ES2659222T3 - 7-azabicíclicos sustituidos y su uso para moduladores de receptores de orexina - Google Patents

7-azabicíclicos sustituidos y su uso para moduladores de receptores de orexina Download PDF

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Publication number
ES2659222T3
ES2659222T3 ES14717297.7T ES14717297T ES2659222T3 ES 2659222 T3 ES2659222 T3 ES 2659222T3 ES 14717297 T ES14717297 T ES 14717297T ES 2659222 T3 ES2659222 T3 ES 2659222T3
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alkyl
pyrazolyl
pyridyl
alkoxy
group
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Spanish (es)
Inventor
Heather R. COATE
Curt A. Dvorak
Anne E. Fitzgerald
Terry P. LEBOLD
Cathy PREVILLE
Brock T. Shireman
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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ES14717297.7T 2013-03-13 2014-03-12 7-azabicíclicos sustituidos y su uso para moduladores de receptores de orexina Active ES2659222T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361780428P 2013-03-13 2013-03-13
US201361780428P 2013-03-13
PCT/US2014/024322 WO2014159591A1 (en) 2013-03-13 2014-03-12 Substituted 7-azabicycles and their use as orexin receptor modulators

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ES2659222T3 true ES2659222T3 (es) 2018-03-14

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US (4) US9062078B2 (enExample)
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JP (1) JP6337082B2 (enExample)
KR (1) KR102209432B1 (enExample)
CN (1) CN105209468B (enExample)
AR (1) AR095424A1 (enExample)
AU (2) AU2014240388B2 (enExample)
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CA (1) CA2905012C (enExample)
CL (1) CL2015002616A1 (enExample)
CR (1) CR20150434A (enExample)
EA (1) EA028386B1 (enExample)
ES (1) ES2659222T3 (enExample)
IL (1) IL240929B (enExample)
MX (1) MX360791B (enExample)
NI (1) NI201500129A (enExample)
PE (1) PE20151668A1 (enExample)
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