MX2022008843A - Metodos para tratar cancer con inhibidores de farnesiltransferasa. - Google Patents

Metodos para tratar cancer con inhibidores de farnesiltransferasa.

Info

Publication number
MX2022008843A
MX2022008843A MX2022008843A MX2022008843A MX2022008843A MX 2022008843 A MX2022008843 A MX 2022008843A MX 2022008843 A MX2022008843 A MX 2022008843A MX 2022008843 A MX2022008843 A MX 2022008843A MX 2022008843 A MX2022008843 A MX 2022008843A
Authority
MX
Mexico
Prior art keywords
methods
treating cancer
farnesyltransferase inhibitors
fti
farnesyltransferase
Prior art date
Application number
MX2022008843A
Other languages
English (en)
Inventor
Antonio Gualberto
Catherine Rose Scholz
Original Assignee
Kura Oncology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/820,012 external-priority patent/US10137121B2/en
Application filed by Kura Oncology Inc filed Critical Kura Oncology Inc
Publication of MX2022008843A publication Critical patent/MX2022008843A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención se refiere al campo de la terapia contra el cáncer. Específicamente, se proporcionan métodos para tratar el cáncer, por ejemplo, el linfoma de células T periférico ("PTCL"), con un inhibidor de farnesiltransferasa (FTI) que incluyen determinar si el sujeto puede responder al tratamiento con FTI en función de las características de expresión génica.
MX2022008843A 2017-02-21 2019-08-16 Metodos para tratar cancer con inhibidores de farnesiltransferasa. MX2022008843A (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201762461602P 2017-02-21 2017-02-21
US201762507749P 2017-05-17 2017-05-17
US201762519819P 2017-06-14 2017-06-14
US15/820,012 US10137121B2 (en) 2017-02-21 2017-11-21 Methods of treating cancer with farnesyltransferase inhibitors
US15/820,157 US9956215B1 (en) 2017-02-21 2017-11-21 Methods of treating cancer with farnesyltransferase inhibitors
US201762596653P 2017-12-08 2017-12-08

Publications (1)

Publication Number Publication Date
MX2022008843A true MX2022008843A (es) 2022-08-10

Family

ID=63253363

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2019009821A MX2019009821A (es) 2017-02-21 2018-02-21 Metodos para tratar cancer con inhibidores de farnesiltransferasa.
MX2022008843A MX2022008843A (es) 2017-02-21 2019-08-16 Metodos para tratar cancer con inhibidores de farnesiltransferasa.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2019009821A MX2019009821A (es) 2017-02-21 2018-02-21 Metodos para tratar cancer con inhibidores de farnesiltransferasa.

Country Status (14)

Country Link
EP (3) EP3542800B1 (es)
JP (1) JP7289795B2 (es)
KR (3) KR102003179B1 (es)
CN (4) CN114796218A (es)
AU (3) AU2018225566B2 (es)
BR (1) BR112019017375A2 (es)
CA (1) CA3053795A1 (es)
ES (2) ES2892157T3 (es)
IL (1) IL268722A (es)
MX (2) MX2019009821A (es)
PH (1) PH12019501918A1 (es)
SG (1) SG11201907594TA (es)
TW (3) TWI663974B (es)
WO (1) WO2018156609A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10137121B2 (en) 2017-02-21 2018-11-27 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
TW202108170A (zh) * 2019-03-15 2021-03-01 美商庫拉腫瘤技術股份有限公司 以法呢基轉移酶(farnesyltransferase)抑制劑治療癌症患者之方法

Family Cites Families (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US4018653A (en) 1971-10-29 1977-04-19 U.S. Packaging Corporation Instrument for the detection of Neisseria gonorrhoeae without culture
GB1429184A (en) 1972-04-20 1976-03-24 Allen & Hanburys Ltd Physically anti-inflammatory steroids for use in aerosols
US4044126A (en) 1972-04-20 1977-08-23 Allen & Hanburys Limited Steroidal aerosol compositions and process for the preparation thereof
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4016043A (en) 1975-09-04 1977-04-05 Akzona Incorporated Enzymatic immunological method for the determination of antigens and antibodies
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US4328245A (en) 1981-02-13 1982-05-04 Syntex (U.S.A.) Inc. Carbonate diester solutions of PGE-type compounds
US4410545A (en) 1981-02-13 1983-10-18 Syntex (U.S.A.) Inc. Carbonate diester solutions of PGE-type compounds
US4409239A (en) 1982-01-21 1983-10-11 Syntex (U.S.A.) Inc. Propylene glycol diester solutions of PGE-type compounds
US4424279A (en) 1982-08-12 1984-01-03 Quidel Rapid plunger immunoassay method and apparatus
KR890002631B1 (ko) 1984-10-04 1989-07-21 몬산토 캄파니 생물학적으로 활성인 소마토트로핀을 지속적으로 유리하는 조성물
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US5310652A (en) 1986-08-22 1994-05-10 Hoffman-La Roche Inc. Reverse transcription with thermostable DNA polymerase-high temperature reverse transcription
US5322770A (en) 1989-12-22 1994-06-21 Hoffman-Laroche Inc. Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription
US5693517A (en) 1987-06-17 1997-12-02 Roche Molecular Systems, Inc. Reagents and methods for coupled high temperature reverse transcription and polymerase chain reactions
US5561058A (en) 1986-08-22 1996-10-01 Hoffmann-La Roche Inc. Methods for coupled high temperatures reverse transcription and polymerase chain reactions
WO1989001050A1 (en) 1987-07-31 1989-02-09 The Board Of Trustees Of The Leland Stanford Junior University Selective amplification of target polynucleotide sequences
US5033252A (en) 1987-12-23 1991-07-23 Entravision, Inc. Method of packaging and sterilizing a pharmaceutical product
US5052558A (en) 1987-12-23 1991-10-01 Entravision, Inc. Packaged pharmaceutical product
CA1340807C (en) 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
US4870287A (en) 1988-03-03 1989-09-26 Loma Linda University Medical Center Multi-station proton beam therapy system
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
IT1229203B (it) 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
PH30995A (en) 1989-07-07 1997-12-23 Novartis Inc Sustained release formulations of water soluble peptides.
CA2020958C (en) 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
IL100040A (en) 1990-11-13 1995-12-31 Siska Diagnostics Inc Amplification of nucleic acids by replicating a self-sustaining enzymatic sequence
US5455166A (en) 1991-01-31 1995-10-03 Becton, Dickinson And Company Strand displacement amplification
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
DE69330750T2 (de) 1992-03-04 2002-07-04 Univ California Vergleichende genomhybridisierung
US5323907A (en) 1992-06-23 1994-06-28 Multi-Comp, Inc. Child resistant package assembly for dispensing pharmaceutical medications
US5686472A (en) 1992-10-29 1997-11-11 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
TW333456B (en) 1992-12-07 1998-06-11 Takeda Pharm Ind Co Ltd A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
US6087324A (en) 1993-06-24 2000-07-11 Takeda Chemical Industries, Ltd. Sustained-release preparation
IT1270594B (it) 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
US5491063A (en) 1994-09-01 1996-02-13 Hoffmann-La Roche Inc. Methods for in-solution quenching of fluorescently labeled oligonucleotide probes
US5571673A (en) 1994-11-23 1996-11-05 Hoffmann-La Roche Inc. Methods for in-solution quenching of fluorescently labeled oligonucleotide probes
CA2224381A1 (en) 1995-06-27 1997-01-16 Takeda Chemical Industries, Ltd. Method of producing sustained-release preparation
TW448055B (en) 1995-09-04 2001-08-01 Takeda Chemical Industries Ltd Method of production of sustained-release preparation
JP2909418B2 (ja) 1995-09-18 1999-06-23 株式会社資生堂 薬物の遅延放出型マイクロスフイア
US5874442A (en) 1995-12-22 1999-02-23 Schering-Plough Corporation Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease
US5980945A (en) 1996-01-16 1999-11-09 Societe De Conseils De Recherches Et D'applications Scientifique S.A. Sustained release drug formulations
US6011029A (en) 1996-02-26 2000-01-04 Bristol-Myers Squibb Company Inhibitors of farnesyl protein transferase
US5760395A (en) 1996-04-18 1998-06-02 Universities Research Assoc., Inc. Method and apparatus for laser-controlled proton beam radiology
US6264970B1 (en) 1996-06-26 2001-07-24 Takeda Chemical Industries, Ltd. Sustained-release preparation
US6419961B1 (en) 1996-08-29 2002-07-16 Takeda Chemical Industries, Ltd. Sustained release microcapsules of a bioactive substance and a biodegradable polymer
CA2217134A1 (en) 1996-10-09 1998-04-09 Sumitomo Pharmaceuticals Co., Ltd. Sustained release formulation
CA2219698C (en) 1996-10-31 2007-09-04 Takeda Chemical Industries, Ltd. Sustained-release preparation
ATE233088T1 (de) 1996-12-20 2003-03-15 Takeda Chemical Industries Ltd Verfahren zur herstellung einer zusammensetzung mit verzoegerter abgabe
ATE252104T1 (de) 1996-12-20 2003-11-15 Tovarischestvo S Ogranichennoi Verfahren und gerät zur herstellung von 1ss, 10ss-epoxy-13-dimethylamino-guaia-3(4)-en-6,12- lid- hydrochlorid
US5891474A (en) 1997-01-29 1999-04-06 Poli Industria Chimica, S.P.A. Time-specific controlled release dosage formulations and method of preparing same
EP1048301A4 (en) 1998-01-16 2005-03-09 Takeda Chemical Industries Ltd COMPOSITIONS WITH DELAYED ACTIVE INGREDIENTS, PROCESS FOR THEIR PREPARATION AND THEIR USE
TR200002556T2 (tr) 1998-03-05 2000-11-21 Formula One Administration Limited Veri iletişim sistemi
US6613358B2 (en) 1998-03-18 2003-09-02 Theodore W. Randolph Sustained-release composition including amorphous polymer
KR19990085365A (ko) 1998-05-16 1999-12-06 허영섭 지속적으로 약물 조절방출이 가능한 생분해성 고분자 미립구 및그 제조방법
WO2000001691A1 (en) 1998-07-01 2000-01-13 Merck & Co., Inc. Process for making farnesyl-protein transferase inhibitors
EA003877B1 (ru) 1998-07-06 2003-10-30 Янссен Фармацевтика Н.В. Ингибиторы фарнезилпротеинтрансферазы, обладающие in vivo радиосенсибилизирующими свойствами
OA11645A (en) 1998-08-27 2004-11-16 Pfizer Prod Inc Alkynyl-substituted quinolin-2-one derivatives useful as anticancer agents.
CA2341739C (en) 1998-08-27 2005-07-12 Pfizer Products Inc. Quinolin-2-one derivatives useful as anticancer agents
US6927024B2 (en) 1998-11-30 2005-08-09 Genentech, Inc. PCR assay
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US7186507B2 (en) 1999-12-09 2007-03-06 Indiana University Research And Technology Corporation Fluorescent in situ RT-PCR
US6838467B2 (en) 2000-02-24 2005-01-04 Janssen Pharmaceutica N. V. Dosing regimen
CN100523216C (zh) 2001-03-02 2009-08-05 匹兹堡大学 Pcr方法
US7122799B2 (en) 2003-12-18 2006-10-17 Palo Alto Research Center Incorporated LED or laser enabled real-time PCR system and spectrophotometer
WO2006036892A2 (en) * 2004-09-24 2006-04-06 Sapphire Therapeutics, Inc. Use of inhibitors of 24-hydroxylase in the treatment of cancer
JP5225092B2 (ja) * 2005-10-14 2013-07-03 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ チピファルニブの新規ｉｖ調合物
US8603477B2 (en) * 2008-10-31 2013-12-10 Abbvie Biotherapeutics Inc. Use of anti-CS1 antibodies for treatment of rare lymphomas
WO2010088401A1 (en) * 2009-01-30 2010-08-05 Genzyme Corporation Methods and compositions for treating breast cancer
CN103328971B (zh) * 2010-07-28 2016-09-28 维里德克斯有限责任公司 急性髓细胞性白血病应答法尼基转移酶抑制剂治疗的测定方法
EP2476441A1 (en) * 2011-01-13 2012-07-18 Universitat Autònoma De Barcelona Methods and reagents for efficient and targeted delivery of therapeutic molecules to CXCR4 cells
HUE043001T2 (hu) * 2011-11-09 2019-07-29 Bristol Myers Squibb Co Hematológiai malignómák kezelése anti-CXCR4 antitesttel
CN103787907B (zh) * 2014-02-17 2015-05-27 华东理工大学 作为法尼基转移酶抑制剂的苯胺类化合物及其用途
US20190119758A1 (en) * 2016-04-22 2019-04-25 Kura Oncology, Inc. Methods of selecting cancer patients for treatment with farnesyltransferase inhibitors

Also Published As

Publication number Publication date
AU2018225566B2 (en) 2019-11-07
EP3542800B1 (en) 2022-06-01
JP7289795B2 (ja) 2023-06-12
PH12019501918A1 (en) 2020-06-01
EP3432883A1 (en) 2019-01-30
KR102138904B1 (ko) 2020-07-28
CN114796218A (zh) 2022-07-29
AU2019203548B2 (en) 2019-08-15
JP2020508351A (ja) 2020-03-19
ES2927228T3 (es) 2022-11-03
TWI693074B (zh) 2020-05-11
TW201834652A (zh) 2018-10-01
TWI738314B (zh) 2021-09-01
AU2019203548A1 (en) 2019-06-13
AU2019203548C1 (en) 2020-01-23
IL268722A (en) 2019-10-31
ES2892157T3 (es) 2022-02-02
WO2018156609A1 (en) 2018-08-30
CN109475550A (zh) 2019-03-15
EP3542800A1 (en) 2019-09-25
TW201929903A (zh) 2019-08-01
CN109999037A (zh) 2019-07-12
CN114712354A (zh) 2022-07-08
AU2018225566A1 (en) 2018-11-08
EP3432883B1 (en) 2021-07-28
KR102003179B1 (ko) 2019-07-23
KR20200090982A (ko) 2020-07-29
EP4119142A1 (en) 2023-01-18
CA3053795A1 (en) 2018-08-30
SG11201907594TA (en) 2019-09-27
BR112019017375A2 (pt) 2020-03-31
KR20180123723A (ko) 2018-11-19
TW202031260A (zh) 2020-09-01
KR20190087661A (ko) 2019-07-24
TWI663974B (zh) 2019-07-01
AU2019246922A1 (en) 2019-10-31
MX2019009821A (es) 2019-12-02

Similar Documents

Publication Publication Date Title
PH12018500322A1 (en) Methods of treating cancer patients with farnesyltransferase inhibitors
PH12018502355A1 (en) Enzyme inhibitors
PH12018501268A1 (en) Compounds useful as kinase inhibitors
MX2022001757A (es) Inhibidores de muerte programada 1 (pd-19)/ligando de muerte programada 1 (pd-l1) para el tratamiento de cancer.
PH12018500587A1 (en) Pyrazolopyrimidine derivatives as btk inhibitors for the treatment of cancer
MX2018014435A (es) Inhibidores de muerte programada 1 (pd-1) ligando de muerte programada (pd-l1) para el tratamiento de cancer.
MX2017005929A (es) Terapia de combinacion con agonistas de unión ox40 e inhibidores de tigit.
EA201890961A1 (ru) Комбинированная терапия для лечения злокачественных новообразований
EP4252851A3 (en) Ezh2 inhibitors for treating lymphoma
MX2016016364A (es) Terapia de combinacion con inhibidores de glutaminasa.
MX2016002075A (es) Inhibidores de indolamina 2,3-dioxigenasa (ido).
EA201791736A1 (ru) Комбинированная терапия для лечения рака
MY190411A (en) Improved uricase sequences and methods of treatment
BR112017026201A2 (pt) inibidores de mir-155 para o tratamento de linfoma cutâneo de células t (ctcl)
PH12019500927A1 (en) Farnesyltransferase inhibitors for use in methods of treating cancer
MX2019008233A (es) Nanoconjugados de doxorrubicina y oro dirigidos para terapia tumoral.
PH12019501918A1 (en) Methods of treating cancer with farnesyltransferase inhibitors
NZ740817A (en) Pcna inhibitors
MX2019003603A (es) Terapia de combinacion con un inhibidor de mek, un inhibidor del eje pd-1 y un taxano.
MX2016004212A (es) Inhibidor de tor cinasa en la prevencion o tratamiento de cancer caracterizado por mutaciones genicas.
MX2020012782A (es) Inhibidor de ccr5 para el uso en el tratamiento de cancer.
MX2023011202A (es) Agonistas de receptores alfa de ácido retinoico (rara) para el tratamiento de leucemia mieloide aguda (aml) y síndrome mielodisplásico (mds).
EA201991986A1 (ru) Способы лечения рака ингибиторами фарнезилтрансферазы
AR109498A1 (es) Tratamiento de carcinomas de células escamosas con inhibidores de erk
NZ779757A (en) Pcna inhibitors