MX365707B - 6-cloro-3-(fenil-d5)inden-1-ona y su uso. - Google Patents

6-cloro-3-(fenil-d5)inden-1-ona y su uso.

Info

Publication number
MX365707B
MX365707B MX2015007727A MX2015007727A MX365707B MX 365707 B MX365707 B MX 365707B MX 2015007727 A MX2015007727 A MX 2015007727A MX 2015007727 A MX2015007727 A MX 2015007727A MX 365707 B MX365707 B MX 365707B
Authority
MX
Mexico
Prior art keywords
chloro
phenyl
inden
synthesis
discloses
Prior art date
Application number
MX2015007727A
Other languages
English (en)
Other versions
MX2015007727A (es
Inventor
Brandes Sebastian
Fog Jacobsen Mikkel
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of MX2015007727A publication Critical patent/MX2015007727A/es
Publication of MX365707B publication Critical patent/MX365707B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/004—Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención describe el compuesto 6- cloro-3-(fenil-d5) inden-1-ona (I) y rutas sintéticas para obtener (1) . En un aspecto adicional, la presente invención describe el uso de (I) para la síntesis de (S)-6-cloro-3- (fenil-d5) indan-1-ona.
MX2015007727A 2012-12-19 2013-12-19 6-cloro-3-(fenil-d5)inden-1-ona y su uso. MX365707B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261739095P 2012-12-19 2012-12-19
DKPA201200811 2012-12-19
PCT/EP2013/077314 WO2014096151A2 (en) 2012-12-19 2013-12-19 6-chloro-3-(phenyl-d5)-inden-1-one and use thereof

Publications (2)

Publication Number Publication Date
MX2015007727A MX2015007727A (es) 2015-09-07
MX365707B true MX365707B (es) 2019-06-11

Family

ID=59295365

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015007727A MX365707B (es) 2012-12-19 2013-12-19 6-cloro-3-(fenil-d5)inden-1-ona y su uso.

Country Status (25)

Country Link
US (1) US9309165B2 (es)
EP (1) EP2943460B1 (es)
JP (1) JP6290921B2 (es)
KR (1) KR102212096B1 (es)
CN (1) CN104955796B (es)
AR (1) AR094054A1 (es)
AU (1) AU2013366693B2 (es)
BR (1) BR112015014384A2 (es)
CA (1) CA2893224C (es)
CL (1) CL2015001720A1 (es)
CY (1) CY1122715T1 (es)
DK (1) DK2943460T3 (es)
HR (1) HRP20200385T1 (es)
IL (1) IL239097A (es)
LT (1) LT2943460T (es)
MX (1) MX365707B (es)
PL (1) PL2943460T3 (es)
PT (1) PT2943460T (es)
RS (1) RS59982B1 (es)
RU (1) RU2681221C2 (es)
SG (1) SG11201504437SA (es)
SI (1) SI2943460T1 (es)
SM (1) SMT202000131T1 (es)
WO (1) WO2014096151A2 (es)
ZA (1) ZA201504405B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3135656T1 (sl) 2011-06-20 2019-05-31 H. Lundbeck A/S Devterirani 1-piperazino-3-fenil indani za zdravljenje shizofrenije
CN104628630B (zh) * 2015-03-16 2017-01-18 哈尔滨工业大学 一种茚衍生物1‑吡啶基‑2‑溴茚及其合成方法
CN104892492A (zh) * 2015-06-18 2015-09-09 哈尔滨工业大学 一种茚衍生物1-吡啶基-6-甲基茚及其合成方法
JP2021520382A (ja) * 2018-04-06 2021-08-19 ハー・ルンドベック・アクチエゼルスカベット ２，２−ジメチルピペラジンの調製方法
EP3873885A1 (en) * 2018-10-29 2021-09-08 H. Lundbeck A/S Amorphous compounds of formula (i) and amorphous compounds of formula (i) salts
US11535600B2 (en) 2018-12-03 2022-12-27 H. Lundbeck A/S Prodrugs of 4-((1R,3S)-6-chloro-3-phenyl-2,3-dihydro-1H-inden-1-yl)-1,2,2-trimethylpiperazine and 4-((1R,3S)-6-chloro-3-(phenyl-d5)-2,3-dihydro-1H-inden-1-yl)-2,2-dimethyl-1-(methyl-d3)piperazine
KR102051783B1 (ko) * 2019-09-02 2019-12-03 부산대학교 산학협력단 3,10-이치환 벤조풀벤 유도체의 신규 합성방법
CN116251081A (zh) * 2021-12-09 2023-06-13 复旦大学 3-芳基茚酮类化合物及其药物用途

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62501009A (ja) * 1984-12-04 1987-04-23 サンド・アクチエンゲゼルシヤフト メバロノラクトンのインデン同族体及びその誘導体
DE19538218A1 (de) * 1995-10-13 1997-04-17 Bayer Ag Cyclopentan-1,3-dion-Derivate
WO1999015524A1 (en) * 1997-09-23 1999-04-01 Fujisawa Pharmaceutical Co., Ltd. Thiazole derivatives
SE9904850D0 (sv) * 1999-12-30 1999-12-30 Pharmacia & Upjohn Ab Novel process and intermediates
JP5144930B2 (ja) * 2003-08-18 2013-02-13 ハー・ルンドベック・アクチエゼルスカベット トランス−１−（６−クロロ−３−フェニルインダン−１−イル）−３，３−ジメチルピペラジン
RU2366654C2 (ru) * 2004-06-08 2009-09-10 ЭнЭсЭйБи, ФИЛИАЛ АФ НЕУРОСЕРЧ СВИДЕН АБ, СВЕРИЙЕ Новые дизамещенные фенилпиперидины/пиперазины в качестве модуляторов допаминовой нейротрансмиссии
TWI453198B (zh) * 2005-02-16 2014-09-21 Lundbeck & Co As H 製造反式-1-((1r,3s)-6-氯基-3-苯基茚滿-1-基) -3 , 3 -二甲基六氫吡與其鹽類之方法及製造4-((1r , 3s）-6 -氯基-3-苯基茚滿-1-基 )-1,2,2-三甲基六氫吡與其鹽類之方法
WO2007016431A2 (en) * 2005-07-29 2007-02-08 Concert Pharmaceuticals Inc. Novel benzo [d] [1,3]-dioxol derivatives
WO2008086158A1 (en) * 2007-01-04 2008-07-17 Smithkline Beecham Corporation Benzodihydroquinazoline as pi3 kinase inhibitors
TW201102370A (en) 2009-07-07 2011-01-16 Lundbeck & Co As H Manufacture of 4-((1R,3S)-6-chloro-3-phenyl-indan-1-yl)-1,2,2-trimethyl-piperazine and 1-((1R,3S)-6-chloro-3-phenyl-indan-1-yl)-3,3-dimethyl piperazine
KR101149529B1 (ko) * 2009-09-11 2012-05-25 한국화학연구원 인덴온 유도체 및 이를 포함하는 약학적 조성물
DK2639216T3 (en) 2010-11-09 2018-09-24 Kaneka Corp Halogenated Indones and Methods for Preparation of Optically Active Indanones or Optically Active Indanols Using These
EP2661427A1 (en) 2011-01-07 2013-11-13 H. Lundbeck A/S Method for resolution of 4-((1r,3s)-6-chloro-3-phenyl-indan-1-yl)-1,2,2-trimethyl-piperazine and 1-((1r,3s)-6-chloro-3-phenyl-indan, 1-yl)-3,3-dimethyl-piperazine
SI3135656T1 (sl) * 2011-06-20 2019-05-31 H. Lundbeck A/S Devterirani 1-piperazino-3-fenil indani za zdravljenje shizofrenije

Also Published As

Publication number Publication date
JP2016501901A (ja) 2016-01-21
RS59982B1 (sr) 2020-03-31
US9309165B2 (en) 2016-04-12
CL2015001720A1 (es) 2015-08-21
PL2943460T3 (pl) 2020-06-29
RU2015123308A (ru) 2017-01-26
WO2014096151A2 (en) 2014-06-26
CN104955796B (zh) 2017-05-24
AU2013366693B2 (en) 2017-07-13
HK1217688A1 (en) 2017-01-20
CA2893224C (en) 2021-01-26
AU2013366693A1 (en) 2015-06-11
KR102212096B1 (ko) 2021-02-04
CY1122715T1 (el) 2021-05-05
JP6290921B2 (ja) 2018-03-07
HRP20200385T1 (hr) 2020-06-12
ZA201504405B (en) 2016-11-30
SG11201504437SA (en) 2015-07-30
PT2943460T (pt) 2020-03-25
WO2014096151A3 (en) 2014-08-28
AR094054A1 (es) 2015-07-08
IL239097A (en) 2017-04-30
IL239097A0 (en) 2015-07-30
SI2943460T1 (sl) 2020-04-30
KR20150097511A (ko) 2015-08-26
RU2681221C2 (ru) 2019-03-05
CN104955796A (zh) 2015-09-30
EP2943460A2 (en) 2015-11-18
EP2943460B1 (en) 2020-02-12
MX2015007727A (es) 2015-09-07
CA2893224A1 (en) 2014-06-26
LT2943460T (lt) 2020-04-10
US20150336867A1 (en) 2015-11-26
SMT202000131T1 (it) 2020-05-08
DK2943460T3 (da) 2020-03-16
BR112015014384A2 (pt) 2020-06-16

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