SG11201803646YA - Combinatorial sets of nucleic acid barcodes for analysis of nucleic acids associated with single cells - Google Patents
Combinatorial sets of nucleic acid barcodes for analysis of nucleic acids associated with single cellsInfo
- Publication number
- SG11201803646YA SG11201803646YA SG11201803646YA SG11201803646YA SG11201803646YA SG 11201803646Y A SG11201803646Y A SG 11201803646YA SG 11201803646Y A SG11201803646Y A SG 11201803646YA SG 11201803646Y A SG11201803646Y A SG 11201803646YA SG 11201803646Y A SG11201803646Y A SG 11201803646YA
- Authority
- SG
- Singapore
- Prior art keywords
- analysis
- single cells
- nucleic acid
- acids associated
- nucleic acids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1096—Processes for the isolation, preparation or purification of DNA or RNA cDNA Synthesis; Subtracted cDNA library construction, e.g. RT, RT-PCR
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2523/00—Reactions characterised by treatment of reaction samples
- C12Q2523/30—Characterised by physical treatment
- C12Q2523/319—Photocleavage, photolysis, photoactivation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/173—Modifications characterised by incorporating a polynucleotide run, e.g. polyAs, polyTs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/191—Modifications characterised by incorporating an adaptor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
- C12Q2535/122—Massive parallel sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/149—Particles, e.g. beads
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/159—Microreactors, e.g. emulsion PCR or sequencing, droplet PCR, microcapsules, i.e. non-liquid containers with a range of different permeability's for different reaction components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/179—Nucleic acid detection characterized by the use of physical, structural and functional properties the label being a nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/185—Nucleic acid dedicated to use as a hidden marker/bar code, e.g. inclusion of nucleic acids to mark art objects or animals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/50—Detection characterised by immobilisation to a surface
- C12Q2565/514—Detection characterised by immobilisation to a surface characterised by the use of the arrayed oligonucleotides as identifier tags, e.g. universal addressable array, anti-tag or tag complement array
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562250900P | 2015-11-04 | 2015-11-04 | |
| PCT/US2016/060576 WO2017079593A1 (en) | 2015-11-04 | 2016-11-04 | Combinatorial sets of nucleic acid barcodes for analysis of nucleic acids associated with single cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201803646YA true SG11201803646YA (en) | 2018-05-30 |
Family
ID=57396822
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201803646YA SG11201803646YA (en) | 2015-11-04 | 2016-11-04 | Combinatorial sets of nucleic acid barcodes for analysis of nucleic acids associated with single cells |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11098304B2 (en) |
| EP (1) | EP3371309B1 (en) |
| JP (1) | JP7064439B2 (en) |
| KR (1) | KR20180097536A (en) |
| CN (1) | CN108473984A (en) |
| AU (1) | AU2016348439B2 (en) |
| CA (1) | CA3004310A1 (en) |
| SG (1) | SG11201803646YA (en) |
| WO (1) | WO2017079593A1 (en) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| GB2504240B (en) | 2012-02-27 | 2015-05-27 | Cellular Res Inc | Compositions and kits for molecular counting of nucleic acids |
| US10752949B2 (en) | 2012-08-14 | 2020-08-25 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US9951386B2 (en) | 2014-06-26 | 2018-04-24 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10323279B2 (en) | 2012-08-14 | 2019-06-18 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US9388465B2 (en) | 2013-02-08 | 2016-07-12 | 10X Genomics, Inc. | Polynucleotide barcode generation |
| US9567631B2 (en) | 2012-12-14 | 2017-02-14 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US11591637B2 (en) | 2012-08-14 | 2023-02-28 | 10X Genomics, Inc. | Compositions and methods for sample processing |
| US9701998B2 (en) | 2012-12-14 | 2017-07-11 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| CA2881685C (en) | 2012-08-14 | 2023-12-05 | 10X Genomics, Inc. | Microcapsule compositions and methods |
| US10584381B2 (en) | 2012-08-14 | 2020-03-10 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10829816B2 (en) | 2012-11-19 | 2020-11-10 | Apton Biosystems, Inc. | Methods of analyte detection |
| EP2920725B1 (en) | 2012-11-19 | 2021-11-10 | Apton Biosystems, Inc. | Digital analysis of molecular analytes using single molecule detection |
| US10533221B2 (en) | 2012-12-14 | 2020-01-14 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| KR102536833B1 (en) | 2013-08-28 | 2023-05-26 | 벡톤 디킨슨 앤드 컴퍼니 | Massively parallel single cell analysis |
| RU2717641C2 (en) | 2014-04-21 | 2020-03-24 | Натера, Инк. | Detection of mutations and ploidy in chromosomal segments |
| EP4053292A1 (en) | 2014-06-26 | 2022-09-07 | 10X Genomics, Inc. | Methods of analyzing nucleic acids from individual cells or cell populations |
| CA2972969A1 (en) | 2015-01-12 | 2016-07-21 | 10X Genomics, Inc. | Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same |
| EP3262407B1 (en) | 2015-02-24 | 2023-08-30 | 10X Genomics, Inc. | Partition processing methods and systems |
| EP3262192B1 (en) | 2015-02-27 | 2020-09-16 | Becton, Dickinson and Company | Spatially addressable molecular barcoding |
| EP4180535A1 (en) | 2015-03-30 | 2023-05-17 | Becton, Dickinson and Company | Methods and compositions for combinatorial barcoding |
| EP3286326A1 (en) | 2015-04-23 | 2018-02-28 | Cellular Research, Inc. | Methods and compositions for whole transcriptome amplification |
| US11479812B2 (en) | 2015-05-11 | 2022-10-25 | Natera, Inc. | Methods and compositions for determining ploidy |
| AU2016319110B2 (en) | 2015-09-11 | 2022-01-27 | The General Hospital Corporation | Full interrogation of nuclease DSBs and sequencing (FIND-seq) |
| US10619186B2 (en) | 2015-09-11 | 2020-04-14 | Cellular Research, Inc. | Methods and compositions for library normalization |
| US10301677B2 (en) | 2016-05-25 | 2019-05-28 | Cellular Research, Inc. | Normalization of nucleic acid libraries |
| US10202641B2 (en) | 2016-05-31 | 2019-02-12 | Cellular Research, Inc. | Error correction in amplification of samples |
| US10640763B2 (en) | 2016-05-31 | 2020-05-05 | Cellular Research, Inc. | Molecular indexing of internal sequences |
| SG11201901733PA (en) | 2016-09-26 | 2019-04-29 | Cellular Res Inc | Measurement of protein expression using reagents with barcoded oligonucleotide sequences |
| US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
| EP4029939B1 (en) | 2017-01-30 | 2023-06-28 | 10X Genomics, Inc. | Methods and systems for droplet-based single cell barcoding |
| US11319583B2 (en) | 2017-02-01 | 2022-05-03 | Becton, Dickinson And Company | Selective amplification using blocking oligonucleotides |
| CA3056765C (en) | 2017-03-17 | 2024-04-02 | Apton Biosystems, Inc. | Sequencing and high resolution imaging |
| MX2019013993A (en) * | 2017-05-23 | 2020-07-28 | Harvard College | Multiplex end-tagging amplification of nucleic acids. |
| SG11201901822QA (en) | 2017-05-26 | 2019-03-28 | 10X Genomics Inc | Single cell analysis of transposase accessible chromatin |
| US20180340169A1 (en) | 2017-05-26 | 2018-11-29 | 10X Genomics, Inc. | Single cell analysis of transposase accessible chromatin |
| AU2018281745B2 (en) | 2017-06-05 | 2022-05-19 | Becton, Dickinson And Company | Sample indexing for single cells |
| EP3672612A4 (en) | 2017-08-23 | 2021-09-29 | The General Hospital Corporation | Engineered crispr-cas9 nucleases with altered pam specificity |
| WO2019055852A1 (en) * | 2017-09-15 | 2019-03-21 | Apton Biosystems, Inc. | Heterogeneous single cell profiling using molecular barcoding |
| WO2019075197A1 (en) | 2017-10-11 | 2019-04-18 | The General Hospital Corporation | Methods for detecting site-specific and spurious genomic deamination induced by base editing technologies |
| SG11201913654QA (en) | 2017-11-15 | 2020-01-30 | 10X Genomics Inc | Functionalized gel beads |
| EP4212629A1 (en) * | 2017-11-17 | 2023-07-19 | 10X Genomics, Inc. | Methods and systems for associating physical and genetic properties of biological particles |
| US10829815B2 (en) | 2017-11-17 | 2020-11-10 | 10X Genomics, Inc. | Methods and systems for associating physical and genetic properties of biological particles |
| WO2019126209A1 (en) * | 2017-12-19 | 2019-06-27 | Cellular Research, Inc. | Particles associated with oligonucleotides |
| WO2019191321A1 (en) * | 2018-03-28 | 2019-10-03 | 10X Genomics, Inc. | Nucleic acid enrichment within partitions |
| EP3775271A1 (en) | 2018-04-06 | 2021-02-17 | 10X Genomics, Inc. | Systems and methods for quality control in single cell processing |
| US11466313B2 (en) | 2018-04-13 | 2022-10-11 | The Board Of Trustees Of The Leland Stanford Junior University | Nucleic acid quantification using concentration-specific barcodes |
| CN112313241A (en) | 2018-04-17 | 2021-02-02 | 总医院公司 | Sensitive in vitro assay of substrate preference and site for nucleic acid binding, modification, and cleavage reagents |
| JP7407128B2 (en) | 2018-05-03 | 2023-12-28 | ベクトン・ディキンソン・アンド・カンパニー | High-throughput multi-omics sample analysis |
| WO2019213237A1 (en) | 2018-05-03 | 2019-11-07 | Becton, Dickinson And Company | Molecular barcoding on opposite transcript ends |
| US11525159B2 (en) | 2018-07-03 | 2022-12-13 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| CA3110800A1 (en) * | 2018-07-12 | 2020-01-16 | Board Of Regents, The University Of Texas System | Molecular neighborhood detection by oligonucleotides |
| EP3844299A1 (en) * | 2018-08-28 | 2021-07-07 | Becton Dickinson and Company | Sample multiplexing using carbohydrate-binding and membrane-permeable reagents |
| US20220034881A1 (en) * | 2018-09-24 | 2022-02-03 | Bristol-Myers Squibb Company | Barcoded peptide-mhc complexes and uses thereof |
| CN112805389A (en) * | 2018-10-01 | 2021-05-14 | 贝克顿迪金森公司 | Determination of 5' transcript sequences |
| JP2022506546A (en) | 2018-11-08 | 2022-01-17 | ベクトン・ディキンソン・アンド・カンパニー | Single-cell whole transcriptome analysis using random priming |
| EP3894552A1 (en) | 2018-12-13 | 2021-10-20 | Becton, Dickinson and Company | Selective extension in single cell whole transcriptome analysis |
| EP3908660A4 (en) * | 2019-01-07 | 2022-11-02 | Pivot Bio, Inc. | Plant colonization assays using natural microbial barcodes |
| ES2945227T3 (en) | 2019-01-23 | 2023-06-29 | Becton Dickinson Co | Antibody Associated Oligonucleotides |
| CN113767178A (en) | 2019-03-11 | 2021-12-07 | 10X基因组学有限公司 | Systems and methods for processing optically labeled beads |
| WO2020247950A1 (en) * | 2019-06-07 | 2020-12-10 | Bio-Rad Laboratories, Inc. | Multiple beads per droplet resolution |
| US11939622B2 (en) | 2019-07-22 | 2024-03-26 | Becton, Dickinson And Company | Single cell chromatin immunoprecipitation sequencing assay |
| US11773436B2 (en) | 2019-11-08 | 2023-10-03 | Becton, Dickinson And Company | Using random priming to obtain full-length V(D)J information for immune repertoire sequencing |
| WO2021128036A1 (en) * | 2019-12-25 | 2021-07-01 | 苏州绘真生物科技有限公司 | Kit for constructing human single-cell tcr sequencing library and application thereof |
| WO2021146183A1 (en) * | 2020-01-13 | 2021-07-22 | Fluent Biosciences Inc. | Reverse transcription during template emulsification |
| CN115244184A (en) | 2020-01-13 | 2022-10-25 | 贝克顿迪金森公司 | Methods and compositions for quantifying protein and RNA |
| EP4106769A4 (en) * | 2020-02-17 | 2024-03-27 | Universal Sequencing Tech Corporation | Methods of barcoding nucleic acid for detection and sequencing |
| WO2021231779A1 (en) | 2020-05-14 | 2021-11-18 | Becton, Dickinson And Company | Primers for immune repertoire profiling |
| WO2021241721A1 (en) | 2020-05-29 | 2021-12-02 | 国立研究開発法人理化学研究所 | Method for treating cell population and method for analyzing genes included in cell population |
| US11932901B2 (en) | 2020-07-13 | 2024-03-19 | Becton, Dickinson And Company | Target enrichment using nucleic acid probes for scRNAseq |
| EP4247967A1 (en) | 2020-11-20 | 2023-09-27 | Becton, Dickinson and Company | Profiling of highly expressed and lowly expressed proteins |
| WO2023048300A1 (en) * | 2021-09-27 | 2023-03-30 | 国立大学法人東京大学 | Cell labeling molecule and method for analyzing cell |
| GB202211182D0 (en) * | 2022-08-01 | 2022-09-14 | Univ Oxford Innovation Ltd | Bead-hashing |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5643722A (en) | 1994-05-11 | 1997-07-01 | Trustees Of Boston University | Methods for the detection and isolation of proteins |
| US5962271A (en) | 1996-01-03 | 1999-10-05 | Cloutech Laboratories, Inc. | Methods and compositions for generating full-length cDNA having arbitrary nucleotide sequence at the 3'-end |
| EP1447127B1 (en) | 2001-02-23 | 2007-07-04 | Japan Science and Technology Agency | Apparatus for producing emulsion |
| US20030175749A1 (en) | 2001-12-08 | 2003-09-18 | Jong-Yoon Chun | Annealing control primer and its uses |
| JP4777238B2 (en) | 2004-03-23 | 2011-09-21 | 独立行政法人科学技術振興機構 | Method and apparatus for generating microdroplets |
| ATE510930T1 (en) | 2005-08-02 | 2011-06-15 | Rubicon Genomics Inc | COMPOSITIONS AND METHODS FOR EDITING AND AMPLIFICATION OF DNA USING MULTIPLE ENZYMES IN A SINGLE REACTION |
| WO2008157696A2 (en) * | 2007-06-19 | 2008-12-24 | Stratos Genomics Inc. | High throughput nucleic acid sequencing by expansion |
| WO2009154303A2 (en) | 2008-06-18 | 2009-12-23 | Riken | A method of manufacturing a mixture of amplified double-stranded nucleic acids comprising unknown sequence |
| DK3495498T3 (en) | 2009-03-30 | 2022-01-17 | Illumina Inc | GENE EXPRESSION ANALYSIS IN SINGLE CELLS |
| CN102439177B (en) * | 2009-04-02 | 2014-10-01 | 弗卢伊蒂格姆公司 | Multi-primer amplification method for barcoding of target nucleic acids |
| CN101864477A (en) * | 2009-04-15 | 2010-10-20 | 上海聚类生物科技有限公司 | Method for carrying out determination on microRNA expression profiles by utilizing high-throughput sequencing single-channel multiplexing technology |
| CN102933721B (en) | 2010-06-09 | 2015-12-02 | 凯津公司 | For the composite sequence barcode of high flux screening |
| US9902950B2 (en) * | 2010-10-08 | 2018-02-27 | President And Fellows Of Harvard College | High-throughput single cell barcoding |
| US20140057799A1 (en) | 2010-12-16 | 2014-02-27 | Gigagen | System and Methods for Massively Parallel Analysis of Nucleic Acids in Single Cells |
| CA3078215A1 (en) | 2011-04-28 | 2012-11-01 | Department Of Veterans Affairs | Identification of polynucleotides associated with a sample |
| SG194745A1 (en) * | 2011-05-20 | 2013-12-30 | Fluidigm Corp | Nucleic acid encoding reactions |
| RU2663354C2 (en) * | 2011-12-16 | 2018-08-03 | Таргитджин Байотекнолоджиз Лтд | Compositions and methods for modification of specified target nucleic acid sequence |
| EP3597764A3 (en) * | 2012-02-01 | 2020-05-06 | SGI-DNA, Inc. | Material and methods for the synthesis of error-minimized nucleic acid molecules |
| SG11201406538VA (en) * | 2012-04-13 | 2014-11-27 | Sequenta Inc | Detection and quantitation of sample contamination in immune repertoire analysis |
| AU2013293240A1 (en) * | 2012-07-24 | 2015-03-05 | Adaptive Biotechnologies Corp. | Single cell analysis using sequence tags |
| JP6338221B2 (en) | 2012-10-24 | 2018-06-06 | タカラ バイオ ユーエスエー， インコーポレイテッド | Template switch based method for producing nucleic acid products |
| WO2014071361A1 (en) * | 2012-11-05 | 2014-05-08 | Rubicon Genomics | Barcoding nucleic acids |
| SG10201707394PA (en) * | 2013-03-15 | 2017-10-30 | Adaptive Biotechnologies Corp | Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set |
| US10119134B2 (en) * | 2013-03-15 | 2018-11-06 | Abvitro Llc | Single cell bar-coding for antibody discovery |
| US20160122753A1 (en) | 2013-06-12 | 2016-05-05 | Tarjei Mikkelsen | High-throughput rna-seq |
| CN117568449A (en) | 2013-06-27 | 2024-02-20 | 10X基因组学有限公司 | Compositions and methods for sample processing |
| US9708657B2 (en) * | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
| CN105579587A (en) | 2013-08-23 | 2016-05-11 | 惠氏公司 | Methods and compositions for cDNA synthesis and single-cell transcriptome profiling using template switching reaction |
| KR102536833B1 (en) * | 2013-08-28 | 2023-05-26 | 벡톤 디킨슨 앤드 컴퍼니 | Massively parallel single cell analysis |
| WO2015057319A1 (en) | 2013-10-17 | 2015-04-23 | Clontech Laboratories, Inc. | Methods for adding adapters to nucleic acids and compositions for practicing the same |
| WO2015094861A1 (en) | 2013-12-17 | 2015-06-25 | Clontech Laboratories, Inc. | Methods for adding adapters to nucleic acids and compositions for practicing the same |
| JP6608368B2 (en) * | 2013-12-30 | 2019-11-20 | アトレカ インコーポレイテッド | Method for analyzing nucleic acids associated with single cells using nucleic acid barcodes |
| EP3456846B1 (en) * | 2014-04-21 | 2022-06-22 | President and Fellows of Harvard College | Systems and methods for barcoding nucleic acid |
| EP3143139B1 (en) | 2014-05-14 | 2021-12-15 | Ruprecht-Karls-Universität Heidelberg | Synthesis of double-stranded nucleic acids |
| EP4053292A1 (en) * | 2014-06-26 | 2022-09-07 | 10X Genomics, Inc. | Methods of analyzing nucleic acids from individual cells or cell populations |
| KR102541849B1 (en) * | 2014-09-15 | 2023-06-09 | 에이비비트로, 엘엘씨 | High-throughput nucleotide library sequencing |
| SG11201706636PA (en) | 2015-02-27 | 2017-09-28 | Fluidigm Corp | Single-cell nucleic acids for high-throughput studies |
| EP4180535A1 (en) | 2015-03-30 | 2023-05-17 | Becton, Dickinson and Company | Methods and compositions for combinatorial barcoding |
| EP3286326A1 (en) * | 2015-04-23 | 2018-02-28 | Cellular Research, Inc. | Methods and compositions for whole transcriptome amplification |
-
2016
- 2016-11-04 EP EP16801644.2A patent/EP3371309B1/en active Active
- 2016-11-04 KR KR1020187015881A patent/KR20180097536A/en not_active Application Discontinuation
- 2016-11-04 CN CN201680077294.5A patent/CN108473984A/en active Pending
- 2016-11-04 US US15/772,723 patent/US11098304B2/en active Active
- 2016-11-04 AU AU2016348439A patent/AU2016348439B2/en active Active
- 2016-11-04 JP JP2018543062A patent/JP7064439B2/en active Active
- 2016-11-04 WO PCT/US2016/060576 patent/WO2017079593A1/en active Application Filing
- 2016-11-04 SG SG11201803646YA patent/SG11201803646YA/en unknown
- 2016-11-04 CA CA3004310A patent/CA3004310A1/en active Pending
-
2021
- 2021-07-28 US US17/443,909 patent/US20210380974A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3004310A1 (en) | 2017-05-11 |
| EP3371309B1 (en) | 2023-07-05 |
| WO2017079593A1 (en) | 2017-05-11 |
| AU2016348439B2 (en) | 2023-03-09 |
| US20180320171A1 (en) | 2018-11-08 |
| US20210380974A1 (en) | 2021-12-09 |
| JP7064439B2 (en) | 2022-05-10 |
| EP3371309A1 (en) | 2018-09-12 |
| KR20180097536A (en) | 2018-08-31 |
| US11098304B2 (en) | 2021-08-24 |
| AU2016348439A1 (en) | 2018-05-10 |
| CN108473984A (en) | 2018-08-31 |
| JP2018538006A (en) | 2018-12-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SG11201803646YA (en) | Combinatorial sets of nucleic acid barcodes for analysis of nucleic acids associated with single cells | |
| HK1250757A1 (en) | Nucleic acid sequence analysis from single cells | |
| IL249617A0 (en) | Methods of analyzing nucleic acids from individual cells or cell populations | |
| SG11201605344YA (en) | Analysis of nucleic acids associated with single cells using nucleic acid barcodes | |
| HK1250245A1 (en) | Spatially distinguished, multiplex nucleic acid analysis of biological specimens | |
| SG11201706636PA (en) | Single-cell nucleic acids for high-throughput studies | |
| HK1250330A1 (en) | Enhancing the effect of car-engineered t cells by means of nucleic acid vaccination | |
| IL249619A0 (en) | Analysis of nucleic acid sequences | |
| SG11201610315YA (en) | Sample preparation for nucleic acid amplification | |
| EP3134550A4 (en) | High-throughput structure determination using nucleic acid calipers | |
| GB2581599B (en) | Tagging nucleic acid molecules from single cells for phased sequencing | |
| GB201403216D0 (en) | Nucleic acid sample preparation | |
| GB201413318D0 (en) | Nucleic acid sample preparation | |
| DK3320111T3 (en) | Sample preparation for nucleic acid amplification | |
| GB201506669D0 (en) | Nucleic acid sample enrichment | |
| GB201415674D0 (en) | Nucleic acid analysis | |
| IL255081A0 (en) | Detection of nucleic acid molecules | |
| GB2553907B (en) | Nucleic acid analyzer | |
| GB201516685D0 (en) | Nucleic acid molecules with enhanced activity | |
| GB201519323D0 (en) | Nucleic acid analysis | |
| GB201503845D0 (en) | Nucleic acid analysis | |
| GB201522270D0 (en) | Nucleic acid sample enrichment | |
| GB201514532D0 (en) | Nucleic acid sample enrichment | |
| GB201508859D0 (en) | Nucleic acid sample enrichment | |
| GB201406580D0 (en) | Nucleic Acid Sample preparation |