MX362820B - Antígenos recombinantes del circovirus porcino tipo 2 (pcv-2) para formulaciones de vacuna, kit de diagnóstico y uso. - Google Patents

Antígenos recombinantes del circovirus porcino tipo 2 (pcv-2) para formulaciones de vacuna, kit de diagnóstico y uso.

Info

Publication number
MX362820B
MX362820B MX2015009507A MX2015009507A MX362820B MX 362820 B MX362820 B MX 362820B MX 2015009507 A MX2015009507 A MX 2015009507A MX 2015009507 A MX2015009507 A MX 2015009507A MX 362820 B MX362820 B MX 362820B
Authority
MX
Mexico
Prior art keywords
pcv
vaccine formulations
porcine circovirus
diagnostic kit
recombinant antigens
Prior art date
Application number
MX2015009507A
Other languages
English (en)
Other versions
MX2015009507A (es
Inventor
Almeida Márcia Rogéria De
Abelardo Silva Junior
Juliana Lopes Rangel Fietto
Gustavo Costa Bressan
Rafael Locatelli Salgado
Thiago Souza Onofre
Mariana Costa Fausto
Pedro Marcus Pereira Vidigal
Sthefany Patareli Kalks
Josicelli Souza Crispim
Silva Leite Roberta Amaziles
Gonzaga Natália Fialho
Zilch Tiago Jaquel
De Souza Luiz Fernando Lino
Cruz Souza Amanda Martins Da
Morais Monteiro Antônio De
De Andrade Teixeira Jackson
Original Assignee
Fund Amparo Pesquisa Estado Minas Gerais Fapemig
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fund Amparo Pesquisa Estado Minas Gerais Fapemig filed Critical Fund Amparo Pesquisa Estado Minas Gerais Fapemig
Publication of MX2015009507A publication Critical patent/MX2015009507A/es
Publication of MX362820B publication Critical patent/MX362820B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/10011—Circoviridae
    • C12N2750/10023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/10011—Circoviridae
    • C12N2750/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/01—DNA viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/01—DNA viruses
    • G01N2333/015—Parvoviridae, e.g. feline panleukopenia virus, human Parvovirus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)

Abstract

La presente invención se refiere a la obtención de antígeno recombinante de la cápside viral de Porcine circovirus 2 (PCV-2) y sus modificaciones, por expresión en sistema procarionte, purificación en forma monomérica, la recuperación de partícula similar a virus (VLP) y su uso en formulaciones de vacuna, kits de diagnóstico y un sistema de cuantificación de lotes de vacuna del antígeno del PVC-2 por un ELISA de captura. Antígenos y formulaciones de vacuna pueden ser usados en la inmunización de animales en programas de control de las enfermedades asociadas con PCV-2 en los sistemas de producción de porcinos convencionales y representan alternativas a las vacunas disponibles en el mercado. El kit de ELISA se puede utilizar para pruebas de calidad en las vacunas comerciales y/o experimentales contra PCV-2.
MX2015009507A 2013-01-25 2014-01-23 Antígenos recombinantes del circovirus porcino tipo 2 (pcv-2) para formulaciones de vacuna, kit de diagnóstico y uso. MX362820B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BR102013001893-7A BR102013001893B1 (pt) 2013-01-25 2013-01-25 Antígenos recombinantes do porcine circovirus 2 (pcv-2) para formulações vacinais, kit de diagnóstico e uso
PCT/BR2014/000019 WO2014113855A1 (pt) 2013-01-25 2014-01-23 Antígenos recombinantes do porcine circovirus 2 (pcv-2) para formulações vacinais, kit de diagnóstico e uso

Publications (2)

Publication Number Publication Date
MX2015009507A MX2015009507A (es) 2016-04-07
MX362820B true MX362820B (es) 2019-02-18

Family

ID=51226766

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015009507A MX362820B (es) 2013-01-25 2014-01-23 Antígenos recombinantes del circovirus porcino tipo 2 (pcv-2) para formulaciones de vacuna, kit de diagnóstico y uso.

Country Status (11)

Country Link
US (2) US9717785B2 (es)
EP (1) EP2949341B1 (es)
CN (1) CN105263515A (es)
AR (1) AR094578A1 (es)
BR (1) BR102013001893B1 (es)
CO (1) CO7461131A2 (es)
ES (1) ES2792510T3 (es)
MX (1) MX362820B (es)
RU (1) RU2687001C2 (es)
UY (1) UY35272A (es)
WO (1) WO2014113855A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106478783B (zh) * 2015-08-24 2021-11-02 兆丰华生物科技(南京)有限公司北京生物医药科技中心 一种猪圆环病毒ii型基因工程亚单位疫苗及其应用
CN105541976B (zh) * 2015-12-25 2019-07-09 华南农业大学 猪圆环病毒2型Cap基因修饰改造重组抗原及其应用
CN109425738B (zh) * 2017-09-01 2022-01-28 洛阳普泰生物技术有限公司 猪圆环病毒3型抗体检测试剂盒及其应用
CN109187774B (zh) * 2018-07-03 2021-09-28 复旦大学 一种猪圆环病毒2型病毒样颗粒的定量检测方法
CN110981945B (zh) * 2019-12-08 2021-10-19 中牧实业股份有限公司 一种猪圆环病毒2型重组Cap蛋白的表达制备及应用
CN111233983A (zh) * 2020-02-26 2020-06-05 郭广君 猪圆环病毒cap蛋白一步法大规模纯化及内毒素去除工艺
CN114354526A (zh) * 2021-12-28 2022-04-15 国药集团动物保健股份有限公司 一种猪圆环病毒3型纯品蛋白的定量检测方法
CN114805501B (zh) * 2022-03-24 2024-06-25 中牧实业股份有限公司 一种猪圆环病毒2型抗原组合物及其在抗原定量方法中的应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2769322B1 (fr) * 1997-10-03 2002-03-08 Merial Sas Nouveaux circovirus porcins, vaccins et reactifs de diagnostic
WO1999045956A1 (en) 1998-03-13 1999-09-16 University Of Georgia Research Foundation, Inc. Vaccines against circovirus infections
WO2005009462A2 (en) 2003-07-24 2005-02-03 Merial Limited Vaccine formulations comprising an oil-in-water emulsion
US7700285B1 (en) 2005-12-29 2010-04-20 Boehringer Ingelheim Vetmedica, Inc. PCV2 immunogenic compositions and methods of producing such compositions
CN101277717A (zh) 2005-09-09 2008-10-01 英特威国际有限公司 Pcv-2疫苗
JP5394750B2 (ja) 2005-12-29 2014-01-22 ベーリンガー インゲルハイム フェトメディカ インコーポレイテッド 多価ｐｃｖ２免疫原性組成物及び当該組成物を製造する方法
ME01156B (me) * 2007-12-21 2013-03-20 Zoetis Services Llc Postupci i kompozicije za imunizaciju svinja protiv svinjskog cirkovirusa
EA201100862A1 (ru) * 2008-11-28 2012-01-30 Сева Санте Анималь Новый изолят свиного цирковируса типа 2b и его применения
BR112012009212A2 (pt) * 2009-10-22 2017-06-20 Univ Leipzig 'aplasia de medula óssea com doença hemorrágica em bezerros causada por um novo agente patogênico"
CN102174086B (zh) * 2011-03-07 2014-04-02 南京农业大学 一种猪圆环病毒2型重组Cap蛋白和亚单位疫苗
CN102911947A (zh) * 2011-08-01 2013-02-06 普莱柯生物工程股份有限公司 猪圆环病毒2型Cap蛋白及其制备方法
CN102839195A (zh) * 2012-07-18 2012-12-26 华南农业大学 利用pFast Bac Dual杆状病毒表达PCV 2 Cap蛋白的方法

Also Published As

Publication number Publication date
WO2014113855A1 (pt) 2014-07-31
RU2015135619A (ru) 2017-03-10
AR094578A1 (es) 2015-08-12
US9717785B2 (en) 2017-08-01
CO7461131A2 (es) 2015-11-30
BR102013001893A8 (pt) 2017-12-05
EP2949341B1 (en) 2020-04-01
US20160000897A1 (en) 2016-01-07
EP2949341A4 (en) 2016-07-27
RU2687001C2 (ru) 2019-05-06
BR102013001893A2 (pt) 2014-09-09
EP2949341A1 (en) 2015-12-02
CN105263515A (zh) 2016-01-20
UY35272A (es) 2014-08-29
ES2792510T3 (es) 2020-11-11
US20160015799A1 (en) 2016-01-21
MX2015009507A (es) 2016-04-07
BR102013001893B1 (pt) 2022-01-25

Similar Documents

Publication Publication Date Title
MX2015009507A (es) Antigenos recombinantes del porcine circovirus 2 (pcv-2) para formulaciones de vacuna, kit de diagnostico y uso.
EA201800494A1 (ru) Вакцины против химерного цирковируса свиней типа 2 (pcv2)
NZ741875A (en) Canine parvovirus (cpv) virus-like particle (vlp) vaccines and uses thereof
WO2016176624A3 (en) Porcine pestvirus, vaccines, and assays
EA201071365A1 (ru) Моноклональные антитела, имеющие гомоподтип кросс-нейтрализующих свойств против вируса гриппа а подтипа н1
PH12014502534A1 (en) Effective vaccination against porcine reproductive and respiratory syndrome (prrs) virus prior to weaning
TR201908199T4 (tr) HPV'ye karşı aşılar.
WO2014150822A3 (en) Porcine reproductive and respiratory syndrome virus, compositions, vaccine and methods of use
MX2020010248A (es) Variante del virus prrs, clon de adnc del virus europeo y sus usos.
MX2017005687A (es) Metodos para usar formulaciones para vacuna con microagujas para elicitar en animales inmunidad protectora contra virus de la rabia.
EA201790365A1 (ru) Антигены вируса папилломы человека с хорошими иммунологическими свойствами и содержащая их вакцина
PH12015501721A1 (en) Porcine parvovirus 5b, methods of use and vaccine
PH12018502436A1 (en) Multivalent vaccines major swine viral diseases
WO2018066999A3 (en) Chimeric enterovirus virus-like particles
MY181007A (en) Scale drop disease (sdd) causative virus and derivatives thereof
PH12014501795A1 (en) Rota virus subunit vaccines and methods of making and use thereof
PH12017501100A1 (en) Recombinant swinepox virus and vaccines
Kochinger et al. Vesicular stomatitis virus replicon expressing the VP2 outer capsid protein of bluetongue virus serotype 8 induces complete protection of sheep against challenge infection
EA201500140A1 (ru) Ослабленные вакцины от свиного гриппа и способы их получения и применения
MX2019007924A (es) Vacunas contra la influenza.
Suradhat et al. Transdermal delivery of plasmid encoding truncated nucleocapsid protein enhanced PRRSV-specific immune responses
WO2017116177A3 (ko) 약독화된 돼지열병 바이러스 생마커백신주 및 이를 이용한 경구투여용 백신 조성물
MX360449B (es) Vacunas para el virus del papiloma humano y metodos para su uso.
BR132016015841E2 (pt) antígenos recombinantes do porcine circovirus 2 (pcv-2) para formulações vacinais e uso
EA201270794A8 (ru) Маркерная вакцина против классической чумы свиней

Legal Events

Date Code Title Description
FG Grant or registration