MX2022007905A - Administracion transitoria basada en temperatura de acidos nucleicos y proteinas a celulas y tejidos. - Google Patents
Administracion transitoria basada en temperatura de acidos nucleicos y proteinas a celulas y tejidos.Info
- Publication number
- MX2022007905A MX2022007905A MX2022007905A MX2022007905A MX2022007905A MX 2022007905 A MX2022007905 A MX 2022007905A MX 2022007905 A MX2022007905 A MX 2022007905A MX 2022007905 A MX2022007905 A MX 2022007905A MX 2022007905 A MX2022007905 A MX 2022007905A
- Authority
- MX
- Mexico
- Prior art keywords
- temperature
- cells
- subject
- sensitive
- methods
- Prior art date
Links
- 108091005461 Nucleic proteins Proteins 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 230000001052 transient effect Effects 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 7
- 230000000694 effects Effects 0.000 abstract 3
- 230000003213 activating effect Effects 0.000 abstract 1
- 230000036760 body temperature Effects 0.000 abstract 1
- 230000036757 core body temperature Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
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Family Cites Families (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5217879A (en) | 1989-01-12 | 1993-06-08 | Washington University | Infectious Sindbis virus vectors |
| EP0819250B1 (en) | 1995-04-06 | 2006-09-20 | Miltenyi Biotec Inc. | Multiparameter cell separation using releasable colloidal magnetic particles |
| US6451592B1 (en) | 1996-04-05 | 2002-09-17 | Chiron Corporation | Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis |
| US6465634B1 (en) | 1996-04-05 | 2002-10-15 | Chiron Corporation | Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis |
| WO1999050432A1 (en) * | 1998-03-27 | 1999-10-07 | Cytos Biotechnology Ag | Inducible alphaviral gene expression system |
| HK1038929B (zh) | 1998-07-31 | 2005-05-06 | 株式会社国际癌症免疫研究所 | 基於癌抑制基因wt1的产物的癌抗原 |
| DK1175497T3 (da) | 1999-04-14 | 2010-05-31 | Novartis Vaccines & Diagnostic | Præparater og fremgangsmåder til generering af et immunrespons ved udnyttelse af alfavirusbaserede vektorsystemer |
| US8647864B2 (en) | 1999-04-14 | 2014-02-11 | Novartis Ag | Compositions and methods for generating an immune response utilizing alphavirus-based vector systems |
| ATE367445T1 (de) | 1999-05-18 | 2007-08-15 | Dnavec Research Inc | Viraler paramyxoviridae vektor mit einem defekten hüllprotein-gen |
| AU2002303330B2 (en) | 2001-05-31 | 2008-07-24 | Novartis Vaccines And Diagnostics, Inc. | Chimeric alphavirus replicon particles |
| US20030232324A1 (en) | 2001-05-31 | 2003-12-18 | Chiron Corporation | Chimeric alphavirus replicon particles |
| US7045335B2 (en) | 2001-09-06 | 2006-05-16 | Alphavax, Inc. | Alphavirus replicon vector systems |
| MXPA05001644A (es) | 2002-08-13 | 2005-04-19 | Akzo Nobel Nv | Replicones de pestivirus que no expresan proteina c y/o e1, y particulas virales infecciosas que los contienen y pueden usarse en vacunas. |
| AU2003270824B2 (en) * | 2002-09-18 | 2009-02-19 | The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Recovery of recombinant human parainfluenza virus type 2 (HPIV2) from cDNA and use of recombinant HPIV2 in immunogenic compositions and as vectors to elicit immune responses against PIV and other human pathogens |
| US6943015B2 (en) | 2002-12-12 | 2005-09-13 | Ilya Frolov | Large scale production of packaged alphavirus replicons |
| JP5079981B2 (ja) | 2002-12-13 | 2012-11-21 | アルファバックス,インコーポレイティド | アルファウイルス粒子及び調製方法 |
| KR101518309B1 (ko) | 2003-03-20 | 2015-05-08 | 알파벡스, 인크. | 개선된 알파바이러스 레플리콘 및 헬퍼 구축물 |
| US20050282279A1 (en) * | 2003-05-29 | 2005-12-22 | Hwu Paul L | Expression vector encoding coronavirus-like particle |
| EP1629104A4 (en) * | 2003-06-04 | 2006-11-02 | Bioleaders Corp | CELL SURFACE EXPRESSION VECTOR OF SARS VIRUS ANTIGEN AND TRANSFORMED MICROORGANISMS |
| SI1629004T1 (sl) | 2003-06-05 | 2008-12-31 | Wyeth Corp | Imunogeni sestavki, ki vsebujejo vektorski replikon virusa venezuelskega konjskega encefalitisa in antigen za protein paramiksovirusa |
| ES2321212T3 (es) | 2004-05-18 | 2009-06-03 | Alphavax, Inc. | Vectores alfavirus derivados de tc-83, particulas y metodos antecentes de la invencion. |
| US7332322B2 (en) | 2004-09-14 | 2008-02-19 | Ilya Frolov | Venezuelan equine encephalitis virus replicons with adaptive mutations in the genome and uses thereof |
| US7998733B2 (en) * | 2004-10-05 | 2011-08-16 | Merial Limited | Chimeric vectors |
| JP4478788B2 (ja) | 2005-05-27 | 2010-06-09 | 独立行政法人産業技術総合研究所 | センダイウイルス温度感受性株由来のウイルスベクター |
| HUE043492T2 (hu) | 2005-08-23 | 2019-08-28 | Univ Pennsylvania | Módosított nukleozidokat tartalmazó RNS és eljárások az alkalmazására |
| CA2626238C (en) | 2005-10-17 | 2015-10-06 | Memorial Sloan Kettering Cancer Center | Wt1 hla class ii-binding peptides and compositions and methods comprising same |
| AP2008004629A0 (en) | 2006-02-27 | 2008-10-31 | Univ Texas | Pseudoinfectious flavivirus and uses thereof |
| CA2668417A1 (en) | 2006-11-03 | 2008-05-15 | Alphavax, Inc. | Alphavirus and alphavirus replicon particle formulations and methods |
| PL2119778T3 (pl) | 2007-02-27 | 2016-04-29 | Int Inst Cancer Immunology Inc | Sposób aktywacji pomocniczej komórki T oraz kompozycja do zastosowania w tym sposobie |
| US8748591B2 (en) | 2007-04-17 | 2014-06-10 | The Board Of Regents Of The University Of Texas System | Chimeric sindbis-western equine encephalitis virus and uses thereof |
| US20100203027A1 (en) * | 2007-04-27 | 2010-08-12 | Kyushu Univeristy National University | Viral vector for gene therapy |
| WO2009079185A2 (en) * | 2007-11-26 | 2009-06-25 | Novartis Vaccines And Diagnostics, Inc. | Methods of generating alphavirus particles |
| JP5478260B2 (ja) | 2007-12-05 | 2014-04-23 | 株式会社癌免疫研究所 | 癌ワクチン組成物 |
| CN102083986B (zh) | 2008-01-24 | 2014-06-18 | 德克萨斯大学系统董事会 | 不能在蚊子中复制的减毒重组甲病毒及其用途 |
| EP2130912A1 (en) | 2008-06-04 | 2009-12-09 | Institut für Viruskrankeiten und Immunprophylaxe | Pestivirus replicons providing an RNA-based viral vector system |
| CN102159710B (zh) | 2008-07-16 | 2015-09-02 | 生物载体株式会社 | 使用染色体非整合型病毒载体制造经初始化的细胞的方法 |
| EP2451475A2 (en) | 2009-07-06 | 2012-05-16 | Novartis AG | Self replicating rna molecules and uses thereof |
| US9770463B2 (en) | 2010-07-06 | 2017-09-26 | Glaxosmithkline Biologicals Sa | Delivery of RNA to different cell types |
| EP3520813B1 (en) | 2010-10-11 | 2023-04-19 | GlaxoSmithKline Biologicals S.A. | Antigen delivery platforms |
| US9402890B2 (en) | 2011-02-01 | 2016-08-02 | Uab Research Foundation | Methods and compositions for pseudoinfectious alphaviruses |
| RU2649133C2 (ru) * | 2011-07-06 | 2018-03-29 | Новартис Аг | Катионные эмульсии масло-в-воде |
| CA2861206C (en) | 2012-01-13 | 2021-07-06 | Richard J. O'reilly | Immunogenic wt-1 peptides and methods of use thereof |
| CA2873964C (en) | 2012-05-21 | 2025-09-16 | The Regents Of The University Of California | GENERATION OF HUMAN IP CELLS BY SELF-REPLICATING SYNTHETIC RNA |
| US8961995B2 (en) | 2012-09-20 | 2015-02-24 | Uab Research Foundation | Methods and compositions for alphavirus replicons |
| WO2014089513A1 (en) | 2012-12-06 | 2014-06-12 | Synthetic Genomics, Inc. | Autonomous replication sequences and episomal dna molecules |
| US10815273B2 (en) | 2013-01-15 | 2020-10-27 | Memorial Sloan Kettering Cancer Center | Immunogenic WT-1 peptides and methods of use thereof |
| CN110078813B (zh) | 2013-01-15 | 2023-03-28 | 纪念斯隆凯特林癌症中心 | 免疫原性wt-1肽和其使用方法 |
| KR20160023638A (ko) | 2013-02-28 | 2016-03-03 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 줄기세포를 이동하기 위한 방법 및 조성물 |
| RU2735141C2 (ru) | 2013-03-15 | 2020-10-28 | Иликсиэджен Терапьютикс, Инк. | Способы применения zscan4 для омоложения человеческих клеток |
| WO2014200910A2 (en) | 2013-06-10 | 2014-12-18 | Iogenetics, Llc | Bioinformatic processes for determination of peptide binding |
| CN105916980B (zh) * | 2013-09-24 | 2025-09-16 | 株式会社爱迪药业 | 用于改进诱导多能干细胞的效率的方法 |
| CN105829528B (zh) * | 2013-12-20 | 2019-10-22 | 勃林格殷格翰动物保健有限公司 | PRRS病毒变体、欧洲PRRS病毒cDNA克隆及其用途 |
| WO2015123592A2 (en) | 2014-02-13 | 2015-08-20 | Synthetic Genomics, Inc. | Recombinant rna particles and methods of use |
| US10266834B2 (en) | 2014-02-13 | 2019-04-23 | Synthetic Genomics, Inc. | Recombinant RNA particles and methods of producing proteins |
| WO2016125364A1 (ja) | 2015-02-02 | 2016-08-11 | 株式会社Idファーマ | 改良されたマイナス鎖rnaウイルスベクター |
| EP3061826A1 (en) | 2015-02-27 | 2016-08-31 | Novartis AG | Flavivirus replicons |
| CA2986235A1 (en) * | 2015-05-20 | 2016-11-24 | The Broad Institute, Inc. | Shared neoantigens |
| WO2016208332A1 (ja) | 2015-06-25 | 2016-12-29 | 国立大学法人神戸大学 | 経口腫瘍ワクチン |
| WO2017015457A1 (en) | 2015-07-21 | 2017-01-26 | Modernatx, Inc. | Ebola vaccine |
| EP3334755B1 (en) | 2015-08-10 | 2020-04-08 | Cellivery Therapeutics, Inc. | Improved cell-permeable reprogramming factor (icp-rf) recombinant protein and use thereof |
| US10166281B2 (en) | 2015-09-04 | 2019-01-01 | Vlp Therapeutics, Llc | Method and composition for modulating immune response |
| DK3375874T3 (da) | 2015-11-13 | 2022-05-09 | Id Pharma Co Ltd | Forbedret paramyxovirus-vektor |
| US10801041B2 (en) | 2015-11-18 | 2020-10-13 | Orbis Health Solutions, Llc | T7 alpha viral vector system |
| SMT202200370T1 (it) | 2015-11-20 | 2022-11-18 | Memorial Sloan Kettering Cancer Center | Composizione per il trattamento del cancro |
| GB201603374D0 (en) | 2016-02-26 | 2016-04-13 | Ucl Business Plc | Packaging cell |
| WO2017162265A1 (en) | 2016-03-21 | 2017-09-28 | Biontech Rna Pharmaceuticals Gmbh | Trans-replicating rna |
| WO2017162266A1 (en) | 2016-03-21 | 2017-09-28 | Biontech Rna Pharmaceuticals Gmbh | Rna replicon for versatile and efficient gene expression |
| WO2017180770A1 (en) | 2016-04-13 | 2017-10-19 | Synthetic Genomics, Inc. | Recombinant arterivirus replicon systems and uses thereof |
| US10967057B2 (en) | 2016-06-02 | 2021-04-06 | Glaxosmithkline Biologicals S.A. | Zika viral antigen constructs |
| US20190216956A1 (en) * | 2016-07-27 | 2019-07-18 | The Trustees Of Columbia University In The City Of New York | Compositions for radiotherapy and uses thereof |
| JP7382230B2 (ja) | 2016-10-17 | 2023-11-16 | ヤンセン ファーマシューティカルズ,インコーポレーテッド | 組み換えウイルスレプリコン系及びその使用 |
| WO2018075827A1 (en) | 2016-10-19 | 2018-04-26 | Arcturus Therapeutics, Inc. | Trinucleotide mrna cap analogs |
| EP4599847A3 (en) * | 2016-10-25 | 2025-11-12 | Trustees of Dartmouth College | Prefusion coronavirus spike proteins and their use |
| BR112019011661A2 (pt) | 2016-12-05 | 2020-01-07 | Synthetic Genomics, Inc. | Composições e métodos para aumentar expressão de gene |
| WO2018115527A2 (en) | 2016-12-23 | 2018-06-28 | Curevac Ag | Mers coronavirus vaccine |
| WO2018161092A1 (en) | 2017-03-03 | 2018-09-07 | New York University | Induction and enhancement of antitumor immunity involving virus vectors expressing multiple epitopes of tumor associated antigens and immune checkpoint inhibitors or proteins |
| WO2018170347A1 (en) * | 2017-03-17 | 2018-09-20 | Modernatx, Inc. | Zoonotic disease rna vaccines |
| WO2018222890A1 (en) | 2017-05-31 | 2018-12-06 | Arcturus Therapeutics, Inc. | Synthesis and structure of high potency rna therapeutics |
| SG11202005792RA (en) | 2017-12-20 | 2020-07-29 | Vlp Therapeutics Llc | Alphavirus replicon particle |
| KR20200111729A (ko) | 2018-01-19 | 2020-09-29 | 얀센 파마슈티칼즈, 인코포레이티드 | 재조합 레플리콘 시스템을 이용한 면역 반응 유도 및 증진 |
| AU2019277361B2 (en) | 2018-05-30 | 2025-04-24 | Translate Bio, Inc. | Messenger RNA vaccines and uses thereof |
| WO2021119545A1 (en) | 2019-12-11 | 2021-06-17 | Gritstone Bio, Inc. | Durable vaccination |
| KR20220128367A (ko) | 2019-12-31 | 2022-09-20 | 엘릭서젠 쎄라퓨틱스, 인크. | Zscan4 핵산 및 단백질의 세포 및 조직으로의 온도-기반 일시적 전달 |
| MX2022007905A (es) | 2019-12-31 | 2022-08-25 | Elixirgen Therapeutics Inc | Administracion transitoria basada en temperatura de acidos nucleicos y proteinas a celulas y tejidos. |
| EP4142786A4 (en) | 2020-04-27 | 2024-06-19 | Ohio State Innovation Foundation | LIVE ATTENUATED MEASLES VIRUS VACCINE AGAINST SARS-COV-2 |
| EP4168042A1 (en) | 2020-06-19 | 2023-04-26 | Ziphius Vaccines | Self-amplifying sars-cov-2 rna vaccine |
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