AR094578A1 - Antígenos recombinantes del porcine circovirus 2 (pcv-2) para formulaciones de vacuna, kit de diagnóstico y uso - Google Patents

Antígenos recombinantes del porcine circovirus 2 (pcv-2) para formulaciones de vacuna, kit de diagnóstico y uso

Info

Publication number
AR094578A1
AR094578A1 ARP140100223A ARP140100223A AR094578A1 AR 094578 A1 AR094578 A1 AR 094578A1 AR P140100223 A ARP140100223 A AR P140100223A AR P140100223 A ARP140100223 A AR P140100223A AR 094578 A1 AR094578 A1 AR 094578A1
Authority
AR
Argentina
Prior art keywords
pcv
vaccine formulations
circovirus
swine
diagnostic kit
Prior art date
Application number
ARP140100223A
Other languages
English (en)
Inventor
Rogria De Almeida Lamego Mrcia
Silvia Jnior Abelardo
Lopes Rangel Fietto Juliana
Costa Bressa Gustavo
Locatelli Salgado Rafael
Souza Onofre Thiago
Costa Fausto Mariana
Marcus Pereira Vidigal Pedro
Patareli Kalks Sthefany
Souza Crispim Josicelli
Original Assignee
Fundação De Amparo A Pesquisa Do Estado De Minas Gerais - Fapemig
Univ Fed De Viçosa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fundação De Amparo A Pesquisa Do Estado De Minas Gerais - Fapemig, Univ Fed De Viçosa filed Critical Fundação De Amparo A Pesquisa Do Estado De Minas Gerais - Fapemig
Publication of AR094578A1 publication Critical patent/AR094578A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/10011—Circoviridae
    • C12N2750/10023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/10011—Circoviridae
    • C12N2750/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/01—DNA viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/01—DNA viruses
    • G01N2333/015—Parvoviridae, e.g. feline panleukopenia virus, human Parvovirus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)

Abstract

La presente se refiere a la obtención de antígeno recombinante de la cápside viral de Porcine circovirus 2 (PCV-2) y sus modificaciones, por expresión en sistema procarionte, purificación en forma monomérica, la recuperación de partícula similar a virus (VLP) y su uso en formulaciones de vacuna, kits de diagnóstico y un sistema de cuantificación de lotes de vacuna del antígeno del PVC-2 por un ELISA de captura. Antígenos y formulaciones de vacuna pueden ser usados en la inmunización de animales en programas de control de las enfermedades asociadas con PCV2 en los sistemas de producción de porcinos convencionales y representan alternativas a las vacunas disponibles en el mercado. El kit de ELISA se puede utilizar para pruebas de calidad en las vacunas comerciales y/o experimentales contra PCV-2.
ARP140100223A 2013-01-25 2014-01-24 Antígenos recombinantes del porcine circovirus 2 (pcv-2) para formulaciones de vacuna, kit de diagnóstico y uso AR094578A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BR102013001893-7A BR102013001893B1 (pt) 2013-01-25 2013-01-25 Antígenos recombinantes do porcine circovirus 2 (pcv-2) para formulações vacinais, kit de diagnóstico e uso

Publications (1)

Publication Number Publication Date
AR094578A1 true AR094578A1 (es) 2015-08-12

Family

ID=51226766

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP140100223A AR094578A1 (es) 2013-01-25 2014-01-24 Antígenos recombinantes del porcine circovirus 2 (pcv-2) para formulaciones de vacuna, kit de diagnóstico y uso

Country Status (11)

Country Link
US (2) US9717785B2 (es)
EP (1) EP2949341B1 (es)
CN (1) CN105263515A (es)
AR (1) AR094578A1 (es)
BR (1) BR102013001893B1 (es)
CO (1) CO7461131A2 (es)
ES (1) ES2792510T3 (es)
MX (1) MX362820B (es)
RU (1) RU2687001C2 (es)
UY (1) UY35272A (es)
WO (1) WO2014113855A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106478783B (zh) * 2015-08-24 2021-11-02 兆丰华生物科技(南京)有限公司北京生物医药科技中心 一种猪圆环病毒ii型基因工程亚单位疫苗及其应用
CN105541976B (zh) * 2015-12-25 2019-07-09 华南农业大学 猪圆环病毒2型Cap基因修饰改造重组抗原及其应用
CN109425738B (zh) * 2017-09-01 2022-01-28 洛阳普泰生物技术有限公司 猪圆环病毒3型抗体检测试剂盒及其应用
CN109187774B (zh) * 2018-07-03 2021-09-28 复旦大学 一种猪圆环病毒2型病毒样颗粒的定量检测方法
CN110981945B (zh) * 2019-12-08 2021-10-19 中牧实业股份有限公司 一种猪圆环病毒2型重组Cap蛋白的表达制备及应用
CN111233983A (zh) * 2020-02-26 2020-06-05 郭广君 猪圆环病毒cap蛋白一步法大规模纯化及内毒素去除工艺
CN114354526A (zh) * 2021-12-28 2022-04-15 国药集团动物保健股份有限公司 一种猪圆环病毒3型纯品蛋白的定量检测方法
CN114805501B (zh) * 2022-03-24 2024-06-25 中牧实业股份有限公司 一种猪圆环病毒2型抗原组合物及其在抗原定量方法中的应用

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FR2769322B1 (fr) * 1997-10-03 2002-03-08 Merial Sas Nouveaux circovirus porcins, vaccins et reactifs de diagnostic
WO1999045956A1 (en) 1998-03-13 1999-09-16 University Of Georgia Research Foundation, Inc. Vaccines against circovirus infections
WO2005009462A2 (en) 2003-07-24 2005-02-03 Merial Limited Vaccine formulations comprising an oil-in-water emulsion
US7700285B1 (en) 2005-12-29 2010-04-20 Boehringer Ingelheim Vetmedica, Inc. PCV2 immunogenic compositions and methods of producing such compositions
AU2006289102C1 (en) 2005-09-09 2017-11-30 Intervet International B.V. PCV-2 vaccine
PT3320919T (pt) 2005-12-29 2020-09-03 Boehringer Ingelheim Animal Health Usa Inc Composições imunogénicas de pcv2 multivalentes e métodos para produzir composições deste tipo
BRPI0821286A8 (pt) * 2007-12-21 2017-08-15 Wyeth Llc Métodos e composições para imunizar porcos contra circovirus suino
US8703468B2 (en) * 2008-11-28 2014-04-22 Ceva Sante Animale Porcine circovirus type 2B isolate and uses thereof
US20130251719A1 (en) * 2009-10-22 2013-09-26 Tiergesundheitsdienst Bayern E.V. Bone marrow aplasia with haemorrhagic disease in calves caused by novel pathogen
CN102174086B (zh) 2011-03-07 2014-04-02 南京农业大学 一种猪圆环病毒2型重组Cap蛋白和亚单位疫苗
CN102911947A (zh) * 2011-08-01 2013-02-06 普莱柯生物工程股份有限公司 猪圆环病毒2型Cap蛋白及其制备方法
CN102839195A (zh) * 2012-07-18 2012-12-26 华南农业大学 利用pFast Bac Dual杆状病毒表达PCV 2 Cap蛋白的方法

Also Published As

Publication number Publication date
WO2014113855A1 (pt) 2014-07-31
BR102013001893A2 (pt) 2014-09-09
EP2949341A1 (en) 2015-12-02
EP2949341A4 (en) 2016-07-27
US20160000897A1 (en) 2016-01-07
US20160015799A1 (en) 2016-01-21
ES2792510T3 (es) 2020-11-11
MX362820B (es) 2019-02-18
CN105263515A (zh) 2016-01-20
US9717785B2 (en) 2017-08-01
EP2949341B1 (en) 2020-04-01
UY35272A (es) 2014-08-29
MX2015009507A (es) 2016-04-07
BR102013001893A8 (pt) 2017-12-05
RU2015135619A (ru) 2017-03-10
RU2687001C2 (ru) 2019-05-06
CO7461131A2 (es) 2015-11-30
BR102013001893B1 (pt) 2022-01-25

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