MX343687B - Compuestos sulfonamida tricíclica y métodos para su fabricación y uso. - Google Patents
Compuestos sulfonamida tricíclica y métodos para su fabricación y uso.Info
- Publication number
- MX343687B MX343687B MX2013012922A MX2013012922A MX343687B MX 343687 B MX343687 B MX 343687B MX 2013012922 A MX2013012922 A MX 2013012922A MX 2013012922 A MX2013012922 A MX 2013012922A MX 343687 B MX343687 B MX 343687B
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- making
- same
- sulfonamide compounds
- compounds
- Prior art date
Links
- 229940124530 sulfonamide Drugs 0.000 title abstract 2
- -1 sulfonamide compounds Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 101000979001 Homo sapiens Methionine aminopeptidase 2 Proteins 0.000 abstract 1
- 102100023174 Methionine aminopeptidase 2 Human genes 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161483265P | 2011-05-06 | 2011-05-06 | |
| PCT/US2012/036792 WO2012154678A1 (en) | 2011-05-06 | 2012-05-07 | Tricyclic sulfonamide compounds and methods of making and using same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2013012922A MX2013012922A (es) | 2014-02-27 |
| MX343687B true MX343687B (es) | 2016-11-16 |
Family
ID=46147039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013012922A MX343687B (es) | 2011-05-06 | 2012-05-07 | Compuestos sulfonamida tricíclica y métodos para su fabricación y uso. |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9187494B2 (enExample) |
| EP (1) | EP2705036B1 (enExample) |
| JP (1) | JP5941981B2 (enExample) |
| KR (1) | KR20140053013A (enExample) |
| CN (1) | CN103748094B (enExample) |
| AU (1) | AU2012253759B2 (enExample) |
| BR (1) | BR112013028665A2 (enExample) |
| CA (1) | CA2835195A1 (enExample) |
| MX (1) | MX343687B (enExample) |
| WO (1) | WO2012154678A1 (enExample) |
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| WO2010065883A2 (en) | 2008-12-04 | 2010-06-10 | Zafgen Corporation | Method of treating an overweight or obese subject |
| WO2013055385A2 (en) | 2011-10-03 | 2013-04-18 | Zafgen Corporation | Methods of treating age related disorders |
| US20120004162A1 (en) | 2008-12-04 | 2012-01-05 | Vath James E | Methods of Treating an Overweight or Obese Subject |
| CA2777108A1 (en) | 2009-10-09 | 2011-04-14 | Zafgen Corporation | Sulphone compounds and methods of making and using same |
| US8815309B2 (en) | 2010-01-08 | 2014-08-26 | Zafgen, Inc. | Methods of treating a subject with benign prostate hyperplasia |
| BR112012016793A2 (pt) | 2010-01-08 | 2018-07-31 | Zafgen Corp | compostos tipo fumagilol e métodos de fazer e usar os mesmos |
| WO2011127304A2 (en) | 2010-04-07 | 2011-10-13 | Zafgen Corporation | Methods of treating an overweight subject |
| JP5913310B2 (ja) | 2010-07-22 | 2016-04-27 | ザフゲン，インコーポレイテッド | 三環式化合物ならびにその作製および使用方法 |
| JP5913333B2 (ja) | 2010-10-12 | 2016-04-27 | ザフゲン，インコーポレイテッド | スルホンアミド化合物、およびそれを製造し使用する方法 |
| WO2012075020A1 (en) | 2010-11-29 | 2012-06-07 | Zafgen Corporation | Treatment of obesity using non-daily administration of 6 - 0 - (4 - dimethylaminoethoxy) cinnamoyl fumagillol |
| BR112013018771A2 (pt) | 2011-01-26 | 2019-09-17 | Zafgen Inc | compostos de tetrazol e métodos para fazer e usar os mesmos |
| WO2012122264A1 (en) | 2011-03-08 | 2012-09-13 | Zafgen Corporation | Oxaspiro [2.5] octane derivatives and analogs |
| MX343688B (es) | 2011-05-06 | 2016-11-16 | Zafgen Inc | Compuestos tricíclicos de sulfonamida y pirazolo y métodos para su fabricación y uso. |
| CA2835261C (en) * | 2011-05-06 | 2019-06-04 | Zafgen, Inc. | Partially saturated tricyclic compounds and methods of making and using same |
| US9187494B2 (en) | 2011-05-06 | 2015-11-17 | Zafgen, Inc. | Aryl-substituted tricyclic sulfonamides as methionyl aminopeptidase 2 modulators |
| US9359369B2 (en) | 2012-01-18 | 2016-06-07 | Zafgen, Inc. | Tricyclic sulfonamide compounds and methods of making and using same |
| CN104169268A (zh) | 2012-01-18 | 2014-11-26 | 扎夫根股份有限公司 | 三环砜化合物及其制备和使用方法 |
| WO2013169857A1 (en) | 2012-05-08 | 2013-11-14 | Zafgen, Inc. | Treating hypothalamic obesity with metap2 inhibitors |
| JP6177888B2 (ja) | 2012-05-09 | 2017-08-09 | ザフゲン，インコーポレイテッド | フマギロール型化合物ならびにその製造および使用方法 |
| CA2890344A1 (en) | 2012-11-05 | 2014-05-08 | Zafgen, Inc. | Tricyclic compounds for use in the treatment and/or control of obesity |
| JP2015536981A (ja) | 2012-11-05 | 2015-12-24 | ザフゲン，インコーポレイテッド | 三環式化合物ならびにその製造および使用方法 |
| NZ707773A (en) | 2012-11-05 | 2019-05-31 | Zafgen Inc | Methods of treating liver diseases |
| MX362391B (es) | 2013-03-14 | 2019-01-15 | Zafgen Inc | Métodos de tratamiento de enfermedad renal y otros trastornos. |
| ES2633440T3 (es) * | 2013-03-25 | 2017-09-21 | Sanofi | Derivados de pirazolonaftiridinona como inhibidores de metAP2 (metionina aminopeptidasa 2). |
| CN106432255A (zh) | 2015-08-11 | 2017-02-22 | 扎夫根公司 | 烟曲霉素醇螺环化合物和制备和使用其的方法 |
| AR105671A1 (es) | 2015-08-11 | 2017-10-25 | Zafgen Inc | Compuestos heterocíclicos de fumagillol y sus métodos de elaboración y uso |
| JP6955485B2 (ja) * | 2015-09-09 | 2021-10-27 | アイカーン スクール オブ メディスン アット マウント サイナイＩｃａｈｎ Ｓｃｈｏｏｌ ｏｆ Ｍｅｄｉｃｉｎｅ ａｔ Ｍｔ． Ｓｉｎａｉ | 抗がん剤としての複素環式の限定された三環系スルホンアミド |
| MX2019010404A (es) * | 2017-03-02 | 2019-11-21 | Assembly Biosciences Inc | Compuestos sulfamida cíclicos y métodos de uso de los mismos. |
| CN115286560A (zh) * | 2022-07-28 | 2022-11-04 | 五邑大学 | 一种吲哚亚胺并环戊烯类化合物的合成方法 |
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- 2012-05-07 JP JP2014509511A patent/JP5941981B2/ja not_active Expired - Fee Related
- 2012-05-07 WO PCT/US2012/036792 patent/WO2012154678A1/en not_active Ceased
- 2012-05-07 EP EP12722592.8A patent/EP2705036B1/en active Active
- 2012-05-07 BR BR112013028665A patent/BR112013028665A2/pt not_active IP Right Cessation
- 2012-05-07 AU AU2012253759A patent/AU2012253759B2/en not_active Ceased
- 2012-05-07 MX MX2013012922A patent/MX343687B/es active IP Right Grant
- 2012-05-07 CA CA2835195A patent/CA2835195A1/en not_active Abandoned
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- 2012-05-07 KR KR1020137032334A patent/KR20140053013A/ko not_active Withdrawn
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|---|---|
| AU2012253759B2 (en) | 2016-01-21 |
| US9561230B2 (en) | 2017-02-07 |
| AU2012253759A1 (en) | 2013-11-21 |
| JP5941981B2 (ja) | 2016-06-29 |
| CA2835195A1 (en) | 2012-11-15 |
| CN103748094A (zh) | 2014-04-23 |
| MX2013012922A (es) | 2014-02-27 |
| AU2012253759A8 (en) | 2013-12-05 |
| US20140073623A1 (en) | 2014-03-13 |
| EP2705036A1 (en) | 2014-03-12 |
| BR112013028665A2 (pt) | 2016-09-06 |
| KR20140053013A (ko) | 2014-05-07 |
| EP2705036B1 (en) | 2015-08-12 |
| CN103748094B (zh) | 2016-06-29 |
| JP2014513139A (ja) | 2014-05-29 |
| WO2012154678A1 (en) | 2012-11-15 |
| US9187494B2 (en) | 2015-11-17 |
| US20160256469A1 (en) | 2016-09-08 |
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