MX342289B - Sintesis para compuestos de tiazolidindiona. - Google Patents

Sintesis para compuestos de tiazolidindiona.

Info

Publication number
MX342289B
MX342289B MX2013001475A MX2013001475A MX342289B MX 342289 B MX342289 B MX 342289B MX 2013001475 A MX2013001475 A MX 2013001475A MX 2013001475 A MX2013001475 A MX 2013001475A MX 342289 B MX342289 B MX 342289B
Authority
MX
Mexico
Prior art keywords
synthesis
thiazolidinedione compounds
compounds
thiazolidinedione
thiazolidinediones
Prior art date
Application number
MX2013001475A
Other languages
English (en)
Other versions
MX2013001475A (es
Inventor
D Larsen Scott
C Gadwood Robert
P Tanis Steven
r zeller James
Parker Timothy
D Artman Gerald Iii
Original Assignee
Metabolic Solutions Dev Company Llc *
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolic Solutions Dev Company Llc * filed Critical Metabolic Solutions Dev Company Llc *
Publication of MX2013001475A publication Critical patent/MX2013001475A/es
Publication of MX342289B publication Critical patent/MX342289B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención proporciona nuevos métodos para sintetizar compuestos económicos de PPAR?, por ejemplo, tiazolidindionas, que son útiles para prevenir y/o tratar los trastornos metabólicos tales como la diabetes, la obesidad, la hipertensión, y las enfermedades inflamatorias.
MX2013001475A 2010-08-10 2011-08-09 Sintesis para compuestos de tiazolidindiona. MX342289B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37226910P 2010-08-10 2010-08-10
PCT/US2011/046992 WO2012021467A1 (en) 2010-08-10 2011-08-09 Synthesis for thiazolidinedione compounds

Publications (2)

Publication Number Publication Date
MX2013001475A MX2013001475A (es) 2013-04-29
MX342289B true MX342289B (es) 2016-09-23

Family

ID=44504274

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013001475A MX342289B (es) 2010-08-10 2011-08-09 Sintesis para compuestos de tiazolidindiona.

Country Status (14)

Country Link
US (2) US8895748B2 (es)
EP (1) EP2603507B1 (es)
JP (1) JP5851506B2 (es)
KR (1) KR101857307B1 (es)
CN (1) CN103153991B (es)
AU (1) AU2011289627B2 (es)
CA (1) CA2807815C (es)
ES (1) ES2588769T3 (es)
HU (1) HUE029488T2 (es)
MX (1) MX342289B (es)
NZ (1) NZ606597A (es)
PL (1) PL2603507T3 (es)
RU (1) RU2594725C2 (es)
WO (1) WO2012021467A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011133442A1 (en) 2010-04-19 2011-10-27 Metabolic Solutions Development Company Novel synthesis for thiazolidinedione compounds
WO2012021476A1 (en) * 2010-08-10 2012-02-16 Metabolic Solutions Development Company, Llc Novel synthesis for thiazolidinedione compounds
CN104496935A (zh) * 2014-11-24 2015-04-08 苏州乔纳森新材料科技有限公司 一种胰岛素增敏剂中间体的合成方法
KR102514814B1 (ko) 2016-03-31 2023-03-27 온크터널 테라퓨틱스, 인코포레이티드. 인돌린 유사체 및 이의 용도

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1003445B (zh) 1984-10-03 1989-03-01 武田药品工业株式会社 噻唑烷二酮衍生物，其制备方法和用途
SU1766260A3 (ru) * 1989-11-04 1992-09-30 Пфайзер Инк (Фирма) Способ получени производных тиазолидиндиона-2,4 или их фармацевтически приемлемых солей с щелочными металлами
US5143930A (en) 1990-02-07 1992-09-01 Sankyo Company, Limited Thiazolidine derivatives with anti-diabetic activity, their preparation and their use
SK109993A3 (en) * 1991-04-11 1994-12-07 Upjohn Co Thiazolidinedione derivatives producing and use thereof
SE9702305D0 (sv) 1997-06-17 1997-06-17 Astra Ab New thiazolidinedione, oxazolidinedione and oxadiazolidinedione derivatives
AP869A (en) 1998-01-05 2000-09-04 Pfizer 2,3-Substituted indole compounds as anti-inflammatory and analgesic agents.
US7407978B2 (en) 1999-04-06 2008-08-05 Theracos, Inc. Heterocyclic analogs of diphenylethylene compounds
US6768008B2 (en) 2000-04-24 2004-07-27 Aryx Therapeutics Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis
EP1353727A2 (en) 2000-12-01 2003-10-22 Novartis AG Combinations of an angiotensin receptor antagonist and an anti-hypertensive drugor a statin, for the treatment of sexual dysfunction
WO2003029251A1 (en) * 2001-09-28 2003-04-10 Biocon Limited Novel process for the synthesis of thiazolidinedione derivatives
FR2861069B1 (fr) * 2003-10-17 2005-12-09 Galderma Res & Dev NOUVEAUX LIGANDS ACTIVATEURS DES RECEPTEURS RARs, UTILISATION EN MEDECINE HUMAINE AINSI QU'EN COSMETIQUE
MX356584B (es) * 2006-03-16 2018-06-05 Metabolic Solutions Dev Co Analogos de tiazolidindiona para el tratamiento de enfermedad mediada por inflamacion metabolica.
WO2008118327A1 (en) 2007-03-23 2008-10-02 University Of Toledo Conformationally restrained epothilone analogues as anti-leukemic agents
NZ597381A (en) 2007-09-14 2013-03-28 Metabolic Solutions Dev Co Llc Thiazolidinedione analogues for the treatment of diabetes and inflammatory diseases
WO2009148195A1 (en) 2008-06-02 2009-12-10 Daebong Ls, Ltd. 5-(4-hydroxybenzyl)thiazolidine-2,4-dione as intermediate for synthesis of thiazolidinedione based compounds and process for preparing the same
WO2011133442A1 (en) 2010-04-19 2011-10-27 Metabolic Solutions Development Company Novel synthesis for thiazolidinedione compounds
WO2011133441A2 (en) 2010-04-19 2011-10-27 Metabolic Solutions Development Company Novel synthesis for thiazolidinedione compounds
WO2012021476A1 (en) 2010-08-10 2012-02-16 Metabolic Solutions Development Company, Llc Novel synthesis for thiazolidinedione compounds

Also Published As

Publication number Publication date
CN103153991A (zh) 2013-06-12
WO2012021467A1 (en) 2012-02-16
EP2603507A1 (en) 2013-06-19
HUE029488T2 (en) 2017-02-28
US8946435B2 (en) 2015-02-03
CA2807815C (en) 2018-10-02
MX2013001475A (es) 2013-04-29
US20130211092A1 (en) 2013-08-15
US20140378687A1 (en) 2014-12-25
EP2603507B1 (en) 2016-06-29
ES2588769T3 (es) 2016-11-04
CA2807815A1 (en) 2012-02-16
CN103153991B (zh) 2016-06-29
RU2594725C2 (ru) 2016-08-20
KR101857307B1 (ko) 2018-05-11
AU2011289627B2 (en) 2015-01-15
AU2011289627A1 (en) 2013-02-21
US8895748B2 (en) 2014-11-25
JP2013535503A (ja) 2013-09-12
NZ606597A (en) 2014-12-24
KR20130097750A (ko) 2013-09-03
PL2603507T3 (pl) 2016-12-30
JP5851506B2 (ja) 2016-02-03
RU2013110311A (ru) 2014-09-20

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