MX2018012250A - Agonistas de los receptores de acido retinoico alfa (rara) para el tratamiento de leucemia mieloide aguda (aml) y sindrome mielodisplasico (mds). - Google Patents
Agonistas de los receptores de acido retinoico alfa (rara) para el tratamiento de leucemia mieloide aguda (aml) y sindrome mielodisplasico (mds).Info
- Publication number
- MX2018012250A MX2018012250A MX2018012250A MX2018012250A MX2018012250A MX 2018012250 A MX2018012250 A MX 2018012250A MX 2018012250 A MX2018012250 A MX 2018012250A MX 2018012250 A MX2018012250 A MX 2018012250A MX 2018012250 A MX2018012250 A MX 2018012250A
- Authority
- MX
- Mexico
- Prior art keywords
- treatment
- rara agonists
- mds
- aml
- rara
- Prior art date
Links
- 239000000556 agonist Substances 0.000 title abstract 4
- 230000001413 cellular effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
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Abstract
Se describen en la presente métodos que definen poblaciones celulares que son sensibles a agonistas RARA y que identifican poblaciones de pacientes que se beneficiarán del tratamiento con agonistas RARA. El método puede comprender administrar agonistas RARA a poblaciones de pacientes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662320352P | 2016-04-08 | 2016-04-08 | |
PCT/US2017/026657 WO2017177167A1 (en) | 2016-04-08 | 2017-04-07 | Rara agonists for the treatment of aml and mds |
Publications (1)
Publication Number | Publication Date |
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MX2018012250A true MX2018012250A (es) | 2019-06-24 |
Family
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Application Number | Title | Priority Date | Filing Date |
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MX2018012250A MX2018012250A (es) | 2016-04-08 | 2017-04-07 | Agonistas de los receptores de acido retinoico alfa (rara) para el tratamiento de leucemia mieloide aguda (aml) y sindrome mielodisplasico (mds). |
MX2023011202A MX2023011202A (es) | 2016-04-08 | 2018-10-05 | Agonistas de receptores alfa de ácido retinoico (rara) para el tratamiento de leucemia mieloide aguda (aml) y síndrome mielodisplásico (mds). |
Family Applications After (1)
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MX2023011202A MX2023011202A (es) | 2016-04-08 | 2018-10-05 | Agonistas de receptores alfa de ácido retinoico (rara) para el tratamiento de leucemia mieloide aguda (aml) y síndrome mielodisplásico (mds). |
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US (1) | US20240102106A1 (es) |
EP (1) | EP3452032B1 (es) |
JP (3) | JP7034085B2 (es) |
KR (2) | KR102457851B1 (es) |
CN (2) | CN115737821B (es) |
AU (2) | AU2017248187B2 (es) |
BR (1) | BR112018070547A2 (es) |
CA (1) | CA3020173A1 (es) |
IL (2) | IL307615A (es) |
MX (2) | MX2018012250A (es) |
WO (1) | WO2017177167A1 (es) |
Families Citing this family (2)
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BR122023024814A2 (pt) | 2015-03-31 | 2024-02-20 | Syros Pharmaceuticals, Inc. | Método ex vivo de previsão da eficácia de tamibaroteno, ou um sal farmaceuticamente aceitável do mesmo |
US9868994B2 (en) | 2016-04-08 | 2018-01-16 | Syros Pharmaceuticals, Inc. | Methods of stratifying patients for treatment with retinoic acid receptor-α agonists |
Family Cites Families (25)
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DE3580134D1 (de) | 1984-07-07 | 1990-11-22 | Shudo Koichi Prof Dr Chem | Benzoesaeurederivate. |
US5089509A (en) | 1988-09-15 | 1992-02-18 | Allergan, Inc. | Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity |
JP2752630B2 (ja) | 1988-03-29 | 1998-05-18 | 大鵬薬品工業株式会社 | 新規安息香酸誘導体及びその製造方法 |
US5759785A (en) | 1992-05-14 | 1998-06-02 | Baylor College Of Medicine | Method of identifying hormone antagonists and agonists |
US5455265A (en) | 1993-02-11 | 1995-10-03 | Allergan, Inc. | Method of treatment with compounds having selective agonist-like activity on RXR retinoid receptors |
US5824685A (en) | 1995-02-01 | 1998-10-20 | The Johns Hopkins University School Of Medicine | Method of preventing proliferation of retinal pigment epithelium by retinoic acid receptor agonists |
FR2739777B1 (fr) | 1995-10-11 | 1997-11-14 | Cird Galderma | Ligand antagoniste rar-gamma ou agoniste rar-alpha en tant qu'inhibiteur d'apoptose |
US5675024A (en) | 1995-11-22 | 1997-10-07 | Allergan | Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4,-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity |
US5965606A (en) | 1995-12-29 | 1999-10-12 | Allergan Sales, Inc. | Methods of treatment with compounds having RAR.sub.α receptor specific or selective activity |
HUP9902645A3 (en) | 1996-03-18 | 1999-12-28 | Eisai Co Ltd | Fused-ring carboxylic acid derivatives |
US5919970A (en) | 1997-04-24 | 1999-07-06 | Allergan Sales, Inc. | Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity |
US6355669B1 (en) | 1997-10-22 | 2002-03-12 | Eisai Co., Ltd. | Retinoic acid agonists as preventive and therapeutic agents for nephritis |
TWI281911B (en) | 2000-04-04 | 2007-06-01 | Allergan Inc | Treatment of tumors with RARalpha selective retinoid compounds in combination with other anti-tumor agents |
US20090117203A1 (en) * | 2006-03-23 | 2009-05-07 | Tmrc Co., Ltd. | Kit for cancer treatment and pharmaceutical composition for cancer treatment |
WO2008017025A2 (en) * | 2006-08-02 | 2008-02-07 | Genzyme Corporation | Combination therapy |
EP2143428B1 (en) | 2007-03-30 | 2015-11-04 | TMRC Co., Ltd. | Tamibarotene capsule preparation |
JP2010202553A (ja) * | 2009-03-02 | 2010-09-16 | Unitika Ltd | レチノイン酸受容体(rar)活性化剤 |
JP5748653B2 (ja) * | 2009-04-10 | 2015-07-15 | 協和発酵キリン株式会社 | 抗tim−3抗体を用いた血液腫瘍治療法 |
US20140296218A1 (en) | 2012-10-25 | 2014-10-02 | Whitehead Institute For Biomedical Research | Super-enhancers and methods of use thereof |
WO2015085172A2 (en) * | 2013-12-06 | 2015-06-11 | Celgene Corporation | Methods for determining drug efficacy for the treatment of diffuse large b-cell lymphoma, multiple myeloma, and myeloid cancers |
WO2015101618A1 (en) * | 2013-12-30 | 2015-07-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Combination of an arsenic compound and at least one retinoid for treating acute myeloid leukemia |
JP6367038B2 (ja) * | 2014-07-31 | 2018-08-01 | 学校法人近畿大学 | 受容体の細胞内輸送制御による白血病治療のための新規医薬組成物 |
EP3267969A1 (en) * | 2015-03-09 | 2018-01-17 | King's College London | Combination therapy with rar alpha agonists for enhancing th1 response |
BR122023024814A2 (pt) * | 2015-03-31 | 2024-02-20 | Syros Pharmaceuticals, Inc. | Método ex vivo de previsão da eficácia de tamibaroteno, ou um sal farmaceuticamente aceitável do mesmo |
WO2017091762A1 (en) * | 2015-11-25 | 2017-06-01 | Io Therapeutics, Inc. | Use of cyp26-resistant rar alpha selective agonists in the treatment of cancer |
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- 2017-04-07 EP EP17719772.0A patent/EP3452032B1/en active Active
- 2017-04-07 JP JP2018553078A patent/JP7034085B2/ja active Active
- 2017-04-07 KR KR1020187032334A patent/KR102457851B1/ko active IP Right Grant
- 2017-04-07 IL IL307615A patent/IL307615A/en unknown
- 2017-04-07 CN CN202211503860.8A patent/CN115737821B/zh active Active
- 2017-04-07 AU AU2017248187A patent/AU2017248187B2/en active Active
- 2017-04-07 WO PCT/US2017/026657 patent/WO2017177167A1/en active Application Filing
- 2017-04-07 CA CA3020173A patent/CA3020173A1/en active Pending
- 2017-04-07 MX MX2018012250A patent/MX2018012250A/es unknown
- 2017-04-07 CN CN201780032969.9A patent/CN109310657B/zh active Active
- 2017-04-07 BR BR112018070547-0A patent/BR112018070547A2/pt active Search and Examination
- 2017-04-07 KR KR1020227036152A patent/KR20220148926A/ko active IP Right Grant
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2021
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AU2017248187A1 (en) | 2018-11-01 |
IL262156B2 (en) | 2024-03-01 |
KR20220148926A (ko) | 2022-11-07 |
MX2023011202A (es) | 2023-10-02 |
KR20180132841A (ko) | 2018-12-12 |
JP2023057151A (ja) | 2023-04-20 |
EP3452032B1 (en) | 2024-09-04 |
JP2021185171A (ja) | 2021-12-09 |
CN109310657A (zh) | 2019-02-05 |
EP3452032A1 (en) | 2019-03-13 |
IL307615A (en) | 2023-12-01 |
AU2023203040A1 (en) | 2023-06-08 |
CA3020173A1 (en) | 2017-10-12 |
IL262156B1 (en) | 2023-11-01 |
IL262156A (en) | 2018-11-29 |
JP7284224B2 (ja) | 2023-05-30 |
RU2018135302A (ru) | 2020-05-12 |
WO2017177167A1 (en) | 2017-10-12 |
WO2017177167A4 (en) | 2017-12-21 |
JP2019513758A (ja) | 2019-05-30 |
CN115737821A (zh) | 2023-03-07 |
AU2017248187B2 (en) | 2023-03-16 |
RU2018135302A3 (es) | 2020-11-06 |
CN115737821B (zh) | 2024-04-12 |
US20240102106A1 (en) | 2024-03-28 |
CN109310657B (zh) | 2022-12-13 |
KR102457851B1 (ko) | 2022-10-25 |
JP7034085B2 (ja) | 2022-03-11 |
BR112018070547A2 (pt) | 2019-02-12 |
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