MX2023000051A - Metodos de acondicionamiento de pacientes para tratamiento con linfocitos t. - Google Patents
Metodos de acondicionamiento de pacientes para tratamiento con linfocitos t.Info
- Publication number
- MX2023000051A MX2023000051A MX2023000051A MX2023000051A MX2023000051A MX 2023000051 A MX2023000051 A MX 2023000051A MX 2023000051 A MX2023000051 A MX 2023000051A MX 2023000051 A MX2023000051 A MX 2023000051A MX 2023000051 A MX2023000051 A MX 2023000051A
- Authority
- MX
- Mexico
- Prior art keywords
- treatment
- lymphocytes
- methods
- conditioning
- conditioning patients
- Prior art date
Links
- 210000001744 T-lymphocyte Anatomy 0.000 title abstract 3
- 230000003750 conditioning effect Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 abstract 1
- 229960004397 cyclophosphamide Drugs 0.000 abstract 1
- 229960000390 fludarabine Drugs 0.000 abstract 1
- GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/664—Amides of phosphorus acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2053—IL-8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
- A61K40/421—Immunoglobulin superfamily
- A61K40/4211—CD19 or B4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Mycology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La invención proporciona métodos para incrementar la eficacia de un tratamiento con linfocitos T en un paciente en necesidad de los mismos. La invención incluye un método para acondicionar un paciente antes de un tratamiento con linfocitos T, en donde el acondicionamiento involucra administrar una combinación de ciclofosfamida y fludarabina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562167750P | 2015-05-28 | 2015-05-28 | |
US201562262143P | 2015-12-02 | 2015-12-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2023000051A true MX2023000051A (es) | 2023-02-01 |
Family
ID=57393284
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017015186A MX2017015186A (es) | 2015-05-28 | 2016-05-27 | Metodos de acondicionamiento de pacientes para tratamiento con linfocitos t. |
MX2023000049A MX2023000049A (es) | 2015-05-28 | 2017-11-27 | Metodos de acondicionamiento de pacientes para tratamiento con linfocitos t. |
MX2023000050A MX2023000050A (es) | 2015-05-28 | 2017-11-27 | Metodos de acondicionamiento de pacientes para tratamiento con linfocitos t. |
MX2023000051A MX2023000051A (es) | 2015-05-28 | 2017-11-27 | Metodos de acondicionamiento de pacientes para tratamiento con linfocitos t. |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017015186A MX2017015186A (es) | 2015-05-28 | 2016-05-27 | Metodos de acondicionamiento de pacientes para tratamiento con linfocitos t. |
MX2023000049A MX2023000049A (es) | 2015-05-28 | 2017-11-27 | Metodos de acondicionamiento de pacientes para tratamiento con linfocitos t. |
MX2023000050A MX2023000050A (es) | 2015-05-28 | 2017-11-27 | Metodos de acondicionamiento de pacientes para tratamiento con linfocitos t. |
Country Status (19)
Country | Link |
---|---|
US (4) | US9855298B2 (es) |
EP (2) | EP3851110A1 (es) |
JP (3) | JP7197979B2 (es) |
KR (3) | KR20230147769A (es) |
CN (2) | CN107921066A (es) |
AU (2) | AU2016268864B2 (es) |
BR (1) | BR112017025166A2 (es) |
CA (1) | CA2986798A1 (es) |
CL (1) | CL2017003006A1 (es) |
DO (1) | DOP2017000271A (es) |
EA (1) | EA201792649A1 (es) |
HK (2) | HK1246151A1 (es) |
IL (6) | IL284173B2 (es) |
MA (2) | MA43343A (es) |
MX (4) | MX2017015186A (es) |
PH (1) | PH12017502154A1 (es) |
SG (2) | SG10201913613SA (es) |
TW (2) | TWI803447B (es) |
WO (1) | WO2016191756A1 (es) |
Families Citing this family (110)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10426740B1 (en) | 2010-08-18 | 2019-10-01 | Avm Biotechnology, Llc | Compositions and methods to inhibit stem cell and progenitor cell binding to lymphoid tissue and for regenerating germinal centers in lymphatic tissues |
ES2640813T3 (es) | 2011-09-08 | 2017-11-06 | Yeda Research And Development Co. Ltd. | Linfocitos T de memoria central antiterceros, métodos para producirlos y uso de los mismos en un trasplante y el tratamiento de enfermedades |
WO2014100615A1 (en) | 2012-12-20 | 2014-06-26 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
CA2964941A1 (en) | 2014-10-20 | 2016-04-28 | Juno Therapeutics, Inc. | Methods and compositions for dosing in adoptive cell therapy |
AU2016268864B2 (en) * | 2015-05-28 | 2022-06-02 | Kite Pharma, Inc. | Methods of conditioning patients for T cell therapy |
JP6917903B2 (ja) | 2015-05-28 | 2021-08-11 | カイト ファーマ インコーポレイテッドKite Pharma, Inc | T細胞療法のための診断方法 |
AU2016291825B2 (en) | 2015-07-16 | 2022-08-11 | Yeda Research And Development Co. Ltd. | Genetically modified anti-third party central memory T cells and use of same in immunotherapy |
WO2017075465A1 (en) | 2015-10-28 | 2017-05-04 | The Broad Institute Inc. | Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3 |
WO2017075451A1 (en) | 2015-10-28 | 2017-05-04 | The Broad Institute Inc. | Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1 |
IL261941B2 (en) | 2016-04-01 | 2023-11-01 | Kite Pharma Inc | Chimeric antigen and T cell receptors and methods of use |
CA3019835A1 (en) | 2016-04-08 | 2017-10-12 | Purdue Research Foundation | Methods and compositions for car t cell therapy |
ES2891321T3 (es) | 2016-04-08 | 2022-01-27 | Adaptimmune Ltd | Receptores de células T |
WO2017180587A2 (en) | 2016-04-11 | 2017-10-19 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
US11478508B2 (en) | 2016-05-25 | 2022-10-25 | The Council Of The Queensland Institute Of Medical Research | Methods of immunotherapy |
WO2018049025A2 (en) | 2016-09-07 | 2018-03-15 | The Broad Institute Inc. | Compositions and methods for evaluating and modulating immune responses |
IL268126B2 (en) * | 2017-01-18 | 2024-02-01 | Yeda Res & Dev | Genetically engineered Veto cells and their uses in immunotherapy |
JP2020506901A (ja) * | 2017-01-20 | 2020-03-05 | アタラ バイオセラピューティクス,インコーポレーテッド | 自家t細胞を用いた多発性硬化症の処置方法 |
US11649288B2 (en) | 2017-02-07 | 2023-05-16 | Seattle Children's Hospital | Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents |
EP3585402B1 (en) | 2017-02-27 | 2024-03-06 | Juno Therapeutics, Inc. | Compositions, articles of manufacture and methods related to dosing in cell therapy |
JP7178355B2 (ja) | 2017-02-28 | 2022-11-25 | エンドサイト・インコーポレイテッド | Car t細胞療法のための組成物および方法 |
US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
TW201837175A (zh) | 2017-03-13 | 2018-10-16 | 美商凱特製藥公司 | 用於黑色素瘤之嵌合抗原受體及其用途 |
WO2018183908A1 (en) | 2017-03-31 | 2018-10-04 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating ovarian tumors |
ES2954311T3 (es) * | 2017-04-01 | 2023-11-21 | Avm Biotechnology Llc | Reemplazo de un preacondicionamiento citotóxico antes de una inmunoterapia celular |
US11913075B2 (en) | 2017-04-01 | 2024-02-27 | The Broad Institute, Inc. | Methods and compositions for detecting and modulating an immunotherapy resistance gene signature in cancer |
CN110494158A (zh) | 2017-04-03 | 2019-11-22 | 凯德药业股份有限公司 | 使用包含优化的多功能t细胞的嵌合受体t细胞进行治疗 |
US20200071773A1 (en) | 2017-04-12 | 2020-03-05 | Massachusetts Eye And Ear Infirmary | Tumor signature for metastasis, compositions of matter methods of use thereof |
CN110753555A (zh) | 2017-04-19 | 2020-02-04 | 得克萨斯州大学系统董事会 | 表达工程化抗原受体的免疫细胞 |
BR112019024613A2 (pt) | 2017-05-26 | 2020-06-16 | Kite Pharma, Inc. | Métodos para fazer e usar células mesenquimais progenitoras embrionárias |
CA3065120A1 (en) | 2017-06-02 | 2018-12-06 | Juno Therapeutics, Inc. | Articles of manufacture and methods for treatment using adoptive cell therapy |
US11897953B2 (en) | 2017-06-14 | 2024-02-13 | The Broad Institute, Inc. | Compositions and methods targeting complement component 3 for inhibiting tumor growth |
US12049643B2 (en) | 2017-07-14 | 2024-07-30 | The Broad Institute, Inc. | Methods and compositions for modulating cytotoxic lymphocyte activity |
JP2020535128A (ja) | 2017-09-19 | 2020-12-03 | マサチューセッツ インスティテュート オブ テクノロジー | キメラ抗原受容体t細胞治療のための組成物およびその使用 |
CA3076456A1 (en) * | 2017-10-02 | 2019-04-11 | Gamida-Cell Ltd. | Expansion and use of expanded nk cell fractions |
EP3695408A4 (en) | 2017-10-02 | 2021-12-15 | The Broad Institute, Inc. | METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING A GENETIC SIGNATURE OF IMMUNOTHERAPY RESISTANCE IN CANCER |
US11732257B2 (en) | 2017-10-23 | 2023-08-22 | Massachusetts Institute Of Technology | Single cell sequencing libraries of genomic transcript regions of interest in proximity to barcodes, and genotyping of said libraries |
WO2019089858A2 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Methods of assessing or monitoring a response to a cell therapy |
CN111565730B (zh) | 2017-11-09 | 2024-09-17 | 桑格摩生物治疗股份有限公司 | 细胞因子诱导型含sh2蛋白(cish)基因的遗传修饰 |
US12171783B2 (en) | 2017-11-13 | 2024-12-24 | The Broad Institute, Inc. | Methods and compositions for targeting developmental and oncogenic programs in H3K27M gliomas |
US12018080B2 (en) | 2017-11-13 | 2024-06-25 | The Broad Institute, Inc. | Methods and compositions for treating cancer by targeting the CLEC2D-KLRB1 pathway |
CN111655732B (zh) | 2017-11-14 | 2023-09-12 | Gc细胞治疗 | 抗her2抗体或其抗原结合片段及包含其的嵌合抗原受体 |
KR20200109308A (ko) | 2017-12-08 | 2020-09-22 | 주노 쎄러퓨티크스 인코퍼레이티드 | 세포 요법을 위한 표현형 마커 및 관련 방법 |
US11994512B2 (en) | 2018-01-04 | 2024-05-28 | Massachusetts Institute Of Technology | Single-cell genomic methods to generate ex vivo cell systems that recapitulate in vivo biology with improved fidelity |
TW201932593A (zh) | 2018-01-15 | 2019-08-16 | 美商輝瑞大藥廠 | 合併投與嵌合抗原受體之免疫療法與4-1bb促效劑的方法 |
BR112020014913A2 (pt) | 2018-01-22 | 2020-12-08 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Métodos para uso de células t car |
WO2019170147A1 (zh) * | 2018-03-09 | 2019-09-12 | 科济生物医药(上海)有限公司 | 用于治疗肿瘤的方法和组合物 |
BR112020018658A2 (pt) | 2018-03-15 | 2020-12-29 | KSQ Therapeutics, Inc. | Composições de regulação gênica e métodos para imu-noterapia aprimorada |
CN112074280A (zh) | 2018-03-22 | 2020-12-11 | 温德弥尔治疗公司 | 前列腺癌特异性骨髓浸润淋巴细胞及其用途 |
WO2019191752A1 (en) * | 2018-03-30 | 2019-10-03 | Ohio State Innovation Foundation | Methods for pre-conditioning patients for t-cell therapy |
US11957695B2 (en) | 2018-04-26 | 2024-04-16 | The Broad Institute, Inc. | Methods and compositions targeting glucocorticoid signaling for modulating immune responses |
SG11202010996QA (en) | 2018-05-23 | 2020-12-30 | Nat Univ Singapore | Blockade of cd2 surface expression and expression of chimeric antigen receptors for immunotherapy of t-cell malignancies |
KR20240170582A (ko) | 2018-06-01 | 2024-12-03 | 카이트 파마 인코포레이티드 | 키메라 항원 수용체 t 세포 요법 |
US20210371932A1 (en) | 2018-06-01 | 2021-12-02 | Massachusetts Institute Of Technology | Methods and compositions for detecting and modulating microenvironment gene signatures from the csf of metastasis patients |
US12036240B2 (en) | 2018-06-14 | 2024-07-16 | The Broad Institute, Inc. | Compositions and methods targeting complement component 3 for inhibiting tumor growth |
EP3810780A1 (en) | 2018-06-22 | 2021-04-28 | Kite Pharma Eu B.V. | Compositions and methods for making engineered t cells |
CA3107383A1 (en) * | 2018-07-23 | 2020-01-30 | Magenta Therapeutics, Inc. | Use of anti-cd5 antibody drug conjugate (adc) in allogeneic cell therapy |
EP3826624A4 (en) * | 2018-07-23 | 2022-08-24 | Magenta Therapeutics, Inc. | USE OF ANTI-CD2 ANTIBODY (ADC) DRUG CONJUGATE IN ALLOGENIC CELL THERAPY |
CN112771071A (zh) | 2018-09-28 | 2021-05-07 | 麻省理工学院 | 胶原蛋白定位的免疫调节分子及其方法 |
WO2020072700A1 (en) | 2018-10-02 | 2020-04-09 | Dana-Farber Cancer Institute, Inc. | Hla single allele lines |
EP3632446B3 (en) | 2018-10-03 | 2024-01-24 | AVM Biotechnology, LLC | Immunoablative therapies |
EP3488851A1 (en) | 2018-10-03 | 2019-05-29 | AVM Biotechnology, LLC | Immunoablative therapies |
WO2020081730A2 (en) | 2018-10-16 | 2020-04-23 | Massachusetts Institute Of Technology | Methods and compositions for modulating microenvironment |
AU2019372331A1 (en) * | 2018-11-01 | 2021-05-27 | Juno Therapeutics, Inc. | Methods for treatment using chimeric antigen receptors specific for B-cell maturation antigen |
WO2020131586A2 (en) | 2018-12-17 | 2020-06-25 | The Broad Institute, Inc. | Methods for identifying neoantigens |
US11739156B2 (en) | 2019-01-06 | 2023-08-29 | The Broad Institute, Inc. Massachusetts Institute of Technology | Methods and compositions for overcoming immunosuppression |
WO2020186101A1 (en) | 2019-03-12 | 2020-09-17 | The Broad Institute, Inc. | Detection means, compositions and methods for modulating synovial sarcoma cells |
US20220142948A1 (en) | 2019-03-18 | 2022-05-12 | The Broad Institute, Inc. | Compositions and methods for modulating metabolic regulators of t cell pathogenicity |
IL286482B2 (en) * | 2019-03-21 | 2025-01-01 | Gamida Cell Ltd | Cultured NK cell fractions for use in combination therapy |
JP2022527297A (ja) | 2019-03-27 | 2022-06-01 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | Tn-MUC1キメラ抗原受容体(CAR)T細胞療法 |
CN118593691A (zh) | 2019-05-03 | 2024-09-06 | 凯德药业股份有限公司 | 施用嵌合抗原受体免疫疗法的方法 |
US20220235340A1 (en) | 2019-05-20 | 2022-07-28 | The Broad Institute, Inc. | Novel crispr-cas systems and uses thereof |
US20220226464A1 (en) | 2019-05-28 | 2022-07-21 | Massachusetts Institute Of Technology | Methods and compositions for modulating immune responses |
EP3990476A1 (en) | 2019-06-25 | 2022-05-04 | Gilead Sciences, Inc. | Flt3l-fc fusion proteins and methods of use |
JP2022538974A (ja) | 2019-06-26 | 2022-09-07 | マサチューセッツ インスチテュート オブ テクノロジー | 免疫調節融合タンパク質-金属水酸化物錯体およびその方法 |
MA56388A (fr) | 2019-06-27 | 2022-05-04 | Crispr Therapeutics Ag | Utilisation de lymphocytes t récepteurs d'antigènes chimériques et d'inhibiteurs de cellules nk pour le traitement du cancer |
US20220282333A1 (en) | 2019-08-13 | 2022-09-08 | The General Hospital Corporation | Methods for predicting outcomes of checkpoint inhibition and treatment thereof |
WO2021041922A1 (en) | 2019-08-30 | 2021-03-04 | The Broad Institute, Inc. | Crispr-associated mu transposase systems |
WO2021061648A1 (en) | 2019-09-23 | 2021-04-01 | Massachusetts Institute Of Technology | Methods and compositions for stimulation of endogenous t cell responses |
US12195725B2 (en) | 2019-10-03 | 2025-01-14 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for modulating and detecting tissue specific TH17 cell pathogenicity |
US11981922B2 (en) | 2019-10-03 | 2024-05-14 | Dana-Farber Cancer Institute, Inc. | Methods and compositions for the modulation of cell interactions and signaling in the tumor microenvironment |
US20210161959A1 (en) * | 2019-11-06 | 2021-06-03 | Kite Pharma, Inc. | Chimeric antigen receptor t cell therapy |
US11865168B2 (en) | 2019-12-30 | 2024-01-09 | Massachusetts Institute Of Technology | Compositions and methods for treating bacterial infections |
US12165747B2 (en) | 2020-01-23 | 2024-12-10 | The Broad Institute, Inc. | Molecular spatial mapping of metastatic tumor microenvironment |
WO2021151008A1 (en) * | 2020-01-24 | 2021-07-29 | Juno Therapuetics, Inc. | Methods for dosing and treatment of follicular lymphoma and marginal zone lymphoma in adoptive cell therapy |
US20210322471A1 (en) | 2020-03-27 | 2021-10-21 | Dcprime B.V. | In vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy |
AU2021243864A1 (en) | 2020-03-27 | 2022-11-03 | Mendus B.V. | Ex vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy |
US20210338833A1 (en) | 2020-05-01 | 2021-11-04 | Massachusetts Institute Of Technology | Chimeric antigen receptor-targeting ligands and uses thereof |
WO2021221783A1 (en) | 2020-05-01 | 2021-11-04 | Massachusetts Institute Of Technology | Methods for identifying chimeric antigen receptor-targeting ligands and uses thereof |
US20230293530A1 (en) | 2020-06-24 | 2023-09-21 | Yeda Research And Development Co. Ltd. | Agents for sensitizing solid tumors to treatment |
CN116528879A (zh) | 2020-10-28 | 2023-08-01 | 凯德药业股份有限公司 | 用于表征t细胞杂质的流式细胞术方法 |
US20220168407A1 (en) | 2020-11-05 | 2022-06-02 | Dcprime B.V. | Use of tumor-independent antigens in immunotherapies |
EP4275044A1 (en) | 2021-01-10 | 2023-11-15 | Kite Pharma, Inc. | T cell therapy |
CA3211006A1 (en) | 2021-02-20 | 2022-08-25 | Kite Pharma, Inc. | Gene markers for sellecting immunotherapies |
CA3172530A1 (en) | 2021-02-25 | 2022-09-01 | Spencer PARK | Ror1 targeting chimeric antigen receptor |
AU2022274608A1 (en) | 2021-05-14 | 2023-11-09 | Kite Pharma, Inc. | Chimeric antigen receptor t cell therapy |
TW202313094A (zh) | 2021-05-18 | 2023-04-01 | 美商基利科學股份有限公司 | 使用FLT3L—Fc融合蛋白之方法 |
AU2022366987A1 (en) | 2021-10-14 | 2024-05-16 | Arsenal Biosciences, Inc. | Immune cells having co-expressed shrnas and logic gate systems |
US20250041339A1 (en) | 2021-11-19 | 2025-02-06 | The Trustees Of The University Of Pennsylvania | Engineered Pan-Leukocyte Antigen CD45 to Facilityate CAR T Cell Therapy |
KR20240144434A (ko) | 2022-02-15 | 2024-10-02 | 카이트 파마 인코포레이티드 | 면역요법으로 인한 유해사례 예측 |
US20240002800A1 (en) | 2022-05-16 | 2024-01-04 | Mendus B.V. | Use of leukemia-derived cells for enhancing natural killer (nk) cell therapy |
WO2024092227A1 (en) | 2022-10-28 | 2024-05-02 | Kite Pharma, Inc. | Factors for optimizing immunotherapy |
US20240165160A1 (en) | 2022-10-28 | 2024-05-23 | Kite Pharma, Inc. | Efficacy and durable response of immunotherapy |
WO2024107891A2 (en) * | 2022-11-16 | 2024-05-23 | Nkarta, Inc. | Dosing regimens for combination therapies |
DE102022132082B4 (de) | 2022-12-02 | 2024-08-08 | Horia Hulubei National Institute for R & D in Physics and Nuclear Engineering (IFIN-HH) | Verfahren zur Herstellung von genetisch transfizierten und mit Nanopartikeln und/oder einem zytotoxischen Stoff beladenen immunokompetenten Zellen sowie immunokompetente Zellen und medizinische Zusammensetzung. |
DE102022132083B4 (de) | 2022-12-02 | 2024-08-22 | Horia Hulubei National Institute for R & D in Physics and Nuclear Engineering (IFIN-HH) | Vorrichtung zum Porieren und zum Beladen von Zellen sowie Verfahren hierfür |
DE102022132084B4 (de) | 2022-12-02 | 2024-08-22 | Horia Hulubei National Institute for R & D in Physics and Nuclear Engineering (IFIN-HH) | Vorrichtung zum Porieren und zum Beladen von Zellen sowie Verfahren hierfür |
WO2024124044A1 (en) | 2022-12-07 | 2024-06-13 | The Brigham And Women’S Hospital, Inc. | Compositions and methods targeting sat1 for enhancing anti¬ tumor immunity during tumor progression |
WO2024196689A1 (en) | 2023-03-17 | 2024-09-26 | Kite Pharma, Inc. | Impact of tumor microenvironment on efficacy of immunotherapy |
WO2024211852A1 (en) * | 2023-04-07 | 2024-10-10 | Fate Therapeutics, Inc. | Ipsc-derived nk cell for lymphoma treatment |
WO2024243428A2 (en) * | 2023-05-24 | 2024-11-28 | Instil Bio Inc. | Use of fusion constructs for cell therapy |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5728388A (en) | 1989-10-03 | 1998-03-17 | Terman; David S. | Method of cancer treatment |
US5595756A (en) | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
US6406699B1 (en) | 1999-10-05 | 2002-06-18 | Gary W. Wood | Composition and method of cancer antigen immunotherapy |
US20030031652A1 (en) | 2001-04-16 | 2003-02-13 | Bernhard Hering | Systems and methods for inducing mixed chimerism |
US7718196B2 (en) * | 2001-07-02 | 2010-05-18 | The United States Of America, As Represented By The Department Of Health And Human Services | Rapamycin-resistant T cells and therapeutic uses thereof |
WO2004021995A2 (en) * | 2002-09-06 | 2004-03-18 | The Government Of The United States Of America, Represented By The Secretary, Departement Of Health And Human Services | Immunotherapy with in vitro-selected antigen-specific lymphocytes after nonmyeloablative lymphodepleting chemotherapy |
GB0700058D0 (en) | 2007-01-03 | 2007-02-07 | Scancell Aps | Anti-tumor vaccine based on normal cells |
EP2550359B1 (en) | 2010-03-23 | 2017-08-09 | Intrexon Corporation | Vectors conditionally expressing therapeutic proteins, host cells comprising the vectors, and uses thereof |
PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
SG192010A1 (en) | 2011-01-18 | 2013-08-30 | Univ Pennsylvania | Compositions and methods for treating cancer |
EP2532740A1 (en) | 2011-06-11 | 2012-12-12 | Michael Schmück | Antigen-specific CD4+ and CD8+ central-memory T cell preparations for adoptive T cell therapy |
CA2848410A1 (en) | 2011-09-16 | 2013-03-21 | The Trustees Of The University Of Pennsylvania | Rna engineered t cells for the treatment of cancer |
ES2607148T3 (es) | 2012-05-08 | 2017-03-29 | The Johns Hopkins University | Métodos y composiciones para infusión de poblaciones seleccionadas de linfocitos alogénicos con prendimiento transitorio para tratar cáncer |
US10117896B2 (en) | 2012-10-05 | 2018-11-06 | The Trustees Of The University Of Pennsylvania | Use of a trans-signaling approach in chimeric antigen receptors |
WO2014204762A1 (en) | 2013-06-19 | 2014-12-24 | Massachusetts Institute Of Technology | In vivo targeting of cells with ligand-conjugated particles |
US20150273033A1 (en) | 2013-11-05 | 2015-10-01 | Cognate Bioservices, Inc. | Combinations of checkpoint inhibitors and therapeutics to treat cancer |
IL254817B2 (en) * | 2015-04-08 | 2023-12-01 | Novartis Ag | Cd20 therapies, cd22 therapies, and combination therapies with a cd19 chimeric antigen receptor (car) - expressing cell |
JP6917903B2 (ja) * | 2015-05-28 | 2021-08-11 | カイト ファーマ インコーポレイテッドKite Pharma, Inc | T細胞療法のための診断方法 |
AU2016268864B2 (en) | 2015-05-28 | 2022-06-02 | Kite Pharma, Inc. | Methods of conditioning patients for T cell therapy |
IL261941B2 (en) * | 2016-04-01 | 2023-11-01 | Kite Pharma Inc | Chimeric antigen and T cell receptors and methods of use |
-
2016
- 2016-05-27 AU AU2016268864A patent/AU2016268864B2/en active Active
- 2016-05-27 US US15/167,977 patent/US9855298B2/en active Active
- 2016-05-27 IL IL284173A patent/IL284173B2/en unknown
- 2016-05-27 IL IL295224A patent/IL295224A/en unknown
- 2016-05-27 BR BR112017025166A patent/BR112017025166A2/pt not_active Application Discontinuation
- 2016-05-27 KR KR1020237034999A patent/KR20230147769A/ko not_active Application Discontinuation
- 2016-05-27 IL IL312426A patent/IL312426A/en unknown
- 2016-05-27 SG SG10201913613SA patent/SG10201913613SA/en unknown
- 2016-05-27 KR KR1020227000444A patent/KR20220008388A/ko not_active Application Discontinuation
- 2016-05-27 KR KR1020177037017A patent/KR102349677B1/ko active IP Right Grant
- 2016-05-27 CN CN201680030892.7A patent/CN107921066A/zh active Pending
- 2016-05-27 JP JP2017561794A patent/JP7197979B2/ja active Active
- 2016-05-27 CN CN202210019434.0A patent/CN114344321A/zh active Pending
- 2016-05-27 WO PCT/US2016/034888 patent/WO2016191756A1/en active Application Filing
- 2016-05-27 MX MX2017015186A patent/MX2017015186A/es unknown
- 2016-05-27 IL IL305621A patent/IL305621A/en unknown
- 2016-05-27 EA EA201792649A patent/EA201792649A1/ru unknown
- 2016-05-27 IL IL255887A patent/IL255887B/en unknown
- 2016-05-27 IL IL316196A patent/IL316196A/en unknown
- 2016-05-27 EP EP20204879.9A patent/EP3851110A1/en active Pending
- 2016-05-27 MA MA043343A patent/MA43343A/fr unknown
- 2016-05-27 EP EP16800847.2A patent/EP3302508A4/en not_active Withdrawn
- 2016-05-27 CA CA2986798A patent/CA2986798A1/en active Pending
- 2016-05-27 MA MA055694A patent/MA55694A/fr unknown
- 2016-05-27 SG SG10201913604TA patent/SG10201913604TA/en unknown
- 2016-05-30 TW TW105116879A patent/TWI803447B/zh active
- 2016-05-30 TW TW112135845A patent/TW202419092A/zh unknown
-
2017
- 2017-07-13 US US15/649,369 patent/US10322146B2/en active Active
- 2017-11-27 MX MX2023000049A patent/MX2023000049A/es unknown
- 2017-11-27 MX MX2023000050A patent/MX2023000050A/es unknown
- 2017-11-27 MX MX2023000051A patent/MX2023000051A/es unknown
- 2017-11-27 DO DO2017000271A patent/DOP2017000271A/es unknown
- 2017-11-27 PH PH12017502154A patent/PH12017502154A1/en unknown
- 2017-11-27 CL CL2017003006A patent/CL2017003006A1/es unknown
-
2018
- 2018-04-10 US US15/950,042 patent/US11491187B2/en active Active
- 2018-04-27 HK HK18105541.3A patent/HK1246151A1/zh unknown
- 2018-06-15 HK HK18107815.8A patent/HK1248141A1/zh unknown
-
2021
- 2021-07-02 JP JP2021110476A patent/JP7238030B2/ja active Active
-
2022
- 2022-08-31 AU AU2022224754A patent/AU2022224754A1/en active Pending
- 2022-09-27 US US17/954,070 patent/US20230158075A1/en active Pending
-
2023
- 2023-03-01 JP JP2023030596A patent/JP2023071823A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2023000051A (es) | Metodos de acondicionamiento de pacientes para tratamiento con linfocitos t. | |
CL2017003005A1 (es) | Métodos de diagnóstico para tratamiento con linfocitos t | |
PE20180260A1 (es) | Metodos y kits para tratar la depresion | |
AR101312A1 (es) | Combinaciones de inhibidores de bet e inhibidores de tirosina quinasa de bruton | |
MX2020004467A (es) | Metodos para el tratamiento o la prevencion del asma mediante la administracion de antagonista de il-4r. | |
EA201790142A1 (ru) | Лечение лейкоза ингибиторами гистондеацетилазы | |
SV2017005489A (es) | Terapias de combinación para el tratamiento de cánceres | |
MX2023000796A (es) | Composicion farmaceutica, metodos para tratamiento y sus usos. | |
MX2016013963A (es) | Metodos mejorados para la elaboracion de terapias celulares adoptivas. | |
BR112017016772A2 (pt) | bactérias probióticas recombinantes para uso no tratamento de uma disfunção inflamatória da pele e método para tratá-la | |
CR20160308A (es) | Combinaciones de inhibidores de histona deacetilasa y farmacos inmunomoduladores | |
CL2016001076A1 (es) | (aza) piridopirazolopirimidinonas e indazolopirimidinonas como inhibidores de fibrinolosis. | |
MA40535A (fr) | Imagerie et thérapie d'une inflammation et d'une infection ciblant hsp90 | |
AR112144A1 (es) | Compuestos para el tratamiento del sarcoma | |
AR104598A1 (es) | Métodos para tratar trastornos linfoproliferativos asociados al virus de epstein-barr por terapia con células t | |
TR201905392T4 (tr) | Ağrı tedavisi. | |
MX2018002816A (es) | Metodos de tratamiento de mieloma multiple y leucemia de celulas plasmaticas mediante terapia de celulas t. | |
UA118474C2 (uk) | (s)-пірліндол та його фармацевтично прийнятні солі для застосування в медицині | |
MX2020004513A (es) | Cocristales, composiciones farmacéuticas de los mismos y métodos de tratamiento que los implican. | |
CL2017000884A1 (es) | Composición farmacéutica para usarse en el tratamiento o la prevención de deficiencias de vitaminas y minerales en pacientes que han sido sometidos a cirugía de derivación gástrica | |
MX2016014701A (es) | (r)-pirlindol y sus sales farmaceuticamente aceptables para uso en medicina. | |
AR106415A1 (es) | Composición farmacéutica para el tratamiento del dolor | |
AR105142A1 (es) | Métodos de tratamiento del glioblastoma multiforme con terapia de células t | |
AR097590A1 (es) | Métodos para tratar el síndrome del x frágil y trastornos relacionados | |
UY34667A (es) | ?método y dispositivo para el tratamiento de trastornos del colesterol en la sangre?. |