BR112014006608A2 - formulações com base em dispersões sólidas - Google Patents

formulações com base em dispersões sólidas

Info

Publication number
BR112014006608A2
BR112014006608A2 BR112014006608A BR112014006608A BR112014006608A2 BR 112014006608 A2 BR112014006608 A2 BR 112014006608A2 BR 112014006608 A BR112014006608 A BR 112014006608A BR 112014006608 A BR112014006608 A BR 112014006608A BR 112014006608 A2 BR112014006608 A2 BR 112014006608A2
Authority
BR
Brazil
Prior art keywords
formulations
solid dispersion
based formulations
dispersion based
donor moiety
Prior art date
Application number
BR112014006608A
Other languages
English (en)
Inventor
Woehrle Gerd
Weis Jürgen
Kyeremateng Samuel
Kullmann Simon
Warnecke Svenja
Westedt Ullrich
Original Assignee
Abbvie Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Deutschland filed Critical Abbvie Deutschland
Publication of BR112014006608A2 publication Critical patent/BR112014006608A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)

Abstract

resumo “formulações com base em dispersões sólidas” a presente invenção refere-se a formulações compreendendo um produto de dispersão sólido de um agente ativo tendo pelo menos uma dentre uma porção doadora de ligação de hidrogênio e uma porção doadora de próton e um copolímero de enxerto de polivinillactam polivinilacetato poli(alquileno glicol) farmaceuticamente aceitável, e a métodos para preparar tais formulações.
BR112014006608A 2011-09-26 2012-09-21 formulações com base em dispersões sólidas BR112014006608A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11182792A EP2572731A1 (en) 2011-09-26 2011-09-26 Formulations based on solid dispersions
PCT/EP2012/068661 WO2013045365A1 (en) 2011-09-26 2012-09-21 Formulations based on solid dispersions

Publications (1)

Publication Number Publication Date
BR112014006608A2 true BR112014006608A2 (pt) 2017-04-25

Family

ID=46875866

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014006608A BR112014006608A2 (pt) 2011-09-26 2012-09-21 formulações com base em dispersões sólidas

Country Status (15)

Country Link
US (1) US20140296341A1 (pt)
EP (2) EP2572731A1 (pt)
JP (2) JP2014527976A (pt)
KR (1) KR20140069215A (pt)
CN (1) CN104039354B (pt)
AU (1) AU2012314661B2 (pt)
BR (1) BR112014006608A2 (pt)
CA (1) CA2847800A1 (pt)
CO (1) CO7071123A2 (pt)
HK (1) HK1200700A1 (pt)
IL (1) IL231384A0 (pt)
MX (1) MX2014003673A (pt)
RU (1) RU2014116987A (pt)
SG (1) SG11201400964PA (pt)
WO (1) WO2013045365A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012351948A1 (en) * 2011-12-16 2014-07-10 Allergan, Inc. Ophthalmic compositions comprising polyvinyl capralactam - polyvinyl acetate - polyethylene glycol graft copolymer
EP3091981B1 (en) * 2014-01-09 2021-03-10 Verastem, Inc. Compositions and methods for treatment of abnormal cell growth
CN104857515B (zh) * 2014-02-25 2020-01-10 中国科学院上海药物研究所 一种控释给药的药芯组合物以及包含该药芯组合物的渗透泵制剂
CN105769753B (zh) * 2016-04-19 2019-10-29 浙江工业大学 一种温敏凝胶基质及其制备方法与应用
CN106937943A (zh) * 2017-04-20 2017-07-11 上药东英（江苏）药业有限公司 一种培哚普利及其盐的soluplus复合物固体分散体及其制备
SI3644970T1 (sl) * 2017-06-30 2022-05-31 Acrotech Biopharma Llc Nove oralne formulacije belinostata
CA3107665A1 (en) * 2018-07-30 2020-02-06 Chugai Seiyaku Kabushiki Kaisha Solid dispersion of hydantoin derivative
CN113015561A (zh) * 2018-11-27 2021-06-22 高露洁-棕榄公司 具有释放部件的口腔护理器具

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071643A (en) * 1986-10-17 1991-12-10 R. P. Scherer Corporation Solvent system enhancing the solubility of pharmaceuticals for encapsulation
ES2307482T3 (es) * 1999-02-10 2008-12-01 Pfizer Products Inc. Dispersiones farmaceuticas solidas.
US6264981B1 (en) * 1999-10-27 2001-07-24 Anesta Corporation Oral transmucosal drug dosage using solid solution
DE102005053066A1 (de) 2005-11-04 2007-05-10 Basf Ag Verwendung von Copolymeren als Solubilisatoren für in Wasser schwerlöslichen Verbindungen
WO2008037809A1 (en) * 2006-09-29 2008-04-03 Abbott Gmbh & Co. Kg Transmucosal administration of fibrate compounds and delivery system therefor
WO2009013202A1 (de) 2007-07-26 2009-01-29 Basf Se Verfahren zur herstellung von durch pfropfpolymerisation in lösung erhaltenen copolymeren auf basis von polyethern in fester form
WO2010034688A2 (de) * 2008-09-25 2010-04-01 Basf Se Verwendung von copolymeren auf basis von polyethern und vinylmonomeren als bindemittel für feste wirkstoffhaltige dosierungsformen
BRPI1012651A2 (pt) * 2009-03-31 2016-04-05 Basf Se processo para produzir preparações de substâncias fracamente solúveis em água
WO2010130728A2 (de) * 2009-05-13 2010-11-18 Basf Se Feste pharmazeutischen zubereitungen enthaltend copolymere auf basis von polyethern in kombination mit wasserschwerlöslichen polymeren
WO2011063164A2 (en) * 2009-11-18 2011-05-26 Steady Sleep Rx Co., Inc. Sustained release cannabinoid medicaments
EP2504033A1 (en) * 2009-11-24 2012-10-03 Basf Se Film-like pharmaceutical dosage forms
EP2536393B1 (en) * 2010-02-18 2014-04-16 AbbVie Deutschland GmbH & Co KG Test solvent for evaluating the compatibility of biologically active substances and graft copolymers

Also Published As

Publication number Publication date
IL231384A0 (en) 2014-04-30
JP2017200938A (ja) 2017-11-09
JP2014527976A (ja) 2014-10-23
SG11201400964PA (en) 2014-04-28
EP2760474A1 (en) 2014-08-06
WO2013045365A1 (en) 2013-04-04
NZ621872A (en) 2015-10-30
EP2572731A1 (en) 2013-03-27
RU2014116987A (ru) 2015-11-10
CO7071123A2 (es) 2014-09-30
CA2847800A1 (en) 2013-04-04
CN104039354A (zh) 2014-09-10
HK1200700A1 (en) 2015-08-14
KR20140069215A (ko) 2014-06-09
MX2014003673A (es) 2014-10-13
US20140296341A1 (en) 2014-10-02
AU2012314661B2 (en) 2017-08-03
CN104039354B (zh) 2016-09-21
AU2012314661A1 (en) 2014-03-20

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements
B350 Update of information on the portal [chapter 15.35 patent gazette]