MX381306B - Penicilina-g acilasas. - Google Patents

Penicilina-g acilasas.

Info

Publication number
MX381306B
MX381306B MX2017014213A MX2017014213A MX381306B MX 381306 B MX381306 B MX 381306B MX 2017014213 A MX2017014213 A MX 2017014213A MX 2017014213 A MX2017014213 A MX 2017014213A MX 381306 B MX381306 B MX 381306B
Authority
MX
Mexico
Prior art keywords
enzymes
penicillin
acylases
acylase
pga
Prior art date
Application number
MX2017014213A
Other languages
English (en)
Other versions
MX2017014213A (es
Inventor
Erika M Milczek
Goutami Banerjee
Melissa Ann Mayo
Stephan Jenne
Xiyun Zhang
Jie Yang
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of MX2017014213A publication Critical patent/MX2017014213A/es
Publication of MX381306B publication Critical patent/MX381306B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/84—Penicillin amidase (3.5.1.11)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01011—Penicillin amidase (3.5.1.11), i.e. penicillin-amidohydrolase

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se refiere a enzimas diseñadas de penicilina G acilasa (PGA) que tienen propiedades mejoradas, polinucleótidos que codifican dichas enzimas, composiciones que incluyen las enzimas y métodos para usar las enzimas.
MX2017014213A 2015-05-07 2016-05-06 Penicilina-g acilasas. MX381306B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562158118P 2015-05-07 2015-05-07
PCT/US2016/031132 WO2016179464A1 (en) 2015-05-07 2016-05-06 Penicillin-g acylases

Publications (2)

Publication Number Publication Date
MX2017014213A MX2017014213A (es) 2018-03-28
MX381306B true MX381306B (es) 2025-03-12

Family

ID=57218075

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017014213A MX381306B (es) 2015-05-07 2016-05-06 Penicilina-g acilasas.

Country Status (13)

Country Link
US (6) US9944916B2 (es)
EP (1) EP3292136B1 (es)
JP (1) JP6755886B2 (es)
KR (1) KR102604503B1 (es)
CN (1) CN107531762A (es)
AU (1) AU2016258091B2 (es)
CA (1) CA2983620A1 (es)
DK (1) DK3292136T3 (es)
HU (1) HUE053863T2 (es)
IL (1) IL255245B (es)
MX (1) MX381306B (es)
SG (1) SG11201708356PA (es)
WO (1) WO2016179464A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6755886B2 (ja) 2015-05-07 2020-09-16 コデクシス， インコーポレイテッド ペニシリンｇアシラーゼ
WO2017193022A1 (en) 2016-05-05 2017-11-09 Codexis, Inc. Penicillin-g acylases
CA3048475A1 (en) 2017-01-05 2018-07-12 Codexis, Inc. Penicillin-g acylases
CN117737045A (zh) 2017-06-27 2024-03-22 科德克希思公司 青霉素g酰化酶
KR101985911B1 (ko) * 2017-12-28 2019-06-04 아미코젠주식회사 Achromobacter sp. CCM 4824 유래 페니실린 G 아실라제 변이체 및 이의 이용
CN109207466B (zh) * 2018-11-08 2021-01-08 山东鲁抗医药股份有限公司 一种青霉素酰化酶的固定化方法及固定化酶
KR102363768B1 (ko) * 2019-11-15 2022-02-16 아미코젠주식회사 세파졸린 생산성이 증가된 페니실린 g 아실라제 변이체 및 이의 이용
CN120699946A (zh) * 2024-10-08 2025-09-26 浙江师范大学行知学院 一种嗜柠檬酸克鲁维氏菌来源的青霉素g酰化酶突变体及其应用

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Also Published As

Publication number Publication date
AU2016258091B2 (en) 2020-10-01
US10781436B2 (en) 2020-09-22
JP6755886B2 (ja) 2020-09-16
HUE053863T2 (hu) 2021-07-28
EP3292136A1 (en) 2018-03-14
KR102604503B1 (ko) 2023-11-20
AU2016258091A1 (en) 2017-11-02
US20200385699A1 (en) 2020-12-10
MX2017014213A (es) 2018-03-28
US9944916B2 (en) 2018-04-17
US11180747B2 (en) 2021-11-23
US20160326508A1 (en) 2016-11-10
WO2016179464A1 (en) 2016-11-10
EP3292136B1 (en) 2021-02-17
US20190345474A1 (en) 2019-11-14
US20180201919A1 (en) 2018-07-19
CA2983620A1 (en) 2016-11-10
US10400231B2 (en) 2019-09-03
DK3292136T3 (da) 2021-03-22
KR20180004169A (ko) 2018-01-10
EP3292136A4 (en) 2019-04-10
US20220042004A1 (en) 2022-02-10
US20250346882A1 (en) 2025-11-13
SG11201708356PA (en) 2017-11-29
IL255245A0 (en) 2017-12-31
CN107531762A (zh) 2018-01-02
US12378541B2 (en) 2025-08-05
IL255245B (en) 2020-03-31
JP2018515089A (ja) 2018-06-14
NZ736220A (en) 2024-03-22

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