MX360791B - 7-azabiciclos sustituidos y su uso como moduladores del receptor de orexina. - Google Patents

7-azabiciclos sustituidos y su uso como moduladores del receptor de orexina.

Info

Publication number
MX360791B
MX360791B MX2015011816A MX2015011816A MX360791B MX 360791 B MX360791 B MX 360791B MX 2015011816 A MX2015011816 A MX 2015011816A MX 2015011816 A MX2015011816 A MX 2015011816A MX 360791 B MX360791 B MX 360791B
Authority
MX
Mexico
Prior art keywords
compounds
aikoxy
pyrazolyl
pyridyl
halo
Prior art date
Application number
MX2015011816A
Other languages
English (en)
Spanish (es)
Other versions
MX2015011816A (es
Inventor
Curt A Dvorak
Anne E Fitzgerald
Brock T Shireman
Terry P Lebold
Heather R Coate
Cathy Preville
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX2015011816A publication Critical patent/MX2015011816A/es
Publication of MX360791B publication Critical patent/MX360791B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
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MX2015011816A 2013-03-13 2014-03-12 7-azabiciclos sustituidos y su uso como moduladores del receptor de orexina. MX360791B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361780428P 2013-03-13 2013-03-13
PCT/US2014/024322 WO2014159591A1 (en) 2013-03-13 2014-03-12 Substituted 7-azabicycles and their use as orexin receptor modulators

Publications (2)

Publication Number Publication Date
MX2015011816A MX2015011816A (es) 2016-08-11
MX360791B true MX360791B (es) 2018-11-15

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MX2015011816A MX360791B (es) 2013-03-13 2014-03-12 7-azabiciclos sustituidos y su uso como moduladores del receptor de orexina.

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US (4) US9637496B2 (enExample)
EP (1) EP2970313B1 (enExample)
JP (1) JP6337082B2 (enExample)
KR (1) KR102209432B1 (enExample)
CN (1) CN105209468B (enExample)
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AU (2) AU2014240388B2 (enExample)
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NI (1) NI201500129A (enExample)
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UA (1) UA116132C2 (enExample)
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Families Citing this family (21)

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Publication number Priority date Publication date Assignee Title
TW201444821A (zh) 2013-03-13 2014-12-01 Janssen Pharmaceutica Nv 經取代之哌啶化合物及其作為食慾素受體調節劑之用途
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