MX2022015812A - Inhibidores de cisteina proteasas y sus metodos de uso. - Google Patents
Inhibidores de cisteina proteasas y sus metodos de uso.Info
- Publication number
- MX2022015812A MX2022015812A MX2022015812A MX2022015812A MX2022015812A MX 2022015812 A MX2022015812 A MX 2022015812A MX 2022015812 A MX2022015812 A MX 2022015812A MX 2022015812 A MX2022015812 A MX 2022015812A MX 2022015812 A MX2022015812 A MX 2022015812A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- inhibitors
- cysteine proteases
- compounds
- warheads
- Prior art date
Links
- 102000005927 Cysteine Proteases Human genes 0.000 title 1
- 108010005843 Cysteine Proteases Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 108091005804 Peptidases Proteins 0.000 abstract 2
- 239000004365 Protease Substances 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 102000035195 Peptidases Human genes 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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- A61K31/4164—1,3-Diazoles
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
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- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
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- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
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Abstract
Se proveen compuestos de la Fórmula II con cargas activas ("warheads") y su uso para el tratamiento de enfermedades y trastornos clínicos tales como las infecciones virales; también se proveen composiciones farmacéuticas y métodos para preparar distintos compuestos con carga activa; se observa que los compuestos inhiben proteasas tales como la proteasa tipo 3C, CL- o 3CL.
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Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2021289665A1 (en) | 2020-06-10 | 2022-12-15 | Aligos Therapeutics, Inc. | Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections |
BR112022026899A2 (pt) * | 2020-07-20 | 2023-01-24 | Enanta Pharm Inc | Composto representado pela fórmula (i) ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, método de tratamento ou prevenção de uma infecção por vírus, método de inibição da protease 3c viral ou protease 3cl viral em um mamífero e método de tratamento de um distúrbio respiratório |
US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
WO2022133588A1 (en) * | 2020-12-21 | 2022-06-30 | The Governors Of The University Of Alberta | Rna virus inhibitor compounds and uses thereof |
EP4209494A4 (en) * | 2021-04-16 | 2023-10-04 | Fujian Akeylink Biotechnology Co., Ltd. | SHORT CYCLE-MODIFIED PROLINE PEPTIDE COMPOUND AND USE THEREOF |
WO2022255399A1 (ja) * | 2021-06-01 | 2022-12-08 | 国立研究開発法人理化学研究所 | G9a阻害剤 |
CA3220847A1 (en) * | 2021-06-02 | 2022-12-08 | Long Mao | Protease inhibitors as antivirals |
WO2022266363A1 (en) * | 2021-06-16 | 2022-12-22 | The Scripps Research Institute | Protease inhibitors for the treatment of coronavirus infections |
AU2022306289A1 (en) | 2021-07-09 | 2024-01-18 | Aligos Therapeutics, Inc. | Anti-viral compounds |
WO2023022231A1 (ja) * | 2021-08-20 | 2023-02-23 | 国立大学法人九州大学 | ウイルス感染症を処置または予防するための可逆的共有結合阻害物質 |
CN113698383B (zh) * | 2021-08-26 | 2023-10-13 | 上海药明康德新药开发有限公司 | 一种哌嗪类化合物及其应用 |
WO2023034854A1 (en) * | 2021-08-31 | 2023-03-09 | Pardes Biosciences, Inc. | Crystalline inhibitors of cysteine proteases and methods of use thereof |
WO2023043816A1 (en) * | 2021-09-17 | 2023-03-23 | Aligos Therapeutics, Inc. | Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections |
WO2023044509A1 (en) * | 2021-09-20 | 2023-03-23 | Pardes Biosciences, Inc. | Process for making cysteine protease inhibitors and compounds provided by that process |
WO2023044171A1 (en) * | 2021-09-20 | 2023-03-23 | Pardes Biosciences, Inc. | Inhibitors of cysteine proteases and methods of use thereof |
WO2023078231A1 (en) | 2021-11-02 | 2023-05-11 | Insilico Medicine Ip Limited | Sars-cov-2 inhibitors for treating coronavirus infections |
WO2023086400A1 (en) | 2021-11-12 | 2023-05-19 | Enanta Pharmaceuticals, Inc. | Novel spiropyrrolidine derived antiviral agents |
US11858945B2 (en) | 2021-11-12 | 2024-01-02 | Enanta Pharmaceuticals, Inc. | Alkyne-containing antiviral agents |
WO2023086352A1 (en) | 2021-11-12 | 2023-05-19 | Enanta Pharmaceuticals, Inc. | Novel spiropyrrolidine derived antiviral agents |
CN115806570B (zh) * | 2021-11-15 | 2023-09-12 | 南京知和医药科技有限公司 | 一种拟肽衍生物及其药物组合物和用途 |
WO2023088418A1 (en) * | 2021-11-20 | 2023-05-25 | Fochon Biosciences, Ltd. | Compounds as sars-cov-2 inhibitors |
CN115010639B (zh) * | 2021-12-14 | 2024-03-08 | 上海艾洋化学科技有限公司 | 一种中间体化合物及其制备方法和应用 |
CN117751124A (zh) * | 2021-12-17 | 2024-03-22 | 南京药石科技股份有限公司 | 螺环氧化吲哚类化合物及其用于制备抗病毒蛋白酶抑制剂药物的用途 |
WO2023116734A1 (en) * | 2021-12-21 | 2023-06-29 | Shanghai Micurx Pharmaceutical Co., Ltd. | Fused pyrrolidine compounds and compositions for treatment of respiratory viral infections |
WO2023116811A1 (zh) * | 2021-12-22 | 2023-06-29 | 福建广生中霖生物科技有限公司 | 含β-胺基酮的短肽化合物及其应用 |
WO2023125535A1 (zh) * | 2021-12-28 | 2023-07-06 | 石药集团中奇制药技术(石家庄)有限公司 | 氘代拟肽类化合物及其用途 |
TW202334123A (zh) * | 2021-12-31 | 2023-09-01 | 大陸商蘇州愛科百發生物醫藥技術有限公司 | 用於預防和治療冠狀病毒感染的化合物及其偶聯物和方法 |
WO2023136277A1 (ja) * | 2022-01-12 | 2023-07-20 | 株式会社Preferred Networks | 化合物及びその使用 |
WO2023134730A1 (zh) * | 2022-01-13 | 2023-07-20 | 先声再明医药有限公司 | 一种酰胺类抗病毒化合物 |
US11760722B2 (en) | 2022-01-18 | 2023-09-19 | Ascletis Bioscience Co., Ltd. | Inhibitors of cysteine proteases and methods of use thereof |
CN114230504B (zh) * | 2022-02-24 | 2022-06-03 | 南京桦冠生物技术有限公司 | 一种吡咯烷酮中间体的合成方法 |
CN116768967A (zh) * | 2022-03-07 | 2023-09-19 | 广州谷森制药有限公司 | 氘代内酰胺类化合物及其制备方法、组合物和用途 |
WO2023180189A1 (en) * | 2022-03-23 | 2023-09-28 | Exscientia Ai Limited | Mpro targeting antiviral compounds |
CN114957383A (zh) * | 2022-04-01 | 2022-08-30 | 中国科学院上海药物研究所 | 一种拟肽类化合物及其制备方法、药物组合物和用途 |
WO2023205779A1 (en) * | 2022-04-22 | 2023-10-26 | Pardes Biosciences, Inc. | Process for making cysteine protease inhibitor intermediates |
WO2024079067A1 (en) * | 2022-10-12 | 2024-04-18 | F. Hoffmann-La Roche Ag | Antiviral compounds |
CN115894504A (zh) * | 2022-10-21 | 2023-04-04 | 深圳信立泰药业股份有限公司 | 一种冠状病毒3cl蛋白酶抑制剂及其用途 |
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IL120311A (en) * | 1996-03-01 | 2001-10-31 | Akzo Nobel Nv | Serine protease inhibitors and pharmaceuticals containing them |
ATE479651T1 (de) * | 1997-11-05 | 2010-09-15 | Novartis Pharma Gmbh | Dipeptide nitrile |
EP1218372B1 (en) * | 1999-09-13 | 2003-07-02 | Boehringer Ingelheim Pharmaceuticals, Inc. | Novel heterocyclic compounds useful as reversible inhibitors of cysteine proteases |
AU779855B2 (en) * | 2000-01-06 | 2005-02-17 | Axys Pharmaceuticals, Inc. | Novel compounds and compositions as protease inhibitors |
EP1618127B1 (en) * | 2003-04-10 | 2014-12-10 | Novartis Vaccines and Diagnostics, Inc. | Immunogenic composition comprising a spike protein of the SARS coronavirus |
WO2005113580A1 (en) * | 2004-05-21 | 2005-12-01 | Pfizer Inc. | Anticoronviral compounds and compositions, their pharmaceutical uses and materials for their synthesis |
CN102838523A (zh) * | 2011-06-23 | 2012-12-26 | 南开大学 | 抗肠病毒71(ev71)戊内酰胺类化合物及其制备方法和用途 |
CN110818691A (zh) * | 2018-08-09 | 2020-02-21 | 中国科学院上海药物研究所 | 酮酰胺类化合物及其制备方法、药物组合物和用途 |
CN110105348A (zh) * | 2019-03-08 | 2019-08-09 | 南开大学 | 新型迈克尔受体类肠病毒71型抑制剂的制备及用途 |
CN111135167A (zh) * | 2020-03-05 | 2020-05-12 | 华中农业大学 | GC376在制备新型冠状病毒SARS-CoV-2抑制剂中的应用 |
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