MX355352B - Particulas quimericas de vph. - Google Patents
Particulas quimericas de vph.Info
- Publication number
- MX355352B MX355352B MX2014006520A MX2014006520A MX355352B MX 355352 B MX355352 B MX 355352B MX 2014006520 A MX2014006520 A MX 2014006520A MX 2014006520 A MX2014006520 A MX 2014006520A MX 355352 B MX355352 B MX 355352B
- Authority
- MX
- Mexico
- Prior art keywords
- hpv
- chimaeric
- particle
- vlp
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/295—Polyvalent viral antigens; Mixtures of viral and bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/01—DNA viruses
- C07K14/025—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
- C12N7/045—Pseudoviral particles; Non infectious pseudovirions, e.g. genetically engineered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20023—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La presente invención se refiere a una partícula similar al virus (VLP) quimérica de virus de papiloma humano (VPH) que tiene un diámetro de alrededor de 30 nm, en donde la VLP quimérica de VPH se produce de acuerdo a un método caracterizado porque comprende las etapas de: (i) proporcionar una secuencia quimérica de nucléotidos optimizada por un codón de humano que codifica un polipéptido quimérico L1/L2 de VPH 16, el polipéptido quimérica L1/L2 de VPH 16 comprende un polipéptido L1 de VPH 16 que tiene un péptido L2 de VPH de entre alrededor de 13 aminoácidos a alrededor de 26 aminoácidos insertados a partir del residuo 414 del polipéptido quimérico L1/L2 de VPH 16, en donde los aminoácidos del péptido L2 de VPH insertado remplaza los aminoácidos del polipéptido L1 de VPH 16; (ii) clonar la secuencia quimérica de nucleótidos optimizada por un codón de humano en un vector de expresión adaptado para expresar un polipéptido en una planta; (iii) transformar o infiltrar una célula vegetal con el vector de expresión de la etapa (ii); (iv) expresar el polipéptido quimérico L1/L2 de VPH 16 en la célula vegetal de la etapa (ii) de modo que el polipéptido quimérico L1/L2 de VPH 16 expresado se ensamble en una VLP quimérica de VPH que tiene un diámetro de alrededor de 30 nm; y (v) recuperar la VLP quimérica de VPH a partir de la célula vegetal utilizando un amortiguador de extracción de alta salinidad que tiene una concentración de NaCl de al menos 1M.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ZA201108841 | 2011-12-01 | ||
PCT/IB2012/056912 WO2013080187A1 (en) | 2011-12-01 | 2012-12-03 | Hpv chimaeric particle |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014006520A MX2014006520A (es) | 2014-11-21 |
MX355352B true MX355352B (es) | 2018-04-17 |
Family
ID=48534756
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014006520A MX355352B (es) | 2011-12-01 | 2012-12-03 | Particulas quimericas de vph. |
Country Status (17)
Country | Link |
---|---|
US (1) | US9771397B2 (es) |
EP (1) | EP2785842A4 (es) |
JP (1) | JP6228922B2 (es) |
KR (1) | KR102013801B1 (es) |
CN (1) | CN103890177B (es) |
AU (1) | AU2012345443B2 (es) |
BR (1) | BR112014012491A2 (es) |
CA (1) | CA2850293C (es) |
HK (1) | HK1198703A1 (es) |
IL (1) | IL232584B (es) |
IN (1) | IN2014DN03054A (es) |
MX (1) | MX355352B (es) |
MY (1) | MY184076A (es) |
RU (1) | RU2642287C2 (es) |
SG (1) | SG11201401579UA (es) |
WO (1) | WO2013080187A1 (es) |
ZA (1) | ZA201403557B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2845212T3 (es) | 2009-04-13 | 2021-07-26 | Inst Nat Sante Rech Med | Partículas de HPV y usos de las mismas |
US9700639B2 (en) | 2012-02-07 | 2017-07-11 | Aura Biosciences, Inc. | Virion-derived nanospheres for selective delivery of therapeutic and diagnostic agents to cancer cells |
ES2729841T3 (es) * | 2013-09-18 | 2019-11-06 | Aura Biosciences Inc | Conjugados de partículas similares a virus para tratar tumores |
CN104531741B (zh) * | 2014-08-22 | 2016-08-24 | 天津康希诺生物技术有限公司 | 增强hpv抗原表位肽免疫原性的方法及类病毒颗粒、颗粒制备方法与应用 |
CN105801704B (zh) * | 2014-12-31 | 2020-06-02 | 艾托金生物医药(苏州)有限公司 | 一种具有抗宫颈癌细胞活性的重组疫苗构建方法及应用 |
NZ739780A (en) | 2015-08-18 | 2024-02-23 | Rakuten Medical Inc | Compositions, combinations and related methods for photoimmunotherapy |
EP3777978A1 (en) | 2015-08-18 | 2021-02-17 | Rakuten Medical, Inc. | Phthalocyanine dye conjugates and their storage |
MX2018005468A (es) | 2015-10-30 | 2018-11-09 | The Us Secretary Department Of Health And Man Services | Terapia dirigida contra el cáncer. |
WO2018187515A1 (en) * | 2017-04-04 | 2018-10-11 | Avidea Technologies, Inc. | Peptide-based vaccines, methods of manufacturing, and uses thereof for inducing an immune response |
WO2018237115A2 (en) | 2017-06-23 | 2018-12-27 | Pathovax Llc | CHIMERIC VIRUS-LIKE PARTICLES AND THEIR USES AS SPECIFIC REDIRECTORS OF ANTIGENS OF IMMUNE RESPONSES |
WO2020139978A1 (en) | 2018-12-27 | 2020-07-02 | Verimmune Llc | Conjugated virus-like particles and uses thereof as anti-tumor immune redirectors |
WO2021161179A1 (en) * | 2020-02-10 | 2021-08-19 | University Of Cape Town | Plant produced bovine papillomavirus virus-like particles and pseudovirions |
AU2021364548A1 (en) | 2020-10-19 | 2023-06-08 | Verimmune Inc. | Virus-inspired compositions and methods of redirecting preexisting immune responses using the same for treatment of cancer |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA96005662A (es) * | 1994-05-16 | 2004-08-19 | Merck & Co Inc | Vacunas de papilomavirus. |
PL347472A1 (en) | 1998-08-14 | 2002-04-08 | Merck & Co Inc | Process for purifying human papillomavirus virus-like particles |
US20020016372A1 (en) * | 2000-07-31 | 2002-02-07 | Allison Anthony Clifford | Method for preventing and treating alzheimer's disease and brain damage associated with cardiov ascular disease and head injury |
WO2003068933A2 (en) | 2002-02-14 | 2003-08-21 | Novavax, Inc. | Optimization of gene sequences of virus-like particles for expression in insect cells |
US7407807B2 (en) * | 2002-05-17 | 2008-08-05 | University Of Cape Town | Chimaeric human papillomavirus 16 I1 virus like particles and a method for preparing the particles |
ES2662118T3 (es) | 2005-04-29 | 2018-04-05 | University Of Cape Town | Expresión de proteínas virales en las plantas |
DK2416798T3 (en) * | 2009-04-10 | 2018-01-08 | Univ Johns Hopkins | PAPILLOMAVIRUS-LIKE PARTICLES (VLP) AS WIDE-SPECIFIED VACCINES AGAINST HUMAN PAPILLOMAVIRUS (HPV) |
WO2010147268A1 (ko) * | 2009-06-19 | 2010-12-23 | 아이진 주식회사 | 자궁경부암 백신 |
JP2012530505A (ja) * | 2009-06-25 | 2012-12-06 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 新規ヒトパピローマウイルス(hpv)タンパク質構築物及びhpv疾患の予防におけるそれらの使用 |
WO2011077371A1 (en) * | 2009-12-22 | 2011-06-30 | University Of Cape Town | Method for enhancing the expression of hpv l1 |
-
2012
- 2012-12-03 SG SG11201401579UA patent/SG11201401579UA/en unknown
- 2012-12-03 CA CA2850293A patent/CA2850293C/en not_active Expired - Fee Related
- 2012-12-03 BR BR112014012491A patent/BR112014012491A2/pt not_active IP Right Cessation
- 2012-12-03 RU RU2014126587A patent/RU2642287C2/ru not_active IP Right Cessation
- 2012-12-03 IN IN3054DEN2014 patent/IN2014DN03054A/en unknown
- 2012-12-03 MY MYPI2014700894A patent/MY184076A/en unknown
- 2012-12-03 CN CN201280052968.8A patent/CN103890177B/zh not_active Expired - Fee Related
- 2012-12-03 JP JP2014544038A patent/JP6228922B2/ja not_active Expired - Fee Related
- 2012-12-03 EP EP12853360.1A patent/EP2785842A4/en not_active Withdrawn
- 2012-12-03 KR KR1020147010686A patent/KR102013801B1/ko active IP Right Grant
- 2012-12-03 US US14/360,524 patent/US9771397B2/en not_active Expired - Fee Related
- 2012-12-03 AU AU2012345443A patent/AU2012345443B2/en not_active Ceased
- 2012-12-03 MX MX2014006520A patent/MX355352B/es active IP Right Grant
- 2012-12-03 WO PCT/IB2012/056912 patent/WO2013080187A1/en active Application Filing
-
2014
- 2014-05-13 IL IL232584A patent/IL232584B/en active IP Right Grant
- 2014-05-16 ZA ZA2014/03557A patent/ZA201403557B/en unknown
- 2014-12-02 HK HK14112143.5A patent/HK1198703A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP2785842A4 (en) | 2015-11-25 |
RU2642287C2 (ru) | 2018-01-24 |
CN103890177B (zh) | 2016-03-09 |
BR112014012491A2 (pt) | 2017-06-06 |
CA2850293A1 (en) | 2013-06-06 |
AU2012345443B2 (en) | 2017-10-26 |
IL232584A0 (en) | 2014-06-30 |
JP6228922B2 (ja) | 2017-11-08 |
MY184076A (en) | 2021-03-17 |
HK1198703A1 (en) | 2015-05-29 |
IL232584B (en) | 2018-10-31 |
US20140377367A1 (en) | 2014-12-25 |
ZA201403557B (en) | 2020-10-28 |
WO2013080187A1 (en) | 2013-06-06 |
US9771397B2 (en) | 2017-09-26 |
AU2012345443A1 (en) | 2014-04-17 |
KR102013801B1 (ko) | 2019-08-23 |
IN2014DN03054A (es) | 2015-05-15 |
CA2850293C (en) | 2019-10-08 |
SG11201401579UA (en) | 2014-07-30 |
KR20140098061A (ko) | 2014-08-07 |
MX2014006520A (es) | 2014-11-21 |
NZ622595A (en) | 2016-04-29 |
CN103890177A (zh) | 2014-06-25 |
EP2785842A1 (en) | 2014-10-08 |
RU2014126587A (ru) | 2016-01-27 |
JP2015500229A (ja) | 2015-01-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MY184076A (en) | Hpv chimaeric particle | |
PH12019502269A1 (en) | Quinazoline derivatives for the treatment of viral infections and further diseases | |
EP3463577A4 (en) | COMPOSITIONS AND METHODS FOR TREATING DISEASES ASSOCIATED WITH HUMAN PAPILLOMAVIRUS (HPV) | |
MX2022001105A (es) | Anticuerpos anti tigit. | |
MX2019012233A (es) | Anticuerpos anti-sirpa. | |
MX2022007522A (es) | Anticuerpos anti-cd27. | |
WO2016198531A3 (en) | Hpv vaccines | |
PH12015500274B1 (en) | Alkylpyrimidine derivatives for the treatment of viral infections and further diseases | |
MX340090B (es) | Analogos de spliceostatina. | |
MX2013004817A (es) | Enfermedad inflamatoria. | |
EA032929B1 (ru) | Нейтрализующее вирус иммунодефицита человека антитело и способы его применения | |
MX2013012053A (es) | Inhibidores de replicacion viral, su proceso de preparacion y sus usos terapeuticos. | |
MA40458A (fr) | Méthodes de traitement du cancer du col de l'utérus | |
EP3010507A4 (en) | Compositions and methods for potentiating immune response for the treatment of infectious diseases and cancer | |
EP2555798A4 (en) | METHOD AND COMPOSITIONS FOR INHIBITING HIV TRANSMISSIONS | |
WO2015054678A3 (en) | Human papilloma virus therapeutic vaccine | |
EP2601967A4 (en) | MEDICINE FOR PREVENTING AND TREATING HIV-RELATED OR HIV-RELATED DISEASES, INCLUDING AIDS | |
EP2978449A4 (en) | Compositions and methods for the treatment or prevention of human immunodeficiency virus infection | |
MX364704B (es) | Inhibidores de replicacion viral, su proceso de preparacion y sus usos terapeuticos. | |
IN2011CH03893A (es) | ||
WO2013093629A3 (en) | Modular vaccines, methods and compositions related thereto | |
WO2011054996A3 (es) | Vacunas para el tratamiento de neoplasias a partir de capsides virales de birnavirus conteniendo antigenos del virus del papiloma humano | |
UA90646C2 (ru) | Способ лечения часто рецидивирующей хронической герпетической инфекции, вызванной вирусом герпеса простого и и ии типов | |
UA74055U (ru) | Способ хирургического лечения рефрактерных форм глаукомы | |
UA59657U (ru) | Способ лечения женщин с фоновыми заболеваниями шейки матки на фоне генитальной герпесвирусной инфекции |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |