HUE058723T2 - Molekuláris analitok digitális elemzése egyetlen molekula kimutatásával - Google Patents

Molekuláris analitok digitális elemzése egyetlen molekula kimutatásával

Info

Publication number
HUE058723T2
HUE058723T2 HUE13855452A HUE13855452A HUE058723T2 HU E058723 T2 HUE058723 T2 HU E058723T2 HU E13855452 A HUE13855452 A HU E13855452A HU E13855452 A HUE13855452 A HU E13855452A HU E058723 T2 HUE058723 T2 HU E058723T2
Authority
HU
Hungary
Prior art keywords
single molecule
molecule detection
digital analysis
molecular analytes
analytes
Prior art date
Application number
HUE13855452A
Other languages
English (en)
Inventor
Bryan Staker
Niandong Liu
Bart Staker
Michael Mclaughlin
Original Assignee
Apton Biosystems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apton Biosystems Inc filed Critical Apton Biosystems Inc
Publication of HUE058723T2 publication Critical patent/HUE058723T2/hu

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306Solid-phase reaction mechanisms
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6825Nucleic acid detection involving sensors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6486Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • HELECTRICITY
    • H03ELECTRONIC CIRCUITRY
    • H03MCODING; DECODING; CODE CONVERSION IN GENERAL
    • H03M13/00Coding, decoding or code conversion, for error detection or error correction; Coding theory basic assumptions; Coding bounds; Error probability evaluation methods; Channel models; Simulation or testing of codes
    • H03M13/03Error detection or forward error correction by redundancy in data representation, i.e. code words containing more digits than the source words
    • H03M13/05Error detection or forward error correction by redundancy in data representation, i.e. code words containing more digits than the source words using block codes, i.e. a predetermined number of check bits joined to a predetermined number of information bits
    • H03M13/13Linear codes
    • H03M13/15Cyclic codes, i.e. cyclic shifts of codewords produce other codewords, e.g. codes defined by a generator polynomial, Bose-Chaudhuri-Hocquenghem [BCH] codes
    • H03M13/151Cyclic codes, i.e. cyclic shifts of codewords produce other codewords, e.g. codes defined by a generator polynomial, Bose-Chaudhuri-Hocquenghem [BCH] codes using error location or error correction polynomials
    • H03M13/1515Reed-Solomon codes
HUE13855452A 2012-11-19 2013-11-19 Molekuláris analitok digitális elemzése egyetlen molekula kimutatásával HUE058723T2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261728067P 2012-11-19 2012-11-19
US201361869020P 2013-08-22 2013-08-22

Publications (1)

Publication Number Publication Date
HUE058723T2 true HUE058723T2 (hu) 2022-09-28

Family

ID=50731772

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE13855452A HUE058723T2 (hu) 2012-11-19 2013-11-19 Molekuláris analitok digitális elemzése egyetlen molekula kimutatásával

Country Status (13)

Country Link
US (4) US20150330974A1 (hu)
EP (2) EP2920725B1 (hu)
JP (1) JP6395718B2 (hu)
KR (1) KR102061257B1 (hu)
CN (1) CN105264532B (hu)
AU (1) AU2013344340B2 (hu)
CA (1) CA2891939C (hu)
DK (1) DK2920725T3 (hu)
ES (1) ES2905265T3 (hu)
HU (1) HUE058723T2 (hu)
MX (2) MX2015006219A (hu)
RU (1) RU2670133C2 (hu)
WO (1) WO2014078855A1 (hu)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10829816B2 (en) 2012-11-19 2020-11-10 Apton Biosystems, Inc. Methods of analyte detection
ES2905265T3 (es) 2012-11-19 2022-04-07 Apton Biosystems Inc Análisis digital de analitos moleculares mediante detección de molécula única
US10378053B2 (en) 2017-03-17 2019-08-13 Apton Biosystems, Inc. Sequencing and high resolution imaging
KR102357894B1 (ko) 2013-08-22 2022-02-03 앱톤 바이오시스템즈, 인코포레이티드 전기적 방법을 이용한 분자 분석물질의 디지털 분석
WO2016011429A1 (en) 2014-07-17 2016-01-21 California Institute Of Technology Multiplex analysis of molecules in single cells by image correlation
US20170141793A1 (en) * 2015-11-13 2017-05-18 Microsoft Technology Licensing, Llc Error correction for nucleotide data stores
JP2020514746A (ja) 2016-12-01 2020-05-21 ノーティラス バイオテクノロジー インコーポレイテッド タンパク質をアッセイする方法
WO2018175402A1 (en) * 2017-03-23 2018-09-27 Apton Biosystems, Inc. Polymorphism detection with increased accuracy
WO2018178669A2 (en) 2017-03-31 2018-10-04 University Of Strathclyde Infra-red spectroscopy system
US11721412B2 (en) 2017-10-23 2023-08-08 Nautilus Subsidiary, Inc. Methods for identifying a protein in a sample of unknown proteins
CA3079832A1 (en) * 2017-10-23 2019-05-02 Nautilus Biotechnology, Inc. Methods and systems for protein identification
CA3086915A1 (en) 2017-12-29 2019-07-04 Sujal M. Patel Decoding approaches for protein identification
WO2019148001A1 (en) * 2018-01-25 2019-08-01 Apton Biosystems, Inc. Methods and composition for high throughput single molecule protein detection systems
WO2019195633A1 (en) 2018-04-04 2019-10-10 Ignite Biosciences, Inc. Methods of generating nanoarrays and microarrays
JP2022501026A (ja) * 2018-09-19 2022-01-06 アプトン バイオシステムズ インコーポレイテッド 高密度に詰め込まれた分析物の層および検出方法
GB2603051B (en) 2020-01-30 2023-04-26 Prognomiq Inc Lung biomarkers and methods of use thereof
AU2021378290A1 (en) 2020-11-11 2023-06-29 Nautilus Subsidiary, Inc. Affinity reagents having enhanced binding and detection characteristics
WO2023243922A1 (ko) * 2022-06-15 2023-12-21 주식회사 씨젠 기술 문서를 생성하는 방법 및 장치

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5302509A (en) 1989-08-14 1994-04-12 Beckman Instruments, Inc. Method for sequencing polynucleotides
US5494810A (en) 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
EP0724730B1 (en) 1993-10-20 1999-01-27 Cambridge Imaging Limited Improved imaging method and apparatus
US7569341B2 (en) 1994-01-31 2009-08-04 Trustees Of Boston University Nucleic acid directed immobilization arrays and methods of assembly
US6232465B1 (en) 1994-09-02 2001-05-15 Andrew C. Hiatt Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides
US5763594A (en) 1994-09-02 1998-06-09 Andrew C. Hiatt 3' protected nucleotides for enzyme catalyzed template-independent creation of phosphodiester bonds
US6214987B1 (en) 1994-09-02 2001-04-10 Andrew C. Hiatt Compositions for enzyme catalyzed template-independent formation of phosphodiester bonds using protected nucleotides
US6654505B2 (en) 1994-10-13 2003-11-25 Lynx Therapeutics, Inc. System and apparatus for sequential processing of analytes
US6852487B1 (en) 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US5853993A (en) * 1996-10-21 1998-12-29 Hewlett-Packard Company Signal enhancement method and kit
AU754952B2 (en) * 1998-06-24 2002-11-28 Illumina, Inc. Decoding of array sensors with microspheres
CA2342767C (en) * 1998-09-03 2009-11-03 Trellis Bioinformatics, Inc. Multihued labels
AU3372800A (en) 1999-02-23 2000-09-14 Caliper Technologies Corporation Manipulation of microparticles in microfluidic systems
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US6376191B1 (en) 2000-03-22 2002-04-23 Mergen, Ltd. Microarray-based analysis of polynucleotide sequence variations
US20030207300A1 (en) 2000-04-28 2003-11-06 Matray Tracy J. Multiplex analytical platform using molecular tags
CN100404692C (zh) 2001-05-11 2008-07-23 松下电器产业株式会社 生物分子基底,使用它的检验和诊断方法及装置
US6636623B2 (en) * 2001-08-10 2003-10-21 Visiongate, Inc. Optical projection imaging system and method for automatically detecting cells with molecular marker compartmentalization associated with malignancy and disease
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
GB0129012D0 (en) 2001-12-04 2002-01-23 Solexa Ltd Labelled nucleotides
WO2004061446A1 (en) 2002-12-18 2004-07-22 Aclara Biosciences, Inc. Single cell analysis of membrane molecules
US7932060B2 (en) 2003-04-18 2011-04-26 Becton, Dickinson And Company Immuno-amplification
US20050250094A1 (en) 2003-05-30 2005-11-10 Nanosphere, Inc. Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes
CN1584592A (zh) * 2003-08-22 2005-02-23 中国科学院上海原子核研究所 免疫微阵列蛋白质芯片
US20050049796A1 (en) * 2003-09-03 2005-03-03 Webb Peter G. Methods for encoding non-biological information on microarrays
US20050153320A1 (en) 2003-11-06 2005-07-14 Herron James N. Single base extension
US7447408B2 (en) 2004-07-02 2008-11-04 The General Hospital Corproation Imaging system and related techniques
US7170050B2 (en) 2004-09-17 2007-01-30 Pacific Biosciences Of California, Inc. Apparatus and methods for optical analysis of molecules
CA2611671C (en) 2005-06-15 2013-10-08 Callida Genomics, Inc. Single molecule arrays for genetic and chemical analysis
US20090081688A1 (en) 2005-06-20 2009-03-26 Advanced Cell Diagnostics Methods of detecting nucleic acids in individual cells and of identifying rare cells from large heterogeneous cell populations
EP1937137B1 (en) 2005-09-29 2022-06-15 General Hospital Corporation Method and apparatus for optical imaging via spectral encoding
US7960104B2 (en) 2005-10-07 2011-06-14 Callida Genomics, Inc. Self-assembled single molecule arrays and uses thereof
EP2407093A1 (en) 2006-02-22 2012-01-18 DexCom, Inc. Analyte sensor
WO2008033167A2 (en) 2006-03-28 2008-03-20 Inanovate, Inc. Nano-particle biochip substrates
US20090317810A1 (en) 2006-04-17 2009-12-24 Epigenomics Ag Methods and nucleic acids for the detection of colorectal cell proliferative disorders
US7839507B2 (en) 2006-06-28 2010-11-23 Applied Biosystems, Llc Minimizing effects of dye crosstalk
US7838302B2 (en) 2006-08-07 2010-11-23 President And Fellows Of Harvard College Sub-diffraction limit image resolution and other imaging techniques
JP5622392B2 (ja) 2006-12-14 2014-11-12 ライフ テクノロジーズ コーポレーション 大規模fetアレイを用いた分析物測定のための方法および装置
EP2374902B1 (en) 2007-01-26 2017-11-01 Illumina, Inc. Nucleic acid sequencing system and method
EP2251435B1 (en) 2007-03-02 2013-10-16 DNA Electronics Ltd Sensing apparatus for monitoring nucleic acid amplification, using an ion-sensitive field effect transistor (ISFET) for pH sensing
US7769548B2 (en) 2007-05-10 2010-08-03 Illumina, Inc. Microarray analytical data stitching system and method
US9551026B2 (en) 2007-12-03 2017-01-24 Complete Genomincs, Inc. Method for nucleic acid detection using voltage enhancement
EP2247741A4 (en) 2008-02-03 2011-02-23 Helicos Biosciences Corp READ-ENHANCED READING ELEMENTS IN SYNTHESIS SEQUENCING
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US9524369B2 (en) 2009-06-15 2016-12-20 Complete Genomics, Inc. Processing and analysis of complex nucleic acid sequence data
WO2011032040A1 (en) 2009-09-10 2011-03-17 Centrillion Technology Holding Corporation Methods of targeted sequencing
US8900850B2 (en) 2009-09-17 2014-12-02 Michael J. Lane Lateral flow based methods and assays for rapid and inexpensive diagnostic tests
EP2480875A4 (en) 2009-09-24 2017-10-11 Commonwealth Scientific and Industrial Research Organisation Method of contaminant prediction
CA2775613C (en) 2009-10-13 2018-06-12 Nanostring Technologies, Inc. Protein detection via nanoreporters
US8965076B2 (en) 2010-01-13 2015-02-24 Illumina, Inc. Data processing system and methods
US8774494B2 (en) 2010-04-30 2014-07-08 Complete Genomics, Inc. Method and system for accurate alignment and registration of array for DNA sequencing
CN101865843B (zh) * 2010-05-04 2012-05-23 中国科学院深圳先进技术研究院 多组分生物标识物的检测方法
US8465922B2 (en) 2010-08-26 2013-06-18 Pacific Biosciences Of California, Inc. Methods and systems for monitoring reactions
US9671344B2 (en) 2010-08-31 2017-06-06 Complete Genomics, Inc. High-density biochemical array chips with asynchronous tracks for alignment correction by moiré averaging
US8175452B1 (en) 2010-10-26 2012-05-08 Complete Genomics, Inc. Method and system for imaging high density biochemical arrays with sub-pixel alignment
JP2014516514A (ja) 2011-04-14 2014-07-17 コンプリート・ジェノミックス・インコーポレイテッド 複合核酸配列データの処理および解析
GB201108678D0 (en) 2011-05-24 2011-07-06 Olink Ab Multiplexed proximity ligation assay
US9001231B2 (en) 2011-06-03 2015-04-07 Rambus Inc. Image acquisition using oversampled one-bit poisson statistics
WO2012175245A2 (en) 2011-06-21 2012-12-27 Illumina Cambridge Limited Methods and systems for data analysis
US20130265459A1 (en) 2011-06-28 2013-10-10 Pelican Imaging Corporation Optical arrangements for use with an array camera
US10704164B2 (en) 2011-08-31 2020-07-07 Life Technologies Corporation Methods, systems, computer readable media, and kits for sample identification
EP2875156A4 (en) 2012-07-19 2016-02-24 Ariosa Diagnostics Inc DETECTION BASED ON MULTIPLEX SEQUENTIAL LIGATION OF GENETIC VARIANTS
US10378053B2 (en) 2017-03-17 2019-08-13 Apton Biosystems, Inc. Sequencing and high resolution imaging
US10829816B2 (en) 2012-11-19 2020-11-10 Apton Biosystems, Inc. Methods of analyte detection
ES2905265T3 (es) * 2012-11-19 2022-04-07 Apton Biosystems Inc Análisis digital de analitos moleculares mediante detección de molécula única
JP2014164004A (ja) 2013-02-22 2014-09-08 Hitachi High-Technologies Corp 蛍光顕微鏡
US9193998B2 (en) 2013-03-15 2015-11-24 Illumina, Inc. Super resolution imaging
JP6441893B2 (ja) 2013-03-19 2018-12-19 ディレクティド・ジェノミクス・エル・エル・シー 標的配列の濃縮
US10510435B2 (en) 2013-04-30 2019-12-17 California Institute Of Technology Error correction of multiplex imaging analysis by sequential hybridization
JP6605452B2 (ja) 2013-04-30 2019-11-13 カリフォルニア インスティチュート オブ テクノロジー 逐次ハイブリダイゼーションバーコーディングによる分子の多重標識化
KR102357894B1 (ko) 2013-08-22 2022-02-03 앱톤 바이오시스템즈, 인코포레이티드 전기적 방법을 이용한 분자 분석물질의 디지털 분석
EP3175023A4 (en) 2014-07-30 2018-03-07 President and Fellows of Harvard College Systems and methods for determining nucleic acids
CN104372093B (zh) 2014-11-10 2016-09-21 博奥生物集团有限公司 一种基于高通量测序的snp检测方法
CN107735497B (zh) 2015-02-18 2021-08-20 卓异生物公司 用于单分子检测的测定及其应用
EP3277839B1 (en) 2015-03-31 2020-12-02 Illumina Cambridge Limited Surface concatamerization of templates
JP7064439B2 (ja) 2015-11-04 2022-05-10 アトレカ インコーポレイテッド 単一細胞に関連する核酸の解析のための、核酸バーコードの組み合わせセット
US20170119587A1 (en) 2015-11-04 2017-05-04 The Procter & Gamble Company Thin and flexible absorbent articles
CN108495938B (zh) 2016-01-12 2023-07-14 生物辐射实验室股份有限公司 利用相位移区块合成条码化序列及其用途
US10844426B2 (en) 2016-03-17 2020-11-24 President And Fellows Of Harvard College Methods for detecting and identifying genomic nucleic acids
WO2017196527A1 (en) 2016-05-10 2017-11-16 Arizona Board Of Regents On Behalf Of Arizona State University Consecutive hybridization for multiplexed analysis of biological samples
WO2017205827A1 (en) 2016-05-26 2017-11-30 Singular Bio, Inc. Arrays for single molecule detection and uses thereof
CN109313328A (zh) 2016-06-21 2019-02-05 伊鲁米那股份有限公司 超分辨率显微术
GB201701296D0 (en) 2017-01-26 2017-03-15 Univ College Cork - Nat Univ Of Ireland Smart coded access optical sensor
CN114967111A (zh) 2017-03-03 2022-08-30 雅普顿生物系统公司 具有加速跟踪的高速扫描系统
WO2018175402A1 (en) 2017-03-23 2018-09-27 Apton Biosystems, Inc. Polymorphism detection with increased accuracy
WO2019055852A1 (en) 2017-09-15 2019-03-21 Apton Biosystems, Inc. PROFILING OF HETEROGENEOUS UNICELLULAR ORGANISMS USING MOLECULAR BARCODE CODING
RU2739571C1 (ru) 2018-03-09 2020-12-25 Иллюмина Кембридж Лимитед Генерализованное стохастическое секвенирование сверхразрешения

Also Published As

Publication number Publication date
KR20150095691A (ko) 2015-08-21
CA2891939A1 (en) 2014-05-22
RU2670133C2 (ru) 2018-10-18
US20220214335A1 (en) 2022-07-07
JP2016502079A (ja) 2016-01-21
US20240069012A1 (en) 2024-02-29
EP2920725A1 (en) 2015-09-23
US20210072233A1 (en) 2021-03-11
JP6395718B2 (ja) 2018-09-26
KR102061257B1 (ko) 2019-12-31
DK2920725T3 (da) 2022-02-07
CN105264532A (zh) 2016-01-20
US11650202B2 (en) 2023-05-16
RU2015123570A (ru) 2017-01-10
AU2013344340A1 (en) 2015-07-02
EP2920725A4 (en) 2016-08-31
ES2905265T3 (es) 2022-04-07
MX2022002931A (es) 2022-04-06
CA2891939C (en) 2020-10-27
MX2015006219A (es) 2015-11-13
CN105264532B (zh) 2019-02-26
EP2920725B1 (en) 2021-11-10
AU2013344340B2 (en) 2019-09-19
EP4012716A1 (en) 2022-06-15
US20150330974A1 (en) 2015-11-19
WO2014078855A1 (en) 2014-05-22

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