MX345535B - Compuestos tricíclicos parcialmente saturados y métodos para su fabricación y su uso. - Google Patents
Compuestos tricíclicos parcialmente saturados y métodos para su fabricación y su uso.Info
- Publication number
- MX345535B MX345535B MX2013012921A MX2013012921A MX345535B MX 345535 B MX345535 B MX 345535B MX 2013012921 A MX2013012921 A MX 2013012921A MX 2013012921 A MX2013012921 A MX 2013012921A MX 345535 B MX345535 B MX 345535B
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- tricyclic compounds
- making
- same
- partially saturated
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 229920006395 saturated elastomer Polymers 0.000 title 1
- 101000979001 Homo sapiens Methionine aminopeptidase 2 Proteins 0.000 abstract 1
- 102100023174 Methionine aminopeptidase 2 Human genes 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161483257P | 2011-05-06 | 2011-05-06 | |
| US201161559856P | 2011-11-15 | 2011-11-15 | |
| PCT/US2012/036789 WO2012154676A1 (en) | 2011-05-06 | 2012-05-07 | Partially saturated tricyclic compounds and methods of making and using same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2013012921A MX2013012921A (es) | 2014-02-27 |
| MX345535B true MX345535B (es) | 2017-02-03 |
Family
ID=46147038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013012921A MX345535B (es) | 2011-05-06 | 2012-05-07 | Compuestos tricíclicos parcialmente saturados y métodos para su fabricación y su uso. |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US9290472B2 (enExample) |
| EP (1) | EP2705030B1 (enExample) |
| JP (1) | JP6062423B2 (enExample) |
| KR (1) | KR101979039B1 (enExample) |
| CN (1) | CN103764641B (enExample) |
| AU (1) | AU2012253757B2 (enExample) |
| BR (1) | BR112013028534A2 (enExample) |
| CA (1) | CA2835261C (enExample) |
| EA (1) | EA025526B1 (enExample) |
| IL (1) | IL229246A (enExample) |
| MX (1) | MX345535B (enExample) |
| PH (1) | PH12013502261A1 (enExample) |
| SG (1) | SG194812A1 (enExample) |
| WO (1) | WO2012154676A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8642650B2 (en) | 2008-12-04 | 2014-02-04 | Zafgen, Inc. | Methods of treating an overweight or obese subject |
| WO2013055385A2 (en) | 2011-10-03 | 2013-04-18 | Zafgen Corporation | Methods of treating age related disorders |
| US20120004162A1 (en) | 2008-12-04 | 2012-01-05 | Vath James E | Methods of Treating an Overweight or Obese Subject |
| WO2011044506A2 (en) | 2009-10-09 | 2011-04-14 | Zafgen Corporation | Sulphone compounds and methods of making and using same |
| BR112012016793A2 (pt) | 2010-01-08 | 2018-07-31 | Zafgen Corp | compostos tipo fumagilol e métodos de fazer e usar os mesmos |
| WO2011085198A1 (en) | 2010-01-08 | 2011-07-14 | Zafgen Corporation | Metap-2 inhibitor for use in treating benign prostatic hypertrophy (bph) |
| WO2011127304A2 (en) | 2010-04-07 | 2011-10-13 | Zafgen Corporation | Methods of treating an overweight subject |
| BR112013001613A2 (pt) | 2010-07-22 | 2016-05-24 | Zafgen Inc | compostos tricíclicos e métodos para fazer e usar os mesmos. |
| MX339201B (es) | 2010-10-12 | 2016-05-13 | Zafgen Inc | Compuestos de sulfonamida y métodos para elaborarlos y usarlos. |
| JP2013543899A (ja) | 2010-11-29 | 2013-12-09 | ザフゲン，インコーポレイテッド | ６−ｏ−（４−ジメチルアミノエトキシ）シンナモイルフマギロールの非連日投与を用いた肥満の治療 |
| US9321740B2 (en) | 2011-01-26 | 2016-04-26 | Zafgen, Inc. | Tetrazole compounds and methods of making and using same |
| AU2012225531B2 (en) | 2011-03-08 | 2017-03-30 | Zafgen, Inc | Oxaspiro (2.5) octane derivatives and analogs |
| AU2012253759B2 (en) | 2011-05-06 | 2016-01-21 | Zafgen Inc. | Tricyclic sulfonamide compounds and methods of making and using same |
| WO2012154679A1 (en) | 2011-05-06 | 2012-11-15 | Zafgen Corporation | Tricyclic pyrazole sulfonamide compounds and methods of making and using same |
| US9290472B2 (en) | 2011-05-06 | 2016-03-22 | Zafgen, Inc. | Partially saturated tricyclic compounds and methods of making and using same |
| BR112014017673A8 (pt) | 2012-01-18 | 2017-07-11 | Zafgen Inc | Compostos de sulfonamida tricíclicos e métodos para fazer e usar os mesmos |
| AU2013209719A1 (en) * | 2012-01-18 | 2014-08-07 | Zafgen, Inc. | Tricyclic sulfone compounds and methods of making and using same |
| EP2846792B1 (en) | 2012-05-08 | 2018-08-15 | Zafgen, Inc. | Treating hypothalamic obesity with metap2 inhibitors |
| CN104364251B (zh) | 2012-05-09 | 2017-02-22 | 扎夫根股份有限公司 | 烟曲霉醇型化合物及其制备和使用方法 |
| BR112015010225A2 (pt) * | 2012-11-05 | 2017-07-11 | Zafgen Inc | compostos tricíclicos e seus métodos de produção e utilização |
| NZ707773A (en) | 2012-11-05 | 2019-05-31 | Zafgen Inc | Methods of treating liver diseases |
| CN104918928A (zh) * | 2012-11-05 | 2015-09-16 | 扎夫根股份有限公司 | 三环化合物及其制备方法和用途 |
| KR20150126924A (ko) | 2013-03-14 | 2015-11-13 | 자프겐 인크. | 신장 질환 및 기타 장애의 치료 방법 |
| AR105671A1 (es) | 2015-08-11 | 2017-10-25 | Zafgen Inc | Compuestos heterocíclicos de fumagillol y sus métodos de elaboración y uso |
| CN106432255A (zh) | 2015-08-11 | 2017-02-22 | 扎夫根公司 | 烟曲霉素醇螺环化合物和制备和使用其的方法 |
| WO2026032382A1 (zh) * | 2024-08-09 | 2026-02-12 | 普罗思特(南京)生物科技有限公司 | 取代的1,2,4-三唑衍生物及其应用 |
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2012
- 2012-05-07 US US14/116,023 patent/US9290472B2/en not_active Expired - Fee Related
- 2012-05-07 WO PCT/US2012/036789 patent/WO2012154676A1/en not_active Ceased
- 2012-05-07 EP EP12722591.0A patent/EP2705030B1/en active Active
- 2012-05-07 SG SG2013082219A patent/SG194812A1/en unknown
- 2012-05-07 JP JP2014509510A patent/JP6062423B2/ja not_active Expired - Fee Related
- 2012-05-07 EA EA201391644A patent/EA025526B1/ru not_active IP Right Cessation
- 2012-05-07 CN CN201280033359.8A patent/CN103764641B/zh not_active Expired - Fee Related
- 2012-05-07 KR KR1020137032337A patent/KR101979039B1/ko not_active Ceased
- 2012-05-07 PH PH1/2013/502261A patent/PH12013502261A1/en unknown
- 2012-05-07 BR BR112013028534A patent/BR112013028534A2/pt not_active Application Discontinuation
- 2012-05-07 AU AU2012253757A patent/AU2012253757B2/en not_active Ceased
- 2012-05-07 CA CA2835261A patent/CA2835261C/en not_active Expired - Fee Related
- 2012-05-07 MX MX2013012921A patent/MX345535B/es active IP Right Grant
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2013
- 2013-11-04 IL IL229246A patent/IL229246A/en active IP Right Grant
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2016
- 2016-02-03 US US15/014,524 patent/US9617237B2/en not_active Expired - Fee Related
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- 2017-02-15 US US15/433,452 patent/US20180002307A1/en not_active Abandoned
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| Publication number | Publication date |
|---|---|
| KR101979039B1 (ko) | 2019-05-15 |
| JP6062423B2 (ja) | 2017-01-18 |
| JP2014514349A (ja) | 2014-06-19 |
| CA2835261C (en) | 2019-06-04 |
| SG194812A1 (en) | 2013-12-30 |
| AU2012253757A8 (en) | 2015-10-22 |
| BR112013028534A2 (pt) | 2016-09-06 |
| EA025526B1 (ru) | 2017-01-30 |
| US9290472B2 (en) | 2016-03-22 |
| US9617237B2 (en) | 2017-04-11 |
| IL229246A (en) | 2017-05-29 |
| KR20140047611A (ko) | 2014-04-22 |
| AU2012253757A1 (en) | 2013-11-21 |
| EP2705030A1 (en) | 2014-03-12 |
| CN103764641B (zh) | 2016-10-26 |
| AU2012253757B2 (en) | 2017-04-13 |
| US20140088078A1 (en) | 2014-03-27 |
| IL229246A0 (en) | 2014-01-30 |
| PH12013502261A1 (en) | 2022-10-26 |
| US20170001973A1 (en) | 2017-01-05 |
| US20180002307A1 (en) | 2018-01-04 |
| MX2013012921A (es) | 2014-02-27 |
| WO2012154676A9 (en) | 2014-03-27 |
| CN103764641A (zh) | 2014-04-30 |
| WO2012154676A1 (en) | 2012-11-15 |
| EP2705030B1 (en) | 2016-07-27 |
| NZ617388A (en) | 2015-11-27 |
| EA201391644A1 (ru) | 2014-11-28 |
| CA2835261A1 (en) | 2012-11-15 |
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