MX369930B - Esteres de lactama esteroidal y derivados de acido bis(2-cloroetil)aminofenoxi propanoico. - Google Patents

Esteres de lactama esteroidal y derivados de acido bis(2-cloroetil)aminofenoxi propanoico.

Info

Publication number
MX369930B
MX369930B MX2017016679A MX2017016679A MX369930B MX 369930 B MX369930 B MX 369930B MX 2017016679 A MX2017016679 A MX 2017016679A MX 2017016679 A MX2017016679 A MX 2017016679A MX 369930 B MX369930 B MX 369930B
Authority
MX
Mexico
Prior art keywords
chloroethyl
bis
propanoic acid
esters
acid derivatives
Prior art date
Application number
MX2017016679A
Other languages
English (en)
Other versions
MX2017016679A (es
Inventor
Trafalis Dimitrios
Original Assignee
Galenica S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galenica S A filed Critical Galenica S A
Publication of MX2017016679A publication Critical patent/MX2017016679A/es
Publication of MX369930B publication Critical patent/MX369930B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se describen ésteres homo-aza-esteroidales novedosos con ácido bis(2-cloroetil)aminofenoxi propanoico alquilante y derivados sustituidos, procedimientos para su preparación, composiciones farmacéuticas que los contienen, y su uso en el tratamiento del cáncer.
MX2017016679A 2015-06-29 2016-06-28 Esteres de lactama esteroidal y derivados de acido bis(2-cloroetil)aminofenoxi propanoico. MX369930B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15386022 2015-06-29
PCT/EP2016/065071 WO2017001439A1 (en) 2015-06-29 2016-06-28 Esters of steroidal lactam and bis(2-chloroethyl) aminophenoxy propanoic acid derivatives

Publications (2)

Publication Number Publication Date
MX2017016679A MX2017016679A (es) 2018-07-06
MX369930B true MX369930B (es) 2019-11-26

Family

ID=53716416

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017016679A MX369930B (es) 2015-06-29 2016-06-28 Esteres de lactama esteroidal y derivados de acido bis(2-cloroetil)aminofenoxi propanoico.

Country Status (24)

Country Link
US (1) US10208083B2 (es)
EP (1) EP3186268B1 (es)
JP (1) JP6708670B2 (es)
KR (1) KR102647748B1 (es)
CN (1) CN107835817B (es)
AU (1) AU2016286205B8 (es)
BR (1) BR112017027850B1 (es)
CA (1) CA2990307C (es)
CY (1) CY1121264T1 (es)
DK (1) DK3186268T3 (es)
ES (1) ES2712429T3 (es)
HK (1) HK1248241A1 (es)
HR (1) HRP20190327T1 (es)
HU (1) HUE043468T2 (es)
IL (1) IL256456B (es)
LT (1) LT3186268T (es)
MX (1) MX369930B (es)
PL (1) PL3186268T3 (es)
PT (1) PT3186268T (es)
RS (1) RS58630B1 (es)
RU (1) RU2719457C2 (es)
SI (1) SI3186268T1 (es)
TR (1) TR201902369T4 (es)
WO (1) WO2017001439A1 (es)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1527161A (en) * 1976-02-19 1978-10-04 Leo A Enol esters of steroids
SU1361152A1 (ru) * 1983-07-08 1987-12-23 Всесоюзный онкологический научный центр АМН СССР Сложные моноэфиры 5 @ -андростандиола-3 @ ,17 @ ,про вл ющие противоопухолевую и гормональную активность
US10081592B2 (en) * 2012-03-23 2018-09-25 The Board Of Trustees Of The University Of Illinois Complex and structurally diverse compounds

Also Published As

Publication number Publication date
EP3186268A1 (en) 2017-07-05
JP2018519311A (ja) 2018-07-19
CN107835817A (zh) 2018-03-23
DK3186268T3 (en) 2019-03-18
CA2990307A1 (en) 2017-01-05
IL256456A (en) 2018-02-28
PT3186268T (pt) 2019-02-27
RS58630B1 (sr) 2019-05-31
EP3186268B1 (en) 2018-11-28
KR102647748B1 (ko) 2024-03-14
CY1121264T1 (el) 2020-05-29
RU2018103071A3 (es) 2019-09-30
ES2712429T3 (es) 2019-05-13
RU2719457C2 (ru) 2020-04-17
TR201902369T4 (tr) 2019-03-21
IL256456B (en) 2019-11-28
CA2990307C (en) 2023-09-26
MX2017016679A (es) 2018-07-06
CN107835817B (zh) 2020-04-21
RU2018103071A (ru) 2019-07-30
AU2016286205A1 (en) 2017-12-14
HRP20190327T1 (hr) 2019-05-03
HK1248241A1 (zh) 2018-10-12
KR20180015266A (ko) 2018-02-12
BR112017027850A2 (pt) 2018-09-04
PL3186268T3 (pl) 2019-05-31
BR112017027850B1 (pt) 2024-01-02
SI3186268T1 (sl) 2019-05-31
AU2016286205B2 (en) 2019-11-28
US20180194800A1 (en) 2018-07-12
LT3186268T (lt) 2019-04-25
US10208083B2 (en) 2019-02-19
WO2017001439A1 (en) 2017-01-05
HUE043468T2 (hu) 2019-08-28
AU2016286205B8 (en) 2020-04-16
JP6708670B2 (ja) 2020-06-10

Similar Documents

Publication Publication Date Title
PH12017501956A1 (en) Compositions of obeticholic acid and methods of use
NZ735998A (en) Heterocyclic compounds as lsd1 inhibitors
TN2015000278A1 (en) Autotaxin inhibitors
PH12015500983A1 (en) Heterocyclic substituted 2-amino-quinazoline derivatives for the treatment of viral infections
PH12014501738A1 (en) Piperidino-pyrimidine derivatives for the treatment of viral infections
IN2015DN01156A (es)
MX2015011897A (es) Profarmacos de fumaratos y su uso en el tratamiento de diferentes enfermedades.
IN2015MN00478A (es)
MY191590A (en) 9h-pyrrolo-dipyridine derivatives
PH12014501991B1 (en) Phenicol antibacterials
GEP20196961B (en) 4-oxo-3,4-dihydro-1,2,3 -benzotriazines modulators of gpr139
TW201613864A (en) Novel compounds
PH12017500348B1 (en) Tetrahydroquinoline derivatives as bromodomain inhibitors
MX357284B (es) Compuestos de quinona para tratar enfermedades mediadas por ape1.
MY180844A (en) Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions
MX2017014456A (es) Usos terapeuticos de l-4-cloroquinurenina.
PH12017501735A1 (en) Novel heterocyclic compound, method for preparing the same, and pharmaceutical composition comprising the same
MX2016006544A (es) Witanolidos utiles para el tratamiento de enfermedades neurodegenerativas.
MX2017017119A (es) Formulacion de alta concentracion.
IN2015DN02109A (es)
EA201590615A1 (ru) Стимулирующие лактацию композиции на основе фосфатидилсерина
MX369930B (es) Esteres de lactama esteroidal y derivados de acido bis(2-cloroetil)aminofenoxi propanoico.
AU2016349439A8 (en) Non-bioconvertible C3-substituted pregnenolone derivatives for use in the treatment of substance use disorders
UA116811C2 (uk) Комплекси агомелатину та сульфонових кислот, спосіб їх одержання та фармацевтичні композиції, що їх містять

Legal Events

Date Code Title Description
FG Grant or registration