BR112017027850A2 - composto, composição farmacêutica e uso de um composto - Google Patents

composto, composição farmacêutica e uso de um composto

Info

Publication number
BR112017027850A2
BR112017027850A2 BR112017027850-2A BR112017027850A BR112017027850A2 BR 112017027850 A2 BR112017027850 A2 BR 112017027850A2 BR 112017027850 A BR112017027850 A BR 112017027850A BR 112017027850 A2 BR112017027850 A2 BR 112017027850A2
Authority
BR
Brazil
Prior art keywords
compound
pharmaceutical composition
substituted
aza
chloroethyl
Prior art date
Application number
BR112017027850-2A
Other languages
English (en)
Other versions
BR112017027850B1 (pt
Inventor
Trafalis Dimitrios
Original Assignee
Galenica S.A.
Energonbio Technologies S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galenica S.A., Energonbio Technologies S.A. filed Critical Galenica S.A.
Publication of BR112017027850A2 publication Critical patent/BR112017027850A2/pt
Publication of BR112017027850B1 publication Critical patent/BR112017027850B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

a presente invenção refere-se a ésteres homo-aza-esteroides com ácido bis(2-cloroetil)aminofenóxi propanoico alquilante e derivados substituídos, processos para a sua preparação, composições farmacêuticas contendo-os e seu uso no tratamento de câncer.
BR112017027850-2A 2015-06-29 2016-06-28 Composto, composição farmacêutica e uso de um composto BR112017027850B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15386022 2015-06-29
EP15386022.6 2015-06-29
PCT/EP2016/065071 WO2017001439A1 (en) 2015-06-29 2016-06-28 Esters of steroidal lactam and bis(2-chloroethyl) aminophenoxy propanoic acid derivatives

Publications (2)

Publication Number Publication Date
BR112017027850A2 true BR112017027850A2 (pt) 2018-09-04
BR112017027850B1 BR112017027850B1 (pt) 2024-01-02

Family

ID=53716416

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017027850-2A BR112017027850B1 (pt) 2015-06-29 2016-06-28 Composto, composição farmacêutica e uso de um composto

Country Status (24)

Country Link
US (1) US10208083B2 (pt)
EP (1) EP3186268B1 (pt)
JP (1) JP6708670B2 (pt)
KR (1) KR102647748B1 (pt)
CN (1) CN107835817B (pt)
AU (1) AU2016286205B8 (pt)
BR (1) BR112017027850B1 (pt)
CA (1) CA2990307C (pt)
CY (1) CY1121264T1 (pt)
DK (1) DK3186268T3 (pt)
ES (1) ES2712429T3 (pt)
HK (1) HK1248241A1 (pt)
HR (1) HRP20190327T1 (pt)
HU (1) HUE043468T2 (pt)
IL (1) IL256456B (pt)
LT (1) LT3186268T (pt)
MX (1) MX369930B (pt)
PL (1) PL3186268T3 (pt)
PT (1) PT3186268T (pt)
RS (1) RS58630B1 (pt)
RU (1) RU2719457C2 (pt)
SI (1) SI3186268T1 (pt)
TR (1) TR201902369T4 (pt)
WO (1) WO2017001439A1 (pt)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1527161A (en) * 1976-02-19 1978-10-04 Leo A Enol esters of steroids
SU1361152A1 (ru) * 1983-07-08 1987-12-23 Всесоюзный онкологический научный центр АМН СССР Сложные моноэфиры 5 @ -андростандиола-3 @ ,17 @ ,про вл ющие противоопухолевую и гормональную активность
US10081592B2 (en) * 2012-03-23 2018-09-25 The Board Of Trustees Of The University Of Illinois Complex and structurally diverse compounds

Also Published As

Publication number Publication date
RU2719457C2 (ru) 2020-04-17
CA2990307A1 (en) 2017-01-05
EP3186268A1 (en) 2017-07-05
RU2018103071A (ru) 2019-07-30
WO2017001439A1 (en) 2017-01-05
AU2016286205B8 (en) 2020-04-16
ES2712429T3 (es) 2019-05-13
LT3186268T (lt) 2019-04-25
RU2018103071A3 (pt) 2019-09-30
MX369930B (es) 2019-11-26
IL256456B (en) 2019-11-28
MX2017016679A (es) 2018-07-06
BR112017027850B1 (pt) 2024-01-02
DK3186268T3 (en) 2019-03-18
HRP20190327T1 (hr) 2019-05-03
KR102647748B1 (ko) 2024-03-14
TR201902369T4 (tr) 2019-03-21
CN107835817A (zh) 2018-03-23
AU2016286205B2 (en) 2019-11-28
AU2016286205A1 (en) 2017-12-14
SI3186268T1 (sl) 2019-05-31
RS58630B1 (sr) 2019-05-31
CN107835817B (zh) 2020-04-21
JP6708670B2 (ja) 2020-06-10
JP2018519311A (ja) 2018-07-19
HUE043468T2 (hu) 2019-08-28
PT3186268T (pt) 2019-02-27
KR20180015266A (ko) 2018-02-12
US20180194800A1 (en) 2018-07-12
CY1121264T1 (el) 2020-05-29
IL256456A (en) 2018-02-28
EP3186268B1 (en) 2018-11-28
PL3186268T3 (pl) 2019-05-31
HK1248241A1 (zh) 2018-10-12
US10208083B2 (en) 2019-02-19
CA2990307C (en) 2023-09-26

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/06/2016, OBSERVADAS AS CONDICOES LEGAIS