MX360438B - Metodos para etiquetar bibliotecas codificadas por adn. - Google Patents

Metodos para etiquetar bibliotecas codificadas por adn.

Info

Publication number
MX360438B
MX360438B MX2014002854A MX2014002854A MX360438B MX 360438 B MX360438 B MX 360438B MX 2014002854 A MX2014002854 A MX 2014002854A MX 2014002854 A MX2014002854 A MX 2014002854A MX 360438 B MX360438 B MX 360438B
Authority
MX
Mexico
Prior art keywords
methods
encoded libraries
libraries
tagging dna
tagging
Prior art date
Application number
MX2014002854A
Other languages
English (en)
Spanish (es)
Other versions
MX2014002854A (es
Inventor
D Keefe Anthony
w wagner Richard
Litovchick Alexander
Clark Matthew
W Cuozzo John
Zhang Ying
A Centrella Paolo
D Hupp Christopher
Original Assignee
X Chem Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47832597&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX360438(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by X Chem Inc filed Critical X Chem Inc
Publication of MX2014002854A publication Critical patent/MX2014002854A/es
Publication of MX360438B publication Critical patent/MX360438B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C40B50/16—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support involving encoding steps
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Structural Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
MX2014002854A 2011-09-07 2012-09-07 Metodos para etiquetar bibliotecas codificadas por adn. MX360438B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161531820P 2011-09-07 2011-09-07
US201161536929P 2011-09-20 2011-09-20
PCT/US2012/054228 WO2013036810A1 (en) 2011-09-07 2012-09-07 Methods for tagging dna-encoded libraries

Publications (2)

Publication Number Publication Date
MX2014002854A MX2014002854A (es) 2016-06-24
MX360438B true MX360438B (es) 2018-11-01

Family

ID=47832597

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2014002854A MX360438B (es) 2011-09-07 2012-09-07 Metodos para etiquetar bibliotecas codificadas por adn.
MX2018013367A MX2018013367A (es) 2011-09-07 2014-03-07 Metodos para etiquetar bibliotecas codificadas por adn.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2018013367A MX2018013367A (es) 2011-09-07 2014-03-07 Metodos para etiquetar bibliotecas codificadas por adn.

Country Status (17)

Country Link
US (2) US10865409B2 (OSRAM)
EP (3) EP3828271A1 (OSRAM)
JP (3) JP6674738B2 (OSRAM)
KR (2) KR102242879B1 (OSRAM)
CN (1) CN103998658B (OSRAM)
AP (1) AP2014007483A0 (OSRAM)
AU (3) AU2012304387B2 (OSRAM)
BR (1) BR112014005205A2 (OSRAM)
CA (2) CA3077662A1 (OSRAM)
DK (2) DK3351631T3 (OSRAM)
EA (1) EA032438B1 (OSRAM)
ES (2) ES2852073T3 (OSRAM)
IL (2) IL231191B (OSRAM)
IN (1) IN2014CN02574A (OSRAM)
MX (2) MX360438B (OSRAM)
SG (2) SG10201605812YA (OSRAM)
WO (1) WO2013036810A1 (OSRAM)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL163822A0 (en) * 2002-03-15 2005-12-18 Nuevolution As An improved method for synthesising templated molecules
EP3216874A1 (en) 2008-09-05 2017-09-13 TOMA Biosciences, Inc. Methods for stratifying and annotating cancer drug treatment options
EA035311B1 (ru) 2009-02-13 2020-05-27 Икс-Чем, Инк. Способ маркировки днк-кодируемых химических библиотек
KR20130113447A (ko) 2010-09-24 2013-10-15 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 고정된 프라이머들을 이용하여 표적 dna의 직접적인 캡쳐, 증폭 및 서열화
US10865409B2 (en) * 2011-09-07 2020-12-15 X-Chem, Inc. Methods for tagging DNA-encoded libraries
DK2872680T3 (en) * 2012-07-13 2018-07-09 X Chem Inc DNA-encoded libraries with coding oligonucleotide compounds that cannot be read with polymerases
RU2015126651A (ru) 2012-12-10 2017-01-16 Фред Хатчинсон Кэнсер Рисёрч Сентер Способы скрининга
AU2013361605A1 (en) * 2012-12-20 2015-06-04 Sirna Therapeutics, Inc. Post-synthetic orthogonal amidation plus metal catalyzed azide-alkyne cycloaddition click chemistry on siRNA
CN103882532B (zh) * 2012-12-20 2015-10-21 成都先导药物开发有限公司 一种先导化合物的合成及筛选方法与试剂盒
GB201322692D0 (en) 2013-12-20 2014-02-05 Philochem Ag Production of encoded chemical libraries
GB201404552D0 (en) * 2014-03-14 2014-04-30 Philochem Ag Purification of dna-conjugate products
US10900065B2 (en) 2014-11-14 2021-01-26 University Of Washington Methods and kits for labeling cellular molecules
MA41298A (fr) * 2014-12-30 2017-11-07 X Chem Inc Procédés de marquage de banques codées par de l'adn
CN104894651B (zh) * 2015-06-29 2017-04-12 天津诺禾医学检验所有限公司 微量起始dna的高通量测序文库构建方法及其所构建的高通量测序文库
JP7283727B2 (ja) * 2016-06-16 2023-05-30 ヘイスタック サイエンシィズ コーポレーション コードプローブ分子のコンビナトリアル合成が指令されかつ記録されたオリゴヌクレオチド
CN107130300A (zh) * 2016-10-08 2017-09-05 深圳劲宇生物科技有限公司 一种dna编码分子库的合成方法及dna模板
US11359227B2 (en) * 2016-12-09 2022-06-14 University Of Southern California Genome-wide mapping of DNA-DNA proximities in the nucleus
EP3360962A1 (en) * 2017-02-14 2018-08-15 Technische Universität Dortmund Synthesis of dna-encoded libraries by micellar catalysis
CN110325491B (zh) 2017-03-17 2022-04-19 成都先导药物开发股份有限公司 编码库的合成方法及组合物
EP3619340A4 (en) * 2017-05-02 2021-01-20 Haystack Sciences Corporation OLIGONUCLEOTID-DRIVEN COMBINATORY SYNTHESIS VERIFICATION MOLECULES AND ASSOCIATED MANUFACTURING AND USE PROCESSES
WO2019006269A1 (en) * 2017-06-30 2019-01-03 The Regents Of The University Of California METHODS AND SYSTEMS FOR ASSESSING METHYLATION OF DNA IN ACELLULAR DNA
CN111295444B (zh) * 2017-09-25 2024-08-09 哈斯达克科学公司 用于寡核苷酸指导的组合化学的多项式编码
CN108070009B (zh) * 2017-12-12 2021-04-13 上海药明康德新药开发有限公司 一种制备dna编码化合物文库的方法及起始头片段化合物和制得的dna编码化合物
WO2019140353A1 (en) * 2018-01-12 2019-07-18 Camena Bioscience Limited Compositions and methods for template-free geometric enzymatic nucleic acid synthesis
WO2019149198A1 (zh) * 2018-01-31 2019-08-08 成都先导药物开发股份有限公司 一种dna编码化合物库及化合物筛选方法
WO2019157693A1 (zh) * 2018-02-14 2019-08-22 深圳劲宇生物科技有限公司 Dna编码分子库及应用广的化合物筛选方法
WO2019157692A1 (zh) * 2018-02-14 2019-08-22 深圳劲宇生物科技有限公司 Dna 编码分子库及无靶点限制的化合物筛选方法
WO2019195346A1 (en) 2018-04-02 2019-10-10 Progenity, Inc. Methods, systems, and compositions for counting nucleic acid molecules
CN110658163A (zh) * 2018-06-29 2020-01-07 成都先导药物开发股份有限公司 一种合成dna编码化合物中的反应监测方法
CN109468310B (zh) * 2018-10-25 2020-12-01 深圳劲宇生物科技有限公司 Dna编码碎片分子库的合成方法和连接基团的筛选方法
US12203130B2 (en) 2018-12-20 2025-01-21 Krylov Sergey N Binder selection using capillary electrophoresis
JP7537422B2 (ja) * 2019-02-18 2024-08-21 味の素株式会社 相補部分を含む修飾オリゴヌクレオチドの製造方法
WO2020206170A1 (en) 2019-04-02 2020-10-08 Progenity, Inc. Methods, systems, and compositions for counting nucleic acid molecules
CA3134831A1 (en) * 2019-04-05 2020-10-08 Claret Bioscience, Llc Methods and compositions for analyzing nucleic acid
CA3132835A1 (en) * 2019-05-09 2020-11-12 Pacific Biosciences Of California, Inc. Compositions and methods for improved cdna synthesis
US20220275362A1 (en) * 2019-07-25 2022-09-01 X-Chem, Inc. Methods for tagging and encoding of pre-existing compound libraries
EP4423103A4 (en) * 2021-10-27 2025-12-10 Juan Pablo Maianti DNA-encoded affinity-labeled, masked payload compounds and their use in assembling small-molecule libraries activated for late-stage purification and multiplex screening of covalent ligands
WO2024069235A2 (en) 2022-09-30 2024-04-04 Sixfold Bioscience Ltd. Compositions containing oligonucleotides with theranostic applications
WO2025042899A2 (en) * 2023-08-24 2025-02-27 X-Chem, Inc. Methods for identifying compounds binding to a target molecule using mirror-imaging of the target molecule
KR102774172B1 (ko) * 2023-10-25 2025-02-28 서울대학교산학협력단 Rna 변형의 모든 주변 서열을 포함하는 광범위한 rna 변형 라이브러리 설계법 및 그 이용
WO2025217391A1 (en) * 2024-04-12 2025-10-16 Insitro, Inc. Methods of preparing oligonucleotide-directed combinatorial libraries

Family Cites Families (161)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0260032B1 (en) 1986-09-08 1994-01-26 Ajinomoto Co., Inc. Compounds for the cleavage at a specific position of RNA, oligomers employed for the formation of said compounds, and starting materials for the synthesis of said oligomers
US5585481A (en) 1987-09-21 1996-12-17 Gen-Probe Incorporated Linking reagents for nucleotide probes
US5025388A (en) 1988-08-26 1991-06-18 Cramer Richard D Iii Comparative molecular field analysis (CoMFA)
US5670633A (en) * 1990-01-11 1997-09-23 Isis Pharmaceuticals, Inc. Sugar modified oligonucleotides that detect and modulate gene expression
US6005087A (en) 1995-06-06 1999-12-21 Isis Pharmaceuticals, Inc. 2'-modified oligonucleotides
US5723289A (en) 1990-06-11 1998-03-03 Nexstar Pharmaceuticals, Inc. Parallel selex
US5660985A (en) 1990-06-11 1997-08-26 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands containing modified nucleotides
JP2780572B2 (ja) 1991-09-13 1998-07-30 株式会社島津製作所 オリゴヌクレオチドの酵素的合成法及びオリゴヌクレオチドのプライマーとしての使用
US5639603A (en) 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
EP0773227A1 (en) 1991-09-18 1997-05-14 Affymax Technologies N.V. Diverse collections of oligomers in use to prepare drugs, diagnostic reagents, pesticides or herbicides
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5633360A (en) 1992-04-14 1997-05-27 Gilead Sciences, Inc. Oligonucleotide analogs capable of passive cell membrane permeation
JPH08506175A (ja) 1992-10-01 1996-07-02 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク タグでコードされる複合体の組合せ化学ライブラリー
US6503759B1 (en) 1992-10-01 2003-01-07 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5807683A (en) 1992-11-19 1998-09-15 Combichem, Inc. Combinatorial libraries and methods for their use
US5681943A (en) 1993-04-12 1997-10-28 Northwestern University Method for covalently linking adjacent oligonucleotides
AU684279B2 (en) 1993-04-12 1997-12-11 Northwestern University Method of forming oligonucleotides
US5840485A (en) 1993-05-27 1998-11-24 Selectide Corporation Topologically segregated, encoded solid phase libraries
DE69432147T2 (de) 1993-05-27 2003-11-27 Selectide Corp., Tucson Topologisch getrennte kodierende festphasen-bibliotheken
JPH09500378A (ja) 1993-07-02 1997-01-14 リンクス セラピューティクス，インコーポレイティド 枝分れされそして複雑に結合された高分子構造体の集中的合成
US5571903A (en) 1993-07-09 1996-11-05 Lynx Therapeutics, Inc. Auto-ligating oligonucleotide compounds
US6087186A (en) 1993-07-16 2000-07-11 Irori Methods and apparatus for synthesizing labeled combinatorial chemistry libraries
GB9315847D0 (en) 1993-07-30 1993-09-15 Isis Innovation Tag reagent and assay method
AU7390994A (en) 1993-08-25 1995-03-21 Symbicom Aktiebolag Molecular modelling and drug design
US5658782A (en) 1993-10-20 1997-08-19 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University A Non-Profit Organization Amino acid transporters and uses
JPH09508353A (ja) 1993-11-02 1997-08-26 アフィマックス テクノロジーズ ナムローゼ フェンノートシャップ 分子多様性の合成及びスクリーニング
US6117976A (en) 1993-11-04 2000-09-12 Medical Research Council Manufacture and use of polypeptides tagged using binding molecules
JPH09506629A (ja) 1993-12-17 1997-06-30 キュビッチョッティ，ロジャー・エス ヌクレオチドに支配された生体分子および多分子薬物の集合並びに装置
US6936477B2 (en) 1994-04-13 2005-08-30 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
JPH08268A (ja) 1994-06-16 1996-01-09 Koichi Nishigaki 連結した２本鎖ｄｎａの製造方法
US5525734A (en) 1994-06-22 1996-06-11 Affymax Technologies N.V. Methods for synthesizing diverse collections of pyrrolidine compounds
US5525735A (en) 1994-06-22 1996-06-11 Affymax Technologies Nv Methods for synthesizing diverse collections of pyrrolidine compounds
NZ291554A (en) 1994-07-26 1999-02-25 Scripps Research Inst Production of soluble polymer-linked peptide/nucleic acid libraries
US5846719A (en) 1994-10-13 1998-12-08 Lynx Therapeutics, Inc. Oligonucleotide tags for sorting and identification
US6654505B2 (en) 1994-10-13 2003-11-25 Lynx Therapeutics, Inc. System and apparatus for sequential processing of analytes
US5695934A (en) 1994-10-13 1997-12-09 Lynx Therapeutics, Inc. Massively parallel sequencing of sorted polynucleotides
US6013445A (en) 1996-06-06 2000-01-11 Lynx Therapeutics, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US5604097A (en) 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
WO1996038726A1 (en) 1995-05-30 1996-12-05 Ecole Polytechnique Federale De Lausanne (Epfl) Covalently immobilized phospholipid bilayers on solid surfaces
US5780613A (en) 1995-08-01 1998-07-14 Northwestern University Covalent lock for self-assembled oligonucleotide constructs
DE19646372C1 (de) 1995-11-11 1997-06-19 Evotec Biosystems Gmbh Genotyp und Phänotyp koppelnde Verbindung
US5780231A (en) 1995-11-17 1998-07-14 Lynx Therapeutics, Inc. DNA extension and analysis with rolling primers
US5962228A (en) 1995-11-17 1999-10-05 Lynx Therapeutics, Inc. DNA extension and analysis with rolling primers
US5763175A (en) 1995-11-17 1998-06-09 Lynx Therapeutics, Inc. Simultaneous sequencing of tagged polynucleotides
US6537776B1 (en) 1999-06-14 2003-03-25 Diversa Corporation Synthetic ligation reassembly in directed evolution
US5846839A (en) 1995-12-22 1998-12-08 Glaxo Group Limited Methods for hard-tagging an encoded synthetic library
US6027890A (en) 1996-01-23 2000-02-22 Rapigene, Inc. Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
US5898031A (en) 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
DE19642751A1 (de) 1996-10-16 1998-04-23 Deutsches Krebsforsch Saccharid-Bibliothek
PT1712623E (pt) 1997-01-21 2011-12-21 Gen Hospital Corp Selecção de proteínas utilizando fusões de arn-proteína
US5888737A (en) 1997-04-15 1999-03-30 Lynx Therapeutics, Inc. Adaptor-based sequence analysis
US6969488B2 (en) 1998-05-22 2005-11-29 Solexa, Inc. System and apparatus for sequential processing of analytes
CA2291180A1 (en) 1997-05-23 1998-11-26 Lynx Therapeutics, Inc. System and apparatus for sequential processing of analytes
US20020034732A1 (en) 1997-07-30 2002-03-21 Daniel J. Capon Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening
AU740541B2 (en) 1997-08-29 2001-11-08 Selective Genetics, Inc. Methods using phage display for selecting internalizing ligands for gene delivery
US6607878B2 (en) 1997-10-06 2003-08-19 Stratagene Collections of uniquely tagged molecules
WO1999067413A1 (de) * 1998-06-22 1999-12-29 Larova Biochemie Gmbh Herstellung von polymeren aus nukleotidischen und/oder nicht-nukleotidischen bausteinen auf enzymatischem weg
US6846655B1 (en) 1998-06-29 2005-01-25 Phylos, Inc. Methods for generating highly diverse libraries
AU6502599A (en) 1998-10-05 2000-04-26 Lynx Therapeutics, Inc. Enzymatic synthesis of oligonucleotide tags
WO2000023458A1 (en) 1998-10-19 2000-04-27 The Board Of Trustees Of The Leland Stanford Junior University Dna-templated combinatorial library chemistry
US5942609A (en) 1998-11-12 1999-08-24 The Porkin-Elmer Corporation Ligation assembly and detection of polynucleotides on solid-support
DE69935248T2 (de) 1998-12-02 2007-11-08 Adnexus Therapeutics, Inc., Waltham Dna-protein fusionen sowie anwendungen derselben
US6087112A (en) * 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
US7033753B1 (en) 1999-01-15 2006-04-25 University Of Rochester Compositions and methods for nonenzymatic ligation of oligonucleotides and detection of genetic polymorphisms
AU2951599A (en) 1999-04-08 2000-11-14 Pavel Sergeev Synthesis of biologically active compounds in cells
DE60032235T2 (de) * 1999-04-30 2007-11-15 Cyclops Genome Sciences Ltd., West Kirby Ribonukleinsäurederivate
US7270969B2 (en) 1999-05-05 2007-09-18 Phylogica Limited Methods of constructing and screening diverse expression libraries
US6436665B1 (en) 1999-08-27 2002-08-20 Phylos, Inc Methods for encoding and sorting in vitro translated proteins
EP1212619B1 (en) 1999-09-14 2007-05-23 Xenoport, Inc. Substrates and screening methods for transport proteins
CA2386239A1 (en) 1999-10-04 2001-04-12 University Of Medicine And Dentistry Of New Jersey Methods for identifying rna binding compounds
US6844324B1 (en) 1999-11-12 2005-01-18 Massachusetts Institute Of Technology Modular peptide mediated intracellular delivery system and uses therefore
US20010031475A1 (en) 2000-02-23 2001-10-18 Gallop Mark A. Self-encoded combinatorial synthesis of compound multiplets
US6936467B2 (en) * 2000-03-27 2005-08-30 University Of Delaware Targeted chromosomal genomic alterations with modified single stranded oligonucleotides
US7998673B2 (en) 2000-03-29 2011-08-16 Lgc Limited Hybridisation beacon and method of rapid sequence detection and discrimination
US6479262B1 (en) * 2000-05-16 2002-11-12 Hercules, Incorporated Solid phase enzymatic assembly of polynucleotides
US6994963B1 (en) 2000-07-10 2006-02-07 Ambion, Inc. Methods for recombinatorial nucleic acid synthesis
US20020072887A1 (en) 2000-08-18 2002-06-13 Sandor Szalma Interaction fingerprint annotations from protein structure models
US6627748B1 (en) 2000-09-11 2003-09-30 The Trustees Of Columbia University In The City Of New York Combinatorial fluorescence energy transfer tags and their applications for multiplex genetic analyses
JP4880186B2 (ja) 2000-09-20 2012-02-22 アークレイ株式会社 クライアント支援システム
KR20040036676A (ko) 2000-10-27 2004-04-30 리서치 디벨럽먼트 파운데이션 시그날링 압타머의 시험관내 선별 방법
JP2002315577A (ja) 2000-11-14 2002-10-29 Gencom Co 核酸ライブラリーの作製方法
US20030049616A1 (en) 2001-01-08 2003-03-13 Sydney Brenner Enzymatic synthesis of oligonucleotide tags
DK1423400T4 (da) 2001-03-19 2013-09-02 Harvard College Evolution af hidtil ukendt molekylfunktion
DE60221986D1 (de) 2001-06-20 2007-10-04 Nuevolution As Eine methode zur synthese von matrizenabhängigen molekülen
US20030143561A1 (en) 2001-06-20 2003-07-31 Nuevolution A/S Nucleoside derivatives for library preparation
WO2002102820A1 (en) 2001-06-20 2002-12-27 Nuevolution A/S Nucleoside derivatives for library preparation
US20060234231A1 (en) 2001-06-20 2006-10-19 Nuevolution A/S Microarrays displaying encoded molecules
WO2003078445A2 (en) 2002-03-15 2003-09-25 Nuevolution A/S A building block forming a c=c double bond upon reaction
CA2478203C (en) 2002-03-08 2011-06-14 Eidgenossische Technische Hochschule Zurich Encoded self-assembling chemical libraries (esachel)
WO2003078626A2 (en) 2002-03-15 2003-09-25 Nuevolution A/S A building block capable of transferring a functional entity
IL163822A0 (en) 2002-03-15 2005-12-18 Nuevolution As An improved method for synthesising templated molecules
US20050247001A1 (en) 2002-03-15 2005-11-10 Nuevolution A/S Building block forming a c-c or a c-hetero atom bond uponreaction
US20050221318A1 (en) 2002-03-15 2005-10-06 Gouliaev Alex H Building block forming a c-c bond upon reaction
AU2003240436A1 (en) 2002-06-20 2004-01-06 Nuevolution A/S Microarrays displaying encoded molecules
AU2003256587A1 (en) 2002-07-18 2004-02-09 The Board Of Trustees Of The Leland Stanford Junior University Detection of chemical ligation using fluorescence quenching leaving groups
AU2003242516A1 (en) 2002-07-23 2004-02-09 Nuevolution A/S Gene shuffling by template switching
US10730906B2 (en) 2002-08-01 2020-08-04 Nuevolutions A/S Multi-step synthesis of templated molecules
EP1540013B1 (en) 2002-08-19 2015-07-08 The President and Fellows of Harvard College Evolving new molecular function
EP1539953A2 (en) 2002-09-12 2005-06-15 Nuevolution A/S Proximity-aided synthesis of templated molecules
ES2640279T3 (es) 2002-10-30 2017-11-02 Nuevolution A/S Procedimiento para la síntesis de un complejo bifuncional
US9121110B2 (en) 2002-12-19 2015-09-01 Nuevolution A/S Quasirandom structure and function guided synthesis methods
EP1597394A2 (en) 2003-02-21 2005-11-23 Nuevolution A/S A method for obtaining structural information about an encoded molecule
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
ATE424455T1 (de) 2003-03-20 2009-03-15 Nuevolution As Ligationsvermittelnde codierung von kleinen molekülen
US20070134662A1 (en) 2003-07-03 2007-06-14 Juswinder Singh Structural interaction fingerprint
AU2004257200A1 (en) 2003-07-07 2005-01-27 Cellay Llc Hairpin-labeled probes and methods of use
EP1533385A1 (en) 2003-09-05 2005-05-25 Nuevolution A/S Templated compounds for generation of encoded molecules and directional methods using such compounds
WO2005026686A2 (en) 2003-09-09 2005-03-24 Compass Genetics, Llc Multiplexed analytical platform
US11118215B2 (en) 2003-09-18 2021-09-14 Nuevolution A/S Method for obtaining structural information concerning an encoded molecule and method for selecting compounds
WO2005050224A2 (en) 2003-11-13 2005-06-02 Epitome Biosystems Inc. Small molecule and peptide arrays and uses thereof
BRPI0417830B1 (pt) * 2003-12-17 2021-02-17 Praecis Pharmaceuticals Inc métodos para síntese de uma molécula compreendendo uma porção funcional operativamente ligada a um oligonucleotídeo de codificação
US7972994B2 (en) 2003-12-17 2011-07-05 Glaxosmithkline Llc Methods for synthesis of encoded libraries
US20050153321A1 (en) 2003-12-30 2005-07-14 Saba James A. Libraries of multiple-ligand-conjugated nucleic acids
US7217522B2 (en) 2004-02-12 2007-05-15 Campass Genetics Llc Genetic analysis by sequence-specific sorting
EP1723255B1 (en) 2004-02-17 2010-12-29 Nuevolution A/S Method for enrichment involving elimination by mismatch hybridisation
DK1730277T3 (da) 2004-03-22 2010-03-01 Nuevolution As Kodning ved ligering under anvendelse af byggebloksoligonukleotider
US7405287B2 (en) 2004-08-03 2008-07-29 Board Of Regents, The University Of Texas System Method of treating a cancer
US7745614B2 (en) 2004-09-03 2010-06-29 The Board Of Trustees Of The Leland Stanford Junior University Universal linker compositions for the release or transfer of chemical agents from a polynucleotide
WO2006047791A2 (en) 2004-10-27 2006-05-04 The Board Of Trustees Of The Leland Stanford Junior University Dna-templated combinatorial library device and method for use
JP4931825B2 (ja) 2004-11-08 2012-05-16 ビーパーゲン アンパーツゼルスカブ 構造核酸指向化学合成
DE602005012319D1 (de) 2004-11-22 2009-02-26 Peter Birk Rasmussen Matrizengerichtete split-and-mix-synthese von bibliotheken kleiner moleküle
JP2008524237A (ja) 2004-12-17 2008-07-10 ダイナバックス テクノロジーズ コーポレイション 免疫寛容の誘導又は促進のための方法及び組成物
CN101090979A (zh) * 2004-12-22 2007-12-19 埃克斯魁恩公司 用于分析核酸混合物的探针、文库和试剂盒及其构建方法
EP1856256B1 (en) * 2005-01-21 2009-07-15 President And Fellows Of Harvard College Free reactant use in nucleic acid-templated synthesis
US7407757B2 (en) 2005-02-10 2008-08-05 Population Genetics Technologies Genetic analysis by sequence-specific sorting
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
WO2006099604A2 (en) 2005-03-16 2006-09-21 Compass Genetics, Llc Methods and compositions for assay readouts on multiple analytical platforms
CN101233235B (zh) 2005-06-09 2012-10-03 葛兰素史克有限责任公司 合成编码文库的方法
US20090035824A1 (en) 2005-06-17 2009-02-05 Liu David R Nucleic acid-templated chemistry in organic solvents
US20080220982A1 (en) 2005-07-26 2008-09-11 Vu Tania Q Nanoparticle Probes for Capture, Sorting and Placement of Targets
WO2007016488A2 (en) 2005-07-29 2007-02-08 Ensemble Discovery Corporation Analysis of encoded chemical libraries
WO2007041201A2 (en) 2005-10-03 2007-04-12 Applera Corporation Compositions, methods, and kits for amplifying nucleic acids
EP1940755A2 (en) 2005-10-28 2008-07-09 Praecis Pharmaceuticals Inc. Methods for identifying compounds of interest using encoded libraries
ES2897529T3 (es) 2005-12-01 2022-03-01 Nuevolution As Métodos de codificación enzimática para la síntesis eficiente de bibliotecas grandes
WO2007087312A2 (en) 2006-01-23 2007-08-02 Population Genetics Technologies Ltd. Molecular counting
US7928211B2 (en) 2006-05-03 2011-04-19 Vipergen Pharmaceuticals Aps Method for preparing compounds by nucleic acid directed synthesis
US8153830B2 (en) 2006-10-26 2012-04-10 Sumitomo Chemical Company, Limited Production method of asymmetric copper complex crystal
CN101219219B (zh) 2007-01-10 2013-02-13 北京普罗吉生物科技发展有限公司 包含血管抑素或其片段的复合物、其制备方法及应用
CA2703227C (en) 2007-10-22 2017-02-28 Lgc Limited Oligonucleotides and uses thereof
CA2706222C (en) 2007-11-19 2013-08-27 Japan Advanced Institute Of Science And Technology Light-responsive artificial nucleotide having photo-crosslinking ability
WO2009077173A2 (en) * 2007-12-19 2009-06-25 Philochem Ag Dna-encoded chemical libraries
US20120107840A1 (en) 2008-04-09 2012-05-03 Sru Biosystems, Inc Methods for Label Free Testing of Cells
JP4814904B2 (ja) 2008-04-16 2011-11-16 国立大学法人北陸先端科学技術大学院大学 核酸類の配列選択的な精製方法
EP2283132B1 (en) * 2008-05-02 2016-10-26 Epicentre Technologies Corporation Selective 5' ligation tagging of rna
TW201011006A (en) 2008-06-16 2010-03-16 Nuevolution As IAP binding compounds
EP3629022A1 (en) 2008-07-25 2020-04-01 Richard W. Wagner Protein screening methods
AU2010209508C1 (en) 2009-01-30 2017-10-19 Oxford Nanopore Technologies Limited Hybridization linkers
EA035311B1 (ru) 2009-02-13 2020-05-27 Икс-Чем, Инк. Способ маркировки днк-кодируемых химических библиотек
US20120004137A1 (en) 2009-02-13 2012-01-05 X-Body, Inc. Identification of nucleic acid delivery vehicles using dna display
CN102317475B (zh) 2009-02-16 2014-07-16 阿霹震中科技公司 单链dna的不依赖模板的连接
WO2011005762A1 (en) 2009-07-06 2011-01-13 Trilink Biotechnologies Chemically modified ligase cofactors, donors and acceptors
US8574864B2 (en) * 2009-11-05 2013-11-05 Epicentre Technologies Corporation Methods and kits for 3'-end-tagging of RNA
DE102009058769A1 (de) * 2009-12-16 2011-06-22 MagForce Nanotechnologies AG, 10589 Temperaturabhängige Aktivierung von katalytischen Nukleinsäuren zur kontrollierten Wirkstofffreisetzung
WO2011120042A1 (en) 2010-03-26 2011-09-29 Sru Biosystems, Inc. Use of induced pluripotent cells and other cells for screening compound libraries
WO2011127933A1 (en) 2010-04-16 2011-10-20 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
EP2686349B1 (en) 2011-03-15 2020-12-09 X-Body, Inc. Antibody screening methods
US8846883B2 (en) 2011-08-16 2014-09-30 University Of Southhampton Oligonucleotide ligation
US10865409B2 (en) 2011-09-07 2020-12-15 X-Chem, Inc. Methods for tagging DNA-encoded libraries
DK2872680T3 (en) 2012-07-13 2018-07-09 X Chem Inc DNA-encoded libraries with coding oligonucleotide compounds that cannot be read with polymerases
GB201322692D0 (en) 2013-12-20 2014-02-05 Philochem Ag Production of encoded chemical libraries

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