MX2021012934A - Lipidos de amina ionizables y nanoparticulas lipidicas. - Google Patents
Lipidos de amina ionizables y nanoparticulas lipidicas.Info
- Publication number
- MX2021012934A MX2021012934A MX2021012934A MX2021012934A MX2021012934A MX 2021012934 A MX2021012934 A MX 2021012934A MX 2021012934 A MX2021012934 A MX 2021012934A MX 2021012934 A MX2021012934 A MX 2021012934A MX 2021012934 A MX2021012934 A MX 2021012934A
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- MX
- Mexico
- Prior art keywords
- ionizable
- lipids
- amine lipids
- lipid nanoparticles
- ionizable amine
- Prior art date
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C219/16—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by an inorganic acid or a derivative thereof
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- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- C07C217/08—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom
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- C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
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Abstract
La descripción proporciona lípidos de amina ionizables y sales de estos (por ejemplo, sales farmacéuticamente aceptables de estos) útiles para la administración de agentes biológicamente activos, por ejemplo, la administración de agentes biológicamente activos a las células para preparar células modificadas genéticamente. Los lípidos con amina ionizables que se describen en la presente son útiles como lípidos ionizables en la formulación de composiciones con base en nanopartículas lipídicas.
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US201962838551P | 2019-04-25 | 2019-04-25 | |
US201962843854P | 2019-05-06 | 2019-05-06 | |
PCT/US2020/029812 WO2020219876A1 (en) | 2019-04-25 | 2020-04-24 | Ionizable amine lipids and lipid nanoparticles |
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MX2021012934A MX2021012934A (es) | 2019-04-25 | 2020-04-24 | Lipidos de amina ionizables y nanoparticulas lipidicas. |
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US (1) | US20220402862A1 (es) |
EP (1) | EP3959191A1 (es) |
JP (1) | JP2022530043A (es) |
KR (1) | KR20220005039A (es) |
CN (1) | CN114127044A (es) |
AU (1) | AU2020261419A1 (es) |
BR (1) | BR112021021313A2 (es) |
CA (1) | CA3137956A1 (es) |
CO (1) | CO2021014831A2 (es) |
IL (1) | IL287421A (es) |
MX (1) | MX2021012934A (es) |
SG (1) | SG11202111154WA (es) |
TW (1) | TW202106662A (es) |
WO (1) | WO2020219876A1 (es) |
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