MX367241B - Uso de anticuerpos contra claudina 18.2 en una terapia de combinación para el tratamiento de cáncer. - Google Patents

Uso de anticuerpos contra claudina 18.2 en una terapia de combinación para el tratamiento de cáncer.

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Publication number
MX367241B
MX367241B MX2014014215A MX2014014215A MX367241B MX 367241 B MX367241 B MX 367241B MX 2014014215 A MX2014014215 A MX 2014014215A MX 2014014215 A MX2014014215 A MX 2014014215A MX 367241 B MX367241 B MX 367241B
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MX
Mexico
Prior art keywords
treatment
combination therapy
cancer
antibodies against
against claudin
Prior art date
Application number
MX2014014215A
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English (en)
Other versions
MX2014014215A (es
Inventor
Sahin Ugur
Türeci Özlem
Mitnacht-Kraus Rita
Denis Jacobs Stefan
Jadwiga Utsch Magdalena
Adriana Maria Heinz Cornelia
Regina Stadler Christiane
Original Assignee
Tron Translationale Onkologie An Der Johannes Gutenberg Univ Mainz Gemeinnuetzige Gmbh
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Publication date
Application filed by Tron Translationale Onkologie An Der Johannes Gutenberg Univ Mainz Gemeinnuetzige Gmbh filed Critical Tron Translationale Onkologie An Der Johannes Gutenberg Univ Mainz Gemeinnuetzige Gmbh
Publication of MX2014014215A publication Critical patent/MX2014014215A/es
Publication of MX367241B publication Critical patent/MX367241B/es

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    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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Abstract

La presente invención se refiere a el uso de un anticuerpo que tiene la capacidad de enlazar a la variante 2 de empalme de Clauidina 18 (CLDN18.2) en una terapia de combinación con un agente que estimula las células T???, para la preparación de un medicamento para el tratamiento o prevención de una enfermedad de cáncer.
MX2014014215A 2012-05-23 2013-05-21 Uso de anticuerpos contra claudina 18.2 en una terapia de combinación para el tratamiento de cáncer. MX367241B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2012/002211 WO2013174404A1 (en) 2012-05-23 2012-05-23 Combination therapy involving antibodies against claudin 18.2 for treatment of cancer
PCT/EP2013/001503 WO2013174509A1 (en) 2012-05-23 2013-05-21 Combination therapy involving antibodies against claudin 18.2 for treatment of cancer

Publications (2)

Publication Number Publication Date
MX2014014215A MX2014014215A (es) 2015-06-23
MX367241B true MX367241B (es) 2019-08-09

Family

ID=48651960

Family Applications (5)

Application Number Title Priority Date Filing Date
MX2014014215A MX367241B (es) 2012-05-23 2013-05-21 Uso de anticuerpos contra claudina 18.2 en una terapia de combinación para el tratamiento de cáncer.
MX2020011768A MX2020011768A (es) 2012-05-23 2014-11-21 Terapia de combinacion que involucra anticuerpos contra claudina 18.2 para tratamiento de cancer.
MX2020011795A MX2020011795A (es) 2012-05-23 2014-11-21 Terapia de combinacion que involucra anticuerpos contra claudina 18.2 para tratamiento de cancer.
MX2020011796A MX2020011796A (es) 2012-05-23 2014-11-21 Terapia de combinacion que involucra anticuerpos contra claudina 18.2 para tratamiento de cancer.
MX2019009441A MX2019009441A (es) 2012-05-23 2014-11-21 Terapia de combinacion que involucra anticuerpos contra claudina 18.2 para tratamiento de cancer.

Family Applications After (4)

Application Number Title Priority Date Filing Date
MX2020011768A MX2020011768A (es) 2012-05-23 2014-11-21 Terapia de combinacion que involucra anticuerpos contra claudina 18.2 para tratamiento de cancer.
MX2020011795A MX2020011795A (es) 2012-05-23 2014-11-21 Terapia de combinacion que involucra anticuerpos contra claudina 18.2 para tratamiento de cancer.
MX2020011796A MX2020011796A (es) 2012-05-23 2014-11-21 Terapia de combinacion que involucra anticuerpos contra claudina 18.2 para tratamiento de cancer.
MX2019009441A MX2019009441A (es) 2012-05-23 2014-11-21 Terapia de combinacion que involucra anticuerpos contra claudina 18.2 para tratamiento de cancer.

Country Status (25)

Country Link
US (5) US9433675B2 (es)
JP (6) JP6203830B2 (es)
KR (4) KR102188001B1 (es)
CN (3) CN104427999B (es)
AR (1) AR091131A1 (es)
AU (4) AU2013265637B8 (es)
BR (1) BR112014028941B8 (es)
CA (1) CA2874028A1 (es)
ES (2) ES2924023T3 (es)
HK (1) HK1208151A1 (es)
HR (1) HRP20220897T8 (es)
HU (1) HUE059241T2 (es)
IL (3) IL276434B2 (es)
LT (1) LT3725810T (es)
MX (5) MX367241B (es)
NZ (1) NZ701575A (es)
PL (1) PL3725810T3 (es)
PT (1) PT3725810T (es)
RS (1) RS63437B1 (es)
RU (1) RU2662066C2 (es)
SG (2) SG11201406963RA (es)
SI (1) SI3725810T1 (es)
SM (1) SMT202200325T1 (es)
UA (1) UA115985C2 (es)
WO (2) WO2013174404A1 (es)

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EP1790664A1 (en) 2005-11-24 2007-05-30 Ganymed Pharmaceuticals AG Monoclonal antibodies against claudin-18 for treatment of cancer
US20100183558A1 (en) 2008-10-17 2010-07-22 Zhennan Lai Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules
WO2013167153A1 (en) 2012-05-09 2013-11-14 Ganymed Pharmaceuticals Ag Antibodies useful in cancer diagnosis
EP2852409B1 (en) 2012-05-23 2020-03-25 Astellas Pharma Inc. Combination therapy involving antibodies against claudin 18.2 for treatment of cancer
WO2013174404A1 (en) * 2012-05-23 2013-11-28 Ganymed Pharmaceuticals Ag Combination therapy involving antibodies against claudin 18.2 for treatment of cancer
US10093736B2 (en) 2012-11-13 2018-10-09 Biontech Ag Agents for treatment of claudin expressing cancer diseases
WO2014127785A1 (en) 2013-02-20 2014-08-28 Ganymed Pharmaceuticals Ag Combination therapy involving antibodies against claudin 18.2 for treatment of cancer
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