MX2023005617A - Metodo para purificar sucralosa. - Google Patents
Metodo para purificar sucralosa.Info
- Publication number
- MX2023005617A MX2023005617A MX2023005617A MX2023005617A MX2023005617A MX 2023005617 A MX2023005617 A MX 2023005617A MX 2023005617 A MX2023005617 A MX 2023005617A MX 2023005617 A MX2023005617 A MX 2023005617A MX 2023005617 A MX2023005617 A MX 2023005617A
- Authority
- MX
- Mexico
- Prior art keywords
- sucralose
- temperature
- crude product
- ethyl acetate
- maintaining
- Prior art date
Links
- 239000004376 Sucralose Substances 0.000 title abstract 7
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 title abstract 7
- 235000019408 sucralose Nutrition 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 9
- 239000012043 crude product Substances 0.000 abstract 4
- 239000013078 crystal Substances 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 239000002002 slurry Substances 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 239000012295 chemical reaction liquid Substances 0.000 abstract 1
- 238000004821 distillation Methods 0.000 abstract 1
- 238000005265 energy consumption Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0018—Evaporation of components of the mixture to be separated
- B01D9/0031—Evaporation of components of the mixture to be separated by heating
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0488—Flow sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0492—Applications, solvents used
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0004—Crystallisation cooling by heat exchange
- B01D9/0013—Crystallisation cooling by heat exchange by indirect heat exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0059—General arrangements of crystallisation plant, e.g. flow sheets
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se divulga un método para purificar sucralosa, que incluye: eliminar un disolvente de una solución de reacción de sucralosa para obtener una solución de sucralosa cruda concentrada; bajo agitación, añadir acetato de etilo a la solución concentrada de sucralosa cruda, calentar a una temperatura preestablecida, y mantener a la temperatura preestablecida durante un primer tiempo preestablecido para obtener una suspensión acuosa de producto crudo con una cierta cantidad de un cristal de sucralosa; y someter la suspensión acuosa de producto crudo a un enfriamiento gradiente hasta una temperatura final, mantenerla a la temperatura final durante un segundo tiempo preestablecido y filtrarla para obtener un cristal de sucralosa. El método presenta las ventajas de la sencillez de las operaciones, la pequeña capacidad de tratamiento y el bajo consumo de disolvente. Además, el uso de acetato de etilo no aumentará las especies adicionales en el proceso, y el punto de ebullición del acetato de etilo es mucho más bajo que el del acetato de butilo, de manera que el consumo de energía en la destilación para la recuperación del disolvente se reduce considerablemente, lo que favorece la mejora de la eficacia de la producción y la reducción del coste de producción.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2020/128654 WO2022099606A1 (zh) | 2020-11-13 | 2020-11-13 | 三氯蔗糖的提纯方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023005617A true MX2023005617A (es) | 2023-05-29 |
Family
ID=75145396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023005617A MX2023005617A (es) | 2020-11-13 | 2020-11-13 | Metodo para purificar sucralosa. |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20230399351A1 (es) |
| EP (1) | EP4215538A4 (es) |
| CN (1) | CN112585151A (es) |
| MX (1) | MX2023005617A (es) |
| WO (1) | WO2022099606A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114014897A (zh) * | 2021-12-20 | 2022-02-08 | 安徽金禾实业股份有限公司 | 一种三氯蔗糖的纯化结晶方法 |
| WO2024082175A1 (zh) * | 2022-10-19 | 2024-04-25 | 安徽金禾实业股份有限公司 | 一种三氯蔗糖精品的制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5498709A (en) * | 1994-10-17 | 1996-03-12 | Mcneil-Ppc, Inc. | Production of sucralose without intermediate isolation of crystalline sucralose-6-ester |
| US7049435B2 (en) * | 2002-03-08 | 2006-05-23 | Tate & Lyle Public Limited Company | Extractive methods for purifying sucralose |
| US20040030124A1 (en) * | 2002-08-06 | 2004-02-12 | Catani Steven J. | Process for recovering chlorosucrose compounds |
| US20060188629A1 (en) * | 2005-01-21 | 2006-08-24 | Greg Liesen | Method for the purification of sucralose |
| CN101177437B (zh) * | 2007-12-07 | 2010-10-27 | 浙江普洛医药科技有限公司 | 一种环保的三氯蔗糖的合成方法 |
| CN101768193A (zh) * | 2010-01-14 | 2010-07-07 | 湖北益泰药业有限公司 | 一种高收率制备三氯蔗糖的方法 |
| CN102391319B (zh) * | 2011-10-14 | 2015-01-07 | 山东三和维信生物科技有限公司 | 三氯蔗糖的结晶方法 |
| CN106188166A (zh) * | 2016-07-02 | 2016-12-07 | 安徽广信农化股份有限公司 | 一种用于三氯蔗糖分离提纯的方法 |
| CN106674292B (zh) * | 2016-12-09 | 2019-02-22 | 福建科宏生物工程股份有限公司 | 一种三氯蔗糖水结晶母液的提纯处理方法 |
| CN109503680A (zh) * | 2018-12-12 | 2019-03-22 | 安徽金禾实业股份有限公司 | 一种三氯蔗糖-6-乙酯母液酯相处理方法 |
| CN110372764A (zh) * | 2019-01-12 | 2019-10-25 | 山东康宝生化科技有限公司 | 一种从多重母液里提取三氯蔗糖的方法 |
-
2020
- 2020-11-13 CN CN202080004013.XA patent/CN112585151A/zh active Pending
- 2020-11-13 EP EP20961162.3A patent/EP4215538A4/en active Pending
- 2020-11-13 WO PCT/CN2020/128654 patent/WO2022099606A1/zh unknown
- 2020-11-13 MX MX2023005617A patent/MX2023005617A/es unknown
- 2020-11-13 US US18/250,728 patent/US20230399351A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP4215538A4 (en) | 2023-10-11 |
| CN112585151A (zh) | 2021-03-30 |
| WO2022099606A1 (zh) | 2022-05-19 |
| EP4215538A1 (en) | 2023-07-26 |
| US20230399351A1 (en) | 2023-12-14 |
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