BR112014026399A2 - composto da fórmula (i) e da fórmula (ii), composição farmacêutica, método para o tratamento de uma condição ou distúrbio no qual bloqueadores de canal ttx-s estão envolvidos em um animal, incluindo humano, uso e processo para preparar uma composição farmacêutica - Google Patents
composto da fórmula (i) e da fórmula (ii), composição farmacêutica, método para o tratamento de uma condição ou distúrbio no qual bloqueadores de canal ttx-s estão envolvidos em um animal, incluindo humano, uso e processo para preparar uma composição farmacêuticaInfo
- Publication number
- BR112014026399A2 BR112014026399A2 BR112014026399A BR112014026399A BR112014026399A2 BR 112014026399 A2 BR112014026399 A2 BR 112014026399A2 BR 112014026399 A BR112014026399 A BR 112014026399A BR 112014026399 A BR112014026399 A BR 112014026399A BR 112014026399 A2 BR112014026399 A2 BR 112014026399A2
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- BR
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- Prior art keywords
- formula
- pharmaceutical composition
- ttx
- disorder
- animal
- Prior art date
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201261638108P | 2012-04-25 | 2012-04-25 | |
US61/638,108 | 2012-04-25 | ||
PCT/JP2013/002812 WO2013161308A1 (en) | 2012-04-25 | 2013-04-25 | Amide derivatives as ttx-s blockers |
Publications (3)
Publication Number | Publication Date |
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BR112014026399A2 true BR112014026399A2 (pt) | 2017-06-27 |
BR112014026399A8 BR112014026399A8 (pt) | 2018-01-16 |
BR112014026399B1 BR112014026399B1 (pt) | 2022-11-01 |
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JP (1) | JP6175673B2 (pt) |
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CN (1) | CN104364235B (pt) |
BR (1) | BR112014026399B1 (pt) |
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US10005724B2 (en) * | 2014-07-07 | 2018-06-26 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
SG10201900631TA (en) | 2014-08-01 | 2019-02-27 | Nuevolution As | Compounds active towards bromodomains |
EP3265445B1 (en) | 2015-03-06 | 2021-05-05 | Pharmakea, Inc. | Lysyl oxidase-like 2 inhibitors and uses thereof |
EP3265456B1 (en) * | 2015-03-06 | 2020-11-18 | Pharmakea, Inc. | Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof |
EA201990001A1 (ru) | 2016-06-07 | 2019-05-31 | Джакобио Фармасьютикалс Ко., Лтд. | Новые гетероциклические производные, применимые в качестве ингибиторов shp2 |
MX2019002612A (es) | 2016-09-07 | 2019-08-21 | Pharmakea Inc | Usos de un inhibidor de lisil-oxidasa tipo 2. |
CA3036064A1 (en) | 2016-09-07 | 2018-03-15 | Pharmakea, Inc. | Crystalline forms of a lysyl oxidase-like 2 inhibitor and methods of making |
US10988466B2 (en) | 2017-03-23 | 2021-04-27 | Jacobio Pharmaceuticals Co., Ltd. | Heterocyclic derivatives useful as SHP2 inhibitors |
MX2019012635A (es) * | 2017-06-20 | 2019-12-11 | Raqualia Pharma Inc | Derivados de amida como bloqueadores de nav1.7 y nav1.8. |
JP2020532507A (ja) | 2017-08-31 | 2020-11-12 | ラクオリア創薬株式会社 | Ttx−s遮断薬としてのビアリールオキシ誘導体 |
WO2020138271A1 (en) * | 2018-12-26 | 2020-07-02 | Raqualia Pharma Inc. | HETEROCYCLIC DERIVATIVES AS Nav1.7 and Nav1.8 BLOCKERS |
JP2023509452A (ja) | 2020-01-03 | 2023-03-08 | バーグ エルエルシー | がんを処置するためのube2kモジュレータとしての多環式アミド |
WO2022150962A1 (en) * | 2021-01-12 | 2022-07-21 | Westlake Pharmaceutical (Hangzhou) Co., Ltd. | Protease inhibitors, preparation, and uses thereof |
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ATE455104T1 (de) * | 2001-11-01 | 2010-01-15 | Icagen Inc | Pyrazolamide zur anwendung in der behandlung von schmerz |
WO2008118758A1 (en) | 2007-03-23 | 2008-10-02 | Icagen, Inc. | Inhibitors of ion channels |
MX2009011816A (es) * | 2007-05-03 | 2009-11-19 | Pfizer Ltd | Derivados de piridina. |
WO2010035166A1 (en) * | 2008-09-23 | 2010-04-01 | Pfizer Limited | Benzamide derivatives |
EP3632899A1 (en) * | 2009-05-29 | 2020-04-08 | RaQualia Pharma Inc. | Aryl substituted carboxamide derivatives as calcium or sodium channel blockers |
US8999974B2 (en) * | 2010-08-09 | 2015-04-07 | Raqualia Pharma Inc. | Acyl piperazine derivatives as TTX-S blockers |
TWI546286B (zh) * | 2010-10-18 | 2016-08-21 | 拉夸里亞創藥股份有限公司 | 做為ttx-s阻斷劑的芳醯胺衍生物 |
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2013
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- 2013-04-25 EP EP13781524.7A patent/EP2841421B1/en active Active
- 2013-04-25 CN CN201380020120.1A patent/CN104364235B/zh active Active
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- 2013-04-25 CA CA2870992A patent/CA2870992C/en active Active
- 2013-04-25 US US14/391,241 patent/US9701658B2/en active Active
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- 2013-04-25 JP JP2014551474A patent/JP6175673B2/ja active Active
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- 2013-04-25 TW TW102114785A patent/TWI599562B/zh active
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Also Published As
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BR112014026399B1 (pt) | 2022-11-01 |
JP6175673B2 (ja) | 2017-08-09 |
KR20150013180A (ko) | 2015-02-04 |
RU2632899C2 (ru) | 2017-10-11 |
TWI599562B (zh) | 2017-09-21 |
BR112014026399A8 (pt) | 2018-01-16 |
IN2014MN01982A (pt) | 2015-07-10 |
RU2014147191A (ru) | 2016-06-10 |
EP2841421A1 (en) | 2015-03-04 |
US9701658B2 (en) | 2017-07-11 |
CN104364235B (zh) | 2017-07-04 |
HK1207380A1 (en) | 2016-01-29 |
CA2870992C (en) | 2020-07-14 |
KR102067235B1 (ko) | 2020-01-16 |
JP2015514680A (ja) | 2015-05-21 |
CN104364235A (zh) | 2015-02-18 |
MX366308B (es) | 2019-07-04 |
WO2013161308A1 (en) | 2013-10-31 |
CA2870992A1 (en) | 2013-10-31 |
EP2841421A4 (en) | 2015-11-18 |
MX2014012916A (es) | 2014-11-25 |
TW201348208A (zh) | 2013-12-01 |
US20150105393A1 (en) | 2015-04-16 |
EP2841421B1 (en) | 2019-06-05 |
ES2743402T3 (es) | 2020-02-19 |
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