MX2022002931A - Analisis digital de analitos moleculares usando deteccion de molecula individual. - Google Patents

Analisis digital de analitos moleculares usando deteccion de molecula individual.

Info

Publication number
MX2022002931A
MX2022002931A MX2022002931A MX2022002931A MX2022002931A MX 2022002931 A MX2022002931 A MX 2022002931A MX 2022002931 A MX2022002931 A MX 2022002931A MX 2022002931 A MX2022002931 A MX 2022002931A MX 2022002931 A MX2022002931 A MX 2022002931A
Authority
MX
Mexico
Prior art keywords
single molecule
molecule detection
digital analysis
molecular analytes
detection
Prior art date
Application number
MX2022002931A
Other languages
English (en)
Inventor
Bryan P Staker
Niandong Liu
Bart Lee Staker
Michael David Mclaughlin
Original Assignee
Apton Biosystems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apton Biosystems Inc filed Critical Apton Biosystems Inc
Publication of MX2022002931A publication Critical patent/MX2022002931A/es

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • H—ELECTRICITY
    • H03—ELECTRONIC CIRCUITRY
    • H03M—CODING; DECODING; CODE CONVERSION IN GENERAL
    • H03M13/00—Coding, decoding or code conversion, for error detection or error correction; Coding theory basic assumptions; Coding bounds; Error probability evaluation methods; Channel models; Simulation or testing of codes
    • H03M13/03—Error detection or forward error correction by redundancy in data representation, i.e. code words containing more digits than the source words
    • H03M13/05—Error detection or forward error correction by redundancy in data representation, i.e. code words containing more digits than the source words using block codes, i.e. a predetermined number of check bits joined to a predetermined number of information bits
    • H03M13/13—Linear codes
    • H03M13/15—Cyclic codes, i.e. cyclic shifts of codewords produce other codewords, e.g. codes defined by a generator polynomial, Bose-Chaudhuri-Hocquenghem [BCH] codes
    • H03M13/151—Cyclic codes, i.e. cyclic shifts of codewords produce other codewords, e.g. codes defined by a generator polynomial, Bose-Chaudhuri-Hocquenghem [BCH] codes using error location or error correction polynomials
    • H03M13/1515—Reed-Solomon codes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medical Informatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Theoretical Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Evolutionary Biology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Evolutionary Computation (AREA)
  • Artificial Intelligence (AREA)
  • Bioethics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)

Abstract

Se proporcionan métodos y sistemas para la detección de moléculas pequeñas de analitos usando señales digitales, cifrado de clave, y protocolos de comunicación. Los métodos proporcionan la detección de un gran número de proteínas, péptidos, moléculas de ARN y moléculas de ADN en un único ensayo de detección óptica o eléctrica dentro de un gran rango dinámico.
MX2022002931A 2012-11-19 2015-05-18 Analisis digital de analitos moleculares usando deteccion de molecula individual. MX2022002931A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261728067P 2012-11-19 2012-11-19
US201361869020P 2013-08-22 2013-08-22

Publications (1)

Publication Number Publication Date
MX2022002931A true MX2022002931A (es) 2022-04-06

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015006219A MX2015006219A (es) 2012-11-19 2013-11-19 Analisis digital de analitos moleculares usando deteccion de molecula individual.
MX2022002931A MX2022002931A (es) 2012-11-19 2015-05-18 Analisis digital de analitos moleculares usando deteccion de molecula individual.

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Country Status (13)

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US (4) US20150330974A1 (es)
EP (2) EP4012716A1 (es)
JP (1) JP6395718B2 (es)
KR (1) KR102061257B1 (es)
CN (1) CN105264532B (es)
AU (1) AU2013344340B2 (es)
CA (1) CA2891939C (es)
DK (1) DK2920725T3 (es)
ES (1) ES2905265T3 (es)
HU (1) HUE058723T2 (es)
MX (2) MX2015006219A (es)
RU (1) RU2670133C2 (es)
WO (1) WO2014078855A1 (es)

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WO2014078855A1 (en) 2014-05-22
KR20150095691A (ko) 2015-08-21
JP2016502079A (ja) 2016-01-21
EP2920725A1 (en) 2015-09-23
US20220214335A1 (en) 2022-07-07
EP2920725A4 (en) 2016-08-31
MX2015006219A (es) 2015-11-13
EP4012716A1 (en) 2022-06-15
US20210072233A1 (en) 2021-03-11
ES2905265T3 (es) 2022-04-07
CA2891939A1 (en) 2014-05-22
CN105264532A (zh) 2016-01-20
HUE058723T2 (hu) 2022-09-28
KR102061257B1 (ko) 2019-12-31
US20240069012A1 (en) 2024-02-29
RU2015123570A (ru) 2017-01-10
EP2920725B1 (en) 2021-11-10
CA2891939C (en) 2020-10-27
AU2013344340A1 (en) 2015-07-02
DK2920725T3 (da) 2022-02-07
CN105264532B (zh) 2019-02-26
AU2013344340B2 (en) 2019-09-19
US20150330974A1 (en) 2015-11-19
US11650202B2 (en) 2023-05-16
RU2670133C2 (ru) 2018-10-18
JP6395718B2 (ja) 2018-09-26

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