SI2938597T1 - Sulfatne soli n-(3-(4-(3-(diizobutilamino)propil)piperazin-1-il)propil)-1h- benzo(d)imidazol-2-amin, njihova priprava in uporaba istega - Google Patents

Sulfatne soli n-(3-(4-(3-(diizobutilamino)propil)piperazin-1-il)propil)-1h- benzo(d)imidazol-2-amin, njihova priprava in uporaba istega

Info

Publication number
SI2938597T1
SI2938597T1 SI201330408A SI201330408A SI2938597T1 SI 2938597 T1 SI2938597 T1 SI 2938597T1 SI 201330408 A SI201330408 A SI 201330408A SI 201330408 A SI201330408 A SI 201330408A SI 2938597 T1 SI2938597 T1 SI 2938597T1
Authority
SI
Slovenia
Prior art keywords
propyl
diisobutylamino
piperazin
imidazol
benzo
Prior art date
Application number
SI201330408A
Other languages
English (en)
Inventor
Stephane Burlet
Cecilia Estrella
Mathieu Barrier
Patricia Melnyk
Nicolas Sergeant
Luc Buee
Philippe Verwaerde
Original Assignee
Alzprotect
Inserm
Universite De Lille 2 Droit Et Sante
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alzprotect, Inserm, Universite De Lille 2 Droit Et Sante filed Critical Alzprotect
Publication of SI2938597T1 publication Critical patent/SI2938597T1/sl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41841,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SI201330408A 2012-12-27 2013-12-27 Sulfatne soli n-(3-(4-(3-(diizobutilamino)propil)piperazin-1-il)propil)-1h- benzo(d)imidazol-2-amin, njihova priprava in uporaba istega SI2938597T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12306690 2012-12-27
EP13815780.5A EP2938597B1 (en) 2012-12-27 2013-12-27 Sulphate salts of n-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1h-benzo[d]imidazol-2-amine, preparation thereof and use of the same
PCT/EP2013/078068 WO2014102339A1 (en) 2012-12-27 2013-12-27 Sulphate salts of n-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1h-benzo[d]imidazol-2-amine, preparation thereof and use of the same

Publications (1)

Publication Number Publication Date
SI2938597T1 true SI2938597T1 (sl) 2017-03-31

Family

ID=47501005

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201330408A SI2938597T1 (sl) 2012-12-27 2013-12-27 Sulfatne soli n-(3-(4-(3-(diizobutilamino)propil)piperazin-1-il)propil)-1h- benzo(d)imidazol-2-amin, njihova priprava in uporaba istega

Country Status (24)

Country Link
US (3) US9562018B2 (sl)
EP (1) EP2938597B1 (sl)
JP (1) JP6384923B2 (sl)
KR (1) KR102115060B1 (sl)
CN (1) CN105008333B (sl)
AU (2) AU2013369288B2 (sl)
BR (1) BR112015015474B1 (sl)
CA (1) CA2895285C (sl)
DK (1) DK2938597T3 (sl)
ES (1) ES2605494T3 (sl)
HK (1) HK1215582A1 (sl)
HR (1) HRP20161612T2 (sl)
HU (1) HUE030930T2 (sl)
IL (1) IL239450B (sl)
LT (1) LT2938597T (sl)
MX (1) MX363367B (sl)
NZ (1) NZ708959A (sl)
PL (1) PL2938597T3 (sl)
PT (1) PT2938597T (sl)
RS (1) RS55511B1 (sl)
RU (1) RU2655454C2 (sl)
SI (1) SI2938597T1 (sl)
WO (1) WO2014102339A1 (sl)
ZA (1) ZA201504521B (sl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2938597T (pt) * 2012-12-27 2016-12-09 Université De Lille 2 Droit Et Santé Sais sulfato de n-(3-(4-(3-(isobutilamino)propil)-piperazin-1-il)propil)-1h-benzo[d]imidazol-2-amina, sua preparação e sua utilização
DK3271335T3 (en) 2015-03-16 2019-04-01 Inst Nat Sante Rech Med HIS UNKNOWN 1,4-BIS (3-AMINOPROPYL) PIPERAZINE DERIVATIVES AND USE THEREOF
TWI744300B (zh) * 2016-03-23 2021-11-01 里爾中央醫學中心 改良性熱處理的血小板顆粒裂解液在製備用於治療神經系統疾病的組合物的用途
US20230391729A1 (en) 2020-10-01 2023-12-07 Alzprotect Succinate salts of n-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1h-benzo[d]imidazol-2-amine, preparation thereof and use of the same
EP4225306A1 (en) 2020-10-07 2023-08-16 Alzprotect Use of n-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1h-benzo[d]imidazol-2-amine sulphate salts and solvates thereof for the treatment of motor neuron diseases and neuromuscular junction disorders
WO2023117990A1 (en) 2021-12-20 2023-06-29 Alzprotect USE OF N-(3-(4-(3-(DIISOBUTYLAMINO)PROPYL)PIPERAZIN-1-YL)PROPYL)-1H-BENZO[d]IMIDAZOL-2-AMINE SUCCINATE SALTS AND SOLVATES THEREOF FOR THE TREATMENT OF MOTOR NEURON DISEASES AND NEUROMUSCULAR JUNCTION DISORDERS
WO2023180537A1 (en) 2022-03-25 2023-09-28 Alzprotect Use of n-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1h-benzo[d]imidazol-2-amine salts and solvates thereof for the treatment of sensory neuron diseases

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2674856B1 (fr) * 1991-04-05 1993-07-30 Esteve Labor Dr Nouveaux antihistaminiques non sedatifs, derives de benzimidazole, leur procede de preparation et leur utilisation en tant que medicaments.
WO1998056423A1 (fr) * 1997-06-12 1998-12-17 Transgene S.A. Nouveaux complexes lipidiques pour le transfert d'au moins une substance therapeutiquement active, notamment un polynucleotide, dans une cellule cible et utilisation en therapie genique
WO2000018767A2 (en) 1998-09-30 2000-04-06 Neurogen Corporation 2-piperazino alkylamino benzoazole derivatives: dopamine receptor subtype specific ligands
US20050020582A1 (en) * 2001-05-25 2005-01-27 Prusiner Stanley B Optically active compounds clearing malformed proteins
US20040116441A1 (en) * 2002-10-30 2004-06-17 Pfizer Inc Methods of using sulfonic acid derivatives
ES2282731T3 (es) * 2002-12-23 2007-10-16 Janssen Pharmaceutica N.V. Derivados de 1-piperidin-4-il-4-azetidin-3-il-piperazina sustituida y su uso como antagonistas de neuroquininas.
WO2006051489A1 (en) * 2004-11-10 2006-05-18 Institut National De La Sante Et De La Recherche Medicale (Inserm) Use of 1,4-bis (3-aminoalkyl) piperazine derivatives in the treatment of neurodegenerative diseases
PT2938597T (pt) * 2012-12-27 2016-12-09 Université De Lille 2 Droit Et Santé Sais sulfato de n-(3-(4-(3-(isobutilamino)propil)-piperazin-1-il)propil)-1h-benzo[d]imidazol-2-amina, sua preparação e sua utilização

Also Published As

Publication number Publication date
JP2016503813A (ja) 2016-02-08
US10772884B2 (en) 2020-09-15
HRP20161612T1 (hr) 2017-01-27
AU2018202218B2 (en) 2019-02-21
AU2013369288A8 (en) 2015-07-16
CA2895285C (en) 2021-03-30
HUE030930T2 (hu) 2017-06-28
BR112015015474A2 (sl) 2017-08-15
AU2013369288A1 (en) 2015-07-02
AU2018202218A1 (en) 2018-04-26
US20170151235A1 (en) 2017-06-01
US10537569B2 (en) 2020-01-21
PT2938597T (pt) 2016-12-09
CA2895285A1 (en) 2014-07-03
BR112015015474B1 (pt) 2022-04-19
ES2605494T3 (es) 2017-03-14
IL239450A0 (en) 2015-07-30
EP2938597B1 (en) 2016-10-26
IL239450B (en) 2018-06-28
CN105008333A (zh) 2015-10-28
HRP20161612T2 (hr) 2017-02-24
MX2015008502A (es) 2015-12-16
US20190381036A1 (en) 2019-12-19
ZA201504521B (en) 2016-11-30
AU2013369288B2 (en) 2018-02-22
LT2938597T (lt) 2017-01-25
US9562018B2 (en) 2017-02-07
DK2938597T3 (en) 2017-01-09
HK1215582A1 (zh) 2016-09-02
NZ708959A (en) 2019-11-29
US20160108003A1 (en) 2016-04-21
KR102115060B1 (ko) 2020-05-25
MX363367B (es) 2019-03-20
WO2014102339A1 (en) 2014-07-03
RU2655454C2 (ru) 2018-05-29
RU2015130671A (ru) 2017-01-30
RS55511B1 (sr) 2017-05-31
EP2938597A1 (en) 2015-11-04
KR20150105313A (ko) 2015-09-16
PL2938597T3 (pl) 2017-03-31
CN105008333B (zh) 2018-02-09
JP6384923B2 (ja) 2018-09-05

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