MX2022007155A - Derivados de cromano novedosos que tienen actividad de degradacion de receptor de estrogeno y usos de los mismos. - Google Patents
Derivados de cromano novedosos que tienen actividad de degradacion de receptor de estrogeno y usos de los mismos.Info
- Publication number
- MX2022007155A MX2022007155A MX2022007155A MX2022007155A MX2022007155A MX 2022007155 A MX2022007155 A MX 2022007155A MX 2022007155 A MX2022007155 A MX 2022007155A MX 2022007155 A MX2022007155 A MX 2022007155A MX 2022007155 A MX2022007155 A MX 2022007155A
- Authority
- MX
- Mexico
- Prior art keywords
- estrogen receptor
- degradation activity
- chroman derivatives
- receptor degradation
- novel chroman
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962947213P | 2019-12-12 | 2019-12-12 | |
| PCT/US2020/027895 WO2021118629A1 (en) | 2019-12-12 | 2020-04-13 | Novel chroman derivatives having estrogen receptor degradation activity and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2022007155A true MX2022007155A (es) | 2022-10-07 |
Family
ID=70289288
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022007155A MX2022007155A (es) | 2019-12-12 | 2020-04-13 | Derivados de cromano novedosos que tienen actividad de degradacion de receptor de estrogeno y usos de los mismos. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10800770B1 (https=) |
| EP (2) | EP3835298B1 (https=) |
| JP (2) | JP7662639B2 (https=) |
| KR (1) | KR102942706B1 (https=) |
| CN (2) | CN115003295B (https=) |
| CA (1) | CA3164202A1 (https=) |
| DK (1) | DK3835298T3 (https=) |
| ES (1) | ES2986594T3 (https=) |
| FI (1) | FI3835298T3 (https=) |
| MX (1) | MX2022007155A (https=) |
| WO (1) | WO2021118629A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112019011200B1 (pt) | 2016-12-01 | 2021-12-28 | Arvinas Operations, Inc | Derivados de tetrahidronaftaleno e tetrahidroisoquinolina como degradadores do receptor de estrogênio |
| CN111606883B (zh) | 2019-02-25 | 2023-05-09 | 上海科技大学 | 基于戊二酰亚胺骨架的含硫化合物及其应用 |
| WO2021023233A1 (zh) | 2019-08-05 | 2021-02-11 | 上海科技大学 | Egfr蛋白降解剂及其抗肿瘤应用 |
| KR20220054347A (ko) | 2019-08-26 | 2022-05-02 | 아비나스 오퍼레이션스, 인코포레이티드 | 에스트로겐 수용체 분해제로서의 테트라히드로나프탈렌 유도체로 유방암을 치료하는 방법 |
| EP3835298B1 (en) * | 2019-12-12 | 2024-06-26 | Accutar Biotechnology Inc. | Novel chroman derivatives having estrogen receptor degradation activity and uses thereof |
| JP2023508357A (ja) * | 2019-12-23 | 2023-03-02 | アキュター バイオテクノロジー インコーポレイテッド | エストロゲン受容体分解剤とサイクリン依存性キナーゼ阻害剤との癌治療用組み合わせ |
| AU2021226514B2 (en) * | 2020-02-25 | 2023-10-19 | Shanghaitech University | Glutarimide skeleton-based compounds and application thereof |
| WO2022056368A1 (en) | 2020-09-14 | 2022-03-17 | Arvinas Operations, Inc. | Crystalline forms of a compound for the targeted degradation of estrogen receptor |
| WO2022166879A1 (zh) * | 2021-02-04 | 2022-08-11 | 正大天晴药业集团股份有限公司 | 苯并七元环类双功能化合物及其应用 |
| WO2022187588A1 (en) * | 2021-03-04 | 2022-09-09 | The Regents Of The University Of Michigan | Small molecule degraders of estrogen receptor with cereblon ligands |
| CA3211378A1 (en) | 2021-03-29 | 2022-10-06 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Tetrahydronaphthalene compound, and preparation method therefor and use thereof in medicine |
| CA3227425A1 (en) | 2021-07-26 | 2023-02-02 | Arvinas Operations, Inc. | Methods of manufacturing a bifunctional compound |
| CA3235512A1 (en) * | 2021-10-22 | 2023-04-27 | Xiaobao Yang | Crbn e3 ligase ligand compound, protein degrader developed based thereon and their applications |
| CN113816927B (zh) * | 2021-11-23 | 2022-02-25 | 苏州国匡医药科技有限公司 | 一种arv-471中间体的制备方法 |
| CN117229286A (zh) | 2022-06-14 | 2023-12-15 | 海创药业股份有限公司 | 一种芳香类化合物及其制备方法及在制备雌激素受体降解剂中的用途 |
| US20260000676A1 (en) * | 2022-07-12 | 2026-01-01 | The Regents Of The University Of Michigan | Chroman derivatives as estrogen receptor degraders |
| CN116751186B (zh) * | 2022-12-23 | 2024-10-18 | 南京知和医药科技有限公司 | 一种雌激素受体调节剂的制备及其用途 |
| TWI882643B (zh) * | 2023-01-16 | 2025-05-01 | 大陸商南京明德新藥研發有限公司 | 取代的苯並七元環化合物及其應用 |
| CN119258223A (zh) * | 2023-07-06 | 2025-01-07 | 海创药业股份有限公司 | 一种降解雌激素受体的联合用药物及其用途 |
| US20250381179A1 (en) | 2024-05-22 | 2025-12-18 | Accutar Biotechnology Inc. | Chroman-based compounds for treating cancer |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010021710A1 (en) * | 1996-10-28 | 2001-09-13 | Poul Jacobsen | Novel cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes |
| WO1998018778A1 (en) * | 1996-10-28 | 1998-05-07 | Novo Nordisk A/S | Novel cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes |
| JP2001502711A (ja) * | 1996-10-28 | 2001-02-27 | ノボ ノルディスク アクティーゼルスカブ | エストロゲン関連疾患又は症候群の予防又は治療において有用な新規のシス―３、４―クロマン誘導体 |
| EP1192945A3 (en) * | 2000-09-21 | 2004-03-03 | Pfizer Products Inc. | Use of an estrogen agonist/antagonist for treating osteoarthritis |
| JP2005524630A (ja) * | 2002-01-14 | 2005-08-18 | ノルディック・ビオサイエンス・エー／エス | エストロゲン受容体を介する軟骨破壊の抑制 |
| WO2003063659A1 (de) | 2002-02-01 | 2003-08-07 | Danny Bellens | Ablageständer |
| CA2512000C (en) * | 2002-12-26 | 2011-08-09 | Eisai Co., Ltd. | Selective estrogen receptor modulator |
| PL3202460T3 (pl) * | 2010-02-11 | 2019-12-31 | Celgene Corporation | Pochodne arylometoksyizoindoliny i zawierające je kompozycje oraz sposoby ich zastosowania |
| US10053451B2 (en) * | 2015-05-26 | 2018-08-21 | Genentech, Inc. | Heterocyclic estrogen receptor modulators and uses thereof |
| CN108495618B (zh) * | 2016-07-12 | 2019-08-16 | 冰洲石生物科技公司 | 新的化合物及其用途 |
| BR112019011200B1 (pt) * | 2016-12-01 | 2021-12-28 | Arvinas Operations, Inc | Derivados de tetrahidronaftaleno e tetrahidroisoquinolina como degradadores do receptor de estrogênio |
| EP3835298B1 (en) * | 2019-12-12 | 2024-06-26 | Accutar Biotechnology Inc. | Novel chroman derivatives having estrogen receptor degradation activity and uses thereof |
-
2020
- 2020-04-13 EP EP20169240.7A patent/EP3835298B1/en active Active
- 2020-04-13 CN CN202080092528.XA patent/CN115003295B/zh active Active
- 2020-04-13 WO PCT/US2020/027895 patent/WO2021118629A1/en not_active Ceased
- 2020-04-13 ES ES20169240T patent/ES2986594T3/es active Active
- 2020-04-13 JP JP2022535123A patent/JP7662639B2/ja active Active
- 2020-04-13 CA CA3164202A patent/CA3164202A1/en active Pending
- 2020-04-13 KR KR1020227023616A patent/KR102942706B1/ko active Active
- 2020-04-13 MX MX2022007155A patent/MX2022007155A/es unknown
- 2020-04-13 FI FIEP20169240.7T patent/FI3835298T3/fi active
- 2020-04-13 CN CN202510495956.1A patent/CN120665056A/zh active Pending
- 2020-04-13 DK DK20169240.7T patent/DK3835298T3/da active
- 2020-04-13 US US16/846,492 patent/US10800770B1/en active Active
- 2020-04-13 EP EP24170522.7A patent/EP4420728A3/en active Pending
- 2020-06-22 US US16/907,548 patent/US11261178B2/en active Active
-
2025
- 2025-02-03 JP JP2025015907A patent/JP2025081364A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN120665056A (zh) | 2025-09-19 |
| WO2021118629A1 (en) | 2021-06-17 |
| KR102942706B1 (ko) | 2026-03-20 |
| ES2986594T3 (es) | 2024-11-12 |
| DK3835298T3 (da) | 2024-07-29 |
| CN115003295A (zh) | 2022-09-02 |
| FI3835298T3 (fi) | 2024-07-29 |
| JP2025081364A (ja) | 2025-05-27 |
| CA3164202A1 (en) | 2021-06-17 |
| EP4420728A3 (en) | 2024-10-30 |
| US10800770B1 (en) | 2020-10-13 |
| EP3835298A1 (en) | 2021-06-16 |
| JP2023506155A (ja) | 2023-02-15 |
| KR20220118460A (ko) | 2022-08-25 |
| EP3835298B1 (en) | 2024-06-26 |
| JP7662639B2 (ja) | 2025-04-15 |
| US20210221802A1 (en) | 2021-07-22 |
| CN115003295B (zh) | 2025-05-06 |
| EP4420728A2 (en) | 2024-08-28 |
| US11261178B2 (en) | 2022-03-01 |
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