RS55511B1 - Sulfatne soli n-(3-(4-(3-(diizobutilamino)propil)piperazin-1-il)propil)-1h-benzo[d]imidazol-2-amina, njihova priprema i upotreba - Google Patents
Sulfatne soli n-(3-(4-(3-(diizobutilamino)propil)piperazin-1-il)propil)-1h-benzo[d]imidazol-2-amina, njihova priprema i upotrebaInfo
- Publication number
- RS55511B1 RS55511B1 RS20161055A RSP20161055A RS55511B1 RS 55511 B1 RS55511 B1 RS 55511B1 RS 20161055 A RS20161055 A RS 20161055A RS P20161055 A RSP20161055 A RS P20161055A RS 55511 B1 RS55511 B1 RS 55511B1
- Authority
- RS
- Serbia
- Prior art keywords
- propyl
- diisobutylamino
- piperazin
- imidazol
- benzo
- Prior art date
Links
- KLKKWCPJBTXWOV-UHFFFAOYSA-N n-[3-[4-[3-[bis(2-methylpropyl)amino]propyl]piperazin-1-yl]propyl]-1h-benzimidazol-2-amine Chemical class C1CN(CCCN(CC(C)C)CC(C)C)CCN1CCCNC1=NC2=CC=CC=C2N1 KLKKWCPJBTXWOV-UHFFFAOYSA-N 0.000 title 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12306690 | 2012-12-27 | ||
| EP13815780.5A EP2938597B1 (en) | 2012-12-27 | 2013-12-27 | Sulphate salts of n-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1h-benzo[d]imidazol-2-amine, preparation thereof and use of the same |
| PCT/EP2013/078068 WO2014102339A1 (en) | 2012-12-27 | 2013-12-27 | Sulphate salts of n-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1h-benzo[d]imidazol-2-amine, preparation thereof and use of the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS55511B1 true RS55511B1 (sr) | 2017-05-31 |
Family
ID=47501005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20161055A RS55511B1 (sr) | 2012-12-27 | 2013-12-27 | Sulfatne soli n-(3-(4-(3-(diizobutilamino)propil)piperazin-1-il)propil)-1h-benzo[d]imidazol-2-amina, njihova priprema i upotreba |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US9562018B2 (sr) |
| EP (1) | EP2938597B1 (sr) |
| JP (1) | JP6384923B2 (sr) |
| KR (1) | KR102115060B1 (sr) |
| CN (1) | CN105008333B (sr) |
| AU (2) | AU2013369288B2 (sr) |
| BR (1) | BR112015015474B1 (sr) |
| CA (1) | CA2895285C (sr) |
| DK (1) | DK2938597T3 (sr) |
| ES (1) | ES2605494T3 (sr) |
| HK (1) | HK1215582A1 (sr) |
| HR (1) | HRP20161612T2 (sr) |
| HU (1) | HUE030930T2 (sr) |
| IL (1) | IL239450B (sr) |
| LT (1) | LT2938597T (sr) |
| MX (1) | MX363367B (sr) |
| NZ (1) | NZ708959A (sr) |
| PL (1) | PL2938597T3 (sr) |
| PT (1) | PT2938597T (sr) |
| RS (1) | RS55511B1 (sr) |
| RU (1) | RU2655454C2 (sr) |
| SI (1) | SI2938597T1 (sr) |
| WO (1) | WO2014102339A1 (sr) |
| ZA (1) | ZA201504521B (sr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2938597T (pt) | 2012-12-27 | 2016-12-09 | Université De Lille 2 Droit Et Santé | Sais sulfato de n-(3-(4-(3-(isobutilamino)propil)-piperazin-1-il)propil)-1h-benzo[d]imidazol-2-amina, sua preparação e sua utilização |
| US10017476B2 (en) | 2015-03-16 | 2018-07-10 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | 1,4-bis(3-aminopropyl)piperazine derivative and its use |
| TWI744300B (zh) * | 2016-03-23 | 2021-11-01 | 里爾中央醫學中心 | 改良性熱處理的血小板顆粒裂解液在製備用於治療神經系統疾病的組合物的用途 |
| IL301559A (en) * | 2020-10-01 | 2023-05-01 | Alzprotect | Succinate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[D]imidazol-2-amine, their preparation and use |
| US20230364076A1 (en) | 2020-10-07 | 2023-11-16 | Alzprotect | Use of n-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1h-benzo[d]imidazol-2-amine sulphate salts and solvates thereof for the treatment of motor neuron diseases and neuromuscular junction disorders |
| AU2022422257A1 (en) | 2021-12-20 | 2024-07-04 | Alzprotect | USE OF N-(3-(4-(3-(DIISOBUTYLAMINO)PROPYL)PIPERAZIN-1-YL)PROPYL)-1H-BENZO[d]IMIDAZOL-2-AMINE SUCCINATE SALTS AND SOLVATES THEREOF FOR THE TREATMENT OF MOTOR NEURON DISEASES AND NEUROMUSCULAR JUNCTION DISORDERS |
| WO2023180537A1 (en) | 2022-03-25 | 2023-09-28 | Alzprotect | Use of n-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1h-benzo[d]imidazol-2-amine salts and solvates thereof for the treatment of sensory neuron diseases |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2674856B1 (fr) * | 1991-04-05 | 1993-07-30 | Esteve Labor Dr | Nouveaux antihistaminiques non sedatifs, derives de benzimidazole, leur procede de preparation et leur utilisation en tant que medicaments. |
| JP2001500162A (ja) * | 1997-06-12 | 2001-01-09 | トランジェーヌ、ソシエテ、アノニム | 少なくとも１種の治療上有効な物質、特にポリヌクレオチド、を標的細胞に導入するための新規脂質複合体および遺伝子治療における使用 |
| EP1117663A2 (en) * | 1998-09-30 | 2001-07-25 | Neurogen Corporation | 2-piperazino alkylamino benzoazole derivatives: dopamine receptor subtype specific ligands |
| US20050020582A1 (en) * | 2001-05-25 | 2005-01-27 | Prusiner Stanley B | Optically active compounds clearing malformed proteins |
| US20040116441A1 (en) * | 2002-10-30 | 2004-06-17 | Pfizer Inc | Methods of using sulfonic acid derivatives |
| ES2282731T3 (es) * | 2002-12-23 | 2007-10-16 | Janssen Pharmaceutica N.V. | Derivados de 1-piperidin-4-il-4-azetidin-3-il-piperazina sustituida y su uso como antagonistas de neuroquininas. |
| WO2006051489A1 (en) * | 2004-11-10 | 2006-05-18 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Use of 1,4-bis (3-aminoalkyl) piperazine derivatives in the treatment of neurodegenerative diseases |
| PT2938597T (pt) * | 2012-12-27 | 2016-12-09 | Université De Lille 2 Droit Et Santé | Sais sulfato de n-(3-(4-(3-(isobutilamino)propil)-piperazin-1-il)propil)-1h-benzo[d]imidazol-2-amina, sua preparação e sua utilização |
-
2013
- 2013-12-27 PT PT138157805T patent/PT2938597T/pt unknown
- 2013-12-27 AU AU2013369288A patent/AU2013369288B2/en active Active
- 2013-12-27 EP EP13815780.5A patent/EP2938597B1/en active Active
- 2013-12-27 US US14/655,642 patent/US9562018B2/en active Active
- 2013-12-27 KR KR1020157017192A patent/KR102115060B1/ko active IP Right Grant
- 2013-12-27 DK DK13815780.5T patent/DK2938597T3/en active
- 2013-12-27 SI SI201330408A patent/SI2938597T1/sl unknown
- 2013-12-27 RS RS20161055A patent/RS55511B1/sr unknown
- 2013-12-27 RU RU2015130671A patent/RU2655454C2/ru active
- 2013-12-27 NZ NZ70895913A patent/NZ708959A/en unknown
- 2013-12-27 WO PCT/EP2013/078068 patent/WO2014102339A1/en active Application Filing
- 2013-12-27 BR BR112015015474-3A patent/BR112015015474B1/pt active IP Right Grant
- 2013-12-27 CA CA2895285A patent/CA2895285C/en active Active
- 2013-12-27 ES ES13815780.5T patent/ES2605494T3/es active Active
- 2013-12-27 MX MX2015008502A patent/MX363367B/es unknown
- 2013-12-27 PL PL13815780T patent/PL2938597T3/pl unknown
- 2013-12-27 LT LTEP13815780.5T patent/LT2938597T/lt unknown
- 2013-12-27 JP JP2015550088A patent/JP6384923B2/ja active Active
- 2013-12-27 HU HUE13815780A patent/HUE030930T2/hu unknown
- 2013-12-27 CN CN201380068524.8A patent/CN105008333B/zh active Active
-
2015
- 2015-06-16 IL IL239450A patent/IL239450B/en active IP Right Grant
- 2015-06-23 ZA ZA2015/04521A patent/ZA201504521B/en unknown
-
2016
- 2016-03-29 HK HK16103579.5A patent/HK1215582A1/zh unknown
- 2016-12-01 HR HRP20161612TT patent/HRP20161612T2/hr unknown
- 2016-12-22 US US15/388,349 patent/US10537569B2/en active Active
-
2018
- 2018-03-28 AU AU2018202218A patent/AU2018202218B2/en active Active
-
2019
- 2019-08-27 US US16/552,436 patent/US10772884B2/en active Active
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