MX349551B - Proceso para preparar compuestos tienopirimidinas. - Google Patents

Proceso para preparar compuestos tienopirimidinas.

Info

Publication number
MX349551B
MX349551B MX2015004467A MX2015004467A MX349551B MX 349551 B MX349551 B MX 349551B MX 2015004467 A MX2015004467 A MX 2015004467A MX 2015004467 A MX2015004467 A MX 2015004467A MX 349551 B MX349551 B MX 349551B
Authority
MX
Mexico
Prior art keywords
making
thienopyrimidine compounds
methyl
thienopyrimidine
compounds
Prior art date
Application number
MX2015004467A
Other languages
English (en)
Spanish (es)
Other versions
MX2015004467A (es
Inventor
Babu Srinivasan
Cheng Zhigang
Gosselin Francis
Hidber Pirmin
Hoffmann Ursula
Humphries Theresa
Reents Reinhard
Tian Qingping
Yajima Herbert
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2015004467A publication Critical patent/MX2015004467A/es
Publication of MX349551B publication Critical patent/MX349551B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Health & Medical Sciences (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
MX2015004467A 2012-10-10 2013-10-09 Proceso para preparar compuestos tienopirimidinas. MX349551B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261711900P 2012-10-10 2012-10-10
PCT/EP2013/070994 WO2014056955A1 (fr) 2012-10-10 2013-10-09 Procédé de préparation de composés de thiénopyrimidine

Publications (2)

Publication Number Publication Date
MX2015004467A MX2015004467A (es) 2015-07-14
MX349551B true MX349551B (es) 2017-08-02

Family

ID=49322377

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015004467A MX349551B (es) 2012-10-10 2013-10-09 Proceso para preparar compuestos tienopirimidinas.

Country Status (13)

Country Link
US (1) US8895729B2 (fr)
EP (1) EP2906566B1 (fr)
JP (1) JP6123097B2 (fr)
KR (1) KR101698283B1 (fr)
CN (2) CN104718212B (fr)
AR (1) AR092960A1 (fr)
BR (1) BR112015007970A8 (fr)
CA (1) CA2883513A1 (fr)
ES (1) ES2594078T3 (fr)
HK (2) HK1244272A1 (fr)
MX (1) MX349551B (fr)
RU (1) RU2637309C2 (fr)
WO (1) WO2014056955A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX349551B (es) * 2012-10-10 2017-08-02 Hoffmann La Roche Proceso para preparar compuestos tienopirimidinas.
MX361673B (es) 2013-05-06 2018-12-11 Hoffmann La Roche Procedimiento para la preparación de intermediarios de ácido borónico.
WO2015116735A1 (fr) 2014-01-28 2015-08-06 Mayo Foundation For Medical Education And Research Procédés et combinaisons pour tuer des cellules sénescentes et traiter des maladies et troubles associés à une sénescence
CA2939121C (fr) 2014-01-28 2020-11-24 Mayo Foundation For Medical Education And Research Traitement efficace d'osteoarthrose, de maladie pulmonaire, de maladie ophtalmique et d'atherosclerose par enlevement de cellules senescentes sur le site de la maladie
TW201815787A (zh) 2016-09-23 2018-05-01 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201813963A (zh) 2016-09-23 2018-04-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201825465A (zh) 2016-09-23 2018-07-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
MX2019004842A (es) * 2016-11-02 2019-06-20 Curis Inc Terapia de combinación con un inhibidor fosfoinositida 3-cinasa con un resto de unión a cinc.
WO2019180141A1 (fr) 2018-03-23 2019-09-26 Bayer Aktiengesellschaft Combinaisons de rogaratinib
CN113717049A (zh) * 2021-08-05 2021-11-30 江西兄弟医药有限公司 一种制备（s）-乙酰氧基丙酰氯的半连续方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6274327B1 (en) 1992-04-13 2001-08-14 Ludwig Institute For Cancer Research Polypeptides having kinase activity, their preparation and use
US5846824A (en) 1994-02-07 1998-12-08 Ludwig Institute For Cancer Research Polypeptides having kinase activity, their preparation and use
GB9208135D0 (en) 1992-04-13 1992-05-27 Ludwig Inst Cancer Res Polypeptides having kinase activity,their preparation and use
US6395916B1 (en) 1998-07-10 2002-05-28 Massachusetts Institute Of Technology Ligands for metals and improved metal-catalyzed processes based thereon
US7223879B2 (en) 1998-07-10 2007-05-29 Massachusetts Institute Of Technology Ligands for metals and improved metal-catalyzed processes based thereon
US6307087B1 (en) 1998-07-10 2001-10-23 Massachusetts Institute Of Technology Ligands for metals and improved metal-catalyzed processes based thereon
WO2003006151A1 (fr) 2001-07-12 2003-01-23 Avecia Limited Catalyseur microencapsule, methodes de preparation et methodes d'utilisation associees
GB0423653D0 (en) 2004-10-25 2004-11-24 Piramed Ltd Pharmaceutical compounds
EP2402347A1 (fr) 2006-04-26 2012-01-04 F. Hoffmann-La Roche AG Composés pharmaceutiques
GB0608264D0 (en) * 2006-04-26 2006-06-07 Piramed Ltd Pharmaceutical compounds
KR101507182B1 (ko) * 2006-12-07 2015-03-30 제넨테크, 인크. 포스포이노시타이드 3-키나제 억제제 화합물 및 그의 사용 방법
UA98946C2 (en) * 2006-12-07 2012-07-10 Ф. Хоффманн-Ля Рош Аг Phosphoinositide 3-kinase inhibitor compounds and methods of use
NZ578162A (en) * 2006-12-07 2011-12-22 Genentech Inc Phosphoinositide 3-kinase inhibitor compounds and methods of use
TWI471134B (zh) 2007-09-12 2015-02-01 Genentech Inc 肌醇磷脂３－激酶抑制劑化合物及化療劑之組合及使用方法
CN101909631B (zh) 2007-10-25 2012-09-12 健泰科生物技术公司 制备噻吩并嘧啶化合物的方法
WO2009076622A2 (fr) 2007-12-12 2009-06-18 Massachusetts Institute Of Technology Ligands pour couplages croisés catalysés par un métal de transition et procédés d'utilisation de ceux-ci
WO2010105008A2 (fr) 2009-03-12 2010-09-16 Genentech, Inc. Combinaisons de composés inhibiteurs de phosphoinositide 3-kinase et d'agents chimiothérapeutiques pour le traitement de tumeurs malignes hématopoïétiques
EP2714046A1 (fr) 2011-06-03 2014-04-09 F.Hoffmann-La Roche Ag Méthodes de traitement du mésothéliome au moyen d'un composé inhibiteur de pi3k
CN102399235A (zh) * 2011-10-25 2012-04-04 江苏弘和药物研发有限公司 一种2-氨基-5-嘧啶硼酸频哪醇酯的合成方法
CN102367260A (zh) * 2011-12-12 2012-03-07 南京药石药物研发有限公司 2-氨基嘧啶-5-硼酸的合成方法
CN102675323B (zh) * 2012-06-01 2014-04-09 南京药石药物研发有限公司 吡咯并[2,1-f][1,2,4]三嗪衍生物及其抗肿瘤用途
MX349551B (es) * 2012-10-10 2017-08-02 Hoffmann La Roche Proceso para preparar compuestos tienopirimidinas.
CN102993163A (zh) * 2012-12-07 2013-03-27 青岛前线生物工程有限公司 3-甲基噻吩-2-甲醛的合成方法

Also Published As

Publication number Publication date
HK1244272A1 (zh) 2018-08-03
MX2015004467A (es) 2015-07-14
CN107188898A (zh) 2017-09-22
CA2883513A1 (fr) 2014-04-17
EP2906566B1 (fr) 2016-08-24
CN107188898B (zh) 2019-12-03
CN104718212A (zh) 2015-06-17
AR092960A1 (es) 2015-05-06
WO2014056955A1 (fr) 2014-04-17
ES2594078T3 (es) 2016-12-15
HK1211026A1 (en) 2016-05-13
US20140100366A1 (en) 2014-04-10
EP2906566A1 (fr) 2015-08-19
JP6123097B2 (ja) 2017-05-10
US8895729B2 (en) 2014-11-25
JP2015534572A (ja) 2015-12-03
KR20150054945A (ko) 2015-05-20
CN104718212B (zh) 2017-06-16
BR112015007970A8 (pt) 2019-08-27
RU2637309C2 (ru) 2017-12-04
KR101698283B1 (ko) 2017-01-19
RU2015113747A (ru) 2016-12-10
BR112015007970A2 (pt) 2017-07-04

Similar Documents

Publication Publication Date Title
MX349551B (es) Proceso para preparar compuestos tienopirimidinas.
HRP20180859T1 (hr) 2-amino-6-fluoro-n-(5-fluoro-4-(4-(4-(oksetan-3-il)piperazin-1-karbonil)piperidin-1-il)piridin-3-il)pirazolo[1,5alfa]pirimidin-3-karboksamid kao inhibitor atr kinaze
MX2013011781A (es) Derivados de pirrolotriazinona como inhibidores de pi3k.
MY170878A (en) [1,2,3] triazolo [4,5-d] pyrimidine derivatives as agonists of the cannabinoid receptor 2
CR20140332A (es) Inhibidores de bromodominios
MX348470B (es) Pirimidinas anilladas sustituidas y uso de las mismas.
PH12018501643A1 (en) Tlr7 agonist crystalline form a, preparation method and use thereof
TN2013000400A1 (en) Imidazopyridazines as akt kinase inhibitors
CR20200286A (es) DERIVADOS DE DIHIDRO-BENZO-OXAZINA Y DIHIDRO-PIRIDO-OXAZINA (Divisional 2014-0294)
MX341456B (es) Amino-quinolinas como inhibidores de cinasa.
PH12015500813A1 (en) Pyrrolotriazinone derivatives as pi3k inhibitors
WO2014045162A8 (fr) Composés d'hexahydropyrano[3,4-d][1,3]thiazine-2-amine alkyl-substitués
EA030383B9 (ru) Бициклически замещённые урацилы, способы их получения, их применение, лекарственное средство и способ лечения с их применением
MX346248B (es) Derivados de [1,2,3]triazol[4,5-d]pirimidina como agonistas de los agonistas del receptor canabinoide 2.
MX2013005833A (es) Nuevos compuestos de piridina fusionada como inhibidores de caseina quinasa.
NZ608031A (en) Inhibitors of notum pectinacetylesterase and methods of their use
MX352927B (es) Derivados de 1h-pirrolo [2,3-b] piridina y su uso como inhibidores de quinasa.
GEP20156423B (en) 9-[4-(3-chlor-2-fluorphenylamino)-7-methoxy- quinazolin-6-yloxy]-1,4-diaza-spiro[5.5]undecan-5-one dimaleate, usage thereas drug, and production thereof
MX350419B (es) Compuesto (tieno [2,3-b] [1,5] benzoxazepin -4 -il) piperazin- 1 - ilo como angonistas inversos h1/antagonistas 5 -ht2a de actividad doble.
SG10201408059QA (en) 5-oxo-5, 8-dihydropyrido [2, 3-d] pyrimidine derivatives as camkii kinase inhibitors for treating cardiovascular diseases
MX2017008430A (es) Métodos para preparar derivados de 2,4-diaminopirimidina bíclica fusionada.
MX356804B (es) Polimorfos de 2-(4-(2-(1-isopropil-3-metil-1h-1,2,4-triazol-5-il)- 5,6-dihidrobenzo[f]imidazol[1,2-d][1,4]oxazepin-9-il)-1h-pirazol- 1-il)-2-metilpropanamida, metodos de produccion, y usos farmaceuticos de los mismos.
MX341132B (es) Compuesto (tieno [2-3-b] [1,5] benzoxazepin-4-il) piperazin-1-ilo como agonista h1 inversos/antagonistas 5-ht2a de actividad doble.
AU2013314244A8 (en) Novel inhibitor compounds of phosphodiesterase type 10A
AU2012307449A8 (en) Sulfonic acid salts of heterocyclylamide-substituted imidazoles

Legal Events

Date Code Title Description
FG Grant or registration