MX340329B - Polipeptido de fusion presentador de una secuencia de aminoacidos y uso del mismo. - Google Patents

Polipeptido de fusion presentador de una secuencia de aminoacidos y uso del mismo.

Info

Publication number
MX340329B
MX340329B MX2013012688A MX2013012688A MX340329B MX 340329 B MX340329 B MX 340329B MX 2013012688 A MX2013012688 A MX 2013012688A MX 2013012688 A MX2013012688 A MX 2013012688A MX 340329 B MX340329 B MX 340329B
Authority
MX
Mexico
Prior art keywords
amino acid
polypeptide
acid sequence
fusion polypeptide
derived
Prior art date
Application number
MX2013012688A
Other languages
English (en)
Other versions
MX2013012688A (es
Inventor
Scholz Christian
Schraeml Michael
Andres Herbert
Casagolda Vallribera David
Duefel Hartmut
Gerg Michael
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2013012688A publication Critical patent/MX2013012688A/es
Publication of MX340329B publication Critical patent/MX340329B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/22—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a Strep-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/24—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a MBP (maltose binding protein)-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/41—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a Myc-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y502/00—Cis-trans-isomerases (5.2)
    • C12Y502/01—Cis-trans-Isomerases (5.2.1)
    • C12Y502/01008—Peptidylprolyl isomerase (5.2.1.8), i.e. cyclophilin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/99—Isomerases (5.)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Endocrinology (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)

Abstract

La presente invención se refiere a un polipéptido de fusión para usarse en la inducción de una respuesta inmunológica en un animal experimental contra un polipéptido, en donde el polipéptido de fusión comprende un polipéptido de acuerdo con la fórmula I: NH2-S2-X1-S1-COOH (fórmula I), en donde: X1 comprende una secuencia de aminoácidos aleatorio o una secuencia de aminoácidos derivada de un primer polipéptido, S2 y S1 son secuencias de aminoácidos no solapantes derivadas de un segundo polipéptido, y se refiere a un enlace peptídico, en donde el segundo polipéptido se selecciona del grupo que consiste de FKBP12 humano, FKBP13 de Arabidopsis thaliana, SiyD de Thermococcus gemmatolerans, y en donde X1 está insertada en lugar del dominio de inserción en solapa (dominio IF) del segundo polipéptido, y en donde X1 es la secuencia de aminoácidos del polipéptido.
MX2013012688A 2011-05-05 2012-05-04 Polipeptido de fusion presentador de una secuencia de aminoacidos y uso del mismo. MX340329B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11164957 2011-05-05
EP12155742 2012-02-16
PCT/EP2012/058207 WO2012150320A1 (en) 2011-05-05 2012-05-04 Amino acid sequence presenting fusion polypeptide and its use

Publications (2)

Publication Number Publication Date
MX2013012688A MX2013012688A (es) 2013-12-02
MX340329B true MX340329B (es) 2016-07-06

Family

ID=46022284

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013012688A MX340329B (es) 2011-05-05 2012-05-04 Polipeptido de fusion presentador de una secuencia de aminoacidos y uso del mismo.

Country Status (17)

Country Link
US (5) US9266962B2 (es)
EP (2) EP2705053B1 (es)
JP (3) JP5877893B2 (es)
KR (1) KR101632479B1 (es)
CN (2) CN103620031B (es)
AR (1) AR086250A1 (es)
AU (1) AU2012251584B2 (es)
BR (1) BR112013028134A2 (es)
CA (2) CA2831162C (es)
ES (1) ES2637667T3 (es)
IL (1) IL228983A0 (es)
MX (1) MX340329B (es)
MY (1) MY166542A (es)
RU (1) RU2630660C2 (es)
SG (1) SG194707A1 (es)
WO (2) WO2012150321A1 (es)
ZA (1) ZA201308251B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR086250A1 (es) * 2011-05-05 2013-11-27 Hoffmann La Roche Polipeptido de fusion presentador de una secuencia de aminoacidos y utilizacion del mismo
EP2917388B1 (en) * 2012-11-08 2016-10-05 Roche Diagnostics GmbH Nucleic acids encoding chimeric polypeptides for library screening
WO2014133093A1 (ja) * 2013-02-28 2014-09-04 独立行政法人国立がん研究センター 不溶性フィブリンに対する抗体
WO2014138733A2 (en) * 2013-03-08 2014-09-12 Dessain Scott K Compositions and methods for making human antibodies
WO2015044083A1 (en) * 2013-09-27 2015-04-02 F. Hoffmann-La Roche Ag Thermus thermophilus slyd fkbp domain specific antibodies
BR112016024742A2 (pt) * 2014-05-14 2018-01-30 Hoffmann La Roche método para a seleção de uma proteína, proteínas de ligação ao antígeno, anticorpos, imunoconjugado, formulação farmacêutica, uso do anticorpo, ácido nucleico e polipeptídeo
EP3143049B1 (en) 2014-05-14 2019-08-21 F. Hoffmann-La Roche AG Her3/her2 bispecific antibodies binding to the beta-hairpin of her3 and domain ii of her2
ES2952405T3 (es) 2014-12-01 2023-10-31 Pfenex Inc Parejas de fusión para la producción de péptidos
EP3233896A1 (fr) * 2014-12-18 2017-10-25 Biomérieux Composé synthétique biépitopique
CN107406483B (zh) 2014-12-19 2022-02-22 豪夫迈·罗氏有限公司 微生物转谷氨酰胺酶，其底物和其使用方法
CA2986388C (en) 2015-06-11 2024-02-27 Genexine, Inc. Modified interleukin-7 protein and uses thereof
CN106554420A (zh) * 2015-09-30 2017-04-05 上海众合医药科技股份有限公司 Pcsk9抗体、其抗原结合片段及其医药用途
KR102386735B1 (ko) 2015-11-06 2022-04-14 주식회사 제넥신 변형된 인터루킨-7 융합 단백질의 제형
CN108697764A (zh) 2015-12-04 2018-10-23 格纳西尼有限公司 含有免疫球蛋白fc融合白细胞介素-7融合蛋白的用于预防或治疗流感病毒感染的药物组合物
WO2017095191A1 (ko) 2015-12-04 2017-06-08 주식회사 제넥신 면역글로불린 fc가 융합된 인터루킨-7 융합 단백질을 포함하는 사람 파필로마바이러스 유래 질환의 예방 또는 치료용 약학적 조성물
CN108699104B (zh) * 2015-12-15 2022-07-15 豪夫迈·罗氏有限公司 具有转谷氨酰胺酶识别位点的fkbp结构域
US10093731B2 (en) 2017-02-24 2018-10-09 Kindred Biosciences, Inc. Anti-IL31 antibodies for veterinary use
WO2019167874A1 (ja) * 2018-02-27 2019-09-06 エーザイ・アール・アンド・ディー・マネジメント株式会社 Ａｐｏａ４に対するモノクローナル抗体、免疫学的測定方法及び測定用キット
WO2021058718A1 (en) 2019-09-26 2021-04-01 Roche Diagnostics Gmbh Anti-csf-1r antibody
EP4356135A1 (en) 2021-06-17 2024-04-24 Roche Diagnostics GmbH Thermostable affinity polypeptides
EP4380955A1 (en) * 2021-08-06 2024-06-12 Roche Diagnostics GmbH Chimeric igg-fc-binding ligand polypeptide and uses thereof for igg affinity purification
CN117858905A (zh) 2021-08-19 2024-04-09 豪夫迈·罗氏有限公司 多价抗变体fc区抗体及使用方法
CN116284220A (zh) * 2023-02-24 2023-06-23 浙江兴业集团有限公司 一种胆固醇酯酶抑制多肽组合及其制备方法、应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1232188A (en) 1987-05-29 1988-12-01 Mallinckrodt, Inc. Novel pair of monoclonal antibodies to insulin-like growth factor i permits immunometric assay for igf-i
US5202238A (en) 1987-10-27 1993-04-13 Oncogen Production of chimeric antibodies by homologous recombination
US5204244A (en) 1987-10-27 1993-04-20 Oncogen Production of chimeric antibodies by homologous recombination
US5614547A (en) * 1995-06-07 1997-03-25 Guilford Pharmaceuticals Inc. Small molecule inhibitors of rotamase enzyme
DE60141769D1 (de) 2000-12-26 2010-05-20 Sekisui Chemical Co Ltd Verfahren zur herstellung von rekombinantem protein und fusionsprotein
WO2004056855A1 (en) * 2002-12-20 2004-07-08 Roche Diagnostics Gmbh Soluble complexes of target proteins and peptidyl prolyl isomerase chaperones and methods of making and using them
EP2267452B8 (en) * 2001-06-22 2012-11-14 Roche Diagnostics GmbH A soluble complex comprising a retroviral surface glycoprotein
EP1516928B1 (en) * 2002-06-25 2010-02-17 Sekisui Chemical Co., Ltd. Expression vector, host, fused protein, process for producing fused protein and process for producing protein
WO2004092221A1 (ja) * 2003-04-18 2004-10-28 Sekisui Chemical Co. Ltd. 免疫原及び免疫用組成物、並びにそれらを使用する抗体の製造方法
US7732564B2 (en) * 2005-04-28 2010-06-08 London Health Sciences Centre Research Inc. Serum tumor marker in rodent prostate cancer models
EP2279726A3 (en) * 2005-05-26 2012-06-20 Biorest Ltd. Compositions and methods using same for delivering agents into a target organ protected by a blood barrier
US7604935B2 (en) * 2005-10-26 2009-10-20 Roche Diagnostics Operations, Inc. Soluble rubella E1 envelope protein variants
EP1780282B1 (en) 2005-10-26 2010-12-08 Roche Diagnostics GmbH Recombinant expression of Rubella E1 envelope protein variants as chaperone fusion-proteins, and their use in the detection of anti-Rubella antibodies
ATE527345T1 (de) * 2006-01-03 2011-10-15 Hoffmann La Roche Chimäres fusionsprotein mit überlegenen chaperon- und faltungsaktivitäten
EP2010567A2 (en) * 2006-04-07 2009-01-07 The Government of the United States of America as Represented by The Department of Health and Human Services Antibody compositions and methods for treatment of neoplastic disease
CA2743072A1 (en) * 2008-11-10 2010-05-14 Novartis Ag Antibodies to modified human igf-1/e peptides
AR086250A1 (es) * 2011-05-05 2013-11-27 Hoffmann La Roche Polipeptido de fusion presentador de una secuencia de aminoacidos y utilizacion del mismo
JP6488854B2 (ja) * 2015-04-22 2019-03-27 住友電気工業株式会社 半導体積層体および受光素子

Also Published As

Publication number Publication date
CN103620031B (zh) 2016-11-23
CN103649119A (zh) 2014-03-19
EP2705053A1 (en) 2014-03-12
ES2637667T3 (es) 2017-10-16
RU2630660C2 (ru) 2017-09-11
WO2012150320A1 (en) 2012-11-08
NZ616871A (en) 2015-12-24
CA2831162C (en) 2019-05-28
MX2013012688A (es) 2013-12-02
JP2017048209A (ja) 2017-03-09
US20160137728A1 (en) 2016-05-19
EP2705147A1 (en) 2014-03-12
EP2705147B1 (en) 2019-08-07
JP5877893B2 (ja) 2016-03-08
US20140120561A1 (en) 2014-05-01
MY166542A (en) 2018-07-16
US20140178393A1 (en) 2014-06-26
US20160138004A1 (en) 2016-05-19
RU2013152691A (ru) 2015-06-10
CA2834456A1 (en) 2012-11-08
US9273144B2 (en) 2016-03-01
JP2014515761A (ja) 2014-07-03
JP6165713B2 (ja) 2017-07-19
EP2705053B1 (en) 2017-06-14
US9266962B2 (en) 2016-02-23
CA2831162A1 (en) 2012-11-08
JP2014520073A (ja) 2014-08-21
AU2012251584B2 (en) 2016-07-28
US10647765B2 (en) 2020-05-12
CN103620031A (zh) 2014-03-05
BR112013028134A2 (pt) 2016-11-29
AU2012251584A1 (en) 2013-11-07
KR20140004802A (ko) 2014-01-13
SG194707A1 (en) 2013-12-30
US9938340B2 (en) 2018-04-10
AR086250A1 (es) 2013-11-27
CN103649119B (zh) 2016-06-08
WO2012150321A1 (en) 2012-11-08
IL228983A0 (en) 2013-12-31
KR101632479B1 (ko) 2016-06-21
US20190367601A1 (en) 2019-12-05
ZA201308251B (en) 2014-08-27
US10301383B2 (en) 2019-05-28

Similar Documents

Publication Publication Date Title
MX340329B (es) Polipeptido de fusion presentador de una secuencia de aminoacidos y uso del mismo.
MX2013001580A (es) Composiciones que comprenden un polipeptido que tiene actividad de incremento celulolitico y un licor, y usos de las mismas.
MY160552A (en) Low protein infant formula with increased essential amino acids
NZ702053A (en) Anti-human trop-2 antibody having antitumor activity in vivo
NZ598356A (en) Antigenic tau peptides and uses thereof
GB2492267B (en) Yeast microorganisms with reduced by-product accumulation for improved production of fuels, chemicals and amino acids
TN2012000550A1 (en) THE USE OF sGC STIMULATORS, sGC ACTIVATORS, ALONE AND COMBINATIONS WITH PDE5 INHIBITORS FOR THE TREATMENT OF SYSTEMIC SCLEROSIS (SSc).
IN2014DN09922A (es)
MX355170B (es) Variantes de enzimas mejoradas.
WO2013021212A3 (en) Modified osteopontin peptides having an inactivated rgd domain and uses thereof
EA201492068A1 (ru) Гидрохлоридная соль пептида и ее применение в комбинации с другими пептидами в иммунотерапии
MX2013002390A (es) Tratamiento de infarto de miocardio usando antagonistas de tgf-beta.
NZ604412A (en) Vaccine and methods to reduce campylobacter infection
MX354156B (es) Dipeptido que comprende un aminoacido no proteogenico.
WO2011107948A3 (en) Ligands of insulin degrading enzyme and their uses
MX2012010382A (es) Modulacion de acuaporinas con relaxina.
PE20120019A1 (es) Combinacion de perindopril y n-{[(7s)-3,4-dimetoxibiciclo[4.2.0]octa-1,3,5-trien-7-il]metil}-3-(7,8-dimetoxi-1,2,4,5-tetrahidro-3h-3-benzazepin-3-il)-n-metil-3-oxo-1-propanamina
NZ600818A (en) Cyclic peptides for the regulation of vectorial ion channels
WO2013156458A8 (en) Reduction of formation of amidated amino acids in cell lines for protein expression
RU2012110908A (ru) Синтетические пептиды с ненаркотическим типом анальгетического действия
RU2507212C3 (ru) Способ получения рекомбинантного пептида и полученный пептид
MX2013014999A (es) Peptido mejorador de sabor.
NZ738982A (en) Composition comprising amino acid and cyclic dipeptide
MX2012007260A (es) Peptidos con actividad antibacteriana y antiparasitaria y diseño de los mismos.
NZ588664A (en) Prion epitopes and methods of use thereof

Legal Events

Date Code Title Description
FG Grant or registration