MX2023011202A - Agonistas de receptores alfa de ácido retinoico (rara) para el tratamiento de leucemia mieloide aguda (aml) y síndrome mielodisplásico (mds). - Google Patents

Agonistas de receptores alfa de ácido retinoico (rara) para el tratamiento de leucemia mieloide aguda (aml) y síndrome mielodisplásico (mds).

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Publication number
MX2023011202A
MX2023011202A MX2023011202A MX2023011202A MX2023011202A MX 2023011202 A MX2023011202 A MX 2023011202A MX 2023011202 A MX2023011202 A MX 2023011202A MX 2023011202 A MX2023011202 A MX 2023011202A MX 2023011202 A MX2023011202 A MX 2023011202A
Authority
MX
Mexico
Prior art keywords
treatment
rara agonists
mds
aml
rara
Prior art date
Application number
MX2023011202A
Other languages
English (en)
Inventor
Matthew Lucas Eaton
Christopher Fiore
Emily Payton Lee
Christian Fritz
Michael Robert Mckeown
Original Assignee
Syros Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syros Pharmaceuticals Inc filed Critical Syros Pharmaceuticals Inc
Publication of MX2023011202A publication Critical patent/MX2023011202A/es

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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)

Abstract

Se describen en la presente métodos que definen poblaciones celulares que son sensibles a agonistas RARA y que identifican poblaciones de pacientes que se beneficiarán del tratamiento con agonistas RARA. El método puede comprender administrar agonistas RARA a poblaciones de pacientes.
MX2023011202A 2016-04-08 2018-10-05 Agonistas de receptores alfa de ácido retinoico (rara) para el tratamiento de leucemia mieloide aguda (aml) y síndrome mielodisplásico (mds). MX2023011202A (es)

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MX2023011202A MX2023011202A (es) 2016-04-08 2018-10-05 Agonistas de receptores alfa de ácido retinoico (rara) para el tratamiento de leucemia mieloide aguda (aml) y síndrome mielodisplásico (mds).

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BR122023024814A2 (pt) 2015-03-31 2024-02-20 Syros Pharmaceuticals, Inc. Método ex vivo de previsão da eficácia de tamibaroteno, ou um sal farmaceuticamente aceitável do mesmo
US9868994B2 (en) 2016-04-08 2018-01-16 Syros Pharmaceuticals, Inc. Methods of stratifying patients for treatment with retinoic acid receptor-α agonists

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3580134D1 (de) 1984-07-07 1990-11-22 Shudo Koichi Prof Dr Chem Benzoesaeurederivate.
US5089509A (en) 1988-09-15 1992-02-18 Allergan, Inc. Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity
JP2752630B2 (ja) 1988-03-29 1998-05-18 大鵬薬品工業株式会社 新規安息香酸誘導体及びその製造方法
US5759785A (en) 1992-05-14 1998-06-02 Baylor College Of Medicine Method of identifying hormone antagonists and agonists
US5455265A (en) 1993-02-11 1995-10-03 Allergan, Inc. Method of treatment with compounds having selective agonist-like activity on RXR retinoid receptors
US5824685A (en) 1995-02-01 1998-10-20 The Johns Hopkins University School Of Medicine Method of preventing proliferation of retinal pigment epithelium by retinoic acid receptor agonists
FR2739777B1 (fr) 1995-10-11 1997-11-14 Cird Galderma Ligand antagoniste rar-gamma ou agoniste rar-alpha en tant qu'inhibiteur d'apoptose
US5675024A (en) 1995-11-22 1997-10-07 Allergan Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4,-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity
US5965606A (en) 1995-12-29 1999-10-12 Allergan Sales, Inc. Methods of treatment with compounds having RAR.sub.α receptor specific or selective activity
HUP9902645A3 (en) 1996-03-18 1999-12-28 Eisai Co Ltd Fused-ring carboxylic acid derivatives
US5919970A (en) 1997-04-24 1999-07-06 Allergan Sales, Inc. Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity
US6355669B1 (en) 1997-10-22 2002-03-12 Eisai Co., Ltd. Retinoic acid agonists as preventive and therapeutic agents for nephritis
TWI281911B (en) 2000-04-04 2007-06-01 Allergan Inc Treatment of tumors with RARalpha selective retinoid compounds in combination with other anti-tumor agents
US20090117203A1 (en) * 2006-03-23 2009-05-07 Tmrc Co., Ltd. Kit for cancer treatment and pharmaceutical composition for cancer treatment
WO2008017025A2 (en) * 2006-08-02 2008-02-07 Genzyme Corporation Combination therapy
EP2143428B1 (en) 2007-03-30 2015-11-04 TMRC Co., Ltd. Tamibarotene capsule preparation
JP2010202553A (ja) * 2009-03-02 2010-09-16 Unitika Ltd レチノイン酸受容体（ｒａｒ）活性化剤
JP5748653B2 (ja) * 2009-04-10 2015-07-15 協和発酵キリン株式会社 抗ｔｉｍ−３抗体を用いた血液腫瘍治療法
US20140296218A1 (en) 2012-10-25 2014-10-02 Whitehead Institute For Biomedical Research Super-enhancers and methods of use thereof
WO2015085172A2 (en) * 2013-12-06 2015-06-11 Celgene Corporation Methods for determining drug efficacy for the treatment of diffuse large b-cell lymphoma, multiple myeloma, and myeloid cancers
WO2015101618A1 (en) * 2013-12-30 2015-07-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Combination of an arsenic compound and at least one retinoid for treating acute myeloid leukemia
JP6367038B2 (ja) * 2014-07-31 2018-08-01 学校法人近畿大学 受容体の細胞内輸送制御による白血病治療のための新規医薬組成物
EP3267969A1 (en) * 2015-03-09 2018-01-17 King's College London Combination therapy with rar alpha agonists for enhancing th1 response
BR122023024814A2 (pt) * 2015-03-31 2024-02-20 Syros Pharmaceuticals, Inc. Método ex vivo de previsão da eficácia de tamibaroteno, ou um sal farmaceuticamente aceitável do mesmo
WO2017091762A1 (en) * 2015-11-25 2017-06-01 Io Therapeutics, Inc. Use of cyp26-resistant rar alpha selective agonists in the treatment of cancer

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MX2018012250A (es) 2019-06-24
AU2017248187A1 (en) 2018-11-01
IL262156B2 (en) 2024-03-01
KR20220148926A (ko) 2022-11-07
KR20180132841A (ko) 2018-12-12
JP2023057151A (ja) 2023-04-20
EP3452032B1 (en) 2024-09-04
JP2021185171A (ja) 2021-12-09
CN109310657A (zh) 2019-02-05
EP3452032A1 (en) 2019-03-13
IL307615A (en) 2023-12-01
AU2023203040A1 (en) 2023-06-08
CA3020173A1 (en) 2017-10-12
IL262156B1 (en) 2023-11-01
IL262156A (en) 2018-11-29
JP7284224B2 (ja) 2023-05-30
RU2018135302A (ru) 2020-05-12
WO2017177167A1 (en) 2017-10-12
WO2017177167A4 (en) 2017-12-21
JP2019513758A (ja) 2019-05-30
CN115737821A (zh) 2023-03-07
AU2017248187B2 (en) 2023-03-16
RU2018135302A3 (es) 2020-11-06
CN115737821B (zh) 2024-04-12
US20240102106A1 (en) 2024-03-28
CN109310657B (zh) 2022-12-13
KR102457851B1 (ko) 2022-10-25
JP7034085B2 (ja) 2022-03-11
BR112018070547A2 (pt) 2019-02-12

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