KR102942706B1 - 에스트로겐 수용체 분해 활성을 갖는 신규한 크로만 유도체 및 이의 용도 - Google Patents

에스트로겐 수용체 분해 활성을 갖는 신규한 크로만 유도체 및 이의 용도

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Publication number
KR102942706B1
KR102942706B1 KR1020227023616A KR20227023616A KR102942706B1 KR 102942706 B1 KR102942706 B1 KR 102942706B1 KR 1020227023616 A KR1020227023616 A KR 1020227023616A KR 20227023616 A KR20227023616 A KR 20227023616A KR 102942706 B1 KR102942706 B1 KR 102942706B1
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South Korea
Prior art keywords
piperidine
dione
piperazine
compound
oxoisoindolin
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English (en)
Korean (ko)
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KR20220118460A (ko
Inventor
지에 판
이민 치안
웨이 헤
케 리우
Original Assignee
액큐타 바이오테크놀로지 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020227023616A 2019-12-12 2020-04-13 에스트로겐 수용체 분해 활성을 갖는 신규한 크로만 유도체 및 이의 용도 Active KR102942706B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962947213P 2019-12-12 2019-12-12
US62/947,213 2019-12-12
PCT/US2020/027895 WO2021118629A1 (en) 2019-12-12 2020-04-13 Novel chroman derivatives having estrogen receptor degradation activity and uses thereof

Publications (2)

Publication Number Publication Date
KR20220118460A KR20220118460A (ko) 2022-08-25
KR102942706B1 true KR102942706B1 (ko) 2026-03-20

Family

ID=70289288

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020227023616A Active KR102942706B1 (ko) 2019-12-12 2020-04-13 에스트로겐 수용체 분해 활성을 갖는 신규한 크로만 유도체 및 이의 용도

Country Status (11)

Country Link
US (2) US10800770B1 (https=)
EP (2) EP3835298B1 (https=)
JP (2) JP7662639B2 (https=)
KR (1) KR102942706B1 (https=)
CN (2) CN115003295B (https=)
CA (1) CA3164202A1 (https=)
DK (1) DK3835298T3 (https=)
ES (1) ES2986594T3 (https=)
FI (1) FI3835298T3 (https=)
MX (1) MX2022007155A (https=)
WO (1) WO2021118629A1 (https=)

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BR112019011200B1 (pt) 2016-12-01 2021-12-28 Arvinas Operations, Inc Derivados de tetrahidronaftaleno e tetrahidroisoquinolina como degradadores do receptor de estrogênio
CN111606883B (zh) 2019-02-25 2023-05-09 上海科技大学 基于戊二酰亚胺骨架的含硫化合物及其应用
WO2021023233A1 (zh) 2019-08-05 2021-02-11 上海科技大学 Egfr蛋白降解剂及其抗肿瘤应用
KR20220054347A (ko) 2019-08-26 2022-05-02 아비나스 오퍼레이션스, 인코포레이티드 에스트로겐 수용체 분해제로서의 테트라히드로나프탈렌 유도체로 유방암을 치료하는 방법
EP3835298B1 (en) * 2019-12-12 2024-06-26 Accutar Biotechnology Inc. Novel chroman derivatives having estrogen receptor degradation activity and uses thereof
JP2023508357A (ja) * 2019-12-23 2023-03-02 アキュター バイオテクノロジー インコーポレイテッド エストロゲン受容体分解剤とサイクリン依存性キナーゼ阻害剤との癌治療用組み合わせ
AU2021226514B2 (en) * 2020-02-25 2023-10-19 Shanghaitech University Glutarimide skeleton-based compounds and application thereof
WO2022056368A1 (en) 2020-09-14 2022-03-17 Arvinas Operations, Inc. Crystalline forms of a compound for the targeted degradation of estrogen receptor
WO2022166879A1 (zh) * 2021-02-04 2022-08-11 正大天晴药业集团股份有限公司 苯并七元环类双功能化合物及其应用
WO2022187588A1 (en) * 2021-03-04 2022-09-09 The Regents Of The University Of Michigan Small molecule degraders of estrogen receptor with cereblon ligands
CA3211378A1 (en) 2021-03-29 2022-10-06 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Tetrahydronaphthalene compound, and preparation method therefor and use thereof in medicine
CA3227425A1 (en) 2021-07-26 2023-02-02 Arvinas Operations, Inc. Methods of manufacturing a bifunctional compound
CA3235512A1 (en) * 2021-10-22 2023-04-27 Xiaobao Yang Crbn e3 ligase ligand compound, protein degrader developed based thereon and their applications
CN113816927B (zh) * 2021-11-23 2022-02-25 苏州国匡医药科技有限公司 一种arv-471中间体的制备方法
CN117229286A (zh) 2022-06-14 2023-12-15 海创药业股份有限公司 一种芳香类化合物及其制备方法及在制备雌激素受体降解剂中的用途
US20260000676A1 (en) * 2022-07-12 2026-01-01 The Regents Of The University Of Michigan Chroman derivatives as estrogen receptor degraders
CN116751186B (zh) * 2022-12-23 2024-10-18 南京知和医药科技有限公司 一种雌激素受体调节剂的制备及其用途
TWI882643B (zh) * 2023-01-16 2025-05-01 大陸商南京明德新藥研發有限公司 取代的苯並七元環化合物及其應用
CN119258223A (zh) * 2023-07-06 2025-01-07 海创药业股份有限公司 一种降解雌激素受体的联合用药物及其用途
US20250381179A1 (en) 2024-05-22 2025-12-18 Accutar Biotechnology Inc. Chroman-based compounds for treating cancer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020049198A1 (en) 2000-09-21 2002-04-25 Littman Bruce H. Methods for treating osteoarthritis using an estrogen agonist / antagonist
US20090325930A1 (en) 2002-12-26 2009-12-31 Shinichi Hamaoka Selective estrogen receptor modulator

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010021710A1 (en) * 1996-10-28 2001-09-13 Poul Jacobsen Novel cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
WO1998018778A1 (en) * 1996-10-28 1998-05-07 Novo Nordisk A/S Novel cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
JP2001502711A (ja) * 1996-10-28 2001-02-27 ノボ ノルディスク アクティーゼルスカブ エストロゲン関連疾患又は症候群の予防又は治療において有用な新規のシス―３、４―クロマン誘導体
JP2005524630A (ja) * 2002-01-14 2005-08-18 ノルディック・ビオサイエンス・エー／エス エストロゲン受容体を介する軟骨破壊の抑制
WO2003063659A1 (de) 2002-02-01 2003-08-07 Danny Bellens Ablageständer
PL3202460T3 (pl) * 2010-02-11 2019-12-31 Celgene Corporation Pochodne arylometoksyizoindoliny i zawierające je kompozycje oraz sposoby ich zastosowania
US10053451B2 (en) * 2015-05-26 2018-08-21 Genentech, Inc. Heterocyclic estrogen receptor modulators and uses thereof
CN108495618B (zh) * 2016-07-12 2019-08-16 冰洲石生物科技公司 新的化合物及其用途
BR112019011200B1 (pt) * 2016-12-01 2021-12-28 Arvinas Operations, Inc Derivados de tetrahidronaftaleno e tetrahidroisoquinolina como degradadores do receptor de estrogênio
EP3835298B1 (en) * 2019-12-12 2024-06-26 Accutar Biotechnology Inc. Novel chroman derivatives having estrogen receptor degradation activity and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020049198A1 (en) 2000-09-21 2002-04-25 Littman Bruce H. Methods for treating osteoarthritis using an estrogen agonist / antagonist
US20090325930A1 (en) 2002-12-26 2009-12-31 Shinichi Hamaoka Selective estrogen receptor modulator

Also Published As

Publication number Publication date
CN120665056A (zh) 2025-09-19
WO2021118629A1 (en) 2021-06-17
MX2022007155A (es) 2022-10-07
ES2986594T3 (es) 2024-11-12
DK3835298T3 (da) 2024-07-29
CN115003295A (zh) 2022-09-02
FI3835298T3 (fi) 2024-07-29
JP2025081364A (ja) 2025-05-27
CA3164202A1 (en) 2021-06-17
EP4420728A3 (en) 2024-10-30
US10800770B1 (en) 2020-10-13
EP3835298A1 (en) 2021-06-16
JP2023506155A (ja) 2023-02-15
KR20220118460A (ko) 2022-08-25
EP3835298B1 (en) 2024-06-26
JP7662639B2 (ja) 2025-04-15
US20210221802A1 (en) 2021-07-22
CN115003295B (zh) 2025-05-06
EP4420728A2 (en) 2024-08-28
US11261178B2 (en) 2022-03-01

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