MX374205B - Metodo para preparar amg 416. - Google Patents

Metodo para preparar amg 416.

Info

Publication number
MX374205B
MX374205B MX2016012965A MX2016012965A MX374205B MX 374205 B MX374205 B MX 374205B MX 2016012965 A MX2016012965 A MX 2016012965A MX 2016012965 A MX2016012965 A MX 2016012965A MX 374205 B MX374205 B MX 374205B
Authority
MX
Mexico
Prior art keywords
amg
preparing
preparing amg
shpt
mbd
Prior art date
Application number
MX2016012965A
Other languages
English (en)
Other versions
MX2016012965A (es
Inventor
Asher Lower
Jeroen Bezemer
Kevin Crossley
Krishnakumar Ranganathan
Liang Huang
Richard Crockett
Sheng Cui
Sian Jones
Ying Chen
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54241346&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX374205(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2016012965A publication Critical patent/MX2016012965A/es
Publication of MX374205B publication Critical patent/MX374205B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Glass Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se refiere a un método para preparar AMG 416, o una sal farmacéuticamente aceptable del mismo. El AMG 416 es un agonista de péptido selectivo de ocho aminoácidos, sintético, del receptor sensible al calcio. Está siendo desarrollado como un tratamiento intravenoso de hiperparatiroidismo secundario (SHPT) en pacientes con hemodiálisis con enfermedad renal crónica - trastorno mineral y óseo (CKD-MBD).
MX2016012965A 2014-04-03 2015-04-03 Metodo para preparar amg 416. MX374205B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461974899P 2014-04-03 2014-04-03
PCT/US2015/024347 WO2015154031A1 (en) 2014-04-03 2015-04-03 Method for preparing amg 416

Publications (2)

Publication Number Publication Date
MX2016012965A MX2016012965A (es) 2017-07-06
MX374205B true MX374205B (es) 2025-03-05

Family

ID=54241346

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016012965A MX374205B (es) 2014-04-03 2015-04-03 Metodo para preparar amg 416.

Country Status (27)

Country Link
US (3) US10407464B2 (es)
EP (3) EP3126373B1 (es)
JP (1) JP6710158B2 (es)
KR (1) KR102397271B1 (es)
CN (3) CN119899242A (es)
AU (1) AU2015240527B2 (es)
CA (1) CA2944194C (es)
CL (1) CL2016002513A1 (es)
CY (1) CY1123100T1 (es)
DK (1) DK3126373T3 (es)
EA (1) EA032597B1 (es)
ES (2) ES2786225T3 (es)
HR (1) HRP20200527T1 (es)
HU (1) HUE048489T2 (es)
IL (1) IL248059B2 (es)
LT (1) LT3126373T (es)
MA (2) MA52906A (es)
ME (1) ME03781B (es)
MX (1) MX374205B (es)
PL (1) PL3126373T3 (es)
PT (1) PT3126373T (es)
RS (1) RS60187B1 (es)
SG (1) SG11201608176VA (es)
SI (1) SI3126373T1 (es)
SM (1) SMT202000207T1 (es)
WO (1) WO2015154031A1 (es)
ZA (1) ZA201606844B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114376970A (zh) * 2013-06-28 2022-04-22 美国安进公司 Etelcalcetide (AMG 416)的稳定的液体制剂
MX374205B (es) 2014-04-03 2025-03-05 Amgen Inc Metodo para preparar amg 416.
CN106928321B (zh) * 2015-12-31 2019-07-26 深圳翰宇药业股份有限公司 一种合成Etelcalcetide的方法
CN106928320B (zh) * 2015-12-31 2021-01-15 深圳翰宇药业股份有限公司 一种合成Etelcalcetide的方法
WO2017162650A1 (en) 2016-03-23 2017-09-28 Bachem Holding Ag Method for preparing glucagon-like peptides
US10858390B2 (en) 2016-09-02 2020-12-08 Cem Corporation Use of excess carbodiimide for peptide synthesis at elevated temperatures
CN108101959B (zh) * 2016-11-24 2021-07-09 四川科伦药物研究院有限公司 一种制备高纯度多肽或其类似物的方法
CN106928171B (zh) * 2017-05-03 2019-08-13 成都郑源生化科技有限公司 Fmoc-Arg（Pbf）-OH的合成方法
TW201915009A (zh) * 2017-10-03 2019-04-16 中化合成生技股份有限公司 合成依特卡肽（Ｅｔｅｌｃａｌｃｅｔｉｄｅ）或其鹽類之方法
CN110498835B (zh) * 2018-05-17 2021-06-08 深圳翰宇药业股份有限公司 一种合成etelcalcetide的方法
CN109280078B (zh) * 2018-10-30 2019-06-25 成都诺和晟泰生物科技有限公司 一种制备维拉卡肽的方法
CN112062811B (zh) * 2019-06-10 2022-03-25 深圳翰宇药业股份有限公司 一种维拉卡肽的合成方法
WO2021038431A1 (en) * 2019-08-26 2021-03-04 Auro Peptides Ltd An improved process for the preparation of etelcalcetide hydrochloride
EP3875466A1 (en) * 2020-03-05 2021-09-08 Fresenius Kabi iPSUM S.r.l. Process for the synthesis of etelcalcetide
EP4144747A4 (en) 2020-06-03 2024-05-29 Chugai Seiyaku Kabushiki Kaisha EFFICIENT PEPTIDE CONDENSATION PROCESS FOR DIFFICULT SEQUENCES
CN111925415A (zh) * 2020-08-10 2020-11-13 海南中和药业股份有限公司 一种维拉卡肽杂质的制备方法
TWI792442B (zh) 2021-07-23 2023-02-11 建誼生技股份有限公司 依特卡肽鹽酸鹽之製造方法
CN114524860B (zh) * 2021-12-29 2025-01-24 深圳翰宇药业股份有限公司 一种Etelcalcetide的合成方法及其应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3941763A (en) 1975-03-28 1976-03-02 American Home Products Corporation PGlu-D-Met-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 and intermediates
EP0339695A3 (en) 1988-04-29 1990-05-30 Stichting Voor De Technische Wetenschappen A process for preparing an antigenic or immunogenic conjugate as well as the use of such conjugates
SE9603465D0 (sv) 1996-09-23 1996-09-23 Astra Ab New compounds
NO311807B1 (no) 1999-03-04 2002-01-28 Bionor Immuno As HIV-peptider, antigener, vaksinepreparater, immunoassay- testsett og en metode for påvisning av antistoffer fremkalt av HIV
CA2703113A1 (en) 2007-10-27 2009-04-30 F. Hoffmann-La Roche Ag Insulinotropic peptide synthesis using solid and solution phase combination techniques
CN101250172B (zh) 2008-03-07 2012-05-02 上海瀚鸿化工科技有限公司 精氨酸双保护制备工艺
WO2010129520A1 (en) 2009-05-06 2010-11-11 Mallinckrodt Inc. Solid support for fmoc-solid phase synthesis of peptide acids
JP5270799B2 (ja) * 2009-07-29 2013-08-21 カイ・ファーマシューティカルズ・インコーポレイテッド 副甲状腺ホルモンを低減する治療剤
EP2560491A1 (en) * 2010-04-21 2013-02-27 Signature Therapeutics, Inc. Peripheral opioid agonists and peripheral opioid antagonists
US20140024592A1 (en) * 2010-09-08 2014-01-23 Howard Florey Institute Of Experimental Physiology And Medicine Modified Relaxin Polypeptides
WO2013042129A1 (en) 2011-09-23 2013-03-28 Natco Pharma Limited Improved process for preparation of bivalirudin
CN114376970A (zh) 2013-06-28 2022-04-22 美国安进公司 Etelcalcetide (AMG 416)的稳定的液体制剂
MX374205B (es) 2014-04-03 2025-03-05 Amgen Inc Metodo para preparar amg 416.
CN105504012A (zh) * 2014-09-30 2016-04-20 深圳翰宇药业股份有限公司 一种多肽的制备方法
CN107434820A (zh) * 2017-08-07 2017-12-05 南京工业大学 一种维拉卡肽的合成方法

Also Published As

Publication number Publication date
US11377474B2 (en) 2022-07-05
RS60187B1 (sr) 2020-06-30
EP3126373B1 (en) 2020-03-04
SI3126373T1 (sl) 2020-06-30
BR112016022868A2 (pt) 2018-07-03
HRP20200527T1 (hr) 2020-06-26
JP2017511332A (ja) 2017-04-20
HUE048489T2 (hu) 2020-07-28
SMT202000207T1 (it) 2020-05-08
MA39628B1 (fr) 2020-05-29
US20230099078A1 (en) 2023-03-30
EA201692001A1 (ru) 2017-02-28
LT3126373T (lt) 2020-05-11
CN106795201A (zh) 2017-05-31
CA2944194A1 (en) 2015-10-08
AU2015240527A1 (en) 2016-10-20
EP3126373A1 (en) 2017-02-08
US20190352336A1 (en) 2019-11-21
JP6710158B2 (ja) 2020-06-17
KR102397271B1 (ko) 2022-05-16
EP3126373A4 (en) 2018-06-20
EP4219526A3 (en) 2023-08-30
CA2944194C (en) 2022-04-19
ES2943671T3 (es) 2023-06-15
CN119874825A (zh) 2025-04-25
IL248059B1 (en) 2023-06-01
EA032597B1 (ru) 2019-06-28
CY1123100T1 (el) 2021-10-29
US10407464B2 (en) 2019-09-10
EP3708576A1 (en) 2020-09-16
ME03781B (me) 2021-04-20
SG11201608176VA (en) 2016-10-28
ES2786225T3 (es) 2020-10-09
IL248059B2 (en) 2023-10-01
MA52906A (fr) 2021-04-21
CL2016002513A1 (es) 2018-03-23
DK3126373T3 (da) 2020-05-04
KR20170026326A (ko) 2017-03-08
PT3126373T (pt) 2020-04-24
EP4219526A2 (en) 2023-08-02
ZA201606844B (en) 2018-07-25
US20170190739A1 (en) 2017-07-06
MX2016012965A (es) 2017-07-06
CN119899242A (zh) 2025-04-29
AU2015240527B2 (en) 2019-09-26
IL248059A0 (en) 2016-11-30
WO2015154031A1 (en) 2015-10-08
PL3126373T3 (pl) 2020-07-27
EP3708576B1 (en) 2023-02-22

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