MX2017016679A - Esteres de lactama esteroidal y derivados de acido bis(2-cloroetil)aminofenoxi propanoico. - Google Patents

Esteres de lactama esteroidal y derivados de acido bis(2-cloroetil)aminofenoxi propanoico.

Info

Publication number
MX2017016679A
MX2017016679A MX2017016679A MX2017016679A MX2017016679A MX 2017016679 A MX2017016679 A MX 2017016679A MX 2017016679 A MX2017016679 A MX 2017016679A MX 2017016679 A MX2017016679 A MX 2017016679A MX 2017016679 A MX2017016679 A MX 2017016679A
Authority
MX
Mexico
Prior art keywords
chloroethyl
bis
propanoic acid
esters
acid derivatives
Prior art date
Application number
MX2017016679A
Other languages
English (en)
Other versions
MX369930B (es
Inventor
Trafalis Dimitrios
Original Assignee
Galenica S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galenica S A filed Critical Galenica S A
Publication of MX2017016679A publication Critical patent/MX2017016679A/es
Publication of MX369930B publication Critical patent/MX369930B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se describen ósteres homo-aza-esteroidales novedosos con ácido bis(2-cloroetil)aminofenoxi propanoico alquilante y derivados sustituidos, procedimientos para su preparación, composiciones farmacóuticas que los contienen, y su uso en el tratamiento del cáncer.
MX2017016679A 2015-06-29 2016-06-28 Esteres de lactama esteroidal y derivados de acido bis(2-cloroetil)aminofenoxi propanoico. MX369930B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15386022 2015-06-29
PCT/EP2016/065071 WO2017001439A1 (en) 2015-06-29 2016-06-28 Esters of steroidal lactam and bis(2-chloroethyl) aminophenoxy propanoic acid derivatives

Publications (2)

Publication Number Publication Date
MX2017016679A true MX2017016679A (es) 2018-07-06
MX369930B MX369930B (es) 2019-11-26

Family

ID=53716416

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017016679A MX369930B (es) 2015-06-29 2016-06-28 Esteres de lactama esteroidal y derivados de acido bis(2-cloroetil)aminofenoxi propanoico.

Country Status (24)

Country Link
US (1) US10208083B2 (es)
EP (1) EP3186268B1 (es)
JP (1) JP6708670B2 (es)
KR (1) KR102647748B1 (es)
CN (1) CN107835817B (es)
AU (1) AU2016286205B8 (es)
BR (1) BR112017027850B1 (es)
CA (1) CA2990307C (es)
CY (1) CY1121264T1 (es)
DK (1) DK3186268T3 (es)
ES (1) ES2712429T3 (es)
HK (1) HK1248241A1 (es)
HR (1) HRP20190327T1 (es)
HU (1) HUE043468T2 (es)
IL (1) IL256456B (es)
LT (1) LT3186268T (es)
MX (1) MX369930B (es)
PL (1) PL3186268T3 (es)
PT (1) PT3186268T (es)
RS (1) RS58630B1 (es)
RU (1) RU2719457C2 (es)
SI (1) SI3186268T1 (es)
TR (1) TR201902369T4 (es)
WO (1) WO2017001439A1 (es)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1527161A (en) * 1976-02-19 1978-10-04 Leo A Enol esters of steroids
SU1361152A1 (ru) * 1983-07-08 1987-12-23 Всесоюзный онкологический научный центр АМН СССР Сложные моноэфиры 5 @ -андростандиола-3 @ ,17 @ ,про вл ющие противоопухолевую и гормональную активность
WO2013142873A2 (en) * 2012-03-23 2013-09-26 The Board Of Trustees Of The University Of Illinois Complex and structurally diverse compounds

Also Published As

Publication number Publication date
SI3186268T1 (sl) 2019-05-31
WO2017001439A1 (en) 2017-01-05
RS58630B1 (sr) 2019-05-31
BR112017027850B1 (pt) 2024-01-02
JP2018519311A (ja) 2018-07-19
IL256456A (en) 2018-02-28
AU2016286205B2 (en) 2019-11-28
RU2018103071A3 (es) 2019-09-30
US10208083B2 (en) 2019-02-19
LT3186268T (lt) 2019-04-25
EP3186268A1 (en) 2017-07-05
MX369930B (es) 2019-11-26
CA2990307A1 (en) 2017-01-05
CN107835817A (zh) 2018-03-23
PL3186268T3 (pl) 2019-05-31
TR201902369T4 (tr) 2019-03-21
KR20180015266A (ko) 2018-02-12
CY1121264T1 (el) 2020-05-29
HK1248241A1 (zh) 2018-10-12
JP6708670B2 (ja) 2020-06-10
US20180194800A1 (en) 2018-07-12
PT3186268T (pt) 2019-02-27
CA2990307C (en) 2023-09-26
AU2016286205A1 (en) 2017-12-14
ES2712429T3 (es) 2019-05-13
CN107835817B (zh) 2020-04-21
IL256456B (en) 2019-11-28
BR112017027850A2 (pt) 2018-09-04
EP3186268B1 (en) 2018-11-28
HRP20190327T1 (hr) 2019-05-03
DK3186268T3 (en) 2019-03-18
RU2719457C2 (ru) 2020-04-17
AU2016286205B8 (en) 2020-04-16
KR102647748B1 (ko) 2024-03-14
HUE043468T2 (hu) 2019-08-28
RU2018103071A (ru) 2019-07-30

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