MX363367B - Sales sulfato de n-(3-(4-(3-(diisobutilamino)propil)piperazin-1-il )propil)-1h-benzo [d]imidazol-2-amina, preparación y uso de las mismas. - Google Patents
Sales sulfato de n-(3-(4-(3-(diisobutilamino)propil)piperazin-1-il )propil)-1h-benzo [d]imidazol-2-amina, preparación y uso de las mismas.Info
- Publication number
- MX363367B MX363367B MX2015008502A MX2015008502A MX363367B MX 363367 B MX363367 B MX 363367B MX 2015008502 A MX2015008502 A MX 2015008502A MX 2015008502 A MX2015008502 A MX 2015008502A MX 363367 B MX363367 B MX 363367B
- Authority
- MX
- Mexico
- Prior art keywords
- propyl
- diisobutylamino
- piperazin
- imidazol
- benzo
- Prior art date
Links
- 150000003467 sulfuric acid derivatives Chemical class 0.000 title abstract 2
- KLKKWCPJBTXWOV-UHFFFAOYSA-N n-[3-[4-[3-[bis(2-methylpropyl)amino]propyl]piperazin-1-yl]propyl]-1h-benzimidazol-2-amine Chemical class C1CN(CCCN(CC(C)C)CC(C)C)CCN1CCCNC1=NC2=CC=CC=C2N1 KLKKWCPJBTXWOV-UHFFFAOYSA-N 0.000 title 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12306690 | 2012-12-27 | ||
| PCT/EP2013/078068 WO2014102339A1 (en) | 2012-12-27 | 2013-12-27 | Sulphate salts of n-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1h-benzo[d]imidazol-2-amine, preparation thereof and use of the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015008502A MX2015008502A (es) | 2015-12-16 |
| MX363367B true MX363367B (es) | 2019-03-20 |
Family
ID=47501005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015008502A MX363367B (es) | 2012-12-27 | 2013-12-27 | Sales sulfato de n-(3-(4-(3-(diisobutilamino)propil)piperazin-1-il )propil)-1h-benzo [d]imidazol-2-amina, preparación y uso de las mismas. |
Country Status (23)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112015015474B1 (pt) * | 2012-12-27 | 2022-04-19 | Alzprotect | Sais sulfato de n-(3-(4-(3-(di-isobutilamino)propil) piperazin-1-il)propil)-1h-benzo[d]imidazol-2- amina, seu preparo e uso dos mesmos |
| WO2016146655A1 (en) | 2015-03-16 | 2016-09-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Novel 1,4-bis(3-aminopropyl)piperazine derivative and its use |
| TWI744300B (zh) * | 2016-03-23 | 2021-11-01 | 里爾中央醫學中心 | 改良性熱處理的血小板顆粒裂解液在製備用於治療神經系統疾病的組合物的用途 |
| CA3196403A1 (en) * | 2020-10-01 | 2022-04-07 | Alzprotect | Succinate salts of n-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1h-benzo[d]imidazol-2-amine, preparation thereof and use of the same |
| EP4225306B1 (en) * | 2020-10-07 | 2025-02-12 | Alzprotect | Use of n-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1h-benzo[d]imidazol-2-amine sulphate salts and solvates thereof for the treatment of motor neuron diseases and neuromuscular junction disorders |
| AU2022422257A1 (en) | 2021-12-20 | 2024-07-04 | Alzprotect | USE OF N-(3-(4-(3-(DIISOBUTYLAMINO)PROPYL)PIPERAZIN-1-YL)PROPYL)-1H-BENZO[d]IMIDAZOL-2-AMINE SUCCINATE SALTS AND SOLVATES THEREOF FOR THE TREATMENT OF MOTOR NEURON DISEASES AND NEUROMUSCULAR JUNCTION DISORDERS |
| JP2025510172A (ja) | 2022-03-25 | 2025-04-14 | アルツプロテクト | 感覚ニューロン疾患の治療のためのＮ－（３－（４－（３－（ジイソブチルアミノ）プロピル）ピペラジン－１－イル）プロピル）－１Ｈ－ベンゾ［ｄ］イミダゾール－２－アミン塩及びその溶媒和物の使用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2674856B1 (fr) * | 1991-04-05 | 1993-07-30 | Esteve Labor Dr | Nouveaux antihistaminiques non sedatifs, derives de benzimidazole, leur procede de preparation et leur utilisation en tant que medicaments. |
| CA2263367A1 (fr) * | 1997-06-12 | 1998-12-17 | Transgene S.A. | Nouveaux complexes lipidiques pour le transfert d'au moins une substance therapeutiquement active, notamment un polynucleotide, dans une cellule cible et utilisation en therapie genique |
| CN1325397A (zh) * | 1998-09-30 | 2001-12-05 | 纽罗根公司 | 2－哌嗪烷基氨基苯并吡咯衍生物∶多巴胺受体亚型特异配体 |
| US20050020582A1 (en) * | 2001-05-25 | 2005-01-27 | Prusiner Stanley B | Optically active compounds clearing malformed proteins |
| US20040116441A1 (en) * | 2002-10-30 | 2004-06-17 | Pfizer Inc | Methods of using sulfonic acid derivatives |
| ES2282731T3 (es) * | 2002-12-23 | 2007-10-16 | Janssen Pharmaceutica N.V. | Derivados de 1-piperidin-4-il-4-azetidin-3-il-piperazina sustituida y su uso como antagonistas de neuroquininas. |
| PL1809288T3 (pl) * | 2004-11-10 | 2012-04-30 | Inst Nat Sante Rech Med | Zastosowanie pochodnych 1,4-bis-(3-aminoalkilo)piperazyny do leczenia chorób neurodegeneracyjnych |
| BR112015015474B1 (pt) * | 2012-12-27 | 2022-04-19 | Alzprotect | Sais sulfato de n-(3-(4-(3-(di-isobutilamino)propil) piperazin-1-il)propil)-1h-benzo[d]imidazol-2- amina, seu preparo e uso dos mesmos |
-
2013
- 2013-12-27 BR BR112015015474-3A patent/BR112015015474B1/pt active IP Right Grant
- 2013-12-27 PT PT138157805T patent/PT2938597T/pt unknown
- 2013-12-27 LT LTEP13815780.5T patent/LT2938597T/lt unknown
- 2013-12-27 NZ NZ70895913A patent/NZ708959A/en unknown
- 2013-12-27 HR HRP20161612TT patent/HRP20161612T2/hr unknown
- 2013-12-27 PL PL13815780T patent/PL2938597T3/pl unknown
- 2013-12-27 WO PCT/EP2013/078068 patent/WO2014102339A1/en not_active Ceased
- 2013-12-27 AU AU2013369288A patent/AU2013369288B2/en active Active
- 2013-12-27 US US14/655,642 patent/US9562018B2/en active Active
- 2013-12-27 SI SI201330408A patent/SI2938597T1/sl unknown
- 2013-12-27 KR KR1020157017192A patent/KR102115060B1/ko active Active
- 2013-12-27 CN CN201380068524.8A patent/CN105008333B/zh active Active
- 2013-12-27 RS RS20161055A patent/RS55511B1/sr unknown
- 2013-12-27 ES ES13815780.5T patent/ES2605494T3/es active Active
- 2013-12-27 CA CA2895285A patent/CA2895285C/en active Active
- 2013-12-27 EP EP13815780.5A patent/EP2938597B1/en active Active
- 2013-12-27 DK DK13815780.5T patent/DK2938597T3/en active
- 2013-12-27 MX MX2015008502A patent/MX363367B/es unknown
- 2013-12-27 HU HUE13815780A patent/HUE030930T2/hu unknown
- 2013-12-27 JP JP2015550088A patent/JP6384923B2/ja active Active
- 2013-12-27 RU RU2015130671A patent/RU2655454C2/ru active
-
2015
- 2015-06-16 IL IL239450A patent/IL239450B/en active IP Right Grant
- 2015-06-23 ZA ZA2015/04521A patent/ZA201504521B/en unknown
-
2016
- 2016-12-22 US US15/388,349 patent/US10537569B2/en active Active
-
2018
- 2018-03-28 AU AU2018202218A patent/AU2018202218B2/en active Active
-
2019
- 2019-08-27 US US16/552,436 patent/US10772884B2/en active Active
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