MX2021012934A - Lipidos de amina ionizables y nanoparticulas lipidicas. - Google Patents

Lipidos de amina ionizables y nanoparticulas lipidicas.

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Publication number
MX2021012934A
MX2021012934A MX2021012934A MX2021012934A MX2021012934A MX 2021012934 A MX2021012934 A MX 2021012934A MX 2021012934 A MX2021012934 A MX 2021012934A MX 2021012934 A MX2021012934 A MX 2021012934A MX 2021012934 A MX2021012934 A MX 2021012934A
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MX
Mexico
Prior art keywords
ionizable
lipids
amine lipids
lipid nanoparticles
ionizable amine
Prior art date
Application number
MX2021012934A
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English (en)
Spanish (es)
Inventor
Stephen S Scully
Rubina Giare Parmar
Micah Maetani
Derek Laplaca
Rachel Pelly
Original Assignee
Intellia Therapeutics Inc
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Filing date
Publication date
Application filed by Intellia Therapeutics Inc filed Critical Intellia Therapeutics Inc
Publication of MX2021012934A publication Critical patent/MX2021012934A/es

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    • C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C219/16—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by an inorganic acid or a derivative thereof
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    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
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