MX347170B - Cápsulas de dosis unitaria e inhalador de polvo seco. - Google Patents
Cápsulas de dosis unitaria e inhalador de polvo seco.Info
- Publication number
- MX347170B MX347170B MXPA02000812A MXPA02000812A MX347170B MX 347170 B MX347170 B MX 347170B MX PA02000812 A MXPA02000812 A MX PA02000812A MX PA02000812 A MXPA02000812 A MX PA02000812A MX 347170 B MX347170 B MX 347170B
- Authority
- MX
- Mexico
- Prior art keywords
- dry powder
- section
- mouthpiece
- intake
- powder inhaler
- Prior art date
Links
- 239000002775 capsule Substances 0.000 title abstract 3
- 229940112141 dry powder inhaler Drugs 0.000 title abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/001—Particle size control
- A61M11/002—Particle size control by flow deviation causing inertial separation of transported particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/002—Details of inhalators; Constructional features thereof with air flow regulating means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
- A61M15/0023—Mouthpieces therefor retractable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/04—Tracheal tubes
- A61M16/0488—Mouthpieces; Means for guiding, securing or introducing the tubes
- A61M16/049—Mouthpieces
- A61M16/0495—Mouthpieces with tongue depressors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/08—Bellows; Connecting tubes ; Water traps; Patient circuits
- A61M16/0816—Joints or connectors
- A61M16/0825—Joints or connectors with ball-sockets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/07—General characteristics of the apparatus having air pumping means
- A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
- A61M2205/073—Syringe, piston type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/43—General characteristics of the apparatus making noise when used correctly
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/60—General characteristics of the apparatus with identification means
- A61M2205/6045—General characteristics of the apparatus with identification means having complementary physical shapes for indexing or registration purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2206/00—Characteristics of a physical parameter; associated device therefor
- A61M2206/10—Flow characteristics
- A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Otolaryngology (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nozzles (AREA)
- Package Specialized In Special Use (AREA)
Abstract
El inhalador de polvo seco (10) comprende una sección de entrada (20); una sección de mezclado (30), y una boquilla (40). La boquilla está conectada por medio de una junta giratoria a la sección de mezclado, y puede girar hacia atrás, hacia la sección de entrada y ser cerrada por una tapa o cubierta (290). La cámara de entrada comprende un pistón con una biela de pistón ahusada y un resorte, y uno o más orificios de purga para modular el flujo de aire a través del dispositivo. Opcionalmente comprende un módulo de retroalimentación para generar un tono que indique cuando ha sido alcanzada la velocidad de flujo apropiada. La sección de mezclado contiene una cápsula (300) con orificios que contienen un medicamento en forma de polvo seco y abre y cierra además la cápsula cuando la sección de entrada esté en un cierto ángulo con respecto a la boquilla. La sección de mezclado es una cámara de Venturi para impartir un flujo ciclónico al aire que pasa a través de la cámara de mezclado.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14546499P | 1999-07-23 | 1999-07-23 | |
| US20612300P | 2000-05-22 | 2000-05-22 | |
| PCT/US2000/040454 WO2001007107A2 (en) | 1999-07-23 | 2000-07-21 | Unit dose capsules and dry powder inhaler |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MXPA02000812A MXPA02000812A (es) | 2003-09-25 |
| MX347170B true MX347170B (es) | 2017-04-18 |
Family
ID=26843008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA02000812A MX347170B (es) | 1999-07-23 | 2000-07-21 | Cápsulas de dosis unitaria e inhalador de polvo seco. |
Country Status (15)
| Country | Link |
|---|---|
| EP (2) | EP1923087B1 (es) |
| JP (3) | JP2003508184A (es) |
| AT (2) | ATE390944T1 (es) |
| AU (1) | AU779693B2 (es) |
| BR (2) | BR0017519B8 (es) |
| CA (2) | CA2642084C (es) |
| CY (2) | CY1105860T1 (es) |
| DE (2) | DE60038511T2 (es) |
| DK (3) | DK1649886T3 (es) |
| ES (3) | ES2306002T3 (es) |
| IL (3) | IL147724A0 (es) |
| MX (1) | MX347170B (es) |
| NZ (1) | NZ516811A (es) |
| PT (2) | PT1649886E (es) |
| WO (1) | WO2001007107A2 (es) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| US7305986B1 (en) | 1999-07-23 | 2007-12-11 | Mannkind Corporation | Unit dose capsules for use in a dry powder inhaler |
| US7464706B2 (en) * | 1999-07-23 | 2008-12-16 | Mannkind Corporation | Unit dose cartridge and dry powder inhaler |
| WO2002013897A2 (en) | 2000-08-14 | 2002-02-21 | Advanced Inhalation Research, Inc. | Inhalation device and method |
| US6595204B2 (en) * | 2001-03-01 | 2003-07-22 | Iep Pharmaceutical Devices Inc. | Spacer for an inhaler |
| US6766799B2 (en) | 2001-04-16 | 2004-07-27 | Advanced Inhalation Research, Inc. | Inhalation device |
| CA2444729A1 (en) * | 2001-05-10 | 2002-11-14 | Vectura Delivery Devices Limited | Inhalers |
| WO2003048665A1 (en) | 2001-12-03 | 2003-06-12 | Massachusetts Institute Of Technology | Microscale lyophilization and drying methods for the stabilization of molecules |
| US6923175B2 (en) | 2002-03-20 | 2005-08-02 | Mannkind Corporation | Inhalation apparatus |
| GB0227128D0 (en) | 2002-11-20 | 2002-12-24 | Glaxo Group Ltd | A capsule |
| GB0308969D0 (en) | 2003-04-17 | 2003-05-28 | Glaxo Group Ltd | Capsules |
| CA2540179A1 (en) | 2003-09-24 | 2005-03-31 | Medi-Stream Pty Ltd | Medication holder |
| AU2006225241B2 (en) * | 2003-09-24 | 2008-07-17 | Tianda Pharmaceuticals (Australia) Pty Limited | Medication Holder |
| AU2004273547B2 (en) * | 2003-09-24 | 2006-07-06 | Tianda Pharmaceuticals (Australia) Pty Ltd | Medication holder |
| US7491194B1 (en) | 2004-02-03 | 2009-02-17 | David Oliwa | Remote control valve for urine collection bag |
| US20080090753A1 (en) | 2004-03-12 | 2008-04-17 | Biodel, Inc. | Rapid Acting Injectable Insulin Compositions |
| JP5016486B2 (ja) * | 2004-07-26 | 2012-09-05 | 1355540 オンタリオ インコーポレーテッド | 凝集化の少ない粉体吸入器 |
| ATE486064T1 (de) | 2004-08-20 | 2010-11-15 | Mannkind Corp | Katalyse der diketopiperazinsynthese |
| KR20130066695A (ko) | 2004-08-23 | 2013-06-20 | 맨카인드 코포레이션 | 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염 |
| US8210171B2 (en) | 2004-09-13 | 2012-07-03 | Oriel Therapeutics, Inc. | Tubular dry powder drug containment systems, associated inhalers and methods |
| WO2006066363A1 (en) * | 2004-12-23 | 2006-06-29 | Acrux Dds Pty Ltd | Dispensing device |
| US20070055199A1 (en) | 2005-08-10 | 2007-03-08 | Gilbert Scott J | Drug delivery device for buccal and aural applications and other areas of the body difficult to access |
| MX373000B (es) | 2005-09-14 | 2020-05-21 | Mannkind Corp | Metodo para formulacion de farmaco basado en el aumento de la afinidad de agentes activos hacia las superficies de microparticulas cristalinas. |
| GB2433207B (en) * | 2006-02-21 | 2009-01-07 | Jianhe Li | Active suction actuated inhalers with timing devices |
| EP1986679B1 (en) | 2006-02-22 | 2017-10-25 | MannKind Corporation | A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent |
| WO2007103152A2 (en) * | 2006-03-03 | 2007-09-13 | Stc.Unm | Dry powder inhaler with aeroelastic dispersion mechanism |
| EP1844806A1 (de) | 2006-04-13 | 2007-10-17 | Boehringer Ingelheim Pharma GmbH | Medikamenten-Ausgabevorrichtung, Medikamentenmagazin dafür, und Verfahren zur Entnahme eines Medikaments aus einer Medikamentenkammer |
| US8496002B2 (en) | 2007-06-12 | 2013-07-30 | Civitas Therapeutics, Inc. | Powder inhaler devices |
| EP2020249A1 (de) | 2007-08-01 | 2009-02-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | Inhalator |
| SI2082769T1 (sl) * | 2008-01-24 | 2015-10-30 | Vectura Delivery Devices Limited | Inhalator |
| WO2009121020A1 (en) * | 2008-03-27 | 2009-10-01 | Mannkind Corporation | A dry powder inhalation system |
| CN101827626B (zh) | 2008-06-13 | 2015-03-18 | 曼金德公司 | 干粉吸入器和用于药物输送的系统 |
| US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
| ES2421385T3 (es) | 2008-06-20 | 2013-09-02 | Mannkind Corp | Aparato interactivo y procedimiento para establecer el perfil, en tiempo real, de esfuerzos de inhalación |
| TWI532497B (zh) | 2008-08-11 | 2016-05-11 | 曼凱公司 | 超快起作用胰島素之用途 |
| US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| US9060927B2 (en) | 2009-03-03 | 2015-06-23 | Biodel Inc. | Insulin formulations for rapid uptake |
| CN102438602B (zh) * | 2009-03-04 | 2016-04-13 | 曼金德公司 | 改进的干燥粉末药物输送系统 |
| DK2405963T3 (da) | 2009-03-11 | 2013-12-16 | Mannkind Corp | Apparat, system og fremgangsmåde til at måle modstand i en inhalator |
| KR102584844B1 (ko) | 2009-06-12 | 2023-10-04 | 맨카인드 코포레이션 | 한정된 비표면적을 갖는 디케토피페라진 마이크로입자 |
| CA2778698A1 (en) | 2009-11-03 | 2011-05-12 | Mannkind Corporation | An apparatus and method for simulating inhalation efforts |
| IN2012DN04857A (es) * | 2009-12-23 | 2015-09-25 | Map Pharmaceuticals Inc | |
| CN102985125A (zh) | 2010-06-21 | 2013-03-20 | 曼金德公司 | 干粉药物输送系统和方法 |
| CN102553038B (zh) * | 2010-12-17 | 2014-07-02 | 陈庆堂 | 药粉吸嘴放置盒 |
| SG194034A1 (en) | 2011-04-01 | 2013-11-29 | Mannkind Corp | Blister package for pharmaceutical cartridges |
| GB201107103D0 (en) * | 2011-04-27 | 2011-06-08 | Clement Clarke Int Ltd | Improvements in drug delivery inhaler devices |
| US9579473B2 (en) | 2011-05-12 | 2017-02-28 | Alfred Von Schuckmann | Device for inhaling pulverulent substances |
| WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
| MX2014004983A (es) | 2011-10-24 | 2014-09-22 | Mannkid Corp | Metodos y composiciones para tratar dolor. |
| US9603907B2 (en) | 2012-02-01 | 2017-03-28 | Protalix Ltd. | Dry powder formulations of dNase I |
| US20150174158A1 (en) | 2012-03-07 | 2015-06-25 | Advanced Inhalation Therapies (Ait) Ltd. | Inhalation of nitric oxide for treating respiratory diseases |
| US9427534B2 (en) | 2012-07-05 | 2016-08-30 | Clement Clarke International Ltd. | Drug delivery inhaler devices |
| KR102264177B1 (ko) | 2012-07-12 | 2021-06-11 | 맨카인드 코포레이션 | 건조 분말 약물 전달 시스템 및 방법 |
| WO2014066856A1 (en) | 2012-10-26 | 2014-05-01 | Mannkind Corporation | Inhalable influenza vaccine compositions and methods |
| CA151549S (en) | 2013-02-14 | 2014-06-04 | Clement Clarke Int Ltd | Spacer for an asthma inhaler |
| EP3587404B1 (en) | 2013-03-15 | 2022-07-13 | MannKind Corporation | Microcrystalline diketopiperazine compositions, methods for preparation and use thereof |
| MX375448B (es) | 2013-07-18 | 2025-03-06 | Mannkind Corp | Composiciones farmacéuticas en polvo seco estables al calor y métodos. |
| EP3030294B1 (en) | 2013-08-05 | 2020-10-07 | MannKind Corporation | Insufflation apparatus |
| US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
| US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
| DE102014017065B3 (de) * | 2014-11-20 | 2015-11-19 | Klaus-Dieter Beller | Pulverbehältnis für Pulverinhalatoren |
| CN107961432A (zh) * | 2017-11-16 | 2018-04-27 | 惠水县凡趣创意科技有限公司 | 一种胶囊送药器 |
| KR102694664B1 (ko) | 2018-03-26 | 2024-08-14 | 필립모리스 프로덕츠 에스.에이. | 와류 캡슐 공동을 갖는 흡입기 |
| EP3911390B1 (en) * | 2019-01-14 | 2022-10-26 | Philip Morris Products, S.A. | Dry powder inhaler device, dry powder cartridge, and kit |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE794951A (fr) * | 1972-02-03 | 1973-05-29 | Parke Davis & Co | Conditionnement soluble dans l'eau |
| DE2502251A1 (de) * | 1975-01-17 | 1976-07-22 | Schering Ag | Vorrichtung zur inhalation pulverfoermiger feststoffe |
| US4040536A (en) * | 1975-05-05 | 1977-08-09 | R. P. Scherer Corporation | Locking hard gelatin capsule |
| GB2072536B (en) * | 1980-03-25 | 1983-12-07 | Malem H | Nebuliser |
| US4487327A (en) * | 1982-12-21 | 1984-12-11 | Grayson Robert E | Locking capsule |
| CH661878A5 (de) * | 1983-11-04 | 1987-08-31 | Warner Lambert Co | Kapsel-dosierungsformen. |
| DE3639836A1 (de) * | 1986-11-21 | 1988-06-01 | Sigrid Bechter | Mundstueck fuer ein inhalationsgeraet |
| DE3727894A1 (de) * | 1987-08-21 | 1989-03-02 | Stephan Dieter | Kapsel fuer pharmazeutisch wirksame inhaltsstoffe einer droge |
| US4991605A (en) * | 1989-04-24 | 1991-02-12 | Philip Morris Incorporated | Container for additive materials for smoking articles |
| US5170801A (en) * | 1990-10-02 | 1992-12-15 | Glaxo Inc. | Medical capsule device actuated by radio-frequency (rf) signal |
| US5797391A (en) * | 1991-03-28 | 1998-08-25 | Rhone-Poulenc Rorer Limited | Inhaler |
| US5476093A (en) * | 1992-02-14 | 1995-12-19 | Huhtamaki Oy | Device for more effective pulverization of a powdered inhalation medicament |
| GB9216038D0 (en) * | 1992-07-28 | 1992-09-09 | Bespak Plc | Dispensing apparatus for powdered medicaments |
| US5896855A (en) * | 1992-12-24 | 1999-04-27 | Rhone-Poulenc Rorer Limited | Multi dose inhaler apparatus |
| US5727546A (en) * | 1993-08-18 | 1998-03-17 | Fisons Plc | Powder inhaler with breath flow regulation valve |
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| KR100390480B1 (ko) * | 1995-01-23 | 2003-10-04 | 디렉트-할러 아/에스 | 흡입기 |
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| JP3011898B2 (ja) * | 1997-02-20 | 2000-02-21 | フォルテ グロウ メディカル株式会社 | 吸引器 |
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| SE9700935D0 (sv) * | 1997-03-14 | 1997-03-14 | Astra Ab | Inhalation device |
-
2000
- 2000-07-21 AT AT05077995T patent/ATE390944T1/de active
- 2000-07-21 NZ NZ516811A patent/NZ516811A/xx not_active IP Right Cessation
- 2000-07-21 EP EP08075104A patent/EP1923087B1/en not_active Expired - Lifetime
- 2000-07-21 PT PT05077995T patent/PT1649886E/pt unknown
- 2000-07-21 DE DE60038511T patent/DE60038511T2/de not_active Expired - Lifetime
- 2000-07-21 EP EP00960184A patent/EP1200149B1/en not_active Expired - Lifetime
- 2000-07-21 AU AU71380/00A patent/AU779693B2/en not_active Ceased
- 2000-07-21 DK DK05077995T patent/DK1649886T3/da active
- 2000-07-21 JP JP2001521942A patent/JP2003508184A/ja not_active Withdrawn
- 2000-07-21 IL IL14772400A patent/IL147724A0/xx unknown
- 2000-07-21 DK DK00960184T patent/DK1200149T3/da active
- 2000-07-21 DK DK08075104.3T patent/DK1923087T3/da active
- 2000-07-21 ES ES05077995T patent/ES2306002T3/es not_active Expired - Lifetime
- 2000-07-21 CA CA2642084A patent/CA2642084C/en not_active Expired - Fee Related
- 2000-07-21 ES ES08075104T patent/ES2395051T3/es not_active Expired - Lifetime
- 2000-07-21 WO PCT/US2000/040454 patent/WO2001007107A2/en not_active Ceased
- 2000-07-21 BR BRPI0017519A patent/BR0017519B8/pt not_active IP Right Cessation
- 2000-07-21 BR BRPI0012718-3A patent/BR0012718B1/pt not_active IP Right Cessation
- 2000-07-21 PT PT00960184T patent/PT1200149E/pt unknown
- 2000-07-21 AT AT00960184T patent/ATE339981T1/de active
- 2000-07-21 CA CA002379137A patent/CA2379137C/en not_active Expired - Fee Related
- 2000-07-21 MX MXPA02000812A patent/MX347170B/es active IP Right Grant
- 2000-07-21 ES ES00960184T patent/ES2275544T3/es not_active Expired - Lifetime
- 2000-07-21 DE DE60030862T patent/DE60030862T2/de not_active Expired - Lifetime
-
2002
- 2002-01-17 IL IL147724A patent/IL147724A/en not_active IP Right Cessation
-
2005
- 2005-05-26 JP JP2005154727A patent/JP4608367B2/ja not_active Expired - Fee Related
-
2006
- 2006-12-19 CY CY20061101812T patent/CY1105860T1/el unknown
-
2007
- 2007-11-21 JP JP2007302168A patent/JP5055623B2/ja not_active Expired - Fee Related
- 2007-12-31 IL IL188519A patent/IL188519A/en not_active IP Right Cessation
-
2008
- 2008-06-02 CY CY20081100570T patent/CY1110253T1/el unknown
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