MX2022009094A - Forma de dosificacion solida que tiene excelente estabilidad. - Google Patents

Forma de dosificacion solida que tiene excelente estabilidad.

Info

Publication number
MX2022009094A
MX2022009094A MX2022009094A MX2022009094A MX2022009094A MX 2022009094 A MX2022009094 A MX 2022009094A MX 2022009094 A MX2022009094 A MX 2022009094A MX 2022009094 A MX2022009094 A MX 2022009094A MX 2022009094 A MX2022009094 A MX 2022009094A
Authority
MX
Mexico
Prior art keywords
solid formulation
excellent stability
water
saccharide
flowability
Prior art date
Application number
MX2022009094A
Other languages
English (en)
Inventor
Masaaki Ito
Naoya Mizutani
Masayuki Morimoto
Maki Okabe
Go Kimura
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of MX2022009094A publication Critical patent/MX2022009094A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención puede proporcionar una forma de dosificación sólida que tenga buena estabilidad, capacidad de suspensión en agua y fluidez mediante la preparación de una forma de dosificación sólida que contiene un compuesto representado por la fórmula (I) o una sal farmacéuticamente aceptable del mismo, un estabilizador, un alcohol de azúcar y/o un azúcar, un polímero soluble en agua y una sustancia inorgánica.
MX2022009094A 2018-04-24 2020-10-21 Forma de dosificacion solida que tiene excelente estabilidad. MX2022009094A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2018083006 2018-04-24

Publications (1)

Publication Number Publication Date
MX2022009094A true MX2022009094A (es) 2022-08-18

Family

ID=68295323

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022009094A MX2022009094A (es) 2018-04-24 2020-10-21 Forma de dosificacion solida que tiene excelente estabilidad.

Country Status (11)

Country Link
US (1) US11925648B2 (es)
JP (1) JP6618099B2 (es)
KR (1) KR102501180B1 (es)
CN (1) CN112236146A (es)
AR (1) AR115354A1 (es)
AU (1) AU2019259686B2 (es)
BR (1) BR112020021059B1 (es)
CA (1) CA3098006A1 (es)
MX (1) MX2022009094A (es)
TW (2) TWI788557B (es)
WO (1) WO2019208540A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI795462B (zh) 2017-11-17 2023-03-11 日商鹽野義製藥股份有限公司 光安定性及溶出性優異的醫藥製劑
WO2021230308A1 (ja) 2020-05-15 2021-11-18 塩野義製薬株式会社 不純物の生成を抑制した医薬組成物
CN115551484A (zh) * 2020-06-19 2022-12-30 浙江华海药业股份有限公司 一种法匹拉韦组合物及其制备方法
CN113940918B (zh) * 2020-07-17 2023-06-02 江苏康缘药业股份有限公司 一种药物组合物及制备方法
JP2022108727A (ja) * 2021-01-13 2022-07-26 日曹商事株式会社 フマル酸含有固形製剤
TW202408525A (zh) * 2022-06-27 2024-03-01 太景生物科技股份有限公司 包含帽依賴性核酸內切酶抑制劑的藥物組合物

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09249563A (ja) * 1996-03-11 1997-09-22 Nippon Iyakuhin Kogyo Kk チザニジン含有組成物
FR2759293B1 (fr) * 1997-02-11 1999-04-30 Ethypharm Lab Prod Ethiques Microgranules contenant du cisplatine, procede de fabrication, preparation pharmaceutique et utilisation en polychimiotherapie ou en association avec une radiotherapie
CN100337687C (zh) 1998-05-15 2007-09-19 沃尼尔·朗伯公司 含有γ－氨基丁酸衍生物的固体组合物及其制备方法
DE19831869A1 (de) 1998-07-16 2000-01-20 Merck Patent Gmbh Farbgebung mit Perlglanzpigmenten im Lebensmittel- und Pharmabereich
JP5202856B2 (ja) * 2006-03-06 2013-06-05 富山化学工業株式会社 トシル酸トスフロキサシンを含有する粒状固形製剤
TW200808375A (en) * 2006-05-12 2008-02-16 Otsuka Pharma Co Ltd Hydrogel suspension and manufacturing process thereof
JP2008007420A (ja) 2006-06-27 2008-01-17 Mitsubishi Tanabe Pharma Corp 造粒物
KR100960318B1 (ko) * 2007-08-08 2010-06-04 주식회사 포스코 쌍롤식 박판주조장치의 에지댐 진동조정 장치
EP2213304A1 (en) 2007-10-03 2010-08-04 ASAHI BREWERIES, Ltd. Granule, tablet, and their production methods
JP2010120912A (ja) 2008-11-21 2010-06-03 Lead Chemical Co Ltd ５−メチル−１−フェニル−２−（１ｈ）−ピリドン含有貼付剤
EP2552210B1 (en) * 2010-03-31 2017-12-20 Supernus Pharmaceuticals, Inc. Formulations of mazindol
CA2852912A1 (en) 2011-10-31 2013-05-10 Glaxosmithkline Intellectual Property Limited Pazopanib formulation
JP2016079102A (ja) 2014-10-10 2016-05-16 テバ製薬株式会社 ソリフェナシン含有製剤
CN113004304B (zh) * 2015-04-28 2022-03-18 盐野义制药株式会社 经取代的多环性吡啶酮衍生物及其前药
LT4219508T (lt) * 2015-04-28 2024-08-26 Shionogi & Co., Ltd Pakeistas policiklinis piridono darinys ir jo provaistas
SG11201804348SA (en) 2015-12-15 2018-06-28 Shionogi & Co Medicine for treating influenza characterized by comprising combination of cap-dependent endonuclease inhibitor with anti-influenza drug
EP3473629B1 (en) 2016-06-20 2022-11-16 Shionogi & Co., Ltd. Method for producing substituted polycyclic pyridone derivative and crystal of same
BR112019001911A2 (pt) * 2016-08-10 2019-05-07 Shionogi & Co., Ltd. derivado de piridona policíclica substituída e pró-fármaco contendo composição farmacêutica do mesmo
SG11202002789XA (en) 2017-10-06 2020-04-29 Shionogi & Co Stereoselective process for preparing substituted polycyclic pyridone derivatives
TWI795462B (zh) * 2017-11-17 2023-03-11 日商鹽野義製藥股份有限公司 光安定性及溶出性優異的醫藥製劑
CN108440564B (zh) * 2018-04-11 2019-08-06 安帝康（无锡）生物科技有限公司 被取代的多环氨基甲酰基吡啶酮衍生物及其前药

Also Published As

Publication number Publication date
TW202000206A (zh) 2020-01-01
AU2019259686B2 (en) 2023-05-25
KR102501180B1 (ko) 2023-02-21
JP2019189635A (ja) 2019-10-31
TWI788557B (zh) 2023-01-01
US11925648B2 (en) 2024-03-12
AU2019259686A1 (en) 2020-10-29
US20210106589A1 (en) 2021-04-15
TW202313057A (zh) 2023-04-01
JP6618099B2 (ja) 2019-12-11
TWI822498B (zh) 2023-11-11
CA3098006A1 (en) 2019-10-31
KR20200144127A (ko) 2020-12-28
AR115354A1 (es) 2020-12-23
BR112020021059A2 (pt) 2021-02-17
WO2019208540A1 (ja) 2019-10-31
CN112236146A (zh) 2021-01-15
BR112020021059B1 (pt) 2022-08-30

Similar Documents

Publication Publication Date Title
MX2022009094A (es) Forma de dosificacion solida que tiene excelente estabilidad.
TN2018000395A1 (en) New (hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them
WO2018121559A8 (zh) 甘露糖醛二酸的组合物
WO2019165043A3 (en) Indane-amines as pd-l1 antagonists
WO2018042362A9 (en) Muscarinic m1 receptor positive allosteric modulators
BRPI0814957B8 (pt) composto, agente farmacêutico, e, uso do composto
MX2020009530A (es) Inhibidores de la o-glicoproteína-2-acetamido-2-desoxi-3-dglicopir anosidasa.
WO2019120234A3 (zh) 作为溴结构域蛋白质抑制剂的化合物和组合物
MX2018009459A (es) Derivado de sulfonamida y composicion farmaceutica que contiene el mismo.
DK2046292T3 (da) Formuleringer for benzimidazolylpyridylethere
EP3995489A3 (en) Disulfide compounds for delivery of pharmaceutical agents
ZA202006377B (en) Boronic acid derivatives and therapeutic uses thereof
CA3042181C (en) Pharmaceutical composition for preventing and treating nonalcoholic steatohepatitis, hepatic fibrosis, and liver cirrhosis, comprising adenosine derivatives
EP4041734A4 (en) NOVEL DERIVATIVES WITH 1,2,3,4-TETRAHYDRONAPTHALENE UNIT OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
MX2022001789A (es) Derivados de 2-hidroxicicloalcan-1-carbamoilo.
MX2021014680A (es) Derivado de benzotriazol.
EP3760195A4 (en) COMPOSITION WITH 2,3-BUTANEDIOL AS THE ACTIVE SUBSTANCE
PH12020552186A1 (en) Cyanotriazole compounds and uses thereof
CL2022000723A1 (es) Composiciones de recubrimiento de semillas
MX2020011130A (es) Forma de dosificacion solida que tiene excelente estabilidad.
SA522431777B1 (ar) مشتقات ألفا -d- جالاكتو بيرانوسيد
MX2020011664A (es) Formulacion vaporizable.
MX2022005951A (es) Compuestos de pirrolotriazina que actuan como inhibidor de mnk.
EP4286007A3 (en) Pharmaceutical formulation
UA118581C2 (uk) Зволожувальні агенти