX2022002931A (es) 2022-04-06
US20240069012A1 (en) 2024-02-29
CN105264532B (zh) 2019-02-26
JP6395718B2 (ja) 2018-09-26
US11650202B2 (en) 2023-05-16
US20220214335A1 (en) 2022-07-07
RU2670133C2 (ru) 2018-10-18
CA2891939C (en) 2020-10-27

Similar Documents

Publication Publication Date Title
MX390589B (es) Analisis digital de analitos moleculares usando deteccion de molecula individual.
WO2012139110A3 (en) Peptide constructs and assay systems
MX2021003771A (es) Analisis de analitos multiples usando un ensayo unico.
EA201171148A1 (ru) Антитело-антагонист, специфичное для гетеродимера альфа-4-бета-7
CO6280541A2 (es) Anticuerpos monoclonales o fragmentos del mismo que se unen al recptor humano ox40
WO2008039769A3 (en) Methods and devices for analyzing small rna molecules
EA201690529A1 (ru) Способы модификации клетки-хозяина
BR112015001592A8 (pt) análise de imagem e medidas de amostras biológicas
DK2089343T3 (da) Click-kemi til fremstilling af reportermolekyler
MX2017006443A (es) Proceso para efectuar la prueba de alto rendimiento de la cromatografia liquida de alta resolucion.
EP4613756A3 (en) Hybridization chain reaction methods for in situ molecular detection
HK1214275A1 (zh) 双特异性fc分子
MX376578B (es) Sistemas y métodos para el análisis con dispositivo móvil de ácidos nucleicos y proteínas.
EA202090003A1 (ru) Связывающие молекулы, модулирующие биологическую активность, которую проявляет клетка
GB2538216A (en) Method of screening candidate biochemical entities targeting a target biochemical entity
AU2012262364A8 (en) Systems and methods for genetic and biological analysis
WO2014005125A3 (en) Fluorescent compounds and uses thereof
BR112012028977A2 (pt) polímero estímulo- responsivo para purificação de biomoléculas.
WO2012177940A3 (en) Microfluidic devices and methods for separating and detecting constituents in a fluid sample
WO2012071472A3 (en) Multi-directional microfluidic devices comprising a pan-capture binding region and methods of using the same
BR112017016897A2 (pt) cepas fúngicas e métodos de uso
WO2019060914A3 (en) Methods and systems for performing single cell analysis of molecules and molecular complexes
HK1219534A1 (zh) 分析仪器系统
EP3345024A4 (en) POLARIZATION-RELATED FILTER, SYSTEM AND ASSOCIATED KITS AND METHOD
WO2011127001A3 (en) Quantum dot-based optical sensors for rapid detection and quantitative analysis of biomolecules and biological materials