MX366308B - Derivados de amida como bloqueadores de ttx-s. - Google Patents
Derivados de amida como bloqueadores de ttx-s.Info
- Publication number
- MX366308B MX366308B MX2014012916A MX2014012916A MX366308B MX 366308 B MX366308 B MX 366308B MX 2014012916 A MX2014012916 A MX 2014012916A MX 2014012916 A MX2014012916 A MX 2014012916A MX 366308 B MX366308 B MX 366308B
- Authority
- MX
- Mexico
- Prior art keywords
- ttx
- amide derivatives
- blockers
- gated sodium
- voltage gated
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
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- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract
La presente invención se refiere a derivados de amida los cuales tienen actividades de bloqueo de canales de sodio activados por voltaje como los canales TTX-S, y los cuales son útiles en el tratamiento o prevención de desórdenes y enfermedades en las que están involucrados los canales de sodio activados por voltaje. La invención también se relaciona con composiciones farmacéuticas que comprenden estos compuestos y al uso de estos compuestos y composiciones en la prevención o tratamiento de tales enfermedades en las cuales están involucrados los canales de sodio activados por voltaje. (ver Fórmula).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261638108P | 2012-04-25 | 2012-04-25 | |
PCT/JP2013/002812 WO2013161308A1 (en) | 2012-04-25 | 2013-04-25 | Amide derivatives as ttx-s blockers |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014012916A MX2014012916A (es) | 2014-11-25 |
MX366308B true MX366308B (es) | 2019-07-04 |
Family
ID=49482650
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014012916A MX366308B (es) | 2012-04-25 | 2013-04-25 | Derivados de amida como bloqueadores de ttx-s. |
Country Status (14)
Country | Link |
---|---|
US (1) | US9701658B2 (es) |
EP (1) | EP2841421B1 (es) |
JP (1) | JP6175673B2 (es) |
KR (1) | KR102067235B1 (es) |
CN (1) | CN104364235B (es) |
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RU (1) | RU2632899C2 (es) |
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WO (1) | WO2013161308A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
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US10005724B2 (en) * | 2014-07-07 | 2018-06-26 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
CN106573915B (zh) | 2014-08-01 | 2020-12-25 | 纽韦卢森公司 | 针对布罗莫结构域有活性的化合物 |
EP3265456B1 (en) * | 2015-03-06 | 2020-11-18 | Pharmakea, Inc. | Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof |
WO2016144702A1 (en) | 2015-03-06 | 2016-09-15 | Pharmakea, Inc. | Lysyl oxidase-like 2 inhibitors and uses thereof |
WO2017211303A1 (en) | 2016-06-07 | 2017-12-14 | Jacobio Pharmaceuticals Co., Ltd. | Novel heterocyclic derivatives useful as shp2 inhibitors |
EA201990621A1 (ru) | 2016-09-07 | 2019-09-30 | Фармакеа, Инк. | Кристаллические формы ингибитора лизилоксидаза-подобного белка 2 и способы получения |
KR102615565B1 (ko) | 2016-09-07 | 2023-12-18 | 파마케아, 인크. | 리실 옥시다제 유사 2 억제제의 용도 |
US10988466B2 (en) | 2017-03-23 | 2021-04-27 | Jacobio Pharmaceuticals Co., Ltd. | Heterocyclic derivatives useful as SHP2 inhibitors |
JP6592702B1 (ja) * | 2017-06-20 | 2019-10-23 | ラクオリア創薬株式会社 | Nav1.7およびNav1.8遮断薬としてのアミド誘導体 |
WO2019045035A1 (en) * | 2017-08-31 | 2019-03-07 | Raqualia Pharma Inc. | BIARYLOXY DERIVATIVES AS TTX-S BLOCKERS |
BR112021008995A2 (pt) * | 2018-12-26 | 2021-08-10 | Raqualia Pharma Inc. | derivados heterocíclicos como bloqueadores de nav1.7 e nav1.8 |
AU2020417293A1 (en) | 2020-01-03 | 2022-09-01 | Berg Llc | Polycyclic amides as UBE2K modulators for treating cancer |
WO2022150962A1 (en) | 2021-01-12 | 2022-07-21 | Westlake Pharmaceutical (Hangzhou) Co., Ltd. | Protease inhibitors, preparation, and uses thereof |
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CA2465207C (en) * | 2001-11-01 | 2011-01-04 | Icagen, Inc. | Pyrazole-amides and -sulfonamides |
WO2008118758A1 (en) * | 2007-03-23 | 2008-10-02 | Icagen, Inc. | Inhibitors of ion channels |
CA2684105C (en) * | 2007-05-03 | 2011-09-06 | Pfizer Limited | Pyridine derivatives |
WO2010035166A1 (en) * | 2008-09-23 | 2010-04-01 | Pfizer Limited | Benzamide derivatives |
CN105254557A (zh) | 2009-05-29 | 2016-01-20 | 拉夸里亚创药株式会社 | 作为钙或钠通道阻滞剂的芳基取代羧酰胺衍生物 |
US8999974B2 (en) * | 2010-08-09 | 2015-04-07 | Raqualia Pharma Inc. | Acyl piperazine derivatives as TTX-S blockers |
CA2813708C (en) * | 2010-10-18 | 2019-09-17 | Raqualia Pharma Inc. | Arylamide derivatives as ttx-s blockers |
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CN104364235B (zh) | 2017-07-04 |
CA2870992C (en) | 2020-07-14 |
KR20150013180A (ko) | 2015-02-04 |
RU2632899C2 (ru) | 2017-10-11 |
US20150105393A1 (en) | 2015-04-16 |
CN104364235A (zh) | 2015-02-18 |
TWI599562B (zh) | 2017-09-21 |
BR112014026399A8 (pt) | 2018-01-16 |
BR112014026399A2 (pt) | 2017-06-27 |
KR102067235B1 (ko) | 2020-01-16 |
EP2841421B1 (en) | 2019-06-05 |
US9701658B2 (en) | 2017-07-11 |
BR112014026399B1 (pt) | 2022-11-01 |
MX2014012916A (es) | 2014-11-25 |
JP2015514680A (ja) | 2015-05-21 |
JP6175673B2 (ja) | 2017-08-09 |
CA2870992A1 (en) | 2013-10-31 |
EP2841421A1 (en) | 2015-03-04 |
WO2013161308A1 (en) | 2013-10-31 |
RU2014147191A (ru) | 2016-06-10 |
EP2841421A4 (en) | 2015-11-18 |
ES2743402T3 (es) | 2020-02-19 |
IN2014MN01982A (es) | 2015-07-10 |
HK1207380A1 (en) | 2016-01-29 |
TW201348208A (zh) | 2013-12-01 |
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