MX355217B - Derivados de polimixina. - Google Patents

Derivados de polimixina.

Info

Publication number
MX355217B
MX355217B MX2014005542A MX2014005542A MX355217B MX 355217 B MX355217 B MX 355217B MX 2014005542 A MX2014005542 A MX 2014005542A MX 2014005542 A MX2014005542 A MX 2014005542A MX 355217 B MX355217 B MX 355217B
Authority
MX
Mexico
Prior art keywords
alkyl
compounds
cycloalkyl
group
polymyxin
Prior art date
Application number
MX2014005542A
Other languages
English (en)
Spanish (es)
Other versions
MX2014005542A (es
Inventor
Saadi Mona
Duperchy Esther
Brown Pamela
John Dawson Michael
Nicolaas Wadman Sjoerd
Original Assignee
New Pharma Licence Holdings Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New Pharma Licence Holdings Ltd filed Critical New Pharma Licence Holdings Ltd
Publication of MX2014005542A publication Critical patent/MX2014005542A/es
Publication of MX355217B publication Critical patent/MX355217B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
MX2014005542A 2011-11-18 2012-11-16 Derivados de polimixina. MX355217B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161561361P 2011-11-18 2011-11-18
PCT/GB2012/052844 WO2013072695A1 (en) 2011-11-18 2012-11-16 Polymyxin derivatives

Publications (2)

Publication Number Publication Date
MX2014005542A MX2014005542A (es) 2014-10-24
MX355217B true MX355217B (es) 2018-04-10

Family

ID=47297320

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014005542A MX355217B (es) 2011-11-18 2012-11-16 Derivados de polimixina.

Country Status (15)

Country Link
US (1) US9234006B2 (ja)
EP (1) EP2780357A1 (ja)
JP (1) JP6185920B2 (ja)
KR (1) KR20140091724A (ja)
CN (1) CN103946233A (ja)
AU (1) AU2012338571B2 (ja)
BR (1) BR112014012016A2 (ja)
CA (1) CA2855916A1 (ja)
CO (1) CO7061068A2 (ja)
EA (1) EA024792B1 (ja)
IL (1) IL232278A0 (ja)
MX (1) MX355217B (ja)
SG (1) SG11201402390PA (ja)
TW (1) TWI608019B (ja)
WO (1) WO2013072695A1 (ja)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012338571B2 (en) 2011-11-18 2016-06-16 New Pharma Licence Holdings Limited Polymyxin derivatives
RU2730012C2 (ru) * 2013-05-22 2020-08-14 Сперо Терапьютикс, Инк. Производные полимиксина и их применение в комбинированной терапии совместно с различными антибиотиками
PT3116897T (pt) * 2014-03-11 2022-04-07 Spero Therapeutics Inc Derivados de polimixina e a sua utilização na terapia de combinação em conjunto com antibióticos diferentes
NZ724798A (en) 2014-04-01 2020-05-29 Univ Monash Polymyxin derivatives as antimicrobial compounds
CN107108699A (zh) * 2014-11-26 2017-08-29 新药物许可控股有限公司 化合物
US9771394B2 (en) 2014-12-16 2017-09-26 Micurx Pharmaceuticals, Inc. Antimicrobial polymyxins for treatment of bacterial infections
FI126143B (en) 2015-01-15 2016-07-15 Northern Antibiotics Oy Polymyxine derivative and its uses
US9763996B2 (en) 2015-01-16 2017-09-19 Northern Antibiotics, Ltd. Polymyxin derivative and uses thereof
US10322187B2 (en) 2015-08-10 2019-06-18 Lehigh University Reduced toxicity molecular conjugates of anti-fungal agents
CA3000032A1 (en) 2015-09-29 2017-04-06 Monash University Antimicrobial polymyxin derivative compounds
DK3512544T3 (da) * 2016-09-13 2021-02-01 Centauri Therapeutics Ltd Peptidforbindelser og terapeutiske anvendelser deraf
CN108226315B (zh) * 2016-12-15 2022-04-12 上海医药工业研究院 一种检测多黏菌素e残留量的分析方法
AU2018359018B2 (en) * 2017-11-02 2022-11-24 The University Of Queensland Peptide antibiotics
AU2019294261B2 (en) 2018-06-25 2024-02-29 Spero Therapeutics, Inc. Compounds
CN111690040A (zh) * 2019-03-12 2020-09-22 上海来益生物药物研究开发中心有限责任公司 多粘菌素衍生物、其制备方法和应用
JP7045520B2 (ja) * 2020-01-02 2022-03-31 上海上薬第一生化薬業有限公司 ポリミキシンｂ成分又はその塩、その製造方法及び使用
CN115298198A (zh) 2020-01-21 2022-11-04 上海盟科药业股份有限公司 用于肾相关癌症靶向治疗的新型化合物和组合物
TW202233649A (zh) 2020-11-06 2022-09-01 美商斯佩羅治療學股份有限公司 化合物
CN112755174B (zh) * 2021-02-26 2022-11-18 沈阳药科大学 多粘菌素衍生物及其制备方法和应用
WO2022262823A1 (zh) * 2021-06-18 2022-12-22 华南理工大学 活性氧自由基响应的多粘菌素前药化合物及其应用
NL2030897B1 (en) * 2022-02-11 2023-08-18 Univ Leiden Antibiotic compounds, formulations and methods of use

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2128617A (en) 1982-10-06 1984-05-02 Martti Vaara Polypeptides for use in antibacterial therapy
WO1988000950A2 (en) 1986-08-06 1988-02-11 Fauchere Jean Luc Production of covalent-linked conjugates from an antibiotic and a non-toxic derivative of polymyxine b
US20010021697A1 (en) 1987-09-14 2001-09-13 Henning Lowenstein Methods and compositions for the treatment of mammalian infections employing medicaments comprising hymenoptera venom, proteinageous or polypeptide components thereof, or analogues of such proteinaceous or polypeptide components
TW274552B (ja) 1992-05-26 1996-04-21 Hoechst Ag
US5767068A (en) 1997-02-13 1998-06-16 Pathogenesis Corporation Pure biologically active colistin, its components and a colistin formulation for treatment of pulmonary infections
CN1886128A (zh) 2003-09-30 2006-12-27 柯西有限公司 用于治疗灼伤的组合物及方法
US20060004185A1 (en) * 2004-07-01 2006-01-05 Leese Richard A Peptide antibiotics and peptide intermediates for their prepartion
EP2057185B1 (en) * 2006-08-11 2016-05-11 Northern Antibiotics Oy Polymyxin derivatives and uses thereof
FI20085469A0 (fi) * 2008-02-08 2008-05-16 Northern Antibiotics Oy Polymyksiinijohdannaiset, joissa on lyhyt rasvahappohäntä, ja niiden käyttöjä
US8329645B2 (en) * 2008-02-08 2012-12-11 Northern Antibiotics Ltd. Polymyxin derivatives and uses thereof
US8193148B2 (en) 2008-02-08 2012-06-05 Northern Antibiotics Ltd. Short fatty acid tail polymyxin derivatives and uses thereof
ES2334547B1 (es) 2008-09-10 2010-12-03 Universidad De Barcelona Compuestos peptidicos antibacterianos.
NZ593892A (en) 2008-12-23 2013-11-29 Biosource Pharm Inc Antibiotic compositions for the treatment of gram negative infections
CN101851270A (zh) 2009-04-03 2010-10-06 梁浩 一种多粘菌素衍生物及其制备方法
WO2010130007A1 (en) 2009-05-14 2010-11-18 Monash University Antimicrobial compounds
US8415307B1 (en) 2010-06-23 2013-04-09 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
WO2012051663A1 (en) 2010-10-21 2012-04-26 Monash University Antimicrobial compounds
WO2012168820A1 (en) 2011-06-08 2012-12-13 Pfizer Inc. Polymyxin derivatives useful as antibacterial agents
AU2012338571B2 (en) 2011-11-18 2016-06-16 New Pharma Licence Holdings Limited Polymyxin derivatives
RU2730012C2 (ru) * 2013-05-22 2020-08-14 Сперо Терапьютикс, Инк. Производные полимиксина и их применение в комбинированной терапии совместно с различными антибиотиками
PT3116897T (pt) * 2014-03-11 2022-04-07 Spero Therapeutics Inc Derivados de polimixina e a sua utilização na terapia de combinação em conjunto com antibióticos diferentes

Also Published As

Publication number Publication date
AU2012338571A1 (en) 2014-05-22
EA024792B1 (ru) 2016-10-31
WO2013072695A1 (en) 2013-05-23
TWI608019B (zh) 2017-12-11
EA201490634A1 (ru) 2014-12-30
US9234006B2 (en) 2016-01-12
MX2014005542A (es) 2014-10-24
AU2012338571B2 (en) 2016-06-16
IL232278A0 (en) 2014-06-30
BR112014012016A2 (pt) 2017-05-16
US20150031602A1 (en) 2015-01-29
EP2780357A1 (en) 2014-09-24
KR20140091724A (ko) 2014-07-22
CN103946233A (zh) 2014-07-23
CA2855916A1 (en) 2013-05-23
JP6185920B2 (ja) 2017-08-23
TW201326215A (zh) 2013-07-01
CO7061068A2 (es) 2014-09-19
JP2014533678A (ja) 2014-12-15
SG11201402390PA (en) 2014-06-27

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Legal Events

Date Code Title Description
GB Transfer or rights

Owner name: NEW PHARMA LICENCE HOLDINGS LIMITED

FG Grant or registration