MX2018012250A - Agonistas de los receptores de acido retinoico alfa (rara) para el tratamiento de leucemia mieloide aguda (aml) y sindrome mielodisplasico (mds). - Google Patents

Agonistas de los receptores de acido retinoico alfa (rara) para el tratamiento de leucemia mieloide aguda (aml) y sindrome mielodisplasico (mds).

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Publication number
MX2018012250A
MX2018012250A MX2018012250A MX2018012250A MX2018012250A MX 2018012250 A MX2018012250 A MX 2018012250A MX 2018012250 A MX2018012250 A MX 2018012250A MX 2018012250 A MX2018012250 A MX 2018012250A MX 2018012250 A MX2018012250 A MX 2018012250A
Authority
MX
Mexico
Prior art keywords
treatment
rara agonists
mds
aml
rara
Prior art date
Application number
MX2018012250A
Other languages
English (en)
Inventor
Lucas EATON Matthew
Robert MICKEOWN Michael
Fiore Christopher
Payton Lee Emily
Fritz Christian
Original Assignee
Syros Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syros Pharmaceuticals Inc filed Critical Syros Pharmaceuticals Inc
Publication of MX2018012250A publication Critical patent/MX2018012250A/es

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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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Abstract

Se describen en la presente métodos que definen poblaciones celulares que son sensibles a agonistas RARA y que identifican poblaciones de pacientes que se beneficiarán del tratamiento con agonistas RARA. El método puede comprender administrar agonistas RARA a poblaciones de pacientes.
MX2018012250A 2016-04-08 2017-04-07 Agonistas de los receptores de acido retinoico alfa (rara) para el tratamiento de leucemia mieloide aguda (aml) y sindrome mielodisplasico (mds). MX2018012250A (es)

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US201662320352P 2016-04-08 2016-04-08
PCT/US2017/026657 WO2017177167A1 (en) 2016-04-08 2017-04-07 Rara agonists for the treatment of aml and mds

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MX2023011202A MX2023011202A (es) 2016-04-08 2018-10-05 Agonistas de receptores alfa de ácido retinoico (rara) para el tratamiento de leucemia mieloide aguda (aml) y síndrome mielodisplásico (mds).

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US9868994B2 (en) 2016-04-08 2018-01-16 Syros Pharmaceuticals, Inc. Methods of stratifying patients for treatment with retinoic acid receptor-α agonists

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JP7034085B2 (ja) 2022-03-11
CN109310657A (zh) 2019-02-05
BR112018070547A2 (pt) 2019-02-12
KR20180132841A (ko) 2018-12-12
CN115737821B (zh) 2024-04-12
CN109310657B (zh) 2022-12-13
IL262156A (en) 2018-11-29
JP2023057151A (ja) 2023-04-20
IL262156B1 (en) 2023-11-01
AU2023203040A1 (en) 2023-06-08
AU2017248187A1 (en) 2018-11-01
RU2018135302A3 (es) 2020-11-06
WO2017177167A4 (en) 2017-12-21
JP2019513758A (ja) 2019-05-30
IL307615A (en) 2023-12-01
US20240102106A1 (en) 2024-03-28
KR102457851B1 (ko) 2022-10-25
KR20220148926A (ko) 2022-11-07
WO2017177167A1 (en) 2017-10-12
AU2017248187B2 (en) 2023-03-16
CN115737821A (zh) 2023-03-07
JP7284224B2 (ja) 2023-05-30
CA3020173A1 (en) 2017-10-12
IL262156B2 (en) 2024-03-01
MX2023011202A (es) 2023-10-02
EP3452032B1 (en) 2024-09-04
EP3452032A1 (en) 2019-03-13
JP2021185171A (ja) 2021-12-09

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