EA201800494A1 - Вакцины против химерного цирковируса свиней типа 2 (pcv2) - Google Patents

Вакцины против химерного цирковируса свиней типа 2 (pcv2)

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Publication number
EA201800494A1
EA201800494A1 EA201800494A EA201800494A EA201800494A1 EA 201800494 A1 EA201800494 A1 EA 201800494A1 EA 201800494 A EA201800494 A EA 201800494A EA 201800494 A EA201800494 A EA 201800494A EA 201800494 A1 EA201800494 A1 EA 201800494A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pcv2
circovirus
genotypes
vaccines against
type
Prior art date
Application number
EA201800494A
Other languages
English (en)
Inventor
Сян Чжин Мэнг
Шаннон Р. Матцингер
Натан М. Бич
Original Assignee
Вирджиния Тех Интеллектуал Пропертис, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Вирджиния Тех Интеллектуал Пропертис, Инк. filed Critical Вирджиния Тех Интеллектуал Пропертис, Инк.
Publication of EA201800494A1 publication Critical patent/EA201800494A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/10011—Circoviridae
    • C12N2750/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/10011—Circoviridae
    • C12N2750/10041—Use of virus, viral particle or viral elements as a vector
    • C12N2750/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/10011—Circoviridae
    • C12N2750/10071—Demonstrated in vivo effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Описанными являются вакцинные композиции и способы обеспечения иммунитета к генотипам цирковируса свиней типа два (PCV2), включающие введение рекомбинантного капсидного полипептида PCV2, который содержит антигенные эпитопы из капсидов нескольких генотипов PCV2. В других вариантах осуществления рекомбинантный химерный цирковирус свиней предусматривается для применения в качестве вакцины, которая объединяет непатогенный каркас цирковируса свиней тип 1 (PCV1) с последовательностями, кодирующими капсидный полипептид PCV2, содержит антигенные эпитопы из капсидов нескольких генотипов PCV2.
EA201800494A 2016-03-07 2017-03-03 Вакцины против химерного цирковируса свиней типа 2 (pcv2) EA201800494A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662304596P 2016-03-07 2016-03-07
PCT/IB2017/000966 WO2017187277A2 (en) 2016-03-07 2017-03-03 Chimeric porcine circovirus type 2 (pcv2) vaccines

Publications (1)

Publication Number Publication Date
EA201800494A1 true EA201800494A1 (ru) 2019-07-31

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ID=60160159

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201800494A EA201800494A1 (ru) 2016-03-07 2017-03-03 Вакцины против химерного цирковируса свиней типа 2 (pcv2)

Country Status (11)

Country Link
US (1) US20190091320A1 (ru)
EP (1) EP3426293A4 (ru)
JP (1) JP2019507784A (ru)
KR (1) KR20190017725A (ru)
CN (1) CN109195623A (ru)
AU (1) AU2017257302A1 (ru)
BR (1) BR112018068078A2 (ru)
CA (1) CA3016374A1 (ru)
EA (1) EA201800494A1 (ru)
MX (1) MX2018010796A (ru)
WO (1) WO2017187277A2 (ru)

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US20220265808A1 (en) * 2019-07-26 2022-08-25 Ndsu Research Foundation A porcine circovirus type 2 (pcv2) vaccine
BR112022003137A8 (pt) 2019-08-20 2022-09-27 Km Biologics Co Ltd Vacina de vlp de circovírus porcino de tipo 2
PE20211141A1 (es) * 2019-12-19 2021-06-25 Farm Veterinarios S A C Salmonella enteritidis recombinante y su uso como vacuna porcina
CN111253494B (zh) * 2020-03-10 2022-04-26 天康制药(苏州)有限公司 猪口蹄疫病毒和猪轮状病毒的融合蛋白、类病毒颗粒和疫苗及制备方法
CN111892659A (zh) * 2020-07-20 2020-11-06 武汉科前生物股份有限公司 一种嵌合型猪圆环病毒PCV1-2d疫苗及其制备方法和应用
CN114044805B (zh) * 2020-08-26 2023-10-27 中国农业科学院兰州兽医研究所 一类促进猪机体产生广谱性免疫应答的多肽及其应用
CN112209996B (zh) * 2020-08-26 2021-11-26 中国农业科学院兰州兽医研究所 一类促进猪机体产生非洲猪瘟病毒抗原特异性免疫应答的多肽及其应用
CN113740528B (zh) * 2020-12-08 2024-08-16 山东畜牧兽医职业学院 一种猪传染性胃肠炎病毒抗体检测试剂盒
CN112294953A (zh) * 2020-12-31 2021-02-02 北京科牧丰生物制药有限公司 一种pcv2型杆状病毒载体、猪肺炎支原体、副猪嗜血杆菌三联灭活疫苗及制备方法
KR102646305B1 (ko) * 2021-03-04 2024-03-13 주식회사 이노백 돼지 마이코플라스마균 및 돼지 써코바이러스 감염 예방을 위한 다가 백신 조성물
WO2022186661A1 (ko) * 2021-03-04 2022-09-09 주식회사 이노백 돼지 마이코플라스마균 및 돼지 써코바이러스 감염 예방을 위한 다가 백신 조성물
CN113355292B (zh) * 2021-06-04 2024-02-06 天康制药股份有限公司 一种猪圆环病毒基因改造型弱毒株、构建方法及其应用
CN114487396A (zh) * 2021-12-20 2022-05-13 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） 用于检测猪圆环病毒2型的红色乳胶微球免疫层析试纸条及其制备方法和应用
CN114805501B (zh) * 2022-03-24 2024-06-25 中牧实业股份有限公司 一种猪圆环病毒2型抗原组合物及其在抗原定量方法中的应用
CN117965585B (zh) * 2024-03-29 2024-07-16 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） 猪圆环病毒2d型佐剂嵌合病毒样颗粒疫苗及其制备方法

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US7276353B2 (en) * 2001-12-12 2007-10-02 Virginia Tech Intellectual Properties, Inc. Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
US20090017064A1 (en) * 2007-07-10 2009-01-15 Wyeth Methods and Compositions for Immunizing Pigs Against Porcine Circovirus
RS59952B1 (sr) * 2010-03-16 2020-03-31 Virginia Tech Intellectual Properties Inc Živa atenuisana vakcina protiv himernog svinjskog cirkovirusa
MX2016003855A (es) * 2013-09-25 2016-08-04 Zoetis Services Llc Composicion de vacuna de circovirus porcino tipo 2b divergente y procedimientos de uso.
ES2778425T3 (es) * 2013-10-02 2020-08-10 Boehringer Ingelheim Animal Health Usa Inc Variante de la proteína ORF2 del PCV2 y partículas similares a virus compuestas por esta

Also Published As

Publication number Publication date
MX2018010796A (es) 2019-01-14
WO2017187277A2 (en) 2017-11-02
JP2019507784A (ja) 2019-03-22
KR20190017725A (ko) 2019-02-20
AU2017257302A1 (en) 2018-09-27
CA3016374A1 (en) 2017-11-02
EP3426293A2 (en) 2019-01-16
WO2017187277A3 (en) 2017-12-14
EP3426293A4 (en) 2019-10-30
BR112018068078A2 (pt) 2019-01-08
US20190091320A1 (en) 2019-03-28
CN109195623A (zh) 2019-01-11

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