MX2023006792A - Metodos de alto rendimiento para preparar nanoparticulas lipidicas y sus usos. - Google Patents
Metodos de alto rendimiento para preparar nanoparticulas lipidicas y sus usos.Info
- Publication number
- MX2023006792A MX2023006792A MX2023006792A MX2023006792A MX2023006792A MX 2023006792 A MX2023006792 A MX 2023006792A MX 2023006792 A MX2023006792 A MX 2023006792A MX 2023006792 A MX2023006792 A MX 2023006792A MX 2023006792 A MX2023006792 A MX 2023006792A
- Authority
- MX
- Mexico
- Prior art keywords
- lnp
- manufacturing
- present disclosure
- mixing
- throughput methods
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 150000002632 lipids Chemical class 0.000 title abstract 2
- 239000002105 nanoparticle Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 239000002245 particle Substances 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- 238000009826 distribution Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000005538 encapsulation Methods 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 238000013537 high throughput screening Methods 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 238000005457 optimization Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- 238000001338 self-assembly Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y40/00—Manufacture or treatment of nanostructures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Biochemistry (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Nanotechnology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
En la presente se proporcionan métodos de alto rendimiento para optimizar y elaborar diversas composiciones de nanopartículas lipídicas (LNP) y sus usos. Por ejemplo, en algunas formas de realización, la presente divulgación proporciona un método de cribado de alto rendimiento para elaborar una composición de LNP que comprende obtener al menos dos soluciones que se pueden mezclar entre sí que comprenden una carga útil y una pluralidad de moléculas capaces de autoensamblarse y mezclar dichas al menos dos soluciones en un conjunto de condiciones controladas, mediante las cuales varían la secuencia de inyección, velocidad, volumen, relación de fase y duración de mezclado. En diversas formas de realización, la presente divulgación permite determinar la eficacia de encapsulación, distribución de tamaño de partícula, purificación, tasa de recuperación de partícula y estabilidad de formulación óptimas. Los métodos divulgados en la presente permiten una optimización eficaz de las condiciones de elaboración para la preparación de agentes terapéuticos a base de LNP.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063123343P | 2020-12-09 | 2020-12-09 | |
| PCT/US2021/062344 WO2022125622A1 (en) | 2020-12-09 | 2021-12-08 | High-throughput methods for preparing lipid nanoparticles and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023006792A true MX2023006792A (es) | 2023-06-20 |
Family
ID=80218499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023006792A MX2023006792A (es) | 2020-12-09 | 2021-12-08 | Metodos de alto rendimiento para preparar nanoparticulas lipidicas y sus usos. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20230330023A1 (es) |
| EP (1) | EP4259104A1 (es) |
| JP (1) | JP2023552815A (es) |
| KR (1) | KR20230118129A (es) |
| CN (1) | CN116669711A (es) |
| AR (1) | AR124267A1 (es) |
| AU (1) | AU2021396518A1 (es) |
| CA (1) | CA3203463A1 (es) |
| IL (1) | IL303456A (es) |
| MX (1) | MX2023006792A (es) |
| TW (1) | TW202237068A (es) |
| WO (1) | WO2022125622A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3233239A1 (en) * | 2021-10-26 | 2023-05-04 | Genentech, Inc. | High-throughput methods for preparing lipid nanoparticles and uses thereof |
| WO2024013149A1 (en) * | 2022-07-12 | 2024-01-18 | Sartorius Stedim Biotech Gmbh | Lipid nanoparticle production system and method of monitoring and controlling the same |
| WO2024028492A1 (en) * | 2022-08-04 | 2024-02-08 | Sanofi | Quantitative assessment of rna encapsulation |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4270537A (en) | 1979-11-19 | 1981-06-02 | Romaine Richard A | Automatic hypodermic syringe |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| US4886499A (en) | 1986-12-18 | 1989-12-12 | Hoffmann-La Roche Inc. | Portable injection appliance |
| GB8704027D0 (en) | 1987-02-20 | 1987-03-25 | Owen Mumford Ltd | Syringe needle combination |
| US4940460A (en) | 1987-06-19 | 1990-07-10 | Bioject, Inc. | Patient-fillable and non-invasive hypodermic injection device assembly |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US5339163A (en) | 1988-03-16 | 1994-08-16 | Canon Kabushiki Kaisha | Automatic exposure control device using plural image plane detection areas |
| FR2638359A1 (fr) | 1988-11-03 | 1990-05-04 | Tino Dalto | Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US5190521A (en) | 1990-08-22 | 1993-03-02 | Tecnol Medical Products, Inc. | Apparatus and method for raising a skin wheal and anesthetizing skin |
| US5527288A (en) | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
| GB9118204D0 (en) | 1991-08-23 | 1991-10-09 | Weston Terence E | Needle-less injector |
| SE9102652D0 (sv) | 1991-09-13 | 1991-09-13 | Kabi Pharmacia Ab | Injection needle arrangement |
| US5328483A (en) | 1992-02-27 | 1994-07-12 | Jacoby Richard M | Intradermal injection device with medication and needle guard |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| US5569189A (en) | 1992-09-28 | 1996-10-29 | Equidyne Systems, Inc. | hypodermic jet injector |
| US5334144A (en) | 1992-10-30 | 1994-08-02 | Becton, Dickinson And Company | Single use disposable needleless injector |
| WO1995024176A1 (en) | 1994-03-07 | 1995-09-14 | Bioject, Inc. | Ampule filling device |
| US5466220A (en) | 1994-03-08 | 1995-11-14 | Bioject, Inc. | Drug vial mixing and transfer device |
| US5599302A (en) | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
| US5730723A (en) | 1995-10-10 | 1998-03-24 | Visionary Medical Products Corporation, Inc. | Gas pressured needle-less injection device and method |
| US5893397A (en) | 1996-01-12 | 1999-04-13 | Bioject Inc. | Medication vial/syringe liquid-transfer apparatus |
| GB9607549D0 (en) | 1996-04-11 | 1996-06-12 | Weston Medical Ltd | Spring-powered dispensing device |
| US5993412A (en) | 1997-05-19 | 1999-11-30 | Bioject, Inc. | Injection apparatus |
| IT1298087B1 (it) | 1998-01-08 | 1999-12-20 | Fiderm S R L | Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni |
| US20050222064A1 (en) | 2002-02-20 | 2005-10-06 | Sirna Therapeutics, Inc. | Polycationic compositions for cellular delivery of polynucleotides |
| US9592198B2 (en) * | 2013-10-28 | 2017-03-14 | University Of Maryland, College Park | Microfluidic liposome synthesis, purification and active drug loading |
| US20180000953A1 (en) | 2015-01-21 | 2018-01-04 | Moderna Therapeutics, Inc. | Lipid nanoparticle compositions |
| US20180085474A1 (en) | 2015-01-23 | 2018-03-29 | Moderna Therapeutics, Inc. | Lipid nanoparticle compositions |
| RS63051B1 (sr) | 2015-12-22 | 2022-04-29 | Modernatx Inc | Jedinjenja i kompozicije za intracelularnu isporuku agenasa |
| WO2017147215A1 (en) * | 2016-02-22 | 2017-08-31 | The Methodist Hospital | Biomimetic proteolipid vesicle compositions and uses thereof |
| WO2017180917A2 (en) | 2016-04-13 | 2017-10-19 | Modernatx, Inc. | Lipid compositions and their uses for intratumoral polynucleotide delivery |
| WO2017223135A1 (en) * | 2016-06-24 | 2017-12-28 | Modernatx, Inc. | Lipid nanoparticles |
-
2021
- 2021-12-07 AR ARP210103407A patent/AR124267A1/es unknown
- 2021-12-07 TW TW110145739A patent/TW202237068A/zh unknown
- 2021-12-08 AU AU2021396518A patent/AU2021396518A1/en active Pending
- 2021-12-08 MX MX2023006792A patent/MX2023006792A/es unknown
- 2021-12-08 WO PCT/US2021/062344 patent/WO2022125622A1/en active Application Filing
- 2021-12-08 IL IL303456A patent/IL303456A/en unknown
- 2021-12-08 EP EP21854765.1A patent/EP4259104A1/en active Pending
- 2021-12-08 CN CN202180083381.2A patent/CN116669711A/zh active Pending
- 2021-12-08 KR KR1020237022439A patent/KR20230118129A/ko unknown
- 2021-12-08 JP JP2023534898A patent/JP2023552815A/ja active Pending
- 2021-12-08 CA CA3203463A patent/CA3203463A1/en active Pending
-
2023
- 2023-06-09 US US18/332,324 patent/US20230330023A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20230118129A (ko) | 2023-08-10 |
| CN116669711A (zh) | 2023-08-29 |
| TW202237068A (zh) | 2022-10-01 |
| US20230330023A1 (en) | 2023-10-19 |
| CA3203463A1 (en) | 2022-06-16 |
| WO2022125622A1 (en) | 2022-06-16 |
| AR124267A1 (es) | 2023-03-01 |
| AU2021396518A1 (en) | 2023-07-06 |
| EP4259104A1 (en) | 2023-10-18 |
| JP2023552815A (ja) | 2023-12-19 |
| IL303456A (en) | 2023-08-01 |
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