MX355498B - Derivados de 1,3-dioxoindeno, sal farmaceuticamente aceptable de los mismos, metodos de preparacion de los mismos y composicion farmaceutica para el antivirus que contiene el mismo como un ingrediente activo. - Google Patents

Derivados de 1,3-dioxoindeno, sal farmaceuticamente aceptable de los mismos, metodos de preparacion de los mismos y composicion farmaceutica para el antivirus que contiene el mismo como un ingrediente activo.

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Publication number
MX355498B
MX355498B MX2013014239A MX2013014239A MX355498B MX 355498 B MX355498 B MX 355498B MX 2013014239 A MX2013014239 A MX 2013014239A MX 2013014239 A MX2013014239 A MX 2013014239A MX 355498 B MX355498 B MX 355498B
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MX
Mexico
Prior art keywords
same
derivatives
pharmaceutical composition
active ingredient
pharmaceutically acceptable
Prior art date
Application number
MX2013014239A
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English (en)
Other versions
MX2013014239A (es
Inventor
Neyts Johan
Sik Jung Young
Kgo Lee Chong
Soon Kim Hae
Ho Kim Pil
Bong Han Soo
Jan Thibaut Hendrik
Young Choi Ihl
Original Assignee
Univ Leuven Kath
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Application filed by Univ Leuven Kath filed Critical Univ Leuven Kath
Publication of MX2013014239A publication Critical patent/MX2013014239A/es
Publication of MX355498B publication Critical patent/MX355498B/es

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Abstract

Se describe derivados de 1,3-Dioxoindeno, sales farmacéuticamente aceptables de los mismos o enantiómeros, un método de preparación de los mismos, y una composición farmacéutica para la prevención o tratamiento de enfermedades virales, que comprenden los mismos como un ingrediente activo. Los derivados de 1,3-Dioxoindeno tienen excelente actividad inhibitoria contra picornavirus incluyendo virus coxsackie, enterovirus, ecovirus, poliovirus y rinovirus, así como exhiben baja citotoxicidad, de modo que pueden ser útiles como un ingrediente activo de una composición farmacéutica para la prevención y tratamiento de enfermedades virales incluyendo poliomielitis, parálisis, conjuntivitis hemorrágica aguda, meningitis viral, enfermedad de manos pies y boca, enfermedad vesicular, hepatitis A, miositis, miocarditis, pancreatitis, diabetes, mialgia epidémica, encefalitis, resfriado, herpangina, enfermedad de pies y boca, asma, enfermedad pulmonar obstructiva crónica, neumonía, sinusitis u otitis media.
MX2013014239A 2011-06-16 2012-06-18 Derivados de 1,3-dioxoindeno, sal farmaceuticamente aceptable de los mismos, metodos de preparacion de los mismos y composicion farmaceutica para el antivirus que contiene el mismo como un ingrediente activo. MX355498B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20110058704 2011-06-16
PCT/KR2012/004804 WO2012173447A2 (ko) 2011-06-16 2012-06-18 1,3-다이옥소인덴 유도체, 이의 약학적으로 허용되는 염 또는 이의 광학 이성질체, 이의 제조방법 및 이를 유효성분으로 함유하는 항바이러스용 약학적 조성물
KR1020120065023A KR101391745B1 (ko) 2011-06-16 2012-06-18 1,3-다이옥소인덴 유도체, 이의 약학적으로 허용되는 염 또는 이의 광학 이성질체, 이의 제조방법 및 이를 유효성분으로 함유하는 항바이러스용 약학적 조성물

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MX2013014239A MX2013014239A (es) 2014-05-14
MX355498B true MX355498B (es) 2018-04-20

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JP (2) JP5941142B2 (es)
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CN (1) CN103748060B (es)
AU (1) AU2012270310B2 (es)
BR (1) BR112013032273B1 (es)
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PT3882244T (pt) * 2012-12-14 2025-04-04 Univ Leuven Kath Composto, sal farmaceuticamente aceitável ou isómero ótico do mesmo, método para a sua preparação e composição farmacêutica para prevenção ou tratamento de doenças virais que contenha o mesmo como ingrediente ativo
CN104557559B (zh) * 2015-01-14 2016-08-17 成都中医药大学 茚满二酮手性环己烷螺环化合物及其制备方法与用途
KR102067858B1 (ko) 2016-05-24 2020-01-17 주식회사 엘지화학 화합물 및 이를 포함하는 색재 조성물 및 이를 포함하는 수지 조성물
KR102894005B1 (ko) 2020-04-20 2025-12-03 노파르티스 아게 항바이러스 1,3-다이-옥소-인덴 화합물
CN115916763B (zh) * 2020-04-20 2025-06-03 诺华股份有限公司 抗病毒素1,3-二氧代茚化合物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
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GB1425295A (en) * 1974-01-23 1976-02-18 Rizh Politekhn I Alpha-aminoylidenephthalides and processes for their preparation
GB1533388A (en) * 1975-02-07 1978-11-22 Creat Ninhydrin-phenol condensation products their preparation and use as therapeutic agents
FR2392951A2 (fr) * 1975-02-07 1978-12-29 Creat Lab Nouveaux derives de la ninhydrine, leurs procedes de preparation et medicaments contenant ces derives
GB8327598D0 (en) * 1983-10-14 1983-11-16 Akzo Nv Pharmacologically active diarylindane-13-diones
CO4950519A1 (es) * 1997-02-13 2000-09-01 Novartis Ag Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion
JP2001089455A (ja) * 1999-09-17 2001-04-03 Maruishi Pharmaceutical Co Ltd ５，１０−ジヒドロ−１１Ｈ−インデノ〔１，２−ｂ〕キノリン−１０−オン誘導体
ATE277017T1 (de) * 1999-08-30 2004-10-15 Maruishi Pharma 1,2-disubstituierte 1,4-dihydro-4-oxochinolin- verbindungen
WO2003082265A2 (en) * 2002-04-02 2003-10-09 Fujisawa Pharmaceutical Co Pharmaceutical composition for treating or preventing virus infectious diseases
EP2258365B1 (en) 2003-03-28 2013-05-29 Novartis Vaccines and Diagnostics, Inc. Use of organic compounds for immunopotentiation
WO2008018833A1 (en) * 2006-08-08 2008-02-14 Agency For Science, Technology And Research Methods for electrochemical detection/quantification of a nucleic acid
US20100048638A1 (en) * 2008-07-01 2010-02-25 Zacharon Pharmaceuticals, Inc. Heparan sulfate inhibitors
EP2324820B1 (en) * 2009-11-04 2016-03-02 Inopharm Limited Stable fluindione composition comprising one or more antioxidant agents

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RU2566761C2 (ru) 2015-10-27
AU2012270310A1 (en) 2012-12-20
PT2722322T (pt) 2019-09-27
WO2012173447A2 (ko) 2012-12-20
EA025384B1 (ru) 2016-12-30
EP2722322A2 (en) 2014-04-23
KR101391745B1 (ko) 2014-05-07
CN103748060A (zh) 2014-04-23
EP2722322B8 (en) 2020-03-11
EP4360710A2 (en) 2024-05-01
EP4360710A3 (en) 2024-08-07
CA2838680C (en) 2018-01-02
AU2012270310B2 (en) 2016-01-28
EP2722322A4 (en) 2014-12-17
MX2013014239A (es) 2014-05-14
BR112013032273A2 (pt) 2016-12-20
US9346749B2 (en) 2016-05-24
WO2012173447A3 (ko) 2013-04-04
US9833423B2 (en) 2017-12-05
US20160272564A1 (en) 2016-09-22
US20140121187A1 (en) 2014-05-01
JP2014523416A (ja) 2014-09-11
SI2722322T1 (sl) 2019-11-29
EA201490025A1 (ru) 2014-05-30
EP2722322B1 (en) 2019-06-12
PL2722322T3 (pl) 2020-02-28
JP2016185967A (ja) 2016-10-27
JP5941142B2 (ja) 2016-06-29
JP6373297B2 (ja) 2018-08-15
CA2838680A1 (en) 2012-12-20
EP3611158B1 (en) 2023-12-20
AU2012270310A8 (en) 2014-01-23
RU2014101179A (ru) 2015-07-27
CN103748060B (zh) 2016-04-13
BR112013032273B1 (pt) 2020-11-17
KR20120139606A (ko) 2012-12-27
ES2744982T3 (es) 2020-02-27

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