MX362820B - Antígenos recombinantes del circovirus porcino tipo 2 (pcv-2) para formulaciones de vacuna, kit de diagnóstico y uso. - Google Patents
Antígenos recombinantes del circovirus porcino tipo 2 (pcv-2) para formulaciones de vacuna, kit de diagnóstico y uso.Info
- Publication number
- MX362820B MX362820B MX2015009507A MX2015009507A MX362820B MX 362820 B MX362820 B MX 362820B MX 2015009507 A MX2015009507 A MX 2015009507A MX 2015009507 A MX2015009507 A MX 2015009507A MX 362820 B MX362820 B MX 362820B
- Authority
- MX
- Mexico
- Prior art keywords
- pcv
- vaccine formulations
- porcine circovirus
- diagnostic kit
- recombinant antigens
- Prior art date
Links
- 241001673669 Porcine circovirus 2 Species 0.000 title abstract 6
- 229960005486 vaccine Drugs 0.000 title abstract 6
- 239000000427 antigen Substances 0.000 title abstract 4
- 102000036639 antigens Human genes 0.000 title abstract 4
- 108091007433 antigens Proteins 0.000 title abstract 4
- 238000009472 formulation Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 238000009007 Diagnostic Kit Methods 0.000 title abstract 2
- 238000012286 ELISA Assay Methods 0.000 abstract 1
- 238000008157 ELISA kit Methods 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 241000282898 Sus scrofa Species 0.000 abstract 1
- 238000009395 breeding Methods 0.000 abstract 1
- 230000001488 breeding effect Effects 0.000 abstract 1
- 210000000234 capsid Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/10011—Circoviridae
- C12N2750/10023—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/10011—Circoviridae
- C12N2750/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/01—DNA viruses
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/01—DNA viruses
- G01N2333/015—Parvoviridae, e.g. feline panleukopenia virus, human Parvovirus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2469/00—Immunoassays for the detection of microorganisms
- G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
Abstract
La presente invención se refiere a la obtención de antígeno recombinante de la cápside viral de Porcine circovirus 2 (PCV-2) y sus modificaciones, por expresión en sistema procarionte, purificación en forma monomérica, la recuperación de partícula similar a virus (VLP) y su uso en formulaciones de vacuna, kits de diagnóstico y un sistema de cuantificación de lotes de vacuna del antígeno del PVC-2 por un ELISA de captura. Antígenos y formulaciones de vacuna pueden ser usados en la inmunización de animales en programas de control de las enfermedades asociadas con PCV-2 en los sistemas de producción de porcinos convencionales y representan alternativas a las vacunas disponibles en el mercado. El kit de ELISA se puede utilizar para pruebas de calidad en las vacunas comerciales y/o experimentales contra PCV-2.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR102013001893-7A BR102013001893B1 (pt) | 2013-01-25 | 2013-01-25 | Antígenos recombinantes do porcine circovirus 2 (pcv-2) para formulações vacinais, kit de diagnóstico e uso |
PCT/BR2014/000019 WO2014113855A1 (pt) | 2013-01-25 | 2014-01-23 | Antígenos recombinantes do porcine circovirus 2 (pcv-2) para formulações vacinais, kit de diagnóstico e uso |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015009507A MX2015009507A (es) | 2016-04-07 |
MX362820B true MX362820B (es) | 2019-02-18 |
Family
ID=51226766
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015009507A MX362820B (es) | 2013-01-25 | 2014-01-23 | Antígenos recombinantes del circovirus porcino tipo 2 (pcv-2) para formulaciones de vacuna, kit de diagnóstico y uso. |
Country Status (11)
Country | Link |
---|---|
US (2) | US9717785B2 (es) |
EP (1) | EP2949341B1 (es) |
CN (1) | CN105263515A (es) |
AR (1) | AR094578A1 (es) |
BR (1) | BR102013001893B1 (es) |
CO (1) | CO7461131A2 (es) |
ES (1) | ES2792510T3 (es) |
MX (1) | MX362820B (es) |
RU (1) | RU2687001C2 (es) |
UY (1) | UY35272A (es) |
WO (1) | WO2014113855A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106478783B (zh) * | 2015-08-24 | 2021-11-02 | 兆丰华生物科技(南京)有限公司北京生物医药科技中心 | 一种猪圆环病毒ii型基因工程亚单位疫苗及其应用 |
CN105541976B (zh) * | 2015-12-25 | 2019-07-09 | 华南农业大学 | 猪圆环病毒2型Cap基因修饰改造重组抗原及其应用 |
CN109425738B (zh) * | 2017-09-01 | 2022-01-28 | 洛阳普泰生物技术有限公司 | 猪圆环病毒3型抗体检测试剂盒及其应用 |
CN109187774B (zh) * | 2018-07-03 | 2021-09-28 | 复旦大学 | 一种猪圆环病毒2型病毒样颗粒的定量检测方法 |
CN110981945B (zh) * | 2019-12-08 | 2021-10-19 | 中牧实业股份有限公司 | 一种猪圆环病毒2型重组Cap蛋白的表达制备及应用 |
CN111233983A (zh) * | 2020-02-26 | 2020-06-05 | 郭广君 | 猪圆环病毒cap蛋白一步法大规模纯化及内毒素去除工艺 |
CN114354526A (zh) * | 2021-12-28 | 2022-04-15 | 国药集团动物保健股份有限公司 | 一种猪圆环病毒3型纯品蛋白的定量检测方法 |
CN114805501B (zh) * | 2022-03-24 | 2024-06-25 | 中牧实业股份有限公司 | 一种猪圆环病毒2型抗原组合物及其在抗原定量方法中的应用 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2769322B1 (fr) * | 1997-10-03 | 2002-03-08 | Merial Sas | Nouveaux circovirus porcins, vaccins et reactifs de diagnostic |
WO1999045956A1 (en) | 1998-03-13 | 1999-09-16 | University Of Georgia Research Foundation, Inc. | Vaccines against circovirus infections |
WO2005009462A2 (en) | 2003-07-24 | 2005-02-03 | Merial Limited | Vaccine formulations comprising an oil-in-water emulsion |
US7700285B1 (en) | 2005-12-29 | 2010-04-20 | Boehringer Ingelheim Vetmedica, Inc. | PCV2 immunogenic compositions and methods of producing such compositions |
CN101277717A (zh) | 2005-09-09 | 2008-10-01 | 英特威国际有限公司 | Pcv-2疫苗 |
JP5394750B2 (ja) | 2005-12-29 | 2014-01-22 | ベーリンガー インゲルハイム フェトメディカ インコーポレイテッド | 多価pcv2免疫原性組成物及び当該組成物を製造する方法 |
ME01156B (me) * | 2007-12-21 | 2013-03-20 | Zoetis Services Llc | Postupci i kompozicije za imunizaciju svinja protiv svinjskog cirkovirusa |
EA201100862A1 (ru) * | 2008-11-28 | 2012-01-30 | Сева Санте Анималь | Новый изолят свиного цирковируса типа 2b и его применения |
BR112012009212A2 (pt) * | 2009-10-22 | 2017-06-20 | Univ Leipzig | 'aplasia de medula óssea com doença hemorrágica em bezerros causada por um novo agente patogênico" |
CN102174086B (zh) * | 2011-03-07 | 2014-04-02 | 南京农业大学 | 一种猪圆环病毒2型重组Cap蛋白和亚单位疫苗 |
CN102911947A (zh) * | 2011-08-01 | 2013-02-06 | 普莱柯生物工程股份有限公司 | 猪圆环病毒2型Cap蛋白及其制备方法 |
CN102839195A (zh) * | 2012-07-18 | 2012-12-26 | 华南农业大学 | 利用pFast Bac Dual杆状病毒表达PCV 2 Cap蛋白的方法 |
-
2013
- 2013-01-25 BR BR102013001893-7A patent/BR102013001893B1/pt active IP Right Grant
-
2014
- 2014-01-20 UY UY0001035272A patent/UY35272A/es active IP Right Grant
- 2014-01-23 WO PCT/BR2014/000019 patent/WO2014113855A1/pt active Application Filing
- 2014-01-23 EP EP14742935.1A patent/EP2949341B1/en active Active
- 2014-01-23 CN CN201480006177.0A patent/CN105263515A/zh active Pending
- 2014-01-23 MX MX2015009507A patent/MX362820B/es active IP Right Grant
- 2014-01-23 RU RU2015135619A patent/RU2687001C2/ru active
- 2014-01-23 US US14/763,121 patent/US9717785B2/en active Active
- 2014-01-23 ES ES14742935T patent/ES2792510T3/es active Active
- 2014-01-24 AR ARP140100223A patent/AR094578A1/es active IP Right Grant
-
2015
- 2015-07-15 CO CO15164030A patent/CO7461131A2/es unknown
- 2015-10-05 US US14/875,090 patent/US20160015799A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2014113855A1 (pt) | 2014-07-31 |
RU2015135619A (ru) | 2017-03-10 |
AR094578A1 (es) | 2015-08-12 |
US9717785B2 (en) | 2017-08-01 |
CO7461131A2 (es) | 2015-11-30 |
BR102013001893A8 (pt) | 2017-12-05 |
EP2949341B1 (en) | 2020-04-01 |
US20160000897A1 (en) | 2016-01-07 |
EP2949341A4 (en) | 2016-07-27 |
RU2687001C2 (ru) | 2019-05-06 |
BR102013001893A2 (pt) | 2014-09-09 |
EP2949341A1 (en) | 2015-12-02 |
CN105263515A (zh) | 2016-01-20 |
UY35272A (es) | 2014-08-29 |
ES2792510T3 (es) | 2020-11-11 |
US20160015799A1 (en) | 2016-01-21 |
MX2015009507A (es) | 2016-04-07 |
BR102013001893B1 (pt) | 2022-01-25 |
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