MX2013014239A - Derivados de 1,3-dioxoindeno, sal farmaceuticamente aceptable de los mismos, metodos de preparacion de los mismos y composicion farmaceutica para el antivirus que contiene el mismo como un ingrediente activo. - Google Patents

Derivados de 1,3-dioxoindeno, sal farmaceuticamente aceptable de los mismos, metodos de preparacion de los mismos y composicion farmaceutica para el antivirus que contiene el mismo como un ingrediente activo.

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Publication number
MX2013014239A
MX2013014239A MX2013014239A MX2013014239A MX2013014239A MX 2013014239 A MX2013014239 A MX 2013014239A MX 2013014239 A MX2013014239 A MX 2013014239A MX 2013014239 A MX2013014239 A MX 2013014239A MX 2013014239 A MX2013014239 A MX 2013014239A
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Mexico
Prior art keywords
viral
pharmaceutically acceptable
active ingredient
composition containing
pharmaceutical composition
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MX2013014239A
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English (en)
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MX355498B (es
Inventor
Johan Neyts
Young Sik Jung
Chong Kgo Lee
Hae Soon Kim
Pil Ho Kim
Soo Bong Han
Hendrik Jan Thibaut
Ihl Young Choi
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Univ Leuven Kath
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Publication of MX2013014239A publication Critical patent/MX2013014239A/es
Publication of MX355498B publication Critical patent/MX355498B/es

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Abstract

Se describe derivados de 1,3-Dioxoindeno, sales farmacéuticamente aceptables de los mismos o enantiómeros, un método de preparación de los mismos, y una composición farmacéutica para la prevención o tratamiento de enfermedades virales, que comprenden los mismos como un ingrediente activo. Los derivados de 1,3-Dioxoindeno tienen excelente actividad inhibitoria contra picornavirus incluyendo virus coxsackie, enterovirus, ecovirus, poliovirus y rinovirus, así como exhiben baja citotoxicidad, de modo que pueden ser útiles como un ingrediente activo de una composición farmacéutica para la prevención y tratamiento de enfermedades virales incluyendo poliomielitis, parálisis, conjuntivitis hemorrágica aguda, meningitis viral, enfermedad de manos pies y boca, enfermedad vesicular, hepatitis A, miositis, miocarditis, pancreatitis, diabetes, mialgia epidémica, encefalitis, resfriado, herpangina, enfermedad de pies y boca, asma, enfermedad pulmonar obstructiva crónica, neumonía, sinusitis u otitis media.
MX2013014239A 2011-06-16 2012-06-18 Derivados de 1,3-dioxoindeno, sal farmaceuticamente aceptable de los mismos, metodos de preparacion de los mismos y composicion farmaceutica para el antivirus que contiene el mismo como un ingrediente activo. MX355498B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20110058704 2011-06-16
PCT/KR2012/004804 WO2012173447A2 (ko) 2011-06-16 2012-06-18 1,3-다이옥소인덴 유도체, 이의 약학적으로 허용되는 염 또는 이의 광학 이성질체, 이의 제조방법 및 이를 유효성분으로 함유하는 항바이러스용 약학적 조성물
KR1020120065023A KR101391745B1 (ko) 2011-06-16 2012-06-18 1,3-다이옥소인덴 유도체, 이의 약학적으로 허용되는 염 또는 이의 광학 이성질체, 이의 제조방법 및 이를 유효성분으로 함유하는 항바이러스용 약학적 조성물

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MX2013014239A true MX2013014239A (es) 2014-05-14
MX355498B MX355498B (es) 2018-04-20

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EP2933254B1 (en) * 2012-12-14 2021-01-20 Korea Research Institute of Chemical Technology Novel compound, pharmaceutically acceptable salt or optical isomer thereof, method for preparing same, and pharmaceutical composition for prevention or treatment of viral diseases containing same as active ingredient
CN104557559B (zh) * 2015-01-14 2016-08-17 成都中医药大学 茚满二酮手性环己烷螺环化合物及其制备方法与用途
KR102067858B1 (ko) 2016-05-24 2020-01-17 주식회사 엘지화학 화합물 및 이를 포함하는 색재 조성물 및 이를 포함하는 수지 조성물
EP4139290A1 (en) * 2020-04-20 2023-03-01 Novartis AG Antiviral 1,3-di-oxo-indene compounds

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GB1425295A (en) * 1974-01-23 1976-02-18 Rizh Politekhn I Alpha-aminoylidenephthalides and processes for their preparation
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GB1533388A (en) * 1975-02-07 1978-11-22 Creat Ninhydrin-phenol condensation products their preparation and use as therapeutic agents
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JP2001089455A (ja) * 1999-09-17 2001-04-03 Maruishi Pharmaceutical Co Ltd ５，１０−ジヒドロ−１１Ｈ−インデノ〔１，２−ｂ〕キノリン−１０−オン誘導体
ES2228370T3 (es) * 1999-08-30 2005-04-16 Maruishi Pharmaceutical Co., Ltd. Compuestos de 1,4-dihidro-4-oxoquinolina 1,2-disustituidos.
WO2003082265A2 (en) * 2002-04-02 2003-10-09 Fujisawa Pharmaceutical Co Pharmaceutical composition for treating or preventing virus infectious diseases
ES2423800T3 (es) 2003-03-28 2013-09-24 Novartis Vaccines And Diagnostics, Inc. Uso de compuestos orgánicos para la inmunopotenciación
US20100133117A1 (en) * 2006-08-08 2010-06-03 Agency For Science, Technology And Research Methods for electrochemical detection/quantification of a nucleic acid
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JP2014523416A (ja) 2014-09-11
WO2012173447A3 (ko) 2013-04-04
EP3611158A1 (en) 2020-02-19
PL2722322T3 (pl) 2020-02-28
AU2012270310B2 (en) 2016-01-28
EP4360710A2 (en) 2024-05-01
BR112013032273B1 (pt) 2020-11-17
EP4360710A3 (en) 2024-08-07
EP2722322A2 (en) 2014-04-23
ES2744982T3 (es) 2020-02-27
US9833423B2 (en) 2017-12-05
CN103748060B (zh) 2016-04-13
CA2838680A1 (en) 2012-12-20
MX355498B (es) 2018-04-20
PT2722322T (pt) 2019-09-27
AU2012270310A8 (en) 2014-01-23
EA201490025A1 (ru) 2014-05-30
WO2012173447A2 (ko) 2012-12-20
JP6373297B2 (ja) 2018-08-15
RU2566761C2 (ru) 2015-10-27
SI2722322T1 (sl) 2019-11-29
CA2838680C (en) 2018-01-02
JP2016185967A (ja) 2016-10-27
RU2014101179A (ru) 2015-07-27
KR20120139606A (ko) 2012-12-27
US20140121187A1 (en) 2014-05-01
US20160272564A1 (en) 2016-09-22
US9346749B2 (en) 2016-05-24
EP2722322B1 (en) 2019-06-12
EP2722322B8 (en) 2020-03-11
BR112013032273A2 (pt) 2016-12-20
JP5941142B2 (ja) 2016-06-29
EA025384B1 (ru) 2016-12-30
EP2722322A4 (en) 2014-12-17
CN103748060A (zh) 2014-04-23
AU2012270310A1 (en) 2012-12-20
EP3611158B1 (en) 2023-12-20

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